Decoding mechanisms driving human germ cell development
Key information
Start date: March/ April 2025
Duration: Four years full-time (the first 3.5 years will be fully funded)
Entry requirements: Applicants must hold a 2:1 or above undergraduate degree (or equivalent) in a relevant subject (for example biology, genetics, biochemistry).
Eligibility: Open to UK students only
Application deadline: Closing date is 3 February 2025, with interviews commencing from 10 February 2025.
About the project
In mammals, the formation of gametes ensures the transfer of genetic and epigenetic information to the next generation. Abnormal gamete development can lead to infertility and Type II Germ Cell Tumors. The first step in the development of sperm and eggs is the specification of primordial germ cells (PGCs) in the early post-implantation embryo. During human PGC development, extensive epigenetic remodeling occurs, contributing to the "rejuvenation" of the germline and establishing the foundation for normal gametogenesis and embryonic development.
The overarching goal of our lab is to understand human germ cell development and recapitulate this process in cultured cells, providing a platform for screening risk factors for human fertility.
This project aims to shed light on epigenetic remodeling and transcriptional regulation in the human germline. To achieve this, the project combines advanced human embryonic stem cell-derived organoid systems, with state-of-the-art molecular techniques such as CUT&RUN and CRISPR tools, and computational data integration.
Who we're looking for
This position is ideally suited for a creative, independent-thinking, and ambitious PhD student with a strong interest in epigenetics, transcription regulation, and organoid systems. Experience in stem cell culture, bioinformatic data analysis, or molecular techniques such as ATAC-seq, CUT&RUN, ChIP-seq, or single-cell RNA-seq are advantageous for this project. A background in all these areas is not essential as the academic environment at the University of Warwick offers extensive training to support the development of this skill. Yet, a general interest in these techniques and a proactive approach to developing the associated expertise is essential.
Our lab puts a strong emphasis on providing a collaborative, integrative, academic atmosphere that allows co-workers within and beyond the group to thrive. Therefore, excellent teamwork and communication skills are essential.
How to apply
You can submit an online application for MPhil/PhD in Medicine via this webpage. If you have any queries please contact wmsrdcoord@warwick.ac.uk.