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Oliver Windram

I am a PhD student at Warwick HRI currently in my four year of study.


My thesis title: Using a Systems Biology Approach to Elucidate Transcriptional Networks Regulating Plant Defence

Supervisor: Dr Katherine Denby

Department: Warwick HRI

Project Outline

The necrotrophic fungal pathogen Botrytis cinerea is a major agricultural concern due to its ability to cause significant damage to numerous economically important crops at both the post- and pre-harvest stages. Arabidopsis thaliana with its fully sequenced genome as well as a host of readily available genetic resources makes it a powerful tool for investigating plant pathogen interactions.

The aim of this project is to develop models of the defence signalling network activated in Arabidopsis thaliana in response to an infection by Botrytis cinerea by computational analysis of experimental data . Key regulatory components (genes termed 'hubs') of preliminary network models will be experimentally investigated to determine the interactive properties of these hubs within their local networks. The resulting experimental information will be fed back into the computational modelling process to refine pre-existing defence signalling network models.
Please take a look at my Project overview for a more detailed description.

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