My interests focus on applying and developing statistical and computational models to better understand the dynamics of infectious pathogens and disease control, and evaluating the effectiveness of health interventions.
Current Research
- Reviewing literature on the impact of childhood pneumococcal conjugate vaccines on the epidemiology of pneumococcal carriage and disease (see our Review on the indirect effects of paediatric pneumococcal conjugate vaccines on invasive pneumococcal disease, with author supplied Supplementary Appendix and Supplementary Table of Study Characteristics).
- Developing nuanced transmission models of pneumococcal carriage and disease, pneumococcal disease hospitalisations and assessing the cost-effectiveness of different vaccination strategies
Previous Research
- Quantifying respiratory syncytial virus infection kinetics from in vitro and in vivo infections, and determining antiviral efficacy from clinical trials data
- Modelling pneumococcal carriage transmission between mother-child pairs and assessing the impact of childhood pneumococcal conjugate vaccines on pneumococcal carriage transmission trends in rural and urban households
See Publications
Tinevimbo joined the Warwick Medical School - Clinical Trials Unit in July 2015, having previously worked in the Respiratory and Meningeal Pathogens Research Unit (RMPRU) at the University of the Witwatersrand, South Africa and in the Physical Modelling in Biology, Immunology and Ecology (PHYMBIE) research group at Ryerson University, Toronto, Canada. He was awarded his PhD in Computational and Applied Mathematics in 2011 from the University of the Witwatersrand. His current role within the Clinical Trials Unit is to undertake intensive research on the cost-effectiveness of interventions targeted at infectious diseases in England (see MEMVIE (Mathematical & Economic Modelling for Vaccination and Immunisation Evaluation) projects). He jointly works with a multidisciplinary team of modellers (Profs. Matt J. Keeling and Graham Medley), health economists (Profs. Stavros Petrou and Jason Madan), systematic reviewers (Drs. Pamela Royle and Alex Tsertsvadze ), and epidemiologists (Prof. Noel McCarthy).
- Staniszewska, Sophie, Hill, Edward M., Grant, Richard, Grove, Peter, Porter, Jarina, Shiri, Tinevimbo, Tulip, Sue, Whitehurst, Jane, Wright, Claire, Datta, Samik, Petrou, Stavros, Keeling, Matthew James, 2021. Developing a framework for public involvement in mathematical and economic modelling : bringing new dynamism to vaccination policy recommendations. The Patient - Patient-Centered Outcomes Research, 14, pp. 435-445
- Shiri, T., Kamran, K., Keaney, K., Mukherjee, G., McCarthy, Noel D., Petrou, Stavros, 2019. Pneumococcal disease : a systematic review of health utilities, resource use, costs, and economic evaluations of interventions. Value in Health, 22 (11), pp. 1329-1344
- Shiri, Tinevimbo, McCarthy, Noel D., Petrou, Stavros, 2019. The impact of childhood pneumococcal vaccination on hospital admissions in England : a whole population observational study. BMC Infectious Diseases, 19
- Panovska-Griffiths, Jasmina, Crowe, Sonya, Pagel, Christina, Shiri, Tinevimbo, Grove, Peter, Utley, Martin, 2018. A method for evaluating and comparing immunisation schedules that cover multiple diseases : illustrative application to the UK routine childhood vaccine schedule. Vaccine, 36 (35), pp. 5340-5347
- Shiri, Tinevimbo, Datta, Samik, Madan, Jason, Tsertsvadze, Alexander, Royle, Pamela, Keeling, Matthew James, McCarthy, Noel D., Petrou, Stavros, 2017. Indirect effects of childhood pneumococcal conjugate vaccination on invasive pneumococcal disease: a systematic review and meta-analysis. Lancet Global Health, 5 (1), pp. E51-E59
- Nzenze, Susan A., Madhi, Shabir A., Shiri, Tinevimbo, Klugman, Keith P., de Gouveia, Linda, Moore, David P., Karstaedt, Alan S., Tempia, Stefano, Nunes, Marta C., von Gottberg, Anne, 2017. Imputing direct and indirect vaccine effectiveness of childhood pneumococcal conjugate vaccine against invasive disease by surveying temporal changes in nasopharyngeal pneumococcal colonization. American Journal of Epidemiology, 186 (4), pp. 435-444
- Magombedze, Gesham, Shiri, Tinevimbo, Eda, Shigetoshi, Stabel, Judy R., 2017. Inferring biomarkers for Mycobacterium avium subsp. paratuberculosis infection and disease progression in cattle using experimental data. Scientific Reports, 7
- Kwatra , Gaurav, Adrian, Peter V., Shiri, Tinevimbo, Izu, Alane, Cutland, Clare L., Buchmann, Eckhart J., Madhi, Shabir A., 2016. Serotype-specific cell-mediated immunity associated with clearance of homotypic Group B Streptococcus rectovaginal colonization in pregnant women. The Journal of Infectious Diseases, 213 (12), pp. 1923-1926
- Kwatra, G., Adrian, P. V., Shiri, Tinevimbo, Buchmann, E. J., Cutland, C. L., Madhi, S. A., 2015. Natural acquired humoral immunity against serotype-specific group B Streptococcus rectovaginal colonization acquisition in pregnant women. Clinical Microbiology and Infection, 21 (6), pp. 568.e13-568.e21
- Nzenze, Susan A., von Gottberg, Anne, Shiri, Tinevimbo, van Niekerk, Nadia, de Gouveia, Linda, Violari, Avy, Nunes, Marta C., Madhi, Shabir A., 2015. Temporal changes in pneumococcal colonization in HIV-infected and HIV-uninfected mother-child pairs following transitioning from 7-valent to 13-valent pneumococcal conjugate vaccine, Soweto, South Africa. The Journal of Infectious Diseases, 212 (7), pp. 1082-1092
- Nzenze, S. A., Shiri, Tinevimbo, Nunes, M. C., Klugman, K. P., Kahn, K., Twine, R., de Gouveia, L., von Gottberg, A., Madhi, S. A., 2014. Temporal association of infant immunisation with pneumococcal conjugate vaccine on the ecology of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus nasopharyngeal colonisation in a rural South African community. Vaccine, 32 (42), pp. 5520-5530
- Kwatra , Gaurav, Adrian, Peter V., Shiri, Tinevimbo, Buchmann, Eckhart J., Cutland, Clare L., Madhi, Shabir A., 2014. Serotype-specific acquisition and loss of group B streptococcus recto-vaginal colonization in late pregnancy. PLoS One, 9 (6)
- Shiri, Tinevimbo, Auranen, Kari, Nunes, Marta C., Adrian, Peter V., van Niekerk, Nadia, de Gouveia, Linda, von Gottberg, Anne, Klugman, Keith P., Madhi, Shabir A., 2013. Dynamics of pneumococcal transmission in vaccine-naive children and their HIV-infected or HIV-uninfected mothers during the first 2 years of life. American Journal of Epidemiology, 178 (11), pp. 1629-1637
- Nunes, Marta C., Shiri, Tinevimbo, van Niekerk, Nadia, Cutland, Clare L., Groome, Michelle J., Koen, Anthonet, von Gottberg, Anne, de Gouveia, Linda, Klugman, Keith P., Adrian, Peter V., Madhi, Shabir A., 2013. Acquisition of Streptococcus pneumoniae in pneumococcal conjugate vaccine-naïve South African children and their mothers. The Pediatric infectious disease journal, 32 (5), pp. e192-205
- Nzenze, Susan A., Shiri, Tinevimbo, Nunes, Marta C., Klugman, Keith P., Kahn, Kathleen, Twine, Rhian, de Gouveia, Linda, von Gottberg, Anne, Madhi, Shabir A., 2013. Temporal changes in pneumococcal colonization in a rural African community with high HIV prevalence following routine infant pneumococcal immunization. The Pediatric infectious disease journal, 32 (11), pp. 1270-1278
- Shiri, Tinevimbo, Nunes, Marta C., Adrian, Peter V., Van Niekerk, Nadia, Klugman, Keith P., Madhi, Shabir A., 2013. Interrelationship of Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus colonization within and between pneumococcal-vaccine naïve mother-child dyads. BMC Infectious Diseases, 13
- Shiri, Tinevimbo, Welte, Alex, 2011. Modelling the impact of acute infection dynamics on the accumulation of HIV-1 mutations. Journal of Theoretical Biology, 279 (1), pp. 44-54
- Shiri, Tinevimbo, Welte, Alex, 2008. Transient antiretroviral therapy selecting for common HIV-1 mutations substantially accelerates the appearance of rare mutations. Theoretical Biology and Medical Modelling, 5
- Shiri, Tinevimbo, Garira, Winston, Musekwa, Senelani D., 2005. A two-strain hiv-1 mathematical model to assess the effects of chemotherapy on disease parameters. Mathematical Biosciences and Engineering, 2 (4), pp. 811-832