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Prof Annie Young

Job Title
Professor of Nursing
Department
WMS - Warwick Clinical Trials Unit
Phone
02476 151351
Research Interests

Subsequent to performing numerous clinical trials, there are several linked programmes of research that I am currently running. The unifying theme of my research portfolio is to present a rational basis for nursing intervention through the expedient of the clinical trial or when appropriate, qualitative methodology in the supportive care of patients including symptomatic care due to disease or treatments.

Thrombosis and Cancer: Stemming from my clinical practice, I developed a special interest in a common symptom of cancer and its treatment, thrombosis. I initiated, funded, implemented and completed a UK-wide study, WARP, of thrombosis prophylaxis in cancer patients with warfarin. This largest ever trial of its kind has led to various national and international thrombosis studies. I was invited in 2007, after interview, to join the Clinical Development Group for the National Institute for Clinical Excellence (NICE) clinical guidance on prophylaxis of thrombosis in hospitalised patients, published January 2010. I am currently Chief Investigator of the select-d pilot trial: Anticoagulation Therapy in SELECTeD Cancer Patients at Risk of Recurrence of Venous Thromboembolism (VTE); we are inviting 530 patients to assess the VTE recurrence rate and safety profile in patients receiving low molecular weight heparin or rivaroxaban for 6 months, in addition to assessing optimal duration of anticoagulation treatment (6 v 12 months).

PRO-REHAB: This National Institute for Health Research (NIHR)-funded pilot trial is exploring the optimal model of rehabilitation for patients living with and beyond cancer. After developing the rehabilitation intervention, we are randomising patients with prostate, lung, head and neck, colorectal and breast cancers to usual care vs home-based vs group-based holistic rehabilitation (a psychological, nutritional and exercise-based rehabilitation programme - as per patient needs).

Chemobrain: Following on from patients and carers identifying challenges around cognitive and memory impairment after chemotherapy, we are developing a multi-component study, exploring an intervention memory and attention adaptation therapy (MAAT) for patients; a support package for carers and identification of markers - radiological and blood - of chemobrain.

Mobile Phone Project: Working with the Department of Engineering, University of Oxford Lead Investigator For patients with colorectal and breast cancers, we tested novel technology where patients keyed in their side-effects of chemotherapy treatment via their mobile phones to their specialist nurses to evaluate clinical outcomes of timely monitoring and individual patient feedback. A pilot study of dose optimisation of oral chemotherapy was also successfully completed using this technology. This led to collaboration with the University of Warwick Institute for Digital Health where we implemented a 75 patient pilot study investigating the utility of a home care device (Health Buddy) for cancer patients.

  • Young, Annie M., Phillips, J., Marshall, A., Grumett, J., Dunn, Janet A., Lowe, S., Chapman, O., Lokare, A., 2014. Anticoagulation therapy in selected cancer patients at risk of recurrence of venous thromboembolism. 7th ITHIC, Published in Thrombosis Research, pp. S220-S220
  • Young, Annie M., 2011. Regarding mobile phone monitoring of chemotherapy patients. European Multidisciplinary Cancer Congress - Integrating Basic and Translational Science, Surgery, Radiotherapy, Medical Oncology, Advocacy and Care, Stockholm, Sweden, 23-27 September 2011
  • Larsen, M. E., Farmer, A., Weaver, A., Young, Annie M., Tarassenko, L., 2011. Mobile health for drug dose optimisation. Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS, Boston, MA, USA, 30 Aug -3 Sep 2011, Published in 2011 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 1540-1543
  • Larsen, M. E., Rowntree, J., Young, Annie M., Pearson, S., Smith, J., Gibson, O. J., Weaver, A., Tarassenko, L., 2008. Chemotherapy side-effect management using mobile phones. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology", Vancouver, BC, Canada, 20-25 Aug 2008, Published in 2008 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, pp. 5152-5155
Title Funder Award start Award end
Data Sharing agreement Linked to IDEATE record 33594: "Direct oral anticoagulants versus low-molecular weight heparins for the treatment of cancer-associated venous thromboembolism: an individual patient data meta-analysis Bayer plc 05 Jun 2020 04 Jun 2023
Mammographic surveillance in breast cancer patients aged 50 years or older National Institute for Health Research (DoH) 01 Mar 2013 28 Feb 2022
Strategic bid: NIHR Clinical Research Network West Midlands West Midlands (South) CLRN 01 Oct 2017 30 Sep 2018
Palliative Care CRSL Royal Wolverhampton Hospitals NHS Trust - New Cross Hospital 01 Apr 2017 31 Mar 2018
What factors lead to palliative care patients being admitted to acute hospitals National Institute for Health Research (DoH) 13 Feb 2017 12 Sep 2017
Holistic Needs Assessment and Care Planning Prostate Cancer UK 01 Feb 2016 31 Aug 2017
Palliative Care CRSL 16/17 Royal Wolverhampton Hospitals NHS Trust - New Cross Hospital 01 Dec 2016 30 Jun 2017
Research Capacity Funding for Researcher Support for the development of pilot trials for cancer patients University Hospitals Coventry and Warwickshire NHS Trust 01 Jun 2014 31 May 2017
preliminary work for Chemobrain Andrew Entwhistle 01 Feb 2016 31 Jan 2017
Supplementary funds to PRO-REHAB (33624) Royal Wolverhampton Hospitals NHS Trust - New Cross Hospital 01 Dec 2015 30 Nov 2016
Bladder Path: Image directed redesign of bladder cancer treatment pathways 46647 Award re-cost - HTA Full - Biomarker Trial National Institute for Health Research (DoH) 01 Apr 2016 30 Sep 2016
Select-D Sub-study- ISS-Concept. Bayer plc 01 Sep 2015 31 Aug 2016
CRN Palliative Care Clinical Research Speciality Lead Royal Wolverhampton Hospitals NHS Trust - New Cross Hospital 10 Jun 2015 09 Jun 2016
PPI Bursary - Annie Young National Institute for Health Research (DoH) 01 May 2015 30 Apr 2016
ACRN Funding for 3 years Select D Pharmacy staffing support. University Hospitals Coventry and Warwickshire NHS Trust 01 Apr 2013 31 Mar 2016
Holistic rehabilitation for cancer patients systematic review Royal Wolverhampton Hospitals NHS Trust - New Cross Hospital 04 Jan 2016 03 Mar 2016
The development and pilot trial of two programmes of rehabilitation for cancer survivors and unmet needs PRO REHAB. Recosting National Institute for Health Research (DoH) 01 Mar 2013 29 Feb 2016
BAYER - Investigator led research proposal: *SELECT-D* Duration of anticoagulation therapy in SELECTeD patients with advanced cancer at risk of recurrence of venous thromboembolism - Bayer plc 01 Oct 2012 30 Sep 2015
Potential health economic implications of a generic cancer biomarker screening strategy Cancer Research UK 01 Apr 2014 31 Mar 2015