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Chemistry Tim Bugg Group

Publications - 2006

  • Directed evolution of a non-heme-iron-dependent extradiol catechol dioxygenase: identification of mutants with intradiol oxidative cleavage activity. J. Schlosrich, K. L. Eley, P. J. Crowley, T. D. H. Bugg, ChemBioChem (2006), 7(12), 1899-1908.
  • Fluorescent reagents for in vitro studies of lipid-linked steps of bacterial peptidoglycan biosynthesis: derivatives of UDPMurNAc-pentapeptide containing D-cysteine at position 4 or 5. J. A. Schouten,  S. Bagga, A. J. Lloyd, G. de Pascale, C. G. Dowson, D. I. Roper,  T. D. H. Bugg, Molecular BioSystems (2006), 2(10), 484-491.
  •  Catalytic role for arginine 188 in the C-C hydrolase catalytic mechanism for Escherichia coli MhpC and Burkholderia xenovorans LB400 BphD. C. Li, J.-J. Li, M. G. Montgomery, S. P. Wood, T. D. H. Bugg, Biochemistry (2006), 45(41), 12470-12479.
  • Evidence for a gem-Diol Reaction Intermediate in Bacterial C-C Hydrolase Enzymes BphD and MhpC from 13C NMR Spectroscopy. J.-J. Li, C. Li, C. A. Blindauer, T. D. H. Bugg, Biochemistry (2006), 45(41), 12461-12469.
  • Phospho-MurNAc-pentapeptide translocase (MraY) as a target for antibacterial agents and antibacterial proteins. T. D. H. Bugg, A. J. Lloyd, D. I. Roper, Infectious Disorders: Drug Targets (2006), 6(2), 85-106.
  • Selection of peptide inhibitors against the Pseudomonas aeruginosa MurD cell wall enzyme. C. Paradis-Bleau, M. Beaumont,  L. Boudreault, A. Lloyd, F. Sanschagrin, T. D. H. Bugg, R. C. Levesque, Peptides (2006), 27(7), 1693-1700.
  • Antibiotic action and peptidoglycan formation on tethered lipid bilayer membranes. M. J. Spencelayh, Y. Cheng, R. J. Bushby, T. D. H. Bugg, J.-J. Li, P. J. F. Henderson, J. O'Reilly, S. D. Evans, Angewandte Chemie, (2006), 45(13), 2111-2116.
  • Arene cis-dihydrodiol formation: from biology to application. D. R. Boyd, T. D. H. Bugg, Organic & Biomolecular Chemistry (2006), 4(2), 181-192.
  • Interaction of the transmembrane domain of lysis protein E from bacteriophage phiX174 with bacterial translocase MraY and peptidyl-prolyl isomerase SlyD. S, Mendel, J. M. Holbourn, J. A. Schouten, T. D. H. Bugg Microbiology (2006), 152(10), 2959-67.