DEVELOPMENT OF NEW SOLID-STATE NMR TECHNIQUES FOR THE CHARACTERISATION OF PHARMACEUTICAL COMPOUNDS
Supervisor: Steven P. Brown
PhD Registration: September 2008–March 2012
The aim of the project is the development of Solid-State NMR pulse sequences to assist in structural characterisation and spectral interpretation. The structural and dynamical information captured from solid-state NMR is of particular interest to pharamceutical companies. The project is an industrial collaboration with GlaxoSmithKline and will involve spending time working at their premises over the duration of the project.
As well as results generated from spectrometers my work is complemented by using computational techniques: simulations generated using programs such as Spin Evolution and Simpson are able to focus on specific interactions of interest and investigate the viability of any future experimental work. Additionally experimental interpretations can be assisted by GIPAW calculations using the CASTEP platform.
Investigation into the effects of homonucelar decoupling, particularly within the context of heteronuclear spin echo experiments
14N-1H HMQC experiments
15N-1H spectral editing experiments
"Identifying Guanosine Self Assembly at Natural Isotopic Abundance by High-Resolution 1H and 13C Solid-State NMR Spectroscopy."
Amy L. Webber, Stefano Masiero, Silvia Pieraccini, Jonathan C. Burley, Andrew S. Tatton, Dinu Iuga, Tran N. Pham, Gian Piero Spada, and Steven P. Brown
NMRDG Postgraduate Meeting - June 2011, University of Birmingham
The UK 850 MHz Solid-State NMR Annual Symposium - April 2011, University of Warwick
7th Alpine Conference on Solid State NMR - September 2011, Chamonix
Rocky Mountain Solid State NMR conference - August 2010, Snowmass
RSC Structure Meeting - February 2010, Hinckley
6th Alpine Conference on Solid State NMR - September 2009, Chamonix
Teach in the First Year Undergraduate Electronics Workshop
- CASTEP workshop, Oxford University, August 2009
Department of Physics
University of Warwick
Tel: 024 761 50811
Email: a dot s dot tatton at warwick dot ac dot uk