Physics Department News
Guiding the development of new nanoparticle biosensors
Recent work by the group of Prof. Matt Gibson in the Department of Chemistry, in collaboration with the interdepartmental XPS Facility, is expected to lead to nanoparticle biosensors with enhanced specificity, affinity, and stability. The effect of polymer structure on the coating of gold nanoparticles was studied in the context of grafting density, buffer stability, and in a lectin binding assay. The higher grafting density also enabled an increase in the number of carbohydrates which can be installed per nanoparticle at the chain ends, and gave increased binding in a lectin recognition assay.
For more information, see N.S. Ieong et al., J. Polym. Sci., Part A: Polym. Chem. 2016, 55, 1200–1208.