Publications - 2014

“Identification of novel inhibitors of phospho-MurNAc-pentapeptide translocase MraY from library screening: Isoquinoline alkaloid michellamine B and xanthene dye phloxine B” A. Mihalyi, S. Jamshidi, J. Slikas, and T.D.H. Bugg, Bio-Org. Med. Chem., 22, 4566-4571 (2014).
“Mechanism of action of the uridyl peptide antibiotics: an unexpected link to a protein-protein interaction site in translocase MraY” M.T. Rodolis, A. Mihalyi, C. Ducho, K. Eitel, B. Gust, R.J.M. Goss, and T.D.H. Bugg, Chem Commun., 50, 13023- 13025 (2014)
“Lead structures for new antibacterials: stereocontrolled synthesis of a bioactive muraymycin analogue” A.P. Spork, M. Büschleb, O. Ries, D. Wiegmann, S. Boettcher, A. Mihalyi, T.D.H. Bugg, and C. Ducho, Chem. Eur. J., 20, 15292-15297 (2014).
“Observation of the time-course for peptidoglycan lipid II polymerization by Staphylococcus aureus monofunctional transglycosylase” D. Braddick, S. Sandhu, D.I. Roper, M.J. Chappell and T.D.H. Bugg, Microbiology, 160, 1628-1636 (2014).
“How to break the rules of dioxygen activation” T.D.H. Bugg, Chemistry & Biology, 21, 168-169 (2014).
“Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota" Y. Zhu, E. Jameson, M. Crosatti, H. Schäfer, K. Rajakumar, T.D.H. Bugg, and Y. Chen, Proc. Natl. Acad. Sci. USA, 111, 4268-4273 (2014).
“Periodic root branching in Arabidopsis requires synthesis of an uncharacterized carotenoid derivative" J.M. Van Norman, J. Zhang, C.I. Cazzonelli, B.J. Pogson, P.J. Harrison, T.D.H. Bugg, K.X. Chan, A.J. Thompson and P.N. Benfey, Proc. Natl. Acad. Sci. USA, 111, E1300-E1309 (2014).
“Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage phiX174” M.T. Rodolis, A. Mihalyi, A. O’Reilly, J. Slikas, D.I. Roper, R.E.M. Hancock, and T.D.H. Bugg, ChemBioChem, 15, 1300-1308 (2014).
“Phytotoxic effects of selected N-benzyl-benzoylhydroxamic acid metallo-oxygenase inhibitors: investigation into mechanism of action” M. J. Sergeant, P. J. Harrison, R. Jenkins, G. R. Moran, T. D. H. Bugg & A. J. Thompson, N. J. Chem, 37, 3461 (2013).