Publications - 2008
- Kinetic Characterization of Lipid II-Ala: Alanyl-tRNA Ligase MurN from Streptococcus pneumoniae using semi-synthetic aminoacyl-lipid II substrates G. De Pascale, A. J. Lloyd, J. A. Schouten, A. M. Gilbey, D. I. Roper, C. G. Dowson & T. D. H. Bugg, Journal of Biological Chemistry (2008), 283, 34571-34579.
- Crystal Structure and Functional Assignment of YfaU, a Metal Ion Dependent Class II Aldolase from Escherichia coli K12. D. Rea, R. Hovington, J. F. Rakus, J. A. Gerlt, V. Fulop, T. D. H. Bugg, D. I. Roper, Biochemistry (2008), 47(38), 9955-9965.
- Evidence from Mechanistic Probes for Distinct Hydroperoxide Rearrangement Mechanisms in the Intradiol and Extradiol Catechol Dioxygenases. M. Xin, T. D. H. Bugg, Journal of the American Chemical Society (2008), 130(31), 10422-10430.
- Identification of a novel β-replacement reaction in the biosynthesis of 2,3-diaminobutyric acid in peptidylnucleoside mureidomycin A. W.-H. Lam, K. Rychli, T. D. H. Bugg, Organic & Biomolecular Chemistry (2008), 6(11), 1912-1917.
- Non-heme iron-dependent dioxygenases: unravelling catalytic mechanisms for complex enzymatic oxidations. T. D. H. Bugg, S. Ramaswamy, Current Opinion in Chemical Biology (2008), 12(2), 134-40.
- Evolution of peptidoglycan biosynthesis under the selective pressure of antibiotics in Gram-positive bacteria. J.-L. Mainardi, R. Villet, T. D. H. Bugg, C. Mayer, M. Arthur, FEMS Microbiology Reviews (2008), 32(2), 386-408.
- The biosynthesis of peptidoglycan lipid-linked intermediates. A. Bouhss, A. E. Trunkfield, T. D. H. Bugg, D. Mengin-Lecreulx, FEMS Microbiology Reviews (2008), 32(2), 208-233.
- Characterization of tRNA-dependent Peptide Bond Formation by MurM in the Synthesis of Streptococcus pneumoniae Peptidoglycan. A. J. Lloyd, A. M. Gilbey, A. M. Blewett, G. De Pascale, A. El Zoeiby, R. C. Levesque, A. C. Catherwood, A. Tomasz, T. D. H, Bugg, D. I. Roper, C. G. Dowson, Journal of Biological Chemistry (2008), 283(10), 6402-6417.
- Synthesis of gem-difluorinated nucleoside analogues of the liposidomycins and evaluation as MraY inhibitors. X.-H. Xu, A. E. Trunkfield, T. D. H. Bugg, F.-L. Qing, Organic & Biomolecular Chemistry (2008), 6(1), 157-161.
- Catalytic promiscuity in the alpha/beta-hydrolase superfamily: hydroxamic acid formation, C--C bond formation, ester and thioester hydrolysis in the C--C hydrolase family. C. Li, M. Hassler, T. D. H. Bugg, ChemBioChem (2008), 9(1), 71-76.
- Native E. coli inner membrane incorporation in solid-supported lipid bilayer membranes. C. E. Dodd, B. R. G. Johnson, L. J. C. Jeuken, T. D. H. Bugg, R. J. Bushby, S. D. Evans, Biointerphases (2008), 3(2), FA59-FA67.