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Chemistry Blindauer Group

Publications

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Here are some links to relevant publications (Non-exhaustive list; Subscription might be required for some of them)

Structural and biochemical characterisation of Co2+-binding sites on serum albumins and their interplay with fatty acids (2023) (Published in Chemical Science)Link opens in a new window

Bacterial catabolism of membrane phospholipids links marine biogeochemical cycles (2023) (Published in Science Advances)Link opens in a new window

Direct determination of free Zn concentration in samples of biological interest (2022) (Pubished in Analytica Chimica Acta)Link opens in a new window

A single sensor controls large variations in zinc quotas in a marine cyanobacterium (2022) (Published in Nature Chemical Biology)Link opens in a new window

Albumin-mediated extracellular zinc speciation drives cellular zinc uptake (2022) (Published in Chemical Communications)Link opens in a new window

A metallothionein from an open ocean cyanobacterium removes zinc from the sensor protein controlling its transcription (2022) (Published in Journal of Inorganic Biochemistry)Link opens in a new window

SLink opens in a new windowpeciomics as Link opens in a new windowa concept involving chemical speciation and omics (2022) (Published in Journal of Proteomics)Link opens in a new window

Fatty acids may influence insulin dynamics through modulation of albumin-Zn2+ interactions (2021) (Published in BioEssays)Link opens in a new window

The Interplay between Non-Esterified Fatty Acids and Plasma Zinc and Its Influence on Thrombotic Risk in Obesity and Type 2 Diabetes (2021) (Published in Int. J. Mol. Sci)Link opens in a new window

Albumin Substitution in Decompensated Liver Cirrhosis: Don’t Forget Zinc (2021) (Published in Nutrients)Link opens in a new window

Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes (2021) (published in Chemical Science)Link opens in a new window

A metalloproteomic analysis of interactions between plasma proteins and zinc: elevated fatty acid levels affect zinc distribution (2019) (published in Metallomics)Link opens in a new window

Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes (2019) (published in Nutrients)Link opens in a new window

Crosstalk between zinc and free fatty acids in plasma (2019) (published in BBA Molecular and Cell Biology of Lipids)Link opens in a new window

Book Chapter - Metalloproteomics (2019) (published in Clinical and Translational Perspectives on WILSON DISEASE)

The type 4 metallothionein from Brassica napus seeds folds in a metal-dependent fashion and favours zinc over other metals (2018) (published in Metallomics)Link opens in a new window

Ischemia-modified albumin: Crosstalk between fatty acid and cobalt binding (2018) (published in Prostaglandins, Leukotrienes and Essential Fatty Acids)Link opens in a new window

Bacterial zinc uptake regulator proteins and their regulons (2018) (published in Biochemical Society Transactions)Link opens in a new window
Native electrospray mass spectrometry approaches to probe the interaction between zinc and an anti-angiogenic peptide from histidine-rich glycoprotein (2018) (published in Sci. Rep.)Link opens in a new window
Differential reactivity of closely related zinc(II)-binding metallothioneins from the plant Arabidopsis thaliana (2018) (published in J. Inorg Biol. Chem.)Link opens in a new window
The potent anti-cancer activity of Dioclea lasiocarpa lectin (2017) (published in J. Inorg. Biochem.)Link opens in a new window
Metallothionein from Wild Populations of the African Catfish Clarias gariepinus: From Sequence, Protein Expression and Metal Binding Properties to Transcriptional Biomarker of Metal Pollution (2017) (published in Int. J. Mol. Sci).Link opens in a new window
O2-independent demethylation of trimethylamine N-oxide by Tdm of Methylocella silvestris (2016) (published in FEBS J.) Link opens in a new window
Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins (2016) (published in Chemical Science)Link opens in a new window
Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase (2016) (published in Scientific Reports)Link opens in a new window
Unexpected Interactions of the Cyanobacterial Metallothionein SmtA with Uranium (2016) (published in Inorganic Chemistry)Link opens in a new window

Fatty acid-mediated inhibition of metal binding to the multi-metal site on serum albumin: Implications for cardiovascular disease (2016) (Published in Current Trends in Medicinal Chemistry)Link opens in a new window

Earthworm Lumbricus rubellus MT-2: Metal Binding and Protein Folding of a True Cadmium-MT (2016) (published in International Journal of Molecular Sciences)Link opens in a new window

Advances in the molecular understanding of biological zinc transport (2015) (Feature Article published in Chemical Communications)Link opens in a new window

Plasma free fatty acid levels influence Zn2+-dependent histidine-rich glycoprotein–heparin interactions via an allosteric switch on serum albumin (2015) (published in Journal of Thrombosis and Haemostasis)Link opens in a new window

Identification of major zinc-binding proteins from a marine cyanobacterium: insight into metal uptake in oligotrophic environments (2014) (published in Metallomics) Link opens in a new window

Protein Disulfide-Isomerase Interacts with a Substrate Protein at All Stages along Its Folding Pathway (2014) (Published in PLOSOne)Link opens in a new window

A canonical EF-loop directs Ca2+-sensitivity in phospholipase C-η2 (2014) (published in J. Cell Biochem.)Link opens in a new window

Allosteric modulation of zinc speciation by fatty acids (2013) (published in Biochim. Biophys. Acta General Subjects)Link opens in a new window

Diversity and distribution of plant metallothioneins: a review of structure, properties and functions (2013) (published in Metallomics)Link opens in a new window

Elemental composition of natural populations of key microbial groups in Atlantic waters (2013) (published in Environmental Microbiology)Link opens in a new window

Lessons on the critical interplay between zinc binding and protein structure and dynamics (2013) (published in J. Inorg. Biochem.Link opens in a new window - Early Career Focused Review)

Resolution of a paradox by native mass spectrometry: facile occupation of all four metal binding sites in the dimeric zinc sensor SmtB (2013) (published in Chem. Commun.)Link opens in a new window
Allosteric Inhibition of Cobalt Binding to Albumin by Fatty Acids: Implications for the Detection of Myocardial Ischemia (2012) (published in J. Med. Chem.)Link opens in a new window
Mining genomes of marine cyanobacteria for elements of zinc homeostasis (2012)(published in Frontiers in Microbiology)Link opens in a new window
Protein fractionation and detection for metalloproteomics: challenges and approaches (2012) (published in Anal. Bioanal. Chem.) Link opens in a new window
Fractionation and identification of metalloproteins from a marine cyanobacterium (2012) (published in Anal. Bioanal. Chem.) Link opens in a new window
A Molecular Mechanism for Modulating Plasma Zn Speciation by Fatty Acids (2012). (published in JACS)Link opens in a new window
The Tat protein export pathway and its role in cyanobacterial metalloprotein biosynthesis (2011) (published in FEMS Microbiology Lett.)Link opens in a new window
C. elegans metallothioneins: response to and defence against ROS toxicity (2011). (published in Molecular BioSystems) Link opens in a new window
Bacterial Metallothioneins: past, present and questions for the future (2011). (published in J. Biol. Inorg. Chem.)Link opens in a new window
Tools for metal ion sorting: in vitro evidence for partitioning of zinc and cadmium in C. elegans metallothionein isoforms (2011). (published in Chem. Commun.)Link opens in a new window
Zinc transfer from the embryo-specific metallothionein EC from wheat: a case study (2010). (published in Phys. Chem. Chem. Phys.) Link opens in a new window
Cytosolic metal handling in plants: determinants for zinc specificity in metal transporters and metallothioneins (2010). (published in Metallomics)Link opens in a new window
The two C. elegans metallothioneins (CeMT1 and CeMT2) discriminate between essential zinc and toxic cadmium (2010). (published in FEBS J.)Link opens in a new window
The isolated Cys2His2 site in EC metallothionein mediates metal-specific protein folding (2010) (published in Mol. BioSyst.)Link opens in a new window

Metallothioneins: unparalleled diversity in structures and functions for metal ion homeostasis and more (2010) (published in Nat. Prod. Rep.)Link opens in a new window

Plasma fatty acid levels may regulate the Zn2+-dependent activities of histidine-rich glycoprotein (2009) (published in Biochimie)

Structure, Properties, and Engineering of the Major Zinc Binding Site on Human Albumin (2009)Link opens in a new window(published in J. Biol. Chem.)

Albumin as a zinc carrier – properties of its high-affinity zinc-binding site (2008)Link opens in a new window(published in Biochem. Soc. Trans.)
Zinc-handling in cyanobacteria: an update (2008) (published in Chem. Biodiv.)
Metallothioneins with unusual residues: Histidines as modulators of zinc affinity and reactivity (2008) (published in J. Inorg. Biochem.)Link opens in a new window
Toward a property/function relationship for metallothioneins: Histidine coordination and unusual cluster composition in a zinc-metallothionein from plants (2007) (published in Proteins: Structure, Function and Bioinformatics)
Histidine ligands in bacterial metallothionein enhance cluster stability (2007) (published in J. Biol. Inorg. Chem.)
Differential reactivity of individual zinc ions in clusters from bacterial metallothioneins (2007) (published in Inorg. Chim. Acta)Link opens in a new window
Metal complexes of N,N,N′,N′-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN): Variable coordination numbers and geometries (2006) (published in Polyhedron)
Probing the substrate specificities of human PHOSPHO1 and PHOSPHO2 (2005) (published in BBA: Proteins and Proteomics)Link opens in a new window
Role of Tyr84 in controlling the reactivity of Cys34 of human albumin (2005) (published in FEBS J.)Link opens in a new window
How to Hide Zinc in a Small Protein (2005) (published in Acc. Chem. Res.)

A novel copper site in a cyanobacterial metallochaperone (2004) (published in Biochem. J.)

Comparative modelling of human PHOSPHO1 reveals a new group of phosphatases within the haloacid dehalogenase superfamily (2003) (published in Protein engineering, design and selection)

Interdomain Zinc Site on Human Serum Albumin (2003) (Published in PNAS)

Inert Site in a Protein Zinc Cluster: Isotope Exchange by High Resolution Mass Spectrometry (2003) (published in JACS)
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Multiple bacteria encode metallothioneins and SmtA-like zinc fingers (2002) (published in Mol. Microbiol.)

A metallothionein containing a zinc finger within a four-metal cluster protects a bacterium from zinc toxicity (2001) (published in PNAS)