Job Title
Associate Professor
Department
WMS - Biomedical Sciences
Phone
+44 24 76 522536
Email
Web Link
Research Interests
Trained as a circadian biologist and in vivo pharmacologist, my research is focused on the interplay between the intricate internal timing system significantly modulating most physiological processes, and disease and pharmacotherapy. Understanding - on a mechanistic level - how circadian disruption can lead to and influence disease progression and treatment is the main focus. The perspective of his work include to significantly improve already existing treatment options and to aid in the development of new drugs.
More information can be found on the Group Webpage
- Vlachou, Denise, Veretennikova, Maria, Usselmann, Laura Emma Jane, Vasilyev, Vadim, Ott, Sascha, Bjarnason, Georg A., Dallmann, Robert, Lévi, Francis, Rand, David A., 2024. TimeTeller : a tool to probe the circadian clock as a multigene dynamical system. PLoS Computational Biology
- Tomás, Ruben M. F., Dallmann, Robert, Congdon, Thomas R., Gibson, Matthew I., 2024. Cryopreservation of assay-ready hepatocyte monolayers by chemically-induced ice nucleation : preservation of hepatic function and hepatotoxicity screening capabilities. Biomaterials Science, 11 (23), pp. 7639-7654
- Marok, Fatima Zahra, Wojtyniak, Jan-Georg, Selzer, Dominik, Dallmann, Robert, Swen, Jesse J., Guchelaar, Henk-Jan, Schwab, Matthias, Lehr, Thorsten, 2024. Personalized chronomodulated 5-fluorouracil treatment : a physiologically based pharmacokinetic precision dosing approach for optimizing cancer therapy. Clinical Pharmacology & Therapeutics
- Vlachou, Denise, Veretennikova, Maria, Usselmann, Laura Emma Jane, Vasilyev, Vadim, Ott, Sascha, Bjarnason, Georg A., Dallmann, Robert, Lévi, Francis A., Rand, David A., 2024. TimeTeller : a tool to probe the circadian clock as a multigene dynamical system. PLoS Computational Biology, 20 (2)
- Wang, Jie, Dallmann, Robert, Lu, Renquan, Yan, Jing, Charmet, Jérôme, 2023. Flow rate-independent multiscale liquid biopsy for precision oncology. ACS Sensors, 8 (3), pp. 1200-1210
- Alcántara-Alonso, Viridiana, Dallmann, Robert, Lehnert, Hendrik, de Gortari, Patricia, Grammatopoulos, Dimitris K., 2023. CRH-R2 signalling modulates feeding and circadian gene expression in hypothalamic mHypoA-2/30 neurons. Frontiers in Endocrinology, 14
- Türk, Denise, Scherer, Nina, Selzer, Dominik, Dings, Christiane, Hanke, Nina, Dallmann, Robert, Schwab, Matthias, Timmins, Peter, Nock, Valerie, Lehr, Thorsten, 2023. Significant impact of time-of-day variation on metformin pharmacokinetics. Diabetologia, 66 (6), pp. 1024-1034
- 'Smith, Ciearra B., 'van der Vinne, Vincent, 'McCartney, Eleanor, 'Stowie, Adam C., 'Leise, Tanya L., 'Blanca, Martin-Burgos, 'Molyneux, Penny C., 'Garbutt, Lauren A, 'Brodsky, Michael H., 'Davidson, Alec J., 'Harrington, Mary E., 'Dallmann, Robert, 'Weaver, David R., 2022. 'Cell-type specific circadian bioluminescence rhythms in Dbp reporter mice. Journal of Biological Rhythms, 37 (1), pp. 53-77
- 'Gurnani, Pratik, 'Sanchez-Cano, Carlos, 'Xandri-Monje, Helena, 'Zhang, Junliang, 'Ellacott, Sean H., 'Mansfield, Edward D. H., 'Hartlieb, Matthias, 'Dallmann, Robert, 'Perrier, S?bastien, 2022. 'Probing the effect of rigidity on the cellular uptake of core-shell nanoparticles : stiffness effects are size dependent. Small
- 'Türk, Denise, 'Müller, Fabian, 'Fromm, Martin F., 'Selzer, Dominik, 'Dallmann, Robert, 'Lehr, Thorsten, 2022. 'Renal transporter?mediated drug?biomarker interactions of the endogenous substrates creatinine and N 1 ?methylnicotinamide : a PBPK modeling approach. Clinical Pharmacology & Therapeutics, 112 (3), pp. 687-698
- Jagannath, Aarti, Varga, Norbert, Dallmann, Robert, Rando, Gianpaolo, Gosselin, Pauline, Ebrahimjee, Farid, Taylor, Lewis, Mosneagu, Dragos, Stefaniak, Jakub, Walsh, Steven, Palumaa, Teele, Di Pretoro, Simona, Sanghani, Harshmeena, Wakaf, Zeinab, Churchill, Grant C., Galione, Antony, Peirson, Stuart N., Boison, Detlev, Brown, Steven A., Foster, Russell G. et al (Select to open full list), 2021. Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice. Nature Communications, 12 (1)
- Kumar, Swati, Needham, Russell J., Abraham, Kristin, Bridgewater, Hannah E., Garbutt, Lauren A, Xandri-Monje, Helena, Dallmann, Robert, Perrier, Sébastien, Sadler, Peter J., Lévi, Francis A., 2021. Dose and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice. Metallomics, 13 (2)
- Hancox, Thomas P. M., Skene, Debra J., Dallmann, Robert, Dunn, Warwick B., 2021. Tick-tock consider the clock : the influence of circadian and external cycles on time of day variation in the human metabolome - a review. Metabolites, 11 (5)
- Innominato, Pasquale F., Komarzynski, Sandra, Dallmann, Robert, Wreglesworth, Nicholas, Bouchahda, Mohamed, Karaboué, Abdoulaye, Ulusakarya, Ayhan, Subbe, Christian, Spiegel, David, Lévi, Francis A., 2021. Impact of assessment frequency of patient-reported outcomes : an observational study using an eHealth platform in cancer patients. Supportive Care In Cancer, 29, pp. 6167-6170
- Boltze, Johannes, Didwischus, Nadine, Merrow, Martha, Dallmann, Robert, Plesnila, N., 2021. Circadian effects on stroke outcome ? did we not wake up in time for neuroprotection?. Journal of Cerebral Blood Flow & Metabolism, 41 (3), pp. 684-686
- Stephenson, Ewan Michael, Usselmann, Laura Emma Jane, Tergaonkar, Vinay, Virshup, David, Dallmann, Robert, 2021. Cancer clocks in tumourigenesis : the p53 pathway and beyond. Endocrine-Related Cancer, 28 (4), pp. R95-R110
- Yan, Chang, Luo, Zhuo, Li, Wen, Li, Xue, Dallmann, Robert, Kurihara, Hiroshi, Li, Yi-Fang, He, Rong-Rong, 2020. Disturbed Yin-Yang balance : stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections. Acta Pharmaceutica Sinica B, 10 (3), pp. 383-398
- Charmet, Jérôme, Rodrigues, Rui, Yildirim, Ender, Kumar Challa, Pavan, Roberts, Benjamin, Dallmann, Robert, Whulanza, Yudan, 2020. Low-cost microfabrication tool box. Micromachines, 11 (2)
- Okyar, Alper, Kumar, Swati, Filipski, Elisabeth, Piccolo, Enza, Ozturk, Narin, Xandri-Monje, Helena, Pala-Kara, Zeliha, Abraham, Kristin, Gato de Jesus Gomes, Ana Rita, Orman, Mehmet N., Li, Robert Xiao-Mei, Dallmann, Robert, Lévi, Francis A., Ballesta, Annabelle, 2019. Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling. Scientific Reports, 9
- Cook, Alexander B., Peltier, Raoul, Zhang, Junliang, Gurnani, Pratik, Tanaka, Joji, Burns, James A., Dallmann, Robert, Hartlieb, Matthias, Perrier, Sébastien, 2019. Hyperbranched poly(ethylenimine-co-oxazoline) by thiol?yne chemistry for non-viral gene delivery : investigating the role of polymer architecture. Polymer Chemistry, 10 (10), pp. 1202-1212
- Zhang, Yuan, Giacchetti, Sylvie, Parouchev, Alexandre, Hadadi, Eva, Li, Xiaomei, Dallmann, Robert, Xandri-Monje, Helena, Portier, Lucie, Adam, René, Lévi, Francis A., Dulong, Sandrine, Chang, Yunhua, 2018. Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock. Cell Cycle, 17 (1), pp. 33-42
- Schmitt, Karen, Grimm, Amandine, Dallmann, Robert, Oettinghaus, Bjoern, Restelli, Lisa Michelle, Witzig, Melissa, Ishihara, Naotada, Mihara, Katsuyoshi, Ripperger, Jürgen A., Albrecht, Urs, Frank, Stephan, Brown, Steven A., Eckert, Anne, 2018. Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics. Cell Metabolism, 27 (3), pp. 657-666
- Gurnani, Pratik, Sanchez-Cano, Carlos, Abraham, Kristin, Xandri-Monje, Helena, Cook, Alexander B., Hartlieb, Matthias, Lévi, Francis A., Dallmann, Robert, Perrier, Sébastien, 2018. RAFT emulsion polymerization as a platform to generate well-defined biocompatible latex nanoparticles. Macromolecular Bioscience
- Bergamini, Giorgio, Mechtersheimer, Jonas, Azzinnari, Damiano, Sigrist, Hannes, Buerge, Michaela, Dallmann, Robert, Freije, Robert, Kouraki, Alfroditi, Opacka-Juffry, Jolanta, Seifritz, Erich, Ferger, Boris, Suter, Tobias, Pryce, Christopher R., 2018. Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice. Neurobiology of Stress, 8, pp. 42-56
- Innominato, Pasquale F., Komarzynski, Sandra, Palesh, Oxana G., Dallmann, Robert, Bjarnason, Georg A., Giacchetti , Syvie, Ulusakarya , Ayhan, Bouchahda, Mohamed, Haydar, Mazen, Ballesta, Annabelle, Karaboué, Abdoulaye, Wreglesworth, Nicholas I., Spiegel, David, Lévi, Francis A., 2018. Circadian rest-activity rhythm as an objective biomarker of patient-reported outcomes in patients with advanced cancer. Cancer Medicine, 7 (9), pp. 4396-4405
- Ballesta, Annabelle, Innominato, Pasquale F., Dallmann, Robert, Rand, D. A. (David A.), Lévi, Francis A., 2017. Systems chronotherapeutics. Pharmacological Reviews, 69 (2), pp. 161-199
- Martinez-Lozano Sinues, P., Kohler, M., Brown, S. A., Zenobi, R., Dallmann, Robert, 2017. Gauging circadian variation in ketamine metabolism by real-time breath analysis. Chemical Communications, 53 (14), pp. 2264-2267
- Jansen, Heiko T., Leise, Tanya, Stenhouse, Gordon, Pigeon, Karine, Kasworm, Wayne, Teisberg, Justin, Radandt, Thomas, Dallmann, Robert, Brown, Steven, Robbins, Charles T., 2016. The bear circadian clock doesn't ?sleep? during winter dormancy. Frontiers in Zoology, 13 (42)
- Dallmann, Robert, Okyar, Alper, Lévi, Francis A., 2016. Dosing-time makes the poison : circadian regulation and pharmacotherapy. Trends in Molecular Medicine, 22 (5), pp. 430-445
- Li, Xue, Martinez-Lozano Sinues, Pablo, Dallmann, Robert, Bregy, Lukas, Hollmén, Maija, Proulx, Steven, Brown, Steven A., Detmar, Michael, Kohler, Malcolm, Zenobi, Renato, 2015. Drug pharmacokinetics determined by real-time analysis of mouse breath. Angewandte Chemie International Edition, 54 (27), pp. 7815-7818
- Azzi, Abdelhalim, Dallmann, Robert, Casserly, Alison, Rehrauer, Hubert, Patrignani, Andrea, Maier, Bert, Kramer, Achim, Brown, Steven A., 2014. Circadian behavior is light-reprogrammed by plastic DNA methylation. Nature Neuroscience, 17 (3), pp. 377-382
- Dallmann, Robert, Brown, Steven A., Gachon, F., 2014. Chronopharmacology : new insights and therapeutic implications. Annual Review of Pharmacology and Toxicology, 54, pp. 339-361
- DeBruyne, Jason P., Weaver, David R., Dallmann, Robert, 2014. The hepatic circadian clock modulates xenobiotic metabolism in mice. Journal of Biological Rhythms, 29 (4), pp. 277-87
- DeBruyne, Jason P., Weaver, D. R., Dallmann, Robert, 2014. The hepatic circadian clock modulates xenobiotic metabolism in mice. Journal of Biological Rhythms, 29 (4), pp. 277-287
- Martinez-Lozano Sinues, Pablo, Tarokh, Leila, Li, Xue, Kohler, Malcolm, Brown, Steven A., Zenobi, Renato, Dallmann, Robert, 2014. Circadian variation of the human metabolome captured by real-time breath analysis. PLoS One, 9 (12), pp. 1-16
- Brown, Steven A., Kowalska, Elzbieta, Dallmann, Robert, 2012. (Re)inventing the circadian feedback loop. Developmental Cell, 22 (3), pp. 477-87
- Brown, Steven A., Kowalska, Elzbieta, Dallmann, Robert, 2012. (Re)inventing the circadian feedback loop.. Developmental Cell, 22 (3), pp. 477-87
- Dallmann, Robert, Viola, Antoine U., Tarokh, Leila, Cajochen, Christian, Brown, Steven A., 2012. The human circadian metabolome. Proceedings of the National Academy of Sciences of the United States of America, 109 (7), pp. 2625-2629
- Haefeli, Roman H., Erb, Michael, Gemperli, Anja C., Robay, Dimitri, Fruh, Isabelle Courdier, Anklin, Corinne, Dallmann, Robert, Gueven, Nuri, 2011. NQO1-dependent redox cycling of idebenone : effects on cellular redox potential and energy levels. PLoS One, 6 (3), pp. 1-12
- Dallmann, Robert, DeBruyne, Jason P., Weaver, David R., 2011. Photic resetting and entrainment in CLOCK-deficient mice. Journal of Biological Rhythms, 26 (5), pp. 390-401
- Dallmann, Robert, Weyermann, P., Anklin, C., Boroff, M., Bray-French, K., Cardel, B., Courdier-Fruh, I., Deppe, H., Dubach-Powell, J., Erb, M., Haefeli, R. H., Henneböhle, M., Herzner, H., Hufschmid, M., Marks, D. L., Nordhoff, S., Papp, M., Rummey, C., Santos, G., Schärer, F. et al (Select to open full list), 2011. The orally active melanocortin-4 receptor antagonist BL-6020/979 : a promising candidate for the treatment of cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle, 2 (3), pp. 163-174
| Title | Funder | Award start | Award end |
|---|---|---|---|
| Developing pipelines for organ-osmium compounds in biomedical research | Anglo Platinum Marketing Limited | 01 Jul 2021 | 30 Apr 2024 |
| MRC equipment full proposal | MRC | 01 Oct 2022 | 31 Mar 2023 |
| Imaging neural activity in freely behaving rodents at the single cell level | MRC | 01 Mar 2016 | 31 Aug 2017 |
| CRUK meeting and conference support - Quantitative Biomedicine Programme | Cancer Research UK | 01 Jun 2016 | 30 Sept 2016 |