Please read our student and staff community guidance on COVID-19
Skip to main content Skip to navigation

Dr Matthew Jenner

BBSRC Future Leader Fellow


MJbio
Research Interests:

Application of mass spectrometry to solve complex biological problems. These include:

- Mapping protein-protein interactions in biosynthetic systems.

- Mechanisms and engineering of biosynthetic enzymes.

- Genomics-driven natural product discovery from Burkholderia sp.

M dot jenner at warwick dot ac dot uk

02476 5 72970

Office B4.00

Jenner Group

Groups at Warwick


Affiliations


Biography

  • BBSRC Future Leader Fellow, University of Warwick, (2018 - present).
  • Leverhulme ECF, University of Warwick, (2017 - 2018).
  • Post Doctoral Research Fellow, University of Warwick (Prof. G.L. Challis), (2014 - 2017).
  • DPhil, University of Nottingham (Prof. N.J. Oldham), (2010 - 2014).
  • BSc, University of Nottingham, (2007-2010).

  • 'Mapping protein-protein interactions in polyketide synthases by carbene footprinting.' BBSRC Future Leader Fellowship (BB/R01212/1).

Application of mass spectrometry to solve complex biological problems. These include:

  • Mapping protein-protein interactions in biosynthetic systems.
  • Mechanisms and engineering of biosynthetic enzymes.
  • Genomics-driven natural product discovery from Burkholderia sp.

I teach on the following modules:

  • CH161 - Introduction to Organic Chemistry (Tutorials)
  • CH3F2 - Advanced Analytical Chemistry
  • CH3G0 - Extended Labs (O3 Lab)


I am supervising the following PhD students:

  • Helen Smith (with G. Challis & J. Lewandowski) - 'Mapping Protein-Protein Interactions in Polyketide Synthases'
  • Ioanna Nakou (with G. Challis) - 'Discovery and Biosynthesis of Natural Products from Burkholderia sp.'

I am supervising the following MChem students:

  • Jenna O'Flaherty

Y. Hai, M. Jenner and Y. Tang. Complete stereoinversion of L-tryptophan by a fungal single module nonribosomal peptide synthetase. 
J. Am. Chem. Soc., 2019, 141, 8198-8206.

S. Kosol, A. Gallo, D. Griffiths, T.R. Valentic, J. Masschelein, M. Jenner, E.L.C de los Santos, L. Manzi, P.K. Sydor, D. Rea, S. Zhou, V. Fülöp, N.J. Oldham, S-C. Tsai, G.L. Challis and J.R. Lewandowski. Structural basis for chain release from the enacyloxin polyketide synthase.
Nat. Chem., 2019, 11, 913-923.

M. Jenner. Predicting the peculiar.
Nat. Chem. Biol., 2019, 15, 761-763.

M. Jenner, X. Jian, Y. Dashti, J. Masschelein, C. Hobson, D.M. Roberts, C. Jones, S. Harris, J. Parkhill, H.A. Raja, N.H. Oberlies, C.J. Pearce, E. Mahenthiralingam and G.L. Challis. An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles 'fungal' icosalide antibiotics.
Chem. Sci., 2019, 10, 5489-5494.

A.J. Mullins, J.A.H. Murray, M.J. Bull, M. Jenner, C. Jones, G. Webster, A.E. Green, D.R. Neill, T.R. Connor, J. Parkhill, G.L. Challis and E. Mahenthiralingam. Genome mining identifies cepacin as a key plant-protective metabolite of the biopesticidal bacterium Burkholeria ambifaria.
Nat. Microbiol., 2019, 4, 996-1005.

S. Kosol, M. Jenner, J.R. Lewandowski and G.L. Challis. Protein-protein interactions in trans-AT polyketide synthases.
Nat. Prod. Rep., 2018, 35, 1097-1109.

B. R. K. Menon and M. Jenner. Reprogramming assembly lines.
Nat. Chem., 2018, 10, 245-247.

M. Jenner, S. Kosol , D. Griffiths, P. Prasongpholchai, L. Manzi, A.S. Barrow, J.E. Moses, N.J. Oldham, J.R. Lewandowski  and G.L. Challis. Mechanism of intersubunit ketosynthase–dehydratase interaction in polyketide synthases.
Nat. Chem. Biol., 2018, 14, 270-275.
Nat. Prod. Rep., 2017, 34, 712-783.

L. Song, M. Jenner, J. Masschelein, C. Jones, M. Bull, S. Harris, R. Hartkoorn, A. Vocat, I. Romero-Canelón, P. Coupland, Paul, G. Webster, M. Dunn, R. Weiser, C. Paisey, S. Cole, J. Parkhill, E. Mahenthiralingam and G.L. Challis. Discovery and biosynthesis of gladiolin: a Burkholderia gladioli antibiotic with promising activity against Mycobacterium tuberculosis.
J. Am. Chem. Soc., 2017, 138, 7974-7981.

M. Jenner, J. P Afonso, C. Kohlhaas, P. Karbaum, S. Frank, J. Piel and N. J Oldham. Acyl hydrolases from trans-AT polyketide synthases target acetyl units on acyl carrier proteins.
Chem. Comm., 2016, 52, 5262-5265.

M. Jenner, J. P. Afonso, H. R Bailey, S. Frank, A. Kampa, J. Piel and N. J Oldham. Acyl‐Chain Elongation Drives Ketosynthase Substrate Selectivity in trans‐Acyltransferase Polyketide Synthases.
Angew. Chem. Intl. Ed., 2015, 54, 1817-1821.