Jennifer Collins was born in Yeovil, Somerset in 1989.
In 2012 she completed her 4 year undergraduate studies for a Masters in Chemistry at the University of Warwick graduating with 1st Class Honours. Her masters project was carried out under the supervision of Professor David Haddleton and was entitled 'Synthesis of Short Block Glycopolymers by Single Electron Transfer (SET) Living Radical Polymerisation'.
Jennifer carried out her PhD between October 2012 - September 2016 under the supervision of Professor David Haddleton, funded by an EPSRC (Engineering and Physical Sciences Research Council) doctoral training award.
The title of Jennifer's thesis was 'Polymer synthesis and conjugation strategies for enhancing the stability of oxytocin'.
This project was carried out as part of an international collaboration with Monash University, Melbourne, Australia.
Brief synopsis of research:
- Using a variety of functional chemistries for site-selective targeting of different peptide/proteins.
- Controlled synthesis of end functional polymers (specifically polyPEG) by controlled radical polymerisation techniques.
- Inverstigation into the revsibility of peptide -polymer conjugates.
- Conjugation of different architectures of polymers such as linear PEG and polyPEG onto peptides for enhancing properties e.g. thermal stability.
- Synthesis of alternative polymers for providing interesting characteristics to peptide conjugates.
Jennifer is currently working as a postdoctoral research assistant within the Haddleton group, funded by the EPSRC global challenges research fund continuing some of the research started during her PhD.
Current research interests:
- Polymer design and synthesis for promoting reversible peptide conjugation.
- Synthesis of a range of small peptide analogues with reversibility and degradation testing.
- Biological assaying of peptide conjugates for receptor binding responses.
6) Comb poly(oligo(2-ethyl-2-oxazoline)methacrylate)-peptide conjugates prepared by aqueous Cu(0)-mediated polymerization and reductive amination
Jennifer Collins, Sacha J. Wallis, Alexandre Simula, Michael R. Whittaker, Michelle P. McIntosh, Paul Wilson, Thomas P. Davis, David M. Haddleton and Kristian Kempe
Macromol Rapid Commun, 2016,
5) Controlled aqueous polymerization of acrylamides and acrylates and "in situ" depolymerization in the presence of dissolved CO2
Danielle J. Lloyd, Vasiliki Nikolaou, Jennifer Collins, Christopher Waldron, Athina Anastasaki, Simon P. Bassett, Steven M. Howdle, Adam Blanazs, Paul Wilson, Kristian Kempe and David M. Haddleton
Chem. Commun., 2016, 52, 6533-6536
4) Stability enhancing N-Terminal PEGylation of oxytocin exploiting different polymer architectures and conjugation approaches
Jennifer Collins, Kristian Kempe, Paul Wilson, Claudia A. Blindauer, Michelle P. McIntosh, Thomas P. Davis, Michael R. Whittaker and David M. Haddleton
Biomacromolecules, 2016, 17, 2755-2766
3) In Situ Conjugation of Dithiophenol Maleimide Polymers and Oxytocin for Stable and Reversible Polymer–Peptide Conjugates
Jennifer Collins, Joji Tanaka, Paul Wilson, Kristian Kempe, Thomas P. Davis, Michelle P. McIntosh, Michael R. Whittaker, and David M. Haddleton
Bioconjugate Chem., 2015, 26, 633-638
2) Dendritic Cell Lectin-Targeting Sentinel-like Unimolecular Glycoconjugates to release an Anti-HIV Drug
Qiang Zhang , Lu Su , Jennifer Collins , Guosong Chen , Russell Wallis , Daniel A. Mitchell , David M. Haddleton and C. Remzi Becer
J. Am. Chem. Soc., 2014, 136 (11) 4325-4332
1) Sequence-controlled multi-block glycopolymers to inhibit DC-SIGN-gp120 binding
Qiang Zhang, Jennifer Collins, Athina Anastasaki, Russell Wallis, Daniel A. Mitchell,
C. Remzi Becer, and David M. Haddleton
Angew. Chem. Int. Ed., 2013, 52, 4435 –4439
1) Sequence-Controlled Multi-Block Glycopolymers via Cu(0)Mediated Living Radical Polymerization
Qiang Zhang, Jennifer Collins, Athina Anastasaki, Russell Wallis, Daniel A. Mitchell, C. Remzi Becer, Paul Wilson, David M. Haddleton
In Sequence-Controlled Polymers: Synthesis, Self-Assembly, and Properties
Chapter 22, pp 327–348
RSC; SCI; MacroGroup