Skip to main content

Professor Matthew I. Gibson

MIG192x160

Prof. Matthew I. Gibson

Professor. Joint between Chemistry and Warwick Medical School.

MChem(Hons) and Ph.D (Dunelm)

Group
Site
 
Contact
Details

spacer.jpg

Research Summary
grey-line-1.jpg

We exploit organic, polymer and carbohydrate chemistry to address global healthcare issues, with particular relevance to regenerative medicine and infectious diseases. This covers four main fields: Novel cryoprotectants for biological storage, inspired by antifreeze proteins; Biochemical and thermo-responsive polymers for targeted delivery applications; Materials approaches to glycomics for diagnosis and treament of infection; using synthetic biology to develop methods to remove persistant organic polymers from the environment. The work is highly interdisciplinary and our large and vibrant research group comprises of chemists, biochemists and biologists. We have unique facilities for synthesis, recombinant protein expression /microbiology as well as analytical lab and cell culture. Professor Gibson is jointly appointed between Chemistry and Warwick Medical School.

Selected Publications
grey-line-1.jpg


Biggs, C.I., Bailey, T.L., Graham, B., Stubbs, C., Fayter, A., Gibson, M. I., Nature Communications, 2017, 1546., Polymer Mimics of Biomacromolecular Antifreezes.

Graham, B., Bailey, T.L., Healey, J.R., Marcellini, M., Deville, S., Gibson, M. I., Angewandte Chemie, 2017. ;Polyproline is a minimal antifreeze protein mimetic and enhances the cryopreservation of cell monolayers'

Mitchell, D.E., Clarkson,G., Fox,D.J., Kaner, R.A.,Scott, P., Gibson, M.I., Journal of the American Chemical Society, 2017,139, 9835–9838 Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity.

Mitchell DE., Lovett JR, Armes SP and Gibson MI, Angewandte Chemie, 2016, 55, 2801 - 2804, "Biomimetic Block Copolymer Worms Combined with an Ice-Inhibiting Polymer Enable Solvent-Free Cryopreservation of Red Blood Cells"

Deller, R.C., Vatish, M., Mitchell, D.A., Gibson, M.I., Nature Communications, 2014, 5, 3244, "Synthetic polymers enable non-vitreous cellular cryopreservation by reducing ice crystal growth during thawing"

Jones, MW, Otten, L, Richards, S-J, Lowery, R., Phillips DJ., Haddleton DM., and Gibson MI. Chemical Science. 2014, 5, 1611 - 1616 "Glycopolymers with Secondary Binding Motifs Mimic Glycan Branching and Display Bacterial Lectin Selectivity in Addition to Affinity"

Probing Bacterial Toxin Inhibition with Synthetic Glycopolymers using Tandem Post-Polymerization Modification: Role of Linker and Carbohydrate Density. Richards, S-J., Jones, MW, Hunaban, M., Haddleton, DM., Gibson, M.I., Angewandte Chemie. International Edition., 2012, 51, 7812-7816