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Biological Sciences Seminar

Biological Sciences Seminar: You Wait Ages for a Chaperone then two come along at once! - Hsp70s: an ubiquitous family of molecular chaperones

Date: Friday 10 March 2006

Time: 12:45-14:00

Venue: GLT2 Biological Sciences

Speaker: Professor C. Stirling, Faculty of Life Sciences, University of Manchester

Hsp70s are an ubiquitous family of molecular chaperones involved in many vital cellular processes including protein folding, quality control, organelle biogenesis and stress response. Central to their chaperone function is their ability to reversibly bind unfolded polypeptide chains. This activity requires an ATP-dependent conformational change that is regulated by specific co-chaperone partners. Eukaryotic cells encode numerous distinct Hsp70s of which several have been shown to functionally overlap. It had been assumed that such overlap reflected simple functional redundancy but we have recently found that Hsp70s interact with one another in order to co-ordinate their different activities.

Contact Dianne Brogan, Seminar Administrator on ext. 23508 or email or Hans Burgert, Seminar Organiser on ext. 24744 or email