Skip to main content


A complete up-to-date list of publications can be found on Google Scholar and full-texts might be available from the Warwick Research Active Portal (WRAP).

Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics

Mitochondrial fission-fusion dynamics and mitochondrial bioenergetics, including oxidative phosphorylation and generation of ATP, are strongly clock controlled. Here we show that these circadian oscillations depend on circadian modification of dynamin-related protein 1 (DRP1), a key mediator of mitochondrial fission. We used a combination of in vitro and in vivo models, including human skin fibroblasts and DRP1-deficient or clock-deficient mice, to show that these dynamics are clock controlled via circadian regulation of DRP1. Genetic or pharmacological abrogation of DRP1 activity abolished circadian network dynamics and mitochondrial respiratory activity and eliminated circadian ATP production. Pharmacological silencing of pathways regulating circadian metabolism and mitochondrial function (e.g., sirtuins, AMPK) also altered DRP1 phosphorylation, and abrogation of DRP1 activity impaired circadian function. Our findings provide new insight into the crosstalk between the mitochondrial network and circadian cycles.

Tue 27 February 2018, 21:27 | Tags: 2018 Original Article

Dosing time dependent in vitro pharmacodynamics of Everolimus despite a defective circadian clock

Everolimus (EV), a rapamycin analogue mTOR inhibitor, is used in the clinic to treat Estrogen positive (ER+) breast cancer in order to avoid the resistance to hormonotherapy. Here, we investigate if EV has different effects dependent on time of administration.

Paper in press in Cell Cycle

Tue 03 October 2017, 16:11 | Tags: 2017 Original Article

The bear circadian clock doesn’t ‘sleep’ during winter dormancy

  A new publication on a slightly more zoological topic: “The Bear Circadian Clock Doesn’t “Sleep” in Hibernation” in Frontiers of Zoology. The paper from lead author Heiko Jansen extends out knowledge on the responsiveness of the circadian clock during “hibernation” in bears. Even in torpid animals housed in constant conditions the clock remains responsive to stimuli light light. It also shows that bear fibroblasts grow really well in culture and human Bmal1 reporter constructs are useful to study their cellular clocks.
Wed 15 March 2017, 10:05 | Tags: 2016 Original Article

Gauging circadian variation in ketamine metabolism by real-time breath analysis

Graphical abstract: Gauging circadian variation in ketamine metabolism by real-time breath analysis
P. Martinez-Lozano Sinues, M. Kohler, S. A. Brown, R. Zenobi and R. Dallmann
Chemical Communications, DOI: 10.1039/C6CC09061C

Wed 15 March 2017, 09:52 | Tags: 2017 Original Article

Systems Chronotherapeutics

Annabelle Ballesta, Pasquale F. Innominato, Robert Dallmann, David A. Rand and Francis A. Lévi

Tue 14 March 2017, 16:45 | Tags: Review 2017