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Gregory Kowald

Gregory R. Kowald

MChem


Chemical Biology Research Facility

Department of Chemistry

University of Warwick

Coventry

CV4 7AL


Tel. +44 24 765 73822

g dot r dot kowald at warwick dot ac dot uk

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PhD Project Title: -

"Structure and properties of earthworm metallothionein-2"


Outline: -

To develop and improve the methods used to isolate and characterise the three currently known metallothionein isoforms (wMT-1, wMT-2, wMT-3) in the earthworm Lumbricus rubellus, and to understand the chemical basis of the reactivity of metal ion clusters within earthworm metallothionein in general.

Work will include:

  • Elucidation of structure (as close to native protein as possible) of wMT-2.
  • Investigation of thermodynamics, specificity and affinities for binding metal ions of wMT-2.
  • Investigation into the structural features of wMT-2, with comparison to similar metallothioneins.


Achievements: -
  • Year 2 Departmental Poster Prize - 1st Place
  • Year 3 Departmental Talk Prize - Runner-Up
  • Metallomics 2011 Poster Prize - 1st Place