Job Title
Professor of Metabolic Biochemistry
Department
WMS - Biomedical Sciences
Phone
024 76522798
Research Interests
The overall research interest of the laboratory is the regulation of fatty acid metabolism in health and disease, with particular emphasis on the changes related to insulin resistance and type-2 diabetes.
Specific interests include:
- The role of fatty acids in the control of insulin secretion, and disruption of insulin signalling
- Structure-function relationships of carnitine palmitoyltransferase 1 (CPT 1) and acetyl-CoA carboxylase 2 (ACC-2) with particular reference to the role of malonyl-CoA in the regulation of the intracellular content of long-chain acyl-CoA esters and products of their metabolism to complex lipids, in relation to the aetiology of insulin resistance and apoptosis
- The role of different diacylglycerol acyltransferases in the control, and cellular trafficking, of triacylglycerol in lipoprotein-secretory tissues
- The effects on acute hepatic insulin sensitivity of recurrent high-glycaemic intake
- Park, S. O., Zammit, Victor A., 2023. Effect of digital livestock system on animal behavior and welfare, and fatty acid profiles of egg in laying hens. Journal of Animal and Feed Sciences, 32 (2), pp. 174-180
- 'Villar, Jose, 'Ochieng, Roseline, 'Gunier, Robert B., 'Papageorghiou, Aris T., 'Rauch, Stephen, 'McGready, Rose, 'Gauglitz, Julia M., 'Barros, Fernando C., 'Vatish, Manu, 'Fernandes, Michelle, 'Zammit, Victor, 'Carrara, Verena I., 'Munim, Shama, 'Craik, Rachel, 'Barsosio, Hellen C., 'Carvalho, Maria, 'Berkley, James A., 'Ismail, Leila I. Cheikh, 'Norris, Shane A., 'Tshivuila-Matala, Chrystelle O. O. et al (Select to open full list), 2022. 'Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity : prospective observational multinational INTERBIO-21st fetal study. The Lancet Diabetes & Endocrinology
- Boachie, Joseph, Adaikalakoteswari, Antonysunil, Ga?zquez, Antonio, Zammit, Victor A., Larque?, Elvira, Saravanan, Ponnusamy, 2021. Vitamin B12 induces hepatic fatty infiltration through altered fatty acid metabolism. Cellular Physiology and Biochemistry, 55 (3), pp. 241-255
- Arduini, Arduino, Zammit, Victor A., Bonomini, Mario, 2020. Identification of trimethylamine N-oxide (TMAO)-producer phenotype is interesting, but is it helpful?. Gut, 69 (2), pp. 400-401
- Park, S. O., Zammit, V. A., 2019. Effect of feed restriction with betaine and ascorbic acid supplementation on caecal bacteria, short chain fatty acid, blood biomarker, duodenal morphology and growth performance of meat ducks under heat stress. European Poultry Science, 83
- Irshad, Zehra, Chmel, Nikola Paul, Adya, Raghu, Zammit, Victor A., 2019. Hepatic VLDL secretion : DGAT1 determines particle size but not particle number, which can be supported entirely by DGAT2. Journal of Lipid Research, 60, pp. 111-120
- Park, Byung-Sung, Um, Kyung-Hwan, Park, Sang-O, Zammit, Victor A., 2018. Effect of stocking density on behavioral traits, blood biochemical parameters and immune responses in meat ducks exposed to heat stress. Archives Animal Breeding, 61 (4), pp. 425-432
- Irshad, Zehra, Dimitri, Federica, Christian, Mark, Zammit, Victor A., 2017. Diacylglycerol acyltransferase 2 links glucose utilization to fatty acid oxidation in the brown adipocytes. Journal of Lipid Research, 58 (1), pp. 15-30
- Tarabra, Elena, An Lee, Ting-Wen, Zammit, Victor A., Vatish, Manu, Yamada, Eijiro, Pessin, Jeffrey E., Bastie, Claire C., 2017. Differential activation of Fyn kinase distinguishes saturated and unsaturated fats in mouse macrophages. Oncotarget
- Arduini, Arduino, Bonomini, Mario, Zammit, Victor A., 2016. Defining the potential antidepressant mode of action of acetyl-L-carnitine. Proceedings of the National Academy of Sciences of the United States of America, 113 (39), pp. E5698-E5699
- Casals, Núria, Zammit, Victor A., Herrero, Laura, Fadó, Rut, Rodríguez-Rodríguez, Rosalía, Serra, Dolors, 2016. Carnitine palmitoyltransferase 1C : from cognition to cancer. Progress in Lipid Research, 61, pp. 134-148
- Zammit, Victor A., Arduini, Arduino, 2016. Acetate trafficking in the heart : carnitine acyltransferases matter. Physiological Reports, 4 (19)
- Shaheen, Fozia, Grammatopoulos, Dimitris, Müller, Jürgen, Zammit, Victor A., Lehnert, Hendrik, 2014. Extra-nuclear telomerase reverse transcriptase (TERT) regulates glucose transport in skeletal muscle cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 1842 (9), pp. 1762-1769
- Zammit, Victor A., 2013. Hepatic triacylglycerol synthesis and secretion : DGAT2 as the link between glycaemia and triglyceridaemia. Biochemical Journal, 451 (1), pp. 1-12
- Wurie, Haja R., Buckett, Linda, Zammit, Victor A., 2012. Diacylglycerol acyltransferase 2 acts upstream of diacylglycerol acyltransferase 1 and utilizes nascent diglycerides andde novosynthesized fatty acids in HepG2 cells. FEBS Journal, 279 (17), pp. 3033-3047
- Wurie, Haja R., Buckett, L., Zammit, Victor A., 2011. Evidence that diacylglycerol acyltransferase 1 (DGAT1) has dual membrane topology in the endoplasmic reticulum of HepG2 cells. Journal of Biological Chemistry, Vol.286 (No.42), pp. 36238-36247
- Moran, Colin N., Barwell, Nicholas D., Malkova, Dalia, Cleland, Steve J., McPhee, I., Packard, Christopher J., Zammit, Victor A., Gill, J. M. R. (Jason M. R.), 2011. Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors. Metabolism, 60 (2), pp. 206-214
- Rao, J. N., Warren, G. Z. L., Estolt-Povedano, S., Zammit, Victor A., Ulmer, T. S., 2011. An environment-dependent structural switch underlies the regulation of carnitine palmitoyltransferase 1A. Journal of Biological Chemistry, Vol.286 (No.49), pp. 42545-42554
- Bonomini, Mario, Zammit, Victor A., Pusey, Charles D., De Vecchi, Amedeo, Arduini, Arduino, 2011. Pharmacological use of l-carnitine in uremic anemia : has its full potential been exploited?. Pharmacological Research, Vol.63 (No.3), pp. 157-164
- Jenei, Z. A., Warren, Gemma, Hasan, Muhammad, Zammit, Victor A., Dixon, Ann M., 2011. Packing of transmembrane domain 2 of carnitine palmitoyltransferase-1A affects oligomerization and malonyl-CoA sensitivity of the mitochondrial outer membrane protein. FASEB Journal, Vol.25 (No.12), pp. 4522-4530
- Singh, Harprit, Brindle, Nicholas P. J., Zammit, Victor A., 2010. High glucose and elevated fatty acids suppress signaling by the endothelium protective ligand angiopoietin-1. Microvascular Research, Vol.79 (No.2), pp. 121-127
- Price, Nigel T., Jackson, Vicky N., Müller, Jürgen, Moffat, Kevin G., Matthews, Karen L., Orton, Tim, Zammit, Victor A., 2010. Alternative exon usage in the single CPT1 gene of Drosophila generates functional diversity in the kinetic properties of the enzyme. Differential expression of alternatively spliced variants in Drosophila tissues. Journal of Biological Chemistry, Vol.285 (No.11), pp. 7857-7865
- Zammit, Victor A., 2009. Recent drug development for diabetes and obesity. Primary Health Care, Vol.19 (No.6), pp. 32-35
- Jenei, Zsuzsanna A., Borthwick, Karen, Zammit, Victor A., Dixon, Ann M., 2009. Self-association of transmembrane domain 2 (TM2), but Not TM1, incCarnitine palmitoyltransferase 1A role of GXXXG(A) motifs. Journal of Biological Chemistry, Vol.284 (No.11), pp. 6988-6997
- Moran, Colin N., Barwell, Nicholas D., Malkova, Dalia, Cleland, Steve J., McPhee, I., Packard, Christopher J., Zammit, Victor A., Gill, J. M. R. (Jason M. R.), 2009. Effects of diabetes family history and exercise training on the expression of adiponectin and leptin and their receptors. Proceedings of the Nutrition Society, 68 (OCE2)
- Arduini, Arduino, Bonomini, Mario, Savica, V., Amato, A, Zammit, Victor A., 2008. Carnitine in metabolic disease : potential for pharmacological intervention. Pharmacology & Therapeutics, Vol.120 (No.2), pp. 149-156
- Zammit, Victor A., 2008. Carnitine palmitoyltransferase 1: Central to cell function. IUBMB Life, Vol.60 (No.5), pp. 347-354
- Zammit, Victor A., Buckett, Linda K., Turnbull, Andrew V., Wure, Haja, Proven, Andrew, 2008. Diacylglycerol acyltransferases : potential roles as pharmacological targets. Pharmacology & Therapeutics, Vol.118 (No.3), pp. 295-302
- Barwell, Nicholas D., Malkova, Dalia, Moran, Colin N., Cleland, Steve J., Packard, Christopher J., Zammit, Victor A., Gill, J. M. R. (Jason M. R.), 2008. Exercise training has greater effects on insulin sensitivity in daughters of patients with type 2 diabetes than in women with no family history of diabetes. Diabetologia, 51 (10), pp. 1912-1919
- Borthwick, Karen, Jackson, Vicky N., Price, Nigel T., Zammit, Victor A., 2006. The mitochondrial intermembrane loop region of rat carnitine palmitoyltransferase 1A is a major determinant of its malonyl-CoA sensitivity. JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (44), pp. 32946-32952
- Grima, Joseph N., Gatt, Ruben, Zammit, Victor A., Williams, Jennifer J., Evans, Kenneth E., Alderson, Andrew, Walton, Richard I., 2007. Natrolite: a zeolite with negative Poisson's ratios. 28th International Conference on the Physics of Semiconductors, Vienna, Austria, 2006, Published in Journal of Applied Physics
- Arduini, Arduino, Zammit, Victor A., 2017. Acetate transport into mitochondria does not require a carnitine shuttle mechanism. Magnetic Resonance in Medicine, John Wiley & Sons, Inc
- 'Arduini, Arduino, 'Zammit, Victor A., 2016. 'A tennis lesson : sharp practice in the science behind the Sharapova case. Postgraduate Medical Journal, BMJ, pp. 429-430
- Zammit, Victor A., Ramsay, Rona R., Bonomini, Mario, Arduini, Arduino, 2009. Carnitine, mitochondrial function and therapy. Advanced Drug Delivery Reviews, Elsevier BV, pp. 1353-1362
- Zammit, Victor A., Arduini, Arduino, 2008. The AMPK-Malonyl-CoA-CPT1 axis in the control of hypothalamic neuronal function. Cell Metabolism, Cell Press
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Role of alternative pathways of triglyceride synthesis in muscle insulin resistance in humans at risk of type-2 diabetes | Diabetes UK | 01 Aug 2016 | 30 Nov 2019 |
| Visiting Researcher Agreement - Dr S-O Park | Kangwon National University | 01 Sep 2017 | 31 Jan 2018 |
| Dyslipidaemia and Hepatic Steatosis: Distinct Roles of DGAT2 and DGAT1 in Hepatocytes and Enterocytes | MRC | 01 Apr 2013 | 31 Mar 2017 |
| Amendment 1: Case studentship Haja Wurie - Determination of the intracellular localisation of the DGAT enzymes and the effects on metabolic function in different cell types | AstraZeneca UK Limited | 18 May 2009 | 30 Sep 2011 |
| The Role of Strutural Motifs Within the Transmembrane Domains of Cardiac CPT1B Determining its Distinctive Oligomerisation and Kinetic Characteristics | British Heart Foundation | 01 Sep 2008 | 31 Aug 2011 |
| BHF ACC2 Pilot Study: A pilot study to test the hypothesis that in cardiomyocytes ACC-2 association with mitochondria is reversible and controlled by factors tha affect cardiac fatty acid oxidation. | British Heart Foundation | 01 Mar 2010 | 28 Feb 2011 |
| Use of Pancreatic beta cells for the study of the role of CPT 1 activity in the control of insulin secretion | Royal Society | 04 Aug 2010 | 25 Aug 2010 |
| Determination of the intracellular localisation of the DGAT enzymes and the effects on metabolic function in different cell types | AstraZeneca | 01 Oct 2006 | 30 Sep 2009 |
| Role of DGAT 1 and 2 expression in cardiac muscle triglyceride synthesis and secretion | British Heart Foundation | 01 Jan 2006 | 31 Dec 2008 |
| Do conserved motifs in the transmembrane domains of CPTI from liver and muscle promote oligomerization in situ? | Diabetes UK | 01 Jul 2007 | 31 Mar 2008 |
| Do conserved motifs in the transmembrane domains of CPTI from liver and muscle propmote oligomerizationin situ? | Diabetes UK | 01 Apr 2007 | 31 Mar 2008 |
| MOLECULAR DETERMINANTS OF THE DISTINCTIVE KINETIC CHARACTERISTICS OF THE HUMAN M-CPT 1 ISOFORM | British Heart Foundation | 01 Jan 2005 | 31 Jul 2006 |
| MOLECULAR DETERMINANTS OF ACETYL-COA CARBOXYLASE-2 | British Heart Foundation | 01 Jan 2005 | 28 Feb 2006 |