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Misread heart muscle gene a new clue to risk of sudden cardiac death
Scientists have discovered that a drug which increases the risk of sudden cardiac death interacts with mistranslated protein-coding genes present in heart muscle. Joint work by researchers in the Department of Chemistry, Warwick Medical School
and at the SEEK drug discovery group
, just published in the Royal Society of Chemistry journal Chemical Communications
, shows that flecainide appears to interact with just such an ARF protein, the "normal" version of which is crucial to heart function.