Dr Robert Dallmann

Job Title

Associate Professor

Department

WMS - Biomedical Sciences

Phone

+44 24 76 522536

R.Dallmann@warwick.ac.uk

Web Link

Link

Research Interests

Trained as a circadian biologist and in vivo pharmacologist, my research is focused on the interplay between the intricate internal timing system significantly modulating most physiological processes, and disease and pharmacotherapy. Understanding - on a mechanistic level - how circadian disruption can lead to and influence disease progression and treatment is the main focus. The perspective of his work include to significantly improve already existing treatment options and to aid in the development of new drugs.

More information can be found on the Group Webpage

'Smith, Ciearra B., 'van der Vinne, Vincent, 'McCartney, Eleanor, 'Stowie, Adam C., 'Leise, Tanya L., 'Blanca, Martin-Burgos, 'Molyneux, Penny C., 'Garbutt, Lauren A, 'Brodsky, Michael H., 'Davidson, Alec J., 'Harrington, Mary E., 'Dallmann, Robert, 'Weaver, David R., 2022. 'Cell-type specific circadian bioluminescence rhythms in Dbp reporter mice. Journal of Biological Rhythms, 37 (1), pp. 53-77
'T?rk, Denise, 'M?ller, Fabian, 'Fromm, Martin F., 'Selzer, Dominik, 'Dallmann, Robert, 'Lehr, Thorsten, 2022. 'Renal transporter?mediated drug?biomarker interactions of the endogenous substrates creatinine and N 1 ?methylnicotinamide : a PBPK modeling approach. Clinical Pharmacology & Therapeutics
Boltze, Johannes, Didwischus, Nadine, Merrow, Martha, Dallmann, Robert, Plesnila, N., 2021. Circadian effects on stroke outcome ? did we not wake up in time for neuroprotection?. Journal of Cerebral Blood Flow & Metabolism, 41 (3), pp. 684-686
Hancox, Thomas P. M., Skene, Debra J., Dallmann, Robert, Dunn, Warwick B., 2021. Tick-tock consider the clock : the influence of circadian and external cycles on time of day variation in the human metabolome - a review. Metabolites, 11 (5)
Stephenson, Ewan Michael, Usselmann, Laura Emma Jane, Tergaonkar, Vinay, Virshup, David, Dallmann, Robert, 2021. Cancer clocks in tumourigenesis : the p53 pathway and beyond. Endocrine-Related Cancer
Kumar, Swati, Needham, Russell J., Abraham, Kristin, Bridgewater, Hannah E., Garbutt, Lauren A, Xandri-Monje, Helena, Dallmann, Robert, Perrier, Sébastien, Sadler, Peter J., Lévi, Francis A., 2021. Dose and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice. Metallomics, 13 (2)
Jagannath, Aarti, Varga, Norbert, Dallmann, Robert, Rando, Gianpaolo, Gosselin, Pauline, Ebrahimjee, Farid, Taylor, Lewis, Mosneagu, Dragos, Stefaniak, Jakub, Walsh, Steven, Palumaa, Teele, Di Pretoro, Simona, Sanghani, Harshmeena, Wakaf, Zeinab, Churchill, Grant C., Galione, Antony, Peirson, Stuart N., Boison, Detlev, Brown, Steven A., Foster, Russell G. et al (Select to open full list), 2021.

All authors for Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

Jagannath, Aarti, Varga, Norbert, Dallmann, Robert, Rando, Gianpaolo, Gosselin, Pauline, Ebrahimjee, Farid, Taylor, Lewis, Mosneagu, Dragos, Stefaniak, Jakub, Walsh, Steven, Palumaa, Teele, Di Pretoro, Simona, Sanghani, Harshmeena, Wakaf, Zeinab, Churchill, Grant C., Galione, Antony, Peirson, Stuart N., Boison, Detlev, Brown, Steven A., Foster, Russell G., Vasudevan, Sridhar R.

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice. Nature Communications, 12 (1)
'Innominato, Pasquale F., 'Komarzynski, Sandra, 'Dallmann, Robert, 'Wreglesworth, Nicholas, 'Bouchahda, Mohamed, 'Karabou?, Abdoulaye, 'Ulusakarya, Ayhan, 'Subbe, Christian, 'Spiegel, David, 'L?vi, Francis A., 2021. 'Impact of assessment frequency of patient-reported outcomes : an observational study using an eHealth platform in cancer patients. Supportive Care In Cancer, 29, pp. 6167-6170
Charmet, Jérôme, Rodrigues, Rui, Yildirim, Ender, Kumar Challa, Pavan, Roberts, Benjamin, Dallmann, Robert, Whulanza, Yudan, 2020. Low-cost microfabrication tool box. Micromachines, 11 (2)
Yan, Chang, Luo, Zhuo, Li, Wen, Li, Xue, Dallmann, Robert, Kurihara, Hiroshi, Li, Yi-Fang, He, Rong-Rong, 2020. Disturbed Yin-Yang balance : stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections. Acta Pharmaceutica Sinica B, 10 (3), pp. 383-398
Okyar, Alper, Kumar, Swati, Filipski, Elisabeth, Piccolo, Enza, Ozturk, Narin, Xandri-Monje, Helena, Pala-Kara, Zeliha, Abraham, Kristin, Gato de Jesus Gomes, Ana Rita, Orman, Mehmet N., Li, Robert Xiao-Mei, Dallmann, Robert, Lévi, Francis A., Ballesta, Annabelle, 2019. Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling. Scientific Reports, 9
Cook, Alexander B., Peltier, Raoul, Zhang, Junliang, Gurnani, Pratik, Tanaka, Joji, Burns, James A., Dallmann, Robert, Hartlieb, Matthias, Perrier, Sébastien, 2019. Hyperbranched poly(ethylenimine-co-oxazoline) by thiol?yne chemistry for non-viral gene delivery : investigating the role of polymer architecture. Polymer Chemistry, 10 (10), pp. 1202-1212
Bergamini, Giorgio, Mechtersheimer, Jonas, Azzinnari, Damiano, Sigrist, Hannes, Buerge, Michaela, Dallmann, Robert, Freije, Robert, Kouraki, Alfroditi, Opacka-Juffry, Jolanta, Seifritz, Erich, Ferger, Boris, Suter, Tobias, Pryce, Christopher R., 2018. Chronic social stress induces peripheral and central immune activation, blunted mesolimbic dopamine function, and reduced reward-directed behaviour in mice. Neurobiology of Stress, 8, pp. 42-56
Gurnani, Pratik, Sanchez-Cano, Carlos, Abraham, Kristin, Xandri-Monje, Helena, Cook, Alexander B., Hartlieb, Matthias, Lévi, Francis A., Dallmann, Robert, Perrier, Sébastien, 2018. RAFT emulsion polymerization as a platform to generate well-defined biocompatible latex nanoparticles. Macromolecular Bioscience
Zhang, Yuan, Giacchetti, Sylvie, Parouchev, Alexandre, Hadadi, Eva, Li, Xiaomei, Dallmann, Robert, Xandri-Monje, Helena, Portier, Lucie, Adam, René, Lévi, Francis A., Dulong, Sandrine, Chang, Yunhua, 2018. Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock. Cell Cycle, 17 (1), pp. 33-42
Innominato, Pasquale F., Komarzynski, Sandra, Palesh, Oxana G., Dallmann, Robert, Bjarnason, Georg A., Giacchetti , Syvie, Ulusakarya , Ayhan, Bouchahda, Mohamed, Haydar, Mazen, Ballesta, Annabelle, Karaboué, Abdoulaye, Wreglesworth, Nicholas I., Spiegel, David, Lévi, Francis A., 2018. Circadian rest-activity rhythm as an objective biomarker of patient-reported outcomes in patients with advanced cancer. Cancer Medicine, 7 (9), pp. 4396-4405
Schmitt, Karen, Grimm, Amandine, Dallmann, Robert, Oettinghaus, Bjoern, Restelli, Lisa Michelle, Witzig, Melissa, Ishihara, Naotada, Mihara, Katsuyoshi, Ripperger, Jürgen A., Albrecht, Urs, Frank, Stephan, Brown, Steven A., Eckert, Anne, 2018. Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics. Cell Metabolism, 27 (3), pp. 657-666
Martinez-Lozano Sinues, P., Kohler, M., Brown, S. A., Zenobi, R., Dallmann, Robert, 2017. Gauging circadian variation in ketamine metabolism by real-time breath analysis. Chemical Communications, 53 (14), pp. 2264-2267
Ballesta, Annabelle, Innominato, Pasquale F., Dallmann, Robert, Rand, D. A. (David A.), Lévi, Francis A., 2017. Systems chronotherapeutics. Pharmacological Reviews, 69 (2), pp. 161-199
Dallmann, Robert, Okyar, Alper, Lévi, Francis A., 2016. Dosing-time makes the poison : circadian regulation and pharmacotherapy. Trends in Molecular Medicine, 22 (5), pp. 430-445
Jansen, Heiko T., Leise, Tanya, Stenhouse, Gordon, Pigeon, Karine, Kasworm, Wayne, Teisberg, Justin, Radandt, Thomas, Dallmann, Robert, Brown, Steven, Robbins, Charles T., 2016. The bear circadian clock doesn't ?sleep? during winter dormancy. Frontiers in Zoology, 13 (42)
Li, Xue, Martinez-Lozano Sinues, Pablo, Dallmann, Robert, Bregy, Lukas, Hollmén, Maija, Proulx, Steven, Brown, Steven A., Detmar, Michael, Kohler, Malcolm, Zenobi, Renato, 2015. Drug pharmacokinetics determined by real-time analysis of mouse breath. Angewandte Chemie International Edition, 54 (27), pp. 7815-7818
Dallmann, Robert, Brown, Steven A., Gachon, F., 2014. Chronopharmacology : new insights and therapeutic implications. Annual Review of Pharmacology and Toxicology, 54, pp. 339-361
Azzi, Abdelhalim, Dallmann, Robert, Casserly, Alison, Rehrauer, Hubert, Patrignani, Andrea, Maier, Bert, Kramer, Achim, Brown, Steven A., 2014. Circadian behavior is light-reprogrammed by plastic DNA methylation. Nature Neuroscience, 17 (3), pp. 377-382
Martinez-Lozano Sinues, Pablo, Tarokh, Leila, Li, Xue, Kohler, Malcolm, Brown, Steven A., Zenobi, Renato, Dallmann, Robert, 2014. Circadian variation of the human metabolome captured by real-time breath analysis. PLoS One, 9 (12), pp. 1-16
DeBruyne, Jason P., Weaver, David R., Dallmann, Robert, 2014. The hepatic circadian clock modulates xenobiotic metabolism in mice. Journal of Biological Rhythms, 29 (4), pp. 277-87
DeBruyne, Jason P., Weaver, D. R., Dallmann, Robert, 2014. The hepatic circadian clock modulates xenobiotic metabolism in mice. Journal of Biological Rhythms, 29 (4), pp. 277-287
Brown, Steven A., Kowalska, Elzbieta, Dallmann, Robert, 2012. (Re)inventing the circadian feedback loop. Developmental Cell, 22 (3), pp. 477-87
Brown, Steven A., Kowalska, Elzbieta, Dallmann, Robert, 2012. (Re)inventing the circadian feedback loop.. Developmental Cell, 22 (3), pp. 477-87
Dallmann, Robert, Viola, Antoine U., Tarokh, Leila, Cajochen, Christian, Brown, Steven A., 2012. The human circadian metabolome. Proceedings of the National Academy of Sciences of the United States of America, 109 (7), pp. 2625-2629
Haefeli, Roman H., Erb, Michael, Gemperli, Anja C., Robay, Dimitri, Fruh, Isabelle Courdier, Anklin, Corinne, Dallmann, Robert, Gueven, Nuri, 2011. NQO1-dependent redox cycling of idebenone : effects on cellular redox potential and energy levels. PLoS One, 6 (3), pp. 1-12
Dallmann, Robert, DeBruyne, Jason P., Weaver, David R., 2011. Photic resetting and entrainment in CLOCK-deficient mice. Journal of Biological Rhythms, 26 (5), pp. 390-401
Dallmann, Robert, Weyermann, P., Anklin, C., Boroff, M., Bray-French, K., Cardel, B., Courdier-Fruh, I., Deppe, H., Dubach-Powell, J., Erb, M., Haefeli, R. H., Henneböhle, M., Herzner, H., Hufschmid, M., Marks, D. L., Nordhoff, S., Papp, M., Rummey, C., Santos, G., Schärer, F. et al (Select to open full list), 2011.

All authors for The orally active melanocortin-4 receptor antagonist BL-6020/979 : a promising candidate for the treatment of cancer cachexia

Dallmann, Robert, Weyermann, P., Anklin, C., Boroff, M., Bray-French, K., Cardel, B., Courdier-Fruh, I., Deppe, H., Dubach-Powell, J., Erb, M., Haefeli, R. H., Henneböhle, M., Herzner, H., Hufschmid, M., Marks, D. L., Nordhoff, S., Papp, M., Rummey, C., Santos, G., Schärer, F., Siendt, H., Soeberdt, M., Sumanovski, L. T., Terinek, M., Mondadori, C., Güven, N., Feurer, A.

The orally active melanocortin-4 receptor antagonist BL-6020/979 : a promising candidate for the treatment of cancer cachexia. Journal of Cachexia, Sarcopenia and Muscle, 2 (3), pp. 163-174

Middleton, Bethany J., Couling, Kevin, Dallmann, Robert, Goodship, Vannessa, Charmet, Jérôme, 2018. Low-cost injection moulding strategies for the fabrication of organ on a chip devices. BioMedEng18, London, 6-7 Sep 2018, Published in BioMedEng18

Title	Funder	Award start	Award end
Developing pipelines for organ-osmium compounds in biomedical research	Anglo Platinum Marketing Limited	01 Jul 2021	30 Jun 2023
Imaging neural activity in freely behaving rodents at the single cell level	MRC	01 Mar 2016	31 Aug 2017
CRUK meeting and conference support - Quantitative Biomedicine Programme	Cancer Research UK	01 Jun 2016	30 Sep 2016