Collaborative work between the Blindauer group and the teams of Prof. Wladek Minor (University of Virginia), Dr Maksymilian Chruszcz (University of South Carolina) and Dr Alan Stewart (University of St. Andrews) has been highlighted in a press release entitled “Here’s How Your Body Transports Zinc to Protect Your Health“.

This relates to a recent joint publication which reports the first X-ray crystal structures of human and equine serum albumins bound to zinc. Serum albumin is the major carrier of zinc in the blood and is required for the effective systemic distribution of this essential nutrient. The new findings are published in the RSC journal Chemical Science. Full text of the open-access article is available here.

An antibody that senses one enantiomer of plant hormone abscisic acid (ABA) is characterised and published by Marsh and Napier groups in Chemistry and Life Sciences in PLOS ONE.

Collaborative research with Warwick Medical School and UHCW NHS Trust reveals new clues to widely prescribed therapeutics' actions in body. Simvastatin sodium salt and fluvastatin interact with human gap junction gamma-3 protein in PLOS ONE Press coverage in Health Spectator.

Collaborative work involving Lewandowski group was published in PNAS. The study led P. van der Wel (U. Pittsburgh) provides insights on structure and formation mechanism for huntingtin exon 1 fibrils implicated in Hungtington disease. Read more here.

The GibsonGroup's latest research into the use of biomaterials to increase the availability of donor cells has been published in Angewandte Chemie. Donor cells (e.g blood, bone marrow) are crucial to modern healthcare but due to their short shelf life they must be frozen using organic solvents as 'antifreezes'. The Gibson group has pionnered the use of synthetic polymers which inhibit ice crystal growth and their application to cryopreservation. In this work, a collaboraiton with Prof. Steve Armes at Sheffield, the team used biomimetic block copolymer micelles to provide a hydrated 'matrix' around the cells, which in combination with ice inhibiting polymers enable succesful cryopreservation of red blood cells. This is the first example of a cryopreservation system using entirely synthetic polymer materials, providing control and additional functionality into the system. Post-thawing, the micelles warm up, and become 'worm-like' which enabled the direct formation of a hydrogel, which is of interest for tissue engineering.

Read the paper here

Combining Biomimetic Block Copolymer Worms with an Ice-Inhibiting Polymer for the Solvent-Free Cryopreservation of Red Blood Cells

An Angew. Chem. VIP from Lewandowski group investigates the influence of different intermolecular interactions on protein dynamics. The paper presents first ever extensive site-specific relaxation measurements on a large non-crystalline protein-antibody complex in a few nanomole quantities. The study paves the way for direct characterization of dynamics in biologically important but sensitivity-limited samples of proteins within large complexes.

Warwick Chemistry, Life Science and Medical School team up to make a new generation of readily self-assembled metallohelices kill cancer cells at very low concentration (40 nM) but have low toxicty to microbes, insects and healthy human cells.

A recent paper by the GibsonGroup in Chem Commun has been highlighted in the RSC Magazine 'Chemistry World'. The Gibson Group have a research program focussed on mimicking the function of Antifreeze Proteins which are found in Polar fish species. These proteins can slow the rate of ice growth, which has been identified as a challenge in the cryopreservation of donor cells and tissue for transplantation. In this work they showed a facile route to new cryoprotective polymers, using cheap, commodity polymer starting materials. These polymers were shown to have ice growth inhibition activity and to signficantly reduce the ice-induced damage during red blood cell freeze/thaw storage. In a second paper, the group also reported signficantly enhanced cryopreservation using poly(vinyl alcohol).

Read the Chemistry World article here

Read the Chemical Communications article here; Rational, yet simple, design and synthesis of an antifreeze-protein inspired polymer for cellular cryopreservation

Read our recent ACS Biomaterials Science and Enginneering paper here Glycerol Free Cryopreservation of Red Blood Cells Enabled by Ice Recrystallization Inhibiting Polymers

Józef Lewandowski was awarded Anatole Abragam Prize of International Society of Magnetic Resonance "for his outstanding accomplishments to date and his promise in the development of solid-state NMR methodology and its application to the study of biomolecular structure and dynamics." The prize will be presented during ISMAR Conference in Shanghai.

At the Chemistry Departments annual postgraduate symposium, Robert Deller (GibsonGroup) and Athina anastasaki (HaddletonGroup) won the prizes for the best PhD Theses. The Thesis prize is Sponsored by the Faculty of Science.

The Bugg and Gibson groups are involved in 2 new projects intended to promote translation of new technologies. These projects are funded by the Industrial Biocatalyst program supported by Innovate UK, BBSRC and EPSRC and span a range of UK universities and companies.

Dr Matthew Gibson has been awarded the RSC/Dextra Medal for Carbohydrate Science. This award, which is sponsored by Dextra Laboratories, was founded in 1970. It is presented to a scientist in the early/mid stage of their career for meritorious work in carbohydrate chemistry that has largely been conducted in the UK.

Matt will present a lecture, and recieve the medal at the joint RSc/COST MultiglycoNano Meeting in Bangor, Wales, in April.

To read more about the GibsonGroup's research visit their webpage.