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Department of Physics

Andrew Tatton

DEVELOPMENT OF NEW SOLID-STATE NMR TECHNIQUES FOR THE CHARACTERISATION OF PHARMACEUTICAL COMPOUNDS

Supervisor: Steven P. Brown

PhD Registration: September 2008–March 2012

The aim of the project is the development of Solid-State NMR pulse sequences to assist in structural characterisation and spectral interpretation. The structural and dynamical information captured from solid-state NMR is of particular interest to pharamceutical companies. The project is an industrial collaboration with GlaxoSmithKline and will involve spending time working at their premises over the duration of the project.

As well as results generated from spectrometers my work is complemented by using computational techniques: simulations generated using programs such as Spin Evolution and Simpson are able to focus on specific interactions of interest and investigate the viability of any future experimental work. Additionally experimental interpretations can be assisted by GIPAW calculations using the CASTEP platform.

Current Projects

  • Investigation into the effects of homonucelar decoupling, particularly within the context of heteronuclear spin echo experiments

  • 14N-1H HMQC experiments

  • 15N-1H spectral editing experiments

Publications

  • "Identifying Guanosine Self Assembly at Natural Isotopic Abundance by High-Resolution 1H and 13C Solid-State NMR Spectroscopy."

    Amy L. Webber, Stefano Masiero, Silvia Pieraccini, Jonathan C. Burley, Andrew S. Tatton, Dinu Iuga, Tran N. Pham, Gian Piero Spada, and Steven P. Brown

    DOI

Oral Presentations

  • NMRDG Postgraduate Meeting - June 2011, University of Birmingham

  • The UK 850 MHz Solid-State NMR Annual Symposium - April 2011, University of Warwick

Poster Presentations

  • 7th Alpine Conference on Solid State NMR - September 2011, Chamonix

  • Rocky Mountain Solid State NMR conference - August 2010, Snowmass

  • RSC Structure Meeting - February 2010, Hinckley

  • 6th Alpine Conference on Solid State NMR - September 2009, Chamonix

Additional Training

  • Teach in the First Year Undergraduate Electronics Workshop

  • CASTEP workshop, Oxford University, August 2009

Andy

Contact:

Andrew Tatton
Department of Physics
University of Warwick
Coventry
CV4 7AL

Tel: 024 761 50811
Internal: 50811
Email: a dot s dot tatton at warwick dot ac dot uk