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Department of Chemistry

Dr Matthew Jenner

UKRI Future Leaders Fellow

Assistant Professor of Biological Mass Spectrometry

MJbio
Research Interests:

The application of mass spectrometry to solve complex biological problems. These include:

- Mapping protein-protein interactions in biosynthetic systems.

- Mechanisms and engineering of biosynthetic enzymes.

- Genomics-driven natural product discovery from bacteria and fungi

m dot jenner at warwick dot ac dot uk

+44 (024)76 572970

Office C519

Jenner GroupLink opens in a new window

Groups at Warwick

Affiliations

Biography

  • UKRI Future Leaders Fellow, (2022 - present)
  • Assistant Professor of Biological Mass Spectrometry, (2021 - present)
  • BBSRC Discovery Fellow, University of Warwick, (2018 - 2021).
  • Leverhulme ECF, University of Warwick, (2017 - 2018).
  • Post Doctoral Research Fellow, University of Warwick (Prof. G.L. Challis), (2014 - 2017).
  • DPhil, University of Nottingham (Prof. N.J. Oldham), (2010 - 2014).
  • BSc (Hons), University of Nottingham, (2007-2010).

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Application of mass spectrometry to solve complex biological problems. These include:

  • Mapping protein-protein interactions in biosynthetic systems.
  • Mechanisms and engineering of biosynthetic enzymes.
  • Genomics-driven natural product discovery from Burkholderia sp.

I teach on the following modules:

  • CH161 - Introduction to Organic Chemistry (Biological Chemistry Lectures, Workshops & Tutorials)
  • CH3F2 - Advanced Analytical Chemistry (Lectures & Workshops)
  • CH3G0 - Extended Labs (O3 Lab)

I am supervising the following PhD students:

I am supervising the following MRes students:

  • Karolina Kowalska

I am supervising the following MChem students:

  • Madeleine Summers

S. Wang, W.D.G. Brittain, Q. Zhang, Z. Lu, M.H. Tong, K. Wu, K. Kyeremeh, M. Jenner, Y. Yu, S.L. Cobb and H. Deng. Aminoacyl chain translocation by a type II thioesterase domain in an unusual non-ribosomal peptide synthetase.Link opens in a new window
Nat. Commun., 2022, 13, e62.

M. Passmore, A. Gallo, J.R. Lewandowski and M. Jenner. Molecular basis for acyl carrier protein-ketoreductase interaction in trans-acyltransferase polyketide synthasesLink opens in a new window
Chem. Sci., 2021, 12, 13676–13685.
* Highlighted on the inside coverLink opens in a new window.

C.D. Fage, S. Kosol, M. Jenner, C. Öster, A. Gallo, M. Kaniusaite, R. Steinbach, M. Staniforth, V. Stavros, M. Marahiel, M. Cryle and J.R. Lewandowski. Communication breakdown: dissecting the COM interfaces between the subunits of nonribosomal peptide synthetases.Link opens in a new window
ACS Catal., 2021, 11, 10802–10813.

I.T. Nakou, M. Jenner, Y. Dashti, I. Romero-Canelón, J. Masschelein, E. Mahenthiralingam and G.L. Challis. Genomics‐driven discovery of a novel glutarimide antibiotic from Burkholderia gladioli reveals an unusual polyketide synthase chain release mechanism.Link opens in a new window
Angew. Chem. Int. Ed., 2020, 59, 23145-23153.

Y. Hai, M. Jenner and Y. Tang. Complete stereoinversion of L-tryptophan by a fungal single module nonribosomal peptide synthetase.Link opens in a new window 
J. Am. Chem. Soc., 2019, 141, 8198-8206.

S. Kosol, A. Gallo, D. Griffiths, T.R. Valentic, J. Masschelein, M. Jenner, E.L.C de los Santos, L. Manzi, P.K. Sydor, D. Rea, S. Zhou, V. Fülöp, N.J. Oldham, S-C. Tsai, G.L. Challis and J.R. Lewandowski. Structural basis for chain release from the enacyloxin polyketide synthase.Link opens in a new window
Nat. Chem., 2019, 11, 913-923.

M. Jenner. Predicting the peculiarLink opens in a new window.
Nat. Chem. Biol., 2019, 15, 761-763.

M. Jenner, X. Jian, Y. Dashti, J. Masschelein, C. Hobson, D.M. Roberts, C. Jones, S. Harris, J. Parkhill, H.A. Raja, N.H. Oberlies, C.J. Pearce, E. Mahenthiralingam and G.L. Challis. An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles 'fungal' icosalide antibioticsLink opens in a new window.
Chem. Sci., 2019, 10, 5489-5494.

A.J. Mullins, J.A.H. Murray, M.J. Bull, M. Jenner, C. Jones, G. Webster, A.E. Green, D.R. Neill, T.R. Connor, J. Parkhill, G.L. Challis and E. Mahenthiralingam. Genome mining identifies cepacin as a key plant-protective metabolite of the biopesticidal bacterium Burkholeria ambifariaLink opens in a new window.
Nat. Microbiol., 2019, 4, 996-1005.

Nat. Prod. Rep., 2018, 35, 1097-1109.

Nat. Chem., 2018, 10, 245-247.

M. Jenner, S. Kosol , D. Griffiths, P. Prasongpholchai, L. Manzi, A.S. Barrow, J.E. Moses, N.J. Oldham, J.R. Lewandowski  and G.L. Challis. Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthasesLink opens in a new window.
Nat. Chem. Biol., 2018, 14, 270-275.
Nat. Prod. Rep., 2017, 34, 712-783.

L. Song, M. Jenner, J. Masschelein, C. Jones, M. Bull, S. Harris, R. Hartkoorn, A. Vocat, I. Romero-Canelón, P. Coupland, Paul, G. Webster, M. Dunn, R. Weiser, C. Paisey, S. Cole, J. Parkhill, E. Mahenthiralingam and G.L. Challis. Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis.Link opens in a new window
J. Am. Chem. Soc., 2017, 138, 7974-7981.

M. Jenner, J. P Afonso, C. Kohlhaas, P. Karbaum, S. Frank, J. Piel and N. J Oldham. Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.Link opens in a new window
Chem. Comm., 2016, 52, 5262-5265.

Angew. Chem. Intl. Ed., 2015, 54, 1817-1821.