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Chemistry Peter O'Connor Group

Peter B. O'Connor, Curriculum Vitae


Peter B. O’Connor

Research Interests:

Mass Spectrometry instrumentation and applications are fascinating. The intricate coupling of advanced physics techniques, instrumentation, electronics, and software with chemical and particularly biochemical problems of a previously intractable nature is THE reason that I am a mass spectrometrist. My personal interests lie on the instrumentation side of this field, but no one can deny the tremendous growth in exciting mass spectrometry applications, particularly in the proteomics field.

The Fourier Transform Mass Spectrometer is superior to all other mass spectrometers in virtually all important aspects, although niche applications will always exist for other instruments. However, the electronics and software lag relative to other commercial instrumentation due to the lack of sufficient investment by instrument companies in their development. Additionally, most if not all of the fundamental performance parameters we are familiar with in FTMS are very conservative. For example, physicists measuring single atoms in Penning traps (an FTMS is fundamentally a Penning trap) are able to achieve 0.1 ppb mass accuracies where we struggle to achieve <0.1 ppm. There is much room for improvement.

Current FTMS research projects include:


Instrumentation and Fundamentals:
1) Applications of Electron Capture Dissociation and Ultraviolet Photodissociation
2) Superacid Supercharging of Electrospray Droplets.
3) A new modular FTICR instrument for varied instrument development projects including UV/Vis photodissociation spectroscopy.
4) Designing a quadruple mass spectrometer on printed circuit boards.
5) Development of data analysis python code to assist the huge task of interpreting complex FTMS data on a human timescale.
6) Phasing FTICR mass spectra
7) Chemistry in electrodynamically levitated droplets.
8) Design of a benchtop FTICR mass spectrometer using a cryogen-free superconducting magnets.
9) Development of applications and techniques for 2-Dimensional mass spectrometry.
10) Design of high sensitivity preamplifiers for quadrature FTICR detection.

Selected Applications:
1) Detailed structural analysis of anticoagulative proteins in scorpion venoms.
2) Detailed structural analysis of reaction products between organometallic anticancer drugs and proteins – both in vitro and in vivo.
3) Study of deamidation and isoaspartic acid formation in amyloid proteins and study of inhibition/binding reactions for amyloid.
4) Study of protein flexibility changes upon post-translational modification using IRMPD and ECD.
5) Isoaspartomic studies of yeast with the isoaspartic acid repair enzyme PIMT knocked in/out.
6) Detailed analysis of protein-polymer conjugates used in pharmaceutical formulations.
7) Study of isotopic labelling in amyloid peptides using ultrahigh resolving power.
8) Using advanced mass spectrometry methods to study crosslinks in collagen.
9) Detailed chemical analysis of advanced glycation endproducts in diabetes.
10) Using advanced fragmentation methods to structurally characterise polyketide structures.

Students Advised:

Graduate students:
Parminder Kaur, ECE, PhD thesis defended Dec 7, 2006.
Vera B. Ivleva, Chemistry, PhD thesis defended May 2007.
Bo Xie, Chemistry, PhD thesis defended May 2007.
Raman Mathur, ECE, PhD thesis defended March 2008.
Jason Cournoyer, Chemistry, PhD thesis defended April 2008.
Konstantine Aizikov, ECE, PhD thesis defended Spring 2010.
Xiaojuan Li, Biochemistry, PhD thesis defended July 2010.
Nadezhda Sargaeva, Biochemistry, PhD thesis defended January 2012.
Terry Lin, ECE, PhD thesis defended November 2012.
Andrea Lopez-Clavijo, Chemistry, PhD thesis defended June 2013.
Pilar Perez-Hurtado, Chemistry, PhD thesis defended June 2013.
Huilin Li, Chemistry, PhD thesis defended December 2012.
Rebecca Wills, Chemistry, PhD thesis defended May 2013.
Yulin Qi, Chemistry, PhD thesis defended June 2013.
Juan Wei, Chemistry, PhD thesis defended August 2014.
Christopher A. Wootton, Chemistry, PhD thesis defended July 2015.
Pui Yiu (Yuko) Lam, Chemistry, Autumn 2018.
Federico Floris, Chemistry, Spring 2019.
Cookson Chiu, Chemistry, Spring, 2019.
Meng Li, Chemistry, Spring 2020.
Sam Bisby, Chemistry, Spring 2020.
Tomos Morgan, Chemistry, Spring 2020.
Andrew Soubly, Chemistry, Spring 2018.
Samantha Kilgour, Chemistry, Spring 2018

Undergraduate (MSc and MChem) students:
Eric Fallows, graduated spring 2005.
Marina Belyayev, graduated spring 2006.
Mark Kozlowski, graduated spring 2010.
Sam Peel, graduated spring 2010.
Yuko Lam, graduated September 2011.
Samantha Benson, graduated September 2011.
Matthew Griffiths, graduated spring 2012.
Holly Chan, graduated August 2013
Meng Li, graduated spring 2012.
Hayley Simon, graduated spring 2015.
Cookson Chiu, graduated spring 2015

Postdoctoral fellows:
Ekaterina Mirgorodskaya, 2002-2004
Nancy Leymarie, 2002-2004
Bogdan Budnik, 2003-2005
Jason Pittman, 2003-2005
Susanne Moyer, 2003-2004
Judith Jebanathirajah, 2004-2005
Cheng Lin, 2005-2009
Cheng Zhao, 2005-2007
Chunxiang Yao, 2007-2009
Weidong Cui, 2008-2009
Anna Pashkova, 2009-2011
David Kilgour, 2011 - 2014
Maria van Agthoven, 2012 - present
Christopher A. Wootton, 2015 - present

Professional Positions:

2009-present; Professor of Chemistry, University of Warwick, Coventry
2005-2009; Research Associate Professor of Biochemistry, Boston University School of Medicine, Boston, MA
2000-2005; Research Assistant Professor of Biochemistry, Boston University School of Medicine, Boston, MA
2000-present; Assistant Director, Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA
1999-2000; Senior Research Associate, Mass Spectrometry Resource, Boston University School of Medicine, Boston, MA
1997-1999; Scientist, IonSpec Corporation, Irvine, CA
1995-1997; Post Doctoral Researcher, FOM Institute for Atomic and Molecular physics, Amsterdam, The Netherlands
1992-1995; Research Assistant, Department of Chemistry, Cornell University, Ithaca, NY
1991-1992; Teaching Assistant, Department of Chemistry, Cornell University, Ithaca, NY
1990-1991; Teaching Assistant, Department of Chemistry, University of North Texas, Denton, TX
1989-1991; Undergraduate Research Assistant, Department of Chemistry, University of North Texas, Denton, TX
summer 1989; Undergraduate Research Assistant (NSF REU Fellowship), Department of Chemistry, Florida State University, Tallahassee, FL

Education:

1995-1997; Post Doctoral Researcher, Prof. Jaap J. Boon, Dr. Ron M. A. Heeren, FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
1991-1995; Ph.D., Prof. Fred McLafferty, Chemistry, Cornell University, Ithaca, NY
1991-1993; M.S., Prof. Fred McLafferty, Chemistry, Cornell University, Ithaca, NY
1987-1991; B.S., Chemistry, University of North Texas, Denton, TX

Professional Service:

2018 Training course in FTICR mass spectrometry, Munich, April 2018 (pending)
2017 BMSS short course on mass spectroemtry instrumentation (pending)
2014 - present, Scientific Advisory Board, French FTICR Network.
2017 ASMS meeting FTICR workshop discussion on mass accuracy
2017 - Visiting Professor University of Lorraine, Metz, April - May 2017
2012-2017, BBSRC standing committee member, Committee D (Biotechnology)
2017, BBSRC panel member for instrumentation grants, Birmingham.
2014, EPSRC panel member for physical chemistry, Swindon
2015-present, Elected member BMSS Executive committee (paper secretary – in charge of the scientific programme of the annual meeting).
2016-present, Royal Society of Chemistry Analytical Methods Committee.
2016, PhD Thesis Committee (External Examiner), Frederik Lermyte, University of Antwerp, Belgium.
2012-2015, Co-opted member of BMSS Executive committee.
2016, PhD Thesis Committee (External Examiner), William Johnson,Swansea
2014, PhD Thesis Committee (External Examiner), Sarah Turker,University of Birmingham
2013, PhD Thesis Committee (External Examiner), Michael Smith,Durham University.
2012, Organizer 10th European FTMS conference, April 1-5, Warwick.
2011,PhD Thesis Committee (External Examiner), Jenna Scotcher, University of Edinburgh
2011, ASMS meeting FTICR workshop lecture on space charge
2010, PhD Thesis Committee, Matthew Gill, Warwick, Coventry
2010, PhD Thesis Committee, Kym Wells, Warwick, Coventry
2009, PhD Thesis Committee, Anne Holm, Aarhus, Denmark
2008, Session Chair: “Developments in Ion Trap Instrumentation”, American Society for Mass Spectrometry Meeting, Denver
2008, PhD Thesis Committee (Major Advisor), Jason Cournoyer, Boston University Department of Chemistry.
2008, PhD Thesis Committee (Major Advisor), Raman Mathur, Boston University Department of Electrical and Computer Engineering.
2008, Reviewer NIH Special Emphasis Panel.
2008, Reviewer NIH Instrument and Systems Development Study Section.
2008, Reviewer NSF SBIR/STTR panel.
2008, Reviewer NIH SBIR/STTR panel.
2008, Session Chair: “Advanced Proteomic Technologies”, US HUPO meeting
2008; Program Committee, US HUPO meeting
2007; Program Committee, International FTMS meeting, Moscow, Russia
2007; Reviewer NIH Shared Instrument Grant Panel
2007; PhD Thesis Committee, Vera Ivleva, Boston University Department of Chemistry
2007; Reviewer NIH Special Emphasis Panel on Mass Spectrometry Instrumentation
2007; PhD Thesis Committee, Bo Xie, Boston University Department of Chemistry
2007; PhD Thesis Committee, Romulus Mihalca, FOM Institute for Atomic and Molecular Physics and Utrecht University
2007; Editorial Board, Journal of the American Society for Mass Spectrometry
2007; Reviewer NSF SBIR panel
2006; PhD Thesis Committee (Major Advisor), Parminder Kaur, Boston University Department of Electrical and Computer Engineering.
2006; ASMS Sanibel Committee (Chair)
2006; Oxidative Post Translational Modifications of Proteins in Cardiovascular Disease, program committee
2006; Reviewer NIH-High End Instrumentation Shared Instrument Grant program (chairman)
2005-2006; Reviewer NIH-ISD Instrumentation and Systems Development Study Section (permanent member)
2005; ASMS Sanibel Committee (Treasurer)
2005; Session Chair “FTMS Instrumentation and Methods” 53rd ASMS conference, San Antonio, Texas
2004; ASMS Sanibel Committee (member)
2004; Reviewer NIH-ISD Instrumentation and Systems Development Study Section (temporary member)
2004; Reviewer NIH Special Emphasis Panel, “High End Shared Instrument Grant Program”
2004; Oxidative Post Translational Modifications of Proteins in Cardiovascular Disease, program committee
2002; Reviewer, Phillip-Morris Research Program
2002; Reviewer, DOE “Genomes to Life” Grant Program
2002; Reviewer, NIH-BECM “High End Shared Instrument Grant Program”
2002; Session Chair “High Pressure MALDI”, 50th ASMS meeting, Orlando, FL
2002; BUSM Department of Biochemistry Admissions Committee
2001; ASMS program committee
1995-present; Reviewer, Analytical Chemistry
1995-present; Reviewer, Journal of the American Society for Mass Spectrometry
1995-present; Reviewer, International Journal of Mass Spectrometry
1999-present; Reviewer, Environmental Science and Technology
1999-present; Reviewer, Analytical Biochemistry
2000-present; Reviewer, Reviews of Scientific Instruments
2002-present; Reviewer, Journal of the American Chemical Society

Teaching:

WarwickUniversity

2016-2017

Term 3 CH3F1 3rd year Physical Chemistry labs (9 - 7 hour labs plus, 6 2 hour workshops)
Term 3 CH3F1 New 3rd year Physical Chemistry GCMS lab experiment (9 - 7 hour labs)
Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 5 1-hour labs, 4-3 hour workshops
Term 1 CH3F2 Advanced Analytical Chemistry (12 1-hour lectures, 5-1 hour workshops)
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1 CH222 2nd Year GCMS lab experiment (5, 6-hour labs)

2015-2016

Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 5 1-hour labs, 4-3 hour workshops
Term 1 CH3F2 Advanced Analytical Chemistry (12 1-hour lectures, 5-1 hour workshops)
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1CH222 2nd Year GCMS lab experiment (5, 6-hour labs)

2014-2015

Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 5 1-hour labs, 4-3 hour workshops
Term 1 CH162 Physical Chemistry, Thermodynamics (15 1-hour lectures, 2 1 hour workshops)
Term 1 CH3F2 New Advanced Analytical Chemistry Module (12 1-hour lectures, 5-1 hour workshops)
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1 CH222 2nd Year GCMS lab experiment (5, 6-hour labs)

2013-2014

Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 5 1-hour labs, 4-3 hour workshops
Term 1 CH162 Physical Chemistry, Thermodynamics (15 1-hour lectures, 2-1 hour workshops)
Term 1 CH3A8 Mass Spectrometry and NMR (5 1-hour lectures, 1-1 hour workshop)
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1 CH222 2nd Year GCMS lab experiment (5, 6-hour labs)

2012-2013

Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 5 1-hour labs, 4 3 hour workshops
Term 1 CH162 Physical Chemistry, Thermodynamics (15 1-hour lectures, 2 1 hour workshops)
Term 1 CH3A8 Mass Spectrometry and NMR (5 1-hour lectures, 1-1 hour workshop)
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1 CH222 2nd Year new GCMS lab experiment (5, 6-hour labs)

2011-2012

Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 5 1-hour labs, 4 3 hour workshops
Term 1 CH162 Physical Chemistry, Thermodynamics (15 1-hour lectures, 2 1 hour workshops)
Term 1 CH3A8 Mass Spectrometry and NMR (5 1-hour lectures, 1-1 hour workshop)
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1 CH222 2nd Year spectroscopy laboratory (10 1 hour lectures, 10 8 hour labs

2010-2011

Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 2 1-hour labs, 5 3 hour workshops
Term 1 CH162 Physical Chemistry, Thermodynamics (15 1-hour lectures, 2 1 hour workshops)
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1 CH222 2nd Year spectroscopy laboratory (10 1 hour lectures, 10 8 hour labs

2009-2010

Term 3 Special skills module
Term 2 CH908 Mass Spectrometry (15 1-hour lectures, 20 1-hour labs, 5 3 hour workshops
Term 1 CH921 MOAC spectroscopy (1 2-hour lecture, 5 1 hour labs)
Term 1 CH222 2nd Year spectroscopy lecture (2 1 hour lectures)
Term 1 CH222 2nd Year spectroscopy laboratory (10 1 hour lectures, 10 8 hour labs

Boston University

Spring Semester 2008: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (4, 2-hour lectures)
Spring Semester 2007: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (4, 2-hour lectures)
Spring Semester 2006: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (4, 2-hour lectures)
Fall Semester 2005: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (4, 2-hour lectures)
Spring Semester 2005: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (4, 2-hour lectures)
Spring Semester 2004: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (4, 2-hour lectures)
Spring Semester 2003: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (4, 2-hour lectures)
Spring Semester 2002: GMS_BI_793 Mass Spectrometry, Proteomics, and Functional Genomics (3, 2-hour lectures)

Departmental and University Committees:

2009-present; Warwick Chemistry Department, Final year exam board (secretary)
2009-present; Warwick Centre for Analytical Science Advisory Board
2011-2012; Warwick Chemistry Department, Research Committee
2003-2007; BU Physics Department, Scientific Instrument Facility Advisory Committee
2003-2005; BU School of Medicine, Department of Biochemistry Seminar Committee (chairman)
2002-2005; BU School of Medicine, Department of Biochemistry Seminar Committee
2001-2003; BU School of Medicine, Department of Biochemistry Graduate Admissions and Recruitment Committee

Honors:

1991; Graduated Magna Cum Laude, University of North Texas, Denton, TX
1990; Master’s Award, Department of Chemistry, University of North Texas, Denton, TX
1989; Addie Mae Curbo Lloyd Award, Department of Chemistry, University of North Texas, Denton, TX
1987-1991; Robert A. Welch Foundation Scholarship
1987; University Interscholastic League Science Competition, Division A, 5th in Texas State competition.

Professional Associations:

Royal Society of Chemistry
American Society for Mass Spectrometry
American Association for the Advancement of Science
American Chemical Society
American Physical Society
Alpha Chi Sigma professional chemistry fraternity

Funding:

Warwick:

BBSRC BB/P021875/1, ‘The Next Dimension in Proteomics’, 2017-2020, £781k
Royal Society, ‘Development of 2DMS in a linear ion trap using UV photodissociation’, 2017-2019, £50k
EPSRC N033191, ‘Nanoscale metallomics and mineralization: advanced spectro-microscopy determination of the role of iron and calcium in Alzheimer's disease’, 2016-2020, £514k (with J. Collingwood)
Warwick Research Development Fund, ‘Amyloid Beta Aggregation’, 2016-2018, £67k
EPSRC CASE award ‘Using advanced mass spectrometry methods to characterise block copolymers’, with AstraZeneca, 2016-2019, £100k.
Warwick Impact Fund, ‘Building a prototype 2DMS in a linear ion trap’, 2016-2017, £50k
Warwick Impact Fund, ‘Proof of concept: 2DMS in a linear ion trap’, 2015-2016, £30k
Funds for Woman Graduates, 2016-2017, £6k
The Sir Richard Stapley Education Trust, 2016-2017, £3k
Chinese student awards, 2017-2018, £3k
EPSRC N021630, ‘Preliminary design study for a benchtop, cryogen-free FTICR mass spectrometer’, 2015-2016, £130k
EPSRC J000302, ‘Is a NOESY-like 2 dimensional experiment possible in mass spectrometry?’ 2012-2015, £525k
Warwick Institute for Advanced Studies, "Protein Sequencing using Radical Chemistry.", 2012, £2k

Boston:
NIH/NCRR-R01, “Proteomic analysis using MAF”, P.I. Peter B. O’Connor, ~$1.8M (direct,) 2007-2012. Note: the proposal scored 2.9th percentile. It should have been funded, but was refused because of transfer to the UK.
NIH/NIGMS-R01, “Defining the Isoaspartome”, P.I. Peter B. O’Connor, ~$1M (direct), 2007-2012.
NIH-NCRR-P41, “Mass Spectrometry Resource for Biology and Medicine”, P.I. Cathy Costello, ~$5.5M (direct), FTMS portion ~$1.5M (direct), 2007-2012.
NIH/NHLBI-N01, “Cardiovascular Proteomics Center”, P.I. Cathy Costello and Richard Cohen, ~$8M (direct), FTMS portion ~$2M (direct), 2002-2009.
MDS-Sciex, “ESI-qQq-FTMS”, P.I. Peter B. O’Connor, $150k + ~$50k parts (direct), 2003-2006.
ACS-Petroleum Research Fund, “Which ECD fragments are products of a free radical cascade?”, P.I. Peter B. O’Connor, $120k (direct), 2003-2006.
NIH/NCRR-P41, “Mass Spectrometry Resource for Biology and Medicine”, P.I. Cathy Costello, ~$5.5M (direct), FTMS portion ~$1.5M (direct), 2002-2007.br /> NIH/NCRR-P41, “Mass Spectrometry Resource for Biology and Medicine”, P.I. Cathy Costello, ~$5.5M (direct), FTMS portion ~$1.5M (direct), 1997-2002.

Patents:

1. O'Connor, P. B. Apparatus and Method for Ion Cyclotron Resonance Mass Spectrometry USA 2003 10/338423

2. Mathur, R; O'Connor, P. B. Low-Noise Wideband Preamplifier for Fourier Transform Mass Spectrometry USA WO2008US54815 20080223
3. Peter B. O'Connor, Christopher. A. Wooton, Haytham Hussein, Manying Wong Ionising Molecules and Electrospray Ionisation Apparatus UK Patent Pending GB1605613.7. 1 April, 2016.
4. Maria van Agthoven, Peter B. O'Connor, 2 Dimensional Mass Spectrometry in a Linear Ion Trap UK Patent Pending GB1615469. September, 2016.

PhD Theses:

Dr. Parminder Kaur, January 7th, 2007 Statistical Methods for Interpretation of High Resolution Mass Spectra. Dr. Kaur is currently a Research staff scientist at the Case Western Reserve University Center for Proteomics and Bioinformatics in Cleveland, Ohio.

Dr. Vera Ivleva, 2007 Direct Coupling of Thin Layer Chromatography with Vibrationally Cooled MALDI-MS for the Analysis of Glycolipids from Biological Samples. Dr. Ivleva is currently a staff scientist for Waters in Millford, Massachusetts.

Dr. Raman Mathur, February 28th, 2008 A Cryogenic Low Noise Amplifier for Fourier Transform Mass Spectrometry. Dr. Mathur is an instrumentation research engineer at Thermo-Fisher Scientific, in San Jose, California.

Dr. Jason Cournoyer, February 28th, 2008 Mechanism of Electron Capture Dissociation and The Applicaion to the Differentiation of Isoaspartic and Aspartic Acid Residues. Dr. Cournoyer is a research scientist at Perkin Elmer in Waltham, Massachusetts.

Dr. Konstantine Aizikov, December, 2009 Novel Computationan and Instrumentation Methodologies for Biological Fourier-Transform Ion Cyclotron Resonance Mass Spectrometric (FTICRMS) Imaging. Dr. Aizikov is currently a research scientist for Thermo-Fisher Scientific in Bremen, Germany.

Dr. Xiaojuan Li, June, 2010 Mechanism of Electron Capture Dissociation and the Application to Protein Deamidation. Dr. Li is currently a research Scientist for Merck in upstate New York.

Dr. Nadia Sargaeva, January 13th, 2012 Deamidation and Related Problems in Structural Analysis of Peptides and Proteins.. Dr. Sargaeva is currently on maternity leave in Boston, MA, USA.

Dr. Tzu-Yung (Terry) Lin, November 2012, Advanced Electronics for Fourier Transform Ion Cyclotron Resonance Mass Spectrometry.. Dr. Lin is currently a postdoctoral fellow at Pacific Northwest National Lab.

Dr. Huilin Li, December 12th, 2012. Studies of Protein Post-Translational Modifications using High Resolution Tandem Mass Spectrometry. Dr. Li is currently a postoctoral fellow with Prof. Joe Loo at UCLA.

Dr. Yulin Qi, June 2013, Advanced Methods in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Dr. Qi is currently a Postdoctoral Fellow working with Prof. Dietrich Volmer at Saarland University in Germany.

Dr. Pilar Perez-Hurtado, June, 2013. FTICRMS approqach to Monitor Asparagine Deamidation and its Isomeric Products in Collagen from Ancient Bones. Dr. Perez-Hurtado is currently a sales engineer for Advion.

Dr. Rebecca Wills, May, 2013. High Resolution Tandem Mass Spectrometry of Large Biomolecules. Dr. Wills is currently a research scientist working for Jaguar/Land Rover in Stratford.

Dr. Andrea Lopez-Clavijo, May, 2013. Tandem Mass Spectrometry of Non-Enzymatically Glycated Peptides and Proteins. Dr. Lopez-Clavijo is currently a postdoctoral Fellow at Birmingham University.

Dr. Juan Wei, August 2014, Advanced Applications of High Performance Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. Dr. Wei is currently a postdoctoral fellow at Boston University School of Medicine in the group of Prof. Cheng Lin and Prof. Catherine Costello.

Dr. Christopher A. Wootton, Exploring biomolecules, metallodrugs, and their interactions via the use of UHR-FT-ICR Mass Spectrometry. Dr. Wootton is currently a postdoctoral fellow here at the Ion Cyclotron Resonance laboratory at the University of Warwick.

Papers:

If you can’t get the publication directly, please email me and I’ll forward the .pdf file to you.

Publications (reverse chronological order):

for the most up-to-date list, go here: https://scholar.google.co.uk/citations?hl=en&user=oVnU6OsAAAAJ&view_op=list_works&sortby=pubdate


  • 143. Maria A. van Agthoven, P. B. O. C., Two-Dimensional Mass Spectrometry in a Linear Ion Trap: an In Silico Model. Rapid Comm Mass Spectrom 2017, in press.
  • 142. Rüger, C. P.; Schwemer, T.; Sklorz, M.; O’Connor, P. B.; Barrow, M. P.; Zimmermann, R., Comprehensive chemical comparison of fuel composition and aerosol particles emitted from a ship diesel engine by gas chromatography atmospheric pressure chemical ionisation ultra-high resolution mass spectrometry with improved data processing routines. European Journal of Mass Spectrometry 2017, 23 (1), 28-39.
  • 141. Alessandro Del Grosso, L.-D. G., Cookson K. C. Chiu, Guy C. Clarkson, Peter B. O'Connor, Martin Wills, A Class of Strained Alkyne Derived from 2,2'-Dihydroxy-1,1'Biaryls; Synthesis and Copper-Free Cycloaddition with Azides. Organic and Biomolecular Chemistry 2017, in press.
  • 140. Wootton, C. A.; Lam, Y. P. Y.; Willetts, M.; Agthoven, M. A. v.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B., Automatic Assignment of Metal-containing Peptides in Proteomic LC-MS and MS/MS Datasets. Analyst 2017, in press.
  • 139. Floris, F.; Agthoven, M. A. v.; Chiron, L.; Soulby, A.; Wootton, C. A.; Barrow, M. P.; Delsuc, M.-A.; Rolando, C.; O'Connor, P. B., 2-Dimensional IRMPD/FTICR MS of Calmodulin: A Top-Down and Bottom-Up Approach. J Am Soc Mass Spectrom 2016, 27 (9), 1531-1538.
  • 138. Wei, J.; O'Connor, P. B., Extensive fragmentation of pheophytin-a by infrared multiphoton dissociation tandem mass spectrometry. Rapid Commun. Mass Spectrom. 2015, 29 (24), 2411-2418.
  • 137. Wei, J., et al.,Amyloid Hydrogen Bonding Polymorphism Evaluated by 15N{17O}REAPDOR Solid-State NMR and Ultra-High Resolution FTICR-MS. Biochemistry 2016, 55, 2065.
  • 136. Simon, H. J., et al.,Uncoiling collagen: a multidimensional mass spectrometry study. Analyst 2016, 141, 157.
  • 135. Agthoven, M. A. v., et al.,Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with Cytochrome c. Anal Chem 2016, 88, 4409.
  • 134. Wootton, C. A.; Sanchez-Cano, C.; Liu, H.-K.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B. Binding of an organo-osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top-Down FT-ICR mass spectrometry Dalton Transactions 2015, 44, 3624-3632.
  • 133. Wei, J.; Bristow, A. W. T.; O'Connor, P. B. The Competitive Influence of Li+, Na+, K+, Ag+, and H+ on the Fragmentation of a PEGylated Polymeric Excipient J Am Soc Mass Spectrom 2015, 26, 166-173.
  • 132. Soulby, A. J.; Heal, J. W.; Barrow, M. P.; Roemer, R. A.; O'Connor, P. B. Does deamidation cause protein unfolding? A top-down tandem mass spectrometry study Protein Science 2015, 24, 850-860.
  • 131. Simon, H. J.; Agthoven, M. A. v.; Lam, P. Y.; Floris, F.; Chiron, L.; Coutouly, M.-A.; Delsuc, M.-A.; Rolando, C.; Barrow, M. P.; O'Connor, P. B., Uncoiling Collagen: A Multidimensional Mass Spectrometry Study. Analyst 2015, 141 (1), 157-165.
  • 130. Floris, F.; Agthoven, M. A. v.; Chiron, L.; Soulby, A.; Wootton, C. A.; Barrow, M. P.; Delsuc, M.-A.; Rolando, C.; O'Connor, P. B., 2-Dimensional IRMPD/FTICR MS of Calmodulin: A Top-Down and Bottom-Up Approach. J Am Soc Mass Spectrom 2016, 27 (9), 1531-1538.
  • 129. Agthoven, M. A. v.; Chiron, L.; Coutouly, M.-A.; Wootton, C. A.; Soulby, A.; Wei, J.; Barrow, M. P.; Delsuc, M.-A.; Rolando, C.; O'Connor, P. B., Two-Dimensional Mass Spectrometry for Proteomics, a Comparative Study with Cytochrome c. Anal Chem 2016, 88 (8), 4409-4417.
  • 128. van Agthoven, M.; Barrow, M.; Chiron, L.; Coutouly, M.-A.; Kilgour, D.; Wootton, C.; Wei, J.; Soulby, A.; Delsuc, M.-A.; Rolando, C.; O’Connor, P., Differentiating Fragmentation Pathways of Cholesterol by Two-Dimensional Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J Am Soc Mass Spectrom 2015, 26(12),1-10.
  • 127. Wills, R. H.; O'Connor, P. B. Structural Characterization of Actinomycin D Using Multiple Ion Isolation and Electron Induced Dissociation J Am Soc Mass Spectrom 2014, 25, 186-195.
  • 126. Wills, R. H.; Habtemariam, A.; Lopez-Clavijo, A. F.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B. Insights into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High Resolution Mass Spectrometry J Am Soc Mass Spectrom 2014, 25, 662-672.
  • 125. Wei, J.; Bristow, A.; McBride, E.; Kilgour, D.; O'Connor, P. B. D-alpha-tocopheryl Polyethylene Glycol 1000 Succinate: A View from FTICR MS and Tandem MS Anal Chem 2014, 86, 1567-1574.
  • 124. Qi, Y.; O'Connor, P. B. Data processing in Fourier transform ion cyclotron resonance mass spectrometry Mass Spectrometry Reviews 2014, 33, 333-352.
  • 123. Lopez-Clavijo, A. F.; Duque-Daza, C. A.; Soulby, A.; Canelon, I. R.; Barrow, M.; O'Connor, P. B. Unexpected Crosslinking and Diglycation as Advanced Glycation End-Products from Glyoxal J Am Soc Mass Spectrom 2014, 25, 2125-2133.
  • 122. Lopez-Clavijo, A. F.; Duque-Daza, C. A.; O'Connor, P. B. Tandem mass spectrometry for the study of glyoxal-derived advanced glycation end-products (AGEs) in peptides Rapid Communications in Mass Spectrometry 2014, 28, 25-32.
  • 121. Lopez-Clavijo, A. F.; Duque-Daza, C. A.; Canelon, I. R.; Barrow, M. P.; Kilgour, D.; Rabbani, N.; Thornalley, P. J.; O'Connor, P. B. Study of an Unusual Advanced Glycation End-Product (AGE) Derived from Glyoxal Using Mass Spectrometry J Am Soc Mass Spectrom 2014, 25, 673-683.
  • 120. Li, H.; Snelling, J. R.; Barrow, M. P.; Scrivens, J. H.; Sadler, P. J.; O'Connor, P. B. Mass Spectrometric Strategies to Improve the Identification of Pt(II)-Modification Sites on Peptides and Proteins J Am Soc Mass Spectrom 2014, 25, 1217-1227.
  • 119. Griffiths, M. T.; Da Campo, R.; O'Connor, P. B.; Barrow, M. P. Throwing Light on Petroleum: Simulated Exposure of Crude Oil to Sunlight and Characterization Using Atmospheric Pressure Photoionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometry Anal Chem 2014, 86, 527-534.
  • 118. Cho, Y.; Qi, Y.; O'Connor, P. B.; Barrow, M. P.; Kim, S. Application of Phase Correction to Improve the Interpretation of Crude Oil Spectra Obtained Using 7 T Fourier Transform Ion Cyclotron Resonance Mass Spectrometry J Am Soc Mass Spectrom 2014, 25, 154-157.
  • 117. Wei, J.; Li, H.; Barrow, M. P.; O'Connor, P. B. Structural Characterization of Chlorophyll-a by High Resolution Tandem Mass Spectrometry J Am Soc Mass Spectrom 2013, 24, 753-760.
  • 116. Smith, D. F.; Kilgour, D. P. A.; Konijnenburg, M.; O'Connor, P. B.; Heeren, R. M. A. Absorption Mode FTICR Mass Spectrometry Imaging Anal Chem 2013, 85, 11180-11184.
  • 115. Qi, Y.; Liu, Z.; Li, H.; Sadler, P. J.; O'Connor, P. B. Mapping the protein-binding sites for novel iridium(III) anticancer complexes using electron capture dissociation Rapid Communications in Mass Spectrometry 2013, 27, 2028-2032.
  • 114. Qi, Y.; Li, H.; Wills, R. H.; Perez-Hurtado, P.; Yu, X.; Kilgour, D. P. A.; Barrow, M. P.; Lin, C.; O'Connor, P. B. Absorption-Mode Fourier Transform Mass Spectrometry: The Effects of Apodization and Phasing on Modified Protein Spectra J Am Soc Mass Spectrom 2013, 24, 828-834.
  • 113. Kilgour, D. P. A.; Wills, R.; Qi, Y.; O'Connor, P. B. Autophaser: An Algorithm for Automated Generation of Absorption Mode Spectra for FT-ICR MS Anal Chem 2013, 85, 3903-3911.
  • 112. Kilgour, D. P. A.; Neal, M. J.; Soulby, A. J.; O'Connor, P. B. Improved optimization of the Fourier transform ion cyclotron resonance mass spectrometry phase correction function using a genetic algorithm Rapid Communications in Mass Spectrometry 2013, 27, 1977-1982.
  • 111. Wills, R. H.; Tosin, M.; O'Connor, P. B. Structural Characterization of Polyketides Using High Mass Accuracy Tandem Mass Spectrometry Anal Chem 2012, 84, 8863-8870.
  • 110. Wills, R. H.; Habtemariam, A.; Lopez-Clavijo, A. F.; Barrow, M. P.; Sadler, P. J.; O'Connor, P. B., Insights into the Binding Sites of Organometallic Ruthenium Anticancer Compounds on Peptides Using Ultra-High Resolution Mass Spectrometry. J Am Soc Mass Spectrom 2014, 25 (4), 662-672.
  • 109. Qi, Y.; Witt, M.; Jertz, R.; Baykut, G.; Barrow, M. P.; Nikolaev, E. N.; O'Connor, P. B. Absorption-mode spectra on the dynamically harmonized Fourier transform ion cyclotron resonance cell Rapid Communications in Mass Spectrometry 2012, 26, 2021-2026.
  • 108. Qi, Y.; Barrow, M. P.; Li, H.; Meier, J. E.; Van Orden, S. L.; Thompson, C. J.; O'Connor, P. B. Absorption-Mode: The Next Generation of Fourier Transform Mass Spectra Anal Chem 2012, 84, 2923-2929.
  • 107. Lopez-Clavijo, A. F.; Barrow, M. P.; Rabbani, N.; Thornalley, P. J.; O'Connor, P. B. Determination of Types and Binding Sites of Advanced Glycation End Products for Substance P Anal Chem 2012, 84, 10568-10575.
  • 106. Lin, T.-Y.; Green, R. J.; O'Connor, P. B. A low noise single-transistor transimpedance preamplifier for Fourier-transform mass spectrometry using a T feedback network Rev Sci Instrum 2012, 83(9).
  • 105. Lin, T.-Y.; Green, R. J.; O'Connor, P. B. United Kingdom, 2012; Vol. WO2008103970.
  • 104. Lin, C.; O'Connor, P. B. In Protein and Peptide Mass Spectrometry in Drug Discovery; Gross, M. L., Chen, G., Pramanik, B. N., Eds.; John Wiley & Sons, Inc: Hoboken, New Jerssey, 2012.
  • 103. Li, X.; Yu, X.; Costello, C. E.; Lin, C.; O'Connor, P. B. Top-Down Study of beta(2)-Microglobulin Deamidation Anal Chem 2012, 84, 6150-6157.
  • 102. Li, H.; Wells, S. A.; Jimenez-Roldan, J. E.; Roemer, R. A.; Zhao, Y.; Sadler, P. J.; O'Connor, P. B. Protein flexibility is key to cisplatin crosslinking in calmodulin Protein Science 2012, 21, 1269-1279.
  • 101. Li, H.; O'Connor, P. B. Electron Capture Dissociation of Disulfide, Sulfur-Selenium, and Diselenide Bound Peptides J Am Soc Mass Spectrom 2012, 23, 2001-2010.
  • 100. Leach, F. E., III; Kharchenko, A.; Vladimirov, G.; Aizikov, K.; O'Connor, P. B.; Nikolaev, E.; Heeren, R. M. A.; Amster, I. J. Analysis of phase dependent frequency shifts in simulated FTMS transients using the filter diagonalization method International Journal of Mass Spectrometry 2012, 325, 19-24.
  • 99. Kilgour, D. P. A.; Mackay, C. L.; Langridge-Smith, P. R. R.; O'Connor, P. B. Use of an Artificial Immune System Derived Method for the Charge State Assignment of Small-Molecule Mass Spectra Anal Chem 2012, 84, 7436-7439.
  • 98. Kilgour, D. P. A.; Mackay, C. L.; Langridge-Smith, P. R. R.; O'Connor, P. B. Appropriate Degree of Trust: Deriving Confidence Metrics for Automatic Peak Assignment in High-Resolution Mass Spectrometry Anal Chem 2012, 84, 7431-7435.
  • 97. Hurtado, P. P.; O'Connor, P. B. Differentiation of isomeric amino acid residues in proteins and peptides using mass spectrometry Mass Spectrometry Reviews 2012, 31, 609-625.
  • 96. Hurtado, P. P.; Lam, P. Y.; Kilgour, D.; Bristow, A.; McBride, E.; O'Connor, P. B. Use of High Resolution Mass Spectrometry for Analysis of Polymeric Excipients in Drug Delivery Formulations Anal Chem 2012, 84, 8579-8586.
  • 94. Wills, R. H.; Tosin, M.; O'Connor, P. B., Structural Characterization of Polyketides Using High Mass Accuracy Tandem Mass Spectrometry. Anal Chem 2012, 84 (20), 8863-8870.
  • 93. Qi, Y.; Barrow, M. P.; Li, H.; Meier, J. E.; Van Orden, S. L.; Thompson, C. J.; O'Connor, P. B., Absorption-Mode: The Next Generation of Fourier Transform Mass Spectra. Anal Chem 2012, 84 (6), 2923-2929.
  • 92. Hurtado, P. P.; O'Connor, P. B., Deamidation of Collagen. Anal Chem 2012, 84 (6), 3017-3025.
  • 91. Lopez-Clavijo, A. F.; Barrow, M. P.; Rabbani, N.; Thornalley, P. J.; O'Connor, P. B., Determination of Types and Binding Sites of Advanced Glycation End Products for Substance P. Anal Chem 2012, 84 (24), 10568-10575.
  • 90. T.-Y. Lin, R. J. Green, P. B. O'Connor, A gain and bandwidth enhanced transimpedance preamplifier for Fourier-transform ion cyclotron resonance mass spectrometry. Rev. Sci. Inst. 2011, 82, 124101.
  • 89. D. F. Smith, K. Aizikov, M. C. Duursma, F. Giskes, D.-J. Spaanderman, L. A. McDonnell, P. B. O'Connor, R. M. A. Heeren, An External Matrix-Assisted Laser Desorption Ionization Source for Flexible FT-ICR Mass Spectrometry Imaging with Internal Calibration on Adjacent Samples. J. Am. Soc. Mass Spectrom. 2011, 22. 130-137. Link.
  • 88. N. P. Sargaeva, C. Lin, P. B. O'Connor, Differentiating N-Terminal Aspartic and Isoaspartic Acid Residues in Peptides. Anal. Chem. 2011, 83. 6675-6682 Link.
  • 87. X. Li, Y. Huang, P. B. O'Connor, C. Lin, Structural Heterogeneity of Doubly-Charged Peptide b-Ions. J. Am. Soc. Mass Spectrom. 2011, 22. 245-254. Link.
  • 86. H. Li, Y. Zhao, H. I. A. Phillips, Y. Qi, T.-Y. Lin, P. J. Sadler, P. B. O'Connor, Mass Spectrometry Evidence for Cisplatin As a Protein Cross-Linking Reagent. Anal. Chem. 2011, 83. 5369-5376. Link.
  • 85. K. Aizikov, D. F. Smith, D. A. Chargin, S. Ivanov, T.-Y. Lin, R. M. A. Heeren, P. B. O'Connor, Vacuum compatible sample positioning device for matrix assisted laser desorption/ionization Fourier transform ion cyclotron resonance mass spectrometry imaging. Rev. Sci. Inst. 2011, 82. Link.
  • 84. Y. Qi, M. Barrow, S. L. VanOrden, C. J. Thompson, H. Li, P. Perez-Hurtado, P. B. O'connor, Variation of the Fourier transform mass spectral phase function with experimental parameters. Anal. Chem. 2011. web 5 Oct, 2011. Link.
  • 83. N. P. Sargaeva, C. Lin, P. B. O'Connor, Unusual Fragmentation of beta-Linked Peptides by ExD Tandem Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2011, 22. 480-491. Link.
  • 82. N. P. Sargaeva, A. A. Goloborodko, P. B. O’Connor, E. Moskovets, M. V. Gorshkov, Sequence-specific predictive chromatography to assist mass spectrometric analysis of asparagine deamidation and aspartate isomerization in peptides. Electrophoresis 2010 submitted .
  • 81. Y. Qi, C. J. Thompson, S. L. Van Orden, P. B. O'Connor, Phase Correction of Fourier Transform Ion Cyclotron Resonance Mass Spectra Using MatLab. J. Am. Soc. Mass Spectrom. 2011, 22. 138-147. Link.
  • 80. X. J. Li, C. Lin, P. B. O'Connor, Glutamine Deamidation: Differentiation of Glutamic Acid and gamma-Glutamic Acid in Peptides by Electron Capture Dissociation. Anal. Chem. 2010, 82. 3606-3615 Link.
  • 79. X. J. Li, C. Lin, L. Han, C. E. Costello, P. B. O'Connor, Charge Remote Fragmentation in Electron Capture and Electron Transfer Dissociation. J. Am. Soc. Mass Spectrom. 2010, 21. 646-656 Link.
  • 78. X. Li, C. Lin, P. B. O'Connor, Cyclized B-ions observed using ECD. J. Am. Soc. Mass Spectrom. 2010. manuscript in preparation Link.
  • 77. X. Li, C. Lin, L. Han, C. E. Costello, P. B. O'Connor, Charge Remote Fragmentation in Electron Capture and Electron Transfer Dissociation. J. Am. Soc. Mass Spectrom. 2010, 21. 646-656 .
  • 76. X. Li, C. Lin, W. Cui, P. B. O'Connor, Top-Down Analysis of Deamidation products in Proteins. Anal. Chem. 2010. manuscript in preparation.
  • 75. W. Y. K. Chan, T. W. D. Chan, P. B. O'Connor, Electron Transfer Dissociation with Supplemental Activation to Differentiate Aspartic and Isoaspartic Residues in Doubly Charged Peptide Cations. J. Am. Soc. Mass Spectrom. 2010, 21. 1012-1015 Link.
  • 74. R. Yamin, C. Zhao, P. B. O'Connor, A. C. McKee, C. R. Abraham, Acyl peptide hydrolase degrades monomeric and oligomeric amyloid-beta peptide. Molecular Neurodegeneration 2009, 4. Link.
  • 73. I. Van Rhijn, D. C. Young, A. De Jong, J. Vazquez, T. Y. Cheng, R. Talekar, D. Barral, L. Leon, M. B. Brenner, J. T. Katz, R. Riese, R. M. Ruprecht, P. B. O'Connor, C. E. Costello, S. A. Porcelli, V. Briken, D. B. Moody, CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids. J. Exp. Med. 2009, 206. 1409-1422 Link.
  • 72. N. P. Sargaeva, C. Lin, P. B. O'Connor, Identification of Aspartic and Isoaspartic Acid Residues in Amyloid beta Peptides, Including A beta 1-42, Using Electron-Ion Reactions. Anal. Chem. 2009, 81. 9778-9786 Link.
  • 71. R. Mathur, P. B. O'Connor, Artifacts in Fourier transform mass spectrometry. Rapid Commun. Mass Spectrom. 2009, 23. 523-529 Link.
  • 70. K. Aizikov, R. Mathur, P. B. O'Connor, The Spontaneous Loss of Coherence Catastrophe in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry. J. Am. Soc. Mass Spectrom. 2009, 20. 247-256 Link.
  • 69. R. S. Zee, D. R. Pimentel, X. Hou, M. Zang, C. X. Yao, P. B. O'Connor, M. M. Bachschmid, R. A. Cohen, Sirtuin-1 Zinc Thiolate Center Is a Direct Molecular Target of Oxidants. Free Radic. Biol. Med. 2008, 45. S76-S76 Link.
  • 68. D. Nichols, K. Lewis, J. Oriala, S. Mo, R. Ortenberg, P. B. O'Connor, C. Zhao, P. Vouros, T. Kaeberlein, S. S. Epstein, Short peptide induces an "uncultivable" microorganism to grow in vitro. Applied & Environmental Microbiology 2008. in press Epub May 30, 2008 Link.
  • 67. R. Mathur, R. W. Knepper, P. B. O'Connor, A Low-Noise Broadband Cryogenic Preamplifier Operated in a High-Field Superconducting Magnet. Ieee Transactions on Applied Superconductivity 2008, 18. 1781-1789 Link.
  • 66. Li, X.; Cournoyer, J. C.; Lin, C.; O’Connor, P. B. The effect of fixed charge modifications on electron capture dissociation J. Am. Soc. Mass Spectrom. 2008, in press. Available online 28 June 2008.
  • 65. Li, X.; Cournoyer, J. C.; Lin, C.; O’Connor, P. B. Use of 18O labels to monitor deamidation during protein and peptide sample processing J. Am. Soc. Mass Spectrom. 2008, 19, 855-864.
  • 64. Cournoyer, J. C.; Lin, C.; O’Connor, P. B. Gas-phase structure dissimilarity of protonated isomeric peptides revealed by IR-activated DR-ECD J. Am. Soc. Mass Spectrom. 2008, in revision.
  • 63. Lin, C.; Cournoyer, J. C.; O’Connor, P. B. Probing the gas phase folding kinetics of peptide ions by IR-activated DR-ECD J. Am. Soc. Mass Spectrom. 2008, 19, 780-789.
  • 62. Xie, B.; Luo, X.; Zhao, C.; Priest, C. M.; Chan, S.-Y.; O’Connor, P. B.; Kirschner, D. A.; Costello, C. E. Molecular characterization of myelin protein zero in xenopus laevis peripheral nerve: Equilibrium between non-covalently associated dimer and monomer Int. J. Mass Spectrom. Ion Processes 2007, 268, 304-315 .
  • 61. Lin, C.; Mathur, R.; Aizikov, K.; O’Connor, P. B. First signal on the cryogenic Fourier-transform ion cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2090-2093 Link.
  • 60. Mathur, R.; Knepper, R. W.; O’Connor, P. B. A low-noise, wideband preamplifier for a Fourier-transform ion cyclotron resonance mass spectrometer J. Am. Soc. Mass Spectrom. 2007, 18, 2233-2241 Link.
  • 59. Zhao, C.; Cournoyer, J.; Xie, B.; Zaia, J.; Costello, C. E.; O’Connor, P. B. Structural analysis of milk oligosaccharides and N-linked branched glycans by electron detachment dissociation 2007, in revision.
  • 58. Zhao, C.; Xie, B.; Chan, S.-Y.; Costello, C. E.; O’Connor, P. B. Collisionally activated dissociation and electron capture dissociation provide complementary structural information for permethylated oligosaccharides J. Am. Soc. Mass Spectrom. 2007, 19, 138-150 Link.
  • 57. Zhao, C.; O’Connor, P. B. Removal of polyethylene glycols from protein samples using titanium dioxide Anal. Biochem. 2007, 365, 283-285 .
  • 56. J. J. Cournoyer, P. B. O'Connor, in Protein Mass Spectrometry, ed. J. P. Whitelegge. Elsevier: Amsterdam, The Netherlands, 2009, 375-410.
  • 55. O’Connor, P. B. The development of Matrix-assisted laser desorption ion sources In Electrospray ionization mass spectrometry; Cole, R. B., Ed.; 2007 Wiley Interscience, San Francisco.
  • 54. O’Connor, P. B.; Hillenkamp, F. MALDI mass spectrometry insturmentation In MALDI-MS: a practical guide to instrumentation, methods and applications; Hillenkamp, F., Peter-Katalinic, J., Eds.; 2007, Wiley-VCH Verlag Weinheim, Germany.
  • 53. Kaur, P.; O’Connor, P. B. Quantitative determination of isotope ratios from experimental isotopic distributions Anal. Chem. 2007, 79, 1198-1204 Link.
  • 52. Mathur, R.; O’Connor, P. B. Design and implementation of a high power RF oscillator on a printed circuit board for multipole ion guides Rev. Sci. Instrum. 2006, 77, 114101 Link.
  • 51. Kaur, P.; O’Connor, P. B. Comparison of charge state determination methods for high resolution mass spectra IEEE Int. Conf. on Granular Computing May 10, 2006, 550-553 .
  • 50. Cournoyer, J. C.; Lin, C.; Bowman, M. J.; O’Connor, P. B. Quantitating the relative abundance of isoaspartyl residues in deamidated proteins by electron capture dissociation J. Am. Soc. Mass Spectrom. 2007, 18, 48-56. Link.
  • 49. Belyayev, M. A.; Cournoyer, J. J.; Lin, C.; O’Connor, P. B. The effect of radical trap moieties on electron capture dissociation spectra of substance P J. Am. Soc. Mass Spectrom. 2006, 17, 1428-1436 Link.
  • 48. Lin, C.; Cournoyer, J. J.; O’Connor, P. B. Use of a double resonance electron capture dissociation experiment to probe fragment intermediate lifetimes J. Am. Soc. Mass Spectrom. 2006, 17, 1605-1615. Link.
  • 47. Zhao, C.; Sethuraman, M.; Clavreul, N.; Kaur, P.; Cohen, R. A.; O’Connor, P. B. A detailed map of oxidative post-translational modifications of human p21ras using Fourier transform mass spectrometry Anal. Chem. 2006, 78, 5134-5142. Link.
  • 46. Aizikov, K.; O’Connor, P. B. Use of the filter diagonalization method in the study of space charge related frequency modulation in FTMS J. Am. Soc. Mass Spectrom. 2006, 17, 836-843 Link.
  • 45. O’Connor, P. B.; Cournoyer, J. J.; Pitteri, S. J.; Chrisman, P. A.; McLuckey, S. A. Differentiation of aspartic and isoaspartic acids using electron transfer dissociation J. Am. Soc. Mass Spectrom. 2006, 17, 15-19 Link.
  • 44. Perlman, D. H.; Berg, E. A.; O’Connor, P. B.; Costello, C. E.; Hu, J. Reverse transcription-associated dephosphorylation of hepadnavirus nucleocapsids Proc. Nat. Acad. Sci. USA 2005, 102, 9020-9025 Link.
  • 43. O’Connor, P. B.; Lin, C.; Cournoyer, J. J.; Pittman, J. L.; Belyayev, M.; Budnik, B. A. Long-lived electron capture dissociation product ions experience radical migration via hydrogen abstraction J. Am. Soc. Mass Spectrom. 2006, 17, 576-585 Link.
  • 42. Kaur, P.; O’Connor, P. B. Algorithms for automatic interpretation of high resolution mass spectra J. Am. Soc. Mass Spectrom. 2006, 17, 459-468 Link.
  • 41. Cournoyer, J. J.; Lin, C.; O’Connor, P. B. Detecting deamidation products in proteins by electron capture dissociation Anal. Chem. 2006, 78, 1264-1271 .Link.
  • 40. O’Connor, P. B.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Cournoyer, J. C.; Jebanathirajah, J.; Lin, C.; Moyer, S.; Zhao, C. A new hybrid electrospray Fourier transform mass spectrometer: Design and performance characteristics Rapid Commun Mass Spectrom 2006, 20, 259-266.
  • 39. Jebanathirajah, J. A.; Pittman, J. L.; Thomson, B. A.; Budnik, B. A.; Kaur, P.; Rape, M.; Kirschner, M.; Costello, C. E.; O’Connor, P. B. Characterization of a new qQq-FTICR mass spectrometer for post-translational modification analysis and top-down tandem mass spectrometry of whole proteins J. Am. Soc. Mass Spectrom. 2005, 16, 1985-1999 Link.
  • 38. Ivleva, V. B.; Sapp, L. M.; O’Connor, P. B.; Costello, C. E. Ganglioside analysis by thin-layer chromatography matrix-assisted laser desorption/ionization orthogonal time-of-flight mass spectrometry J. Am. Soc. Mass Spectrom. 2005, 16, 1552-1560 Link.
  • 37. Cournoyer, J. J.; Pittman, J. L.; Ivleva, V. B.; Fallows, E.; Waskell, L.; Costello, C. E.; O’Connor, P. B. Deamidation: Differentiation of aspartyl from isoaspartyl products in peptides by electron capture dissociation Protein Science 2005, 14, 452-463.
  • 36. Pittman, J. L.; O’Connor, P. B. A minimum thickness gate valve with integrated ion optics for mass spectrometry J. Am. Soc. Mass Spectrom. 2005, 16, 441-445 Link.
  • 35. Moody, D. B.; Young, D. C.; Cheng, T.-Y.; Rostat, J.-P.; Roura-mir, C.; O’Connor, P. B.; Zajonc, D. M.; Walz, A.; Miller, M. J.; Levery, S. B.; Wilson, I. A.; Costello, C. E.; Brenner, M. B. T-cell activation by lipopeptide antigens Science 2004, 203, 527-531. Link
  • 34. Kaur, P.; O’Connor, P. B. Use of statistical methods for quantitative determination of the number of trapped ions Anal. Chem. 2003, 76, 2756-2762 Link.
  • 33. Budnik, B. A.; Moyer, S. C.; Pittman, J. L.; Ivleva, V. B.; Sommer, U.; Costello, C. E.; O’Connor, P. B. High pressure MALDI-FTMS: Implications for proteomics Int. J. Mass Spectrom. Ion Processes 2004, 234, 203-212.
  • 32. Ivleva, V. B.; Elkin, Y. N.; Budnik, B. A.; Moyer, S. C.; O’Connor, P. B.; Costello, C. E. Coupling thin layer chromatography with high pressure matrix assisted laser desorption/ionization Fourier transform mass spectrometry for the analysis of ganglioside mixtures Anal. Chem. 2004, 76, 6484-6491 Link.
  • 31. O’Connor, P. B.; Budnik, B. A.; Ivleva, V. B.; Kaur, P.; Moyer, S. C.; Pittman, J. L.; Costello, C. E. A High pressure matrix-assisted laser desorption Fourier-transform mass spectrometry ion source designed to accommodate large targets with diverse surfaces J Am Soc Mass Spectrom 2003, 15, 128-132.
  • 30. Moyer, S. C.; Budnik, B. A.; Pittman, J. L.; Costello, C. E.; O’Connor, P. B. Attomole peptide analysis by high-pressure matrix-assisted laser desorption/ionization Fourier transform mass spectrometry Anal. Chem. 2003, 75, 6449-6454. Link.
  • 29. Leymarie, N.; Costello, C. E.; O’Connor, P. B. Electron capture dissociation initiates a free radical reaction cascade J. Am. Chem. Soc. 2002, 125, 8949-8958. Link
  • 28. O’Connor, P. B.; Costello, C. A.; Earle, W. E. A high voltage RF oscillator for driving multipole ion guides J. Am. Soc. Mass Spectrom. 2002, 13, 1370-1375. Link.
  • 27. Leymarie, N.; Berg, E. A.; McComb, M. E.; O’Connor, P. B.; Grogan, J.; Oppenheim, F. G.; Costello, C. E. Tandem Mass Spectrometry for Structural Characterization of Proline-Rich Proteins: Application to Salivary PRP-3 Anal. Chem. 2002, 74, 4124-4132. Link.
  • 26. Hopkins, C. E.; O’Connor P, B.; Allen, K. N.; Costello, C. E.; Tolan, D. R. Chemical-modification rescue assessed by mass spectrometry demonstrates that γ-thia-lysine yields the same activity as lysine in aldolase Protein Sci 2002, 11, 1591-1599. Link
  • 25. McClellan, J. E.; Costello, C. E.; O’Connor, P. B.; Zaia, J. Influence of charge state on product ion mass spectra and the determination of 4s/6s sulfation sequence of chondroitin sulfate oligosaccharides Anal. Chem. 2002, 74, 3760-3771 Link.
  • 24. O’Connor, P. B. Considerations for the design of a Fourier-transform mass spectrometer in the 4.2K cold bore of a superconducting magnet Rapid Commun Mass Spectrom 2002, 16, 1160-1167. Link
  • 23. Mirgorodskaya, E.; O’Connor, P. B.; Costello, C. E. A general method for precalculation of parameters for sustained off resonance irradiation/collision-induced dissociation J. Am. Soc. Mass Spectrom. 2002, 13, 318-324 Link.
  • 22. O’Connor, P. B.; Mirgorodskaya, E.; Costello, C. E. High pressure matrix-assisted laser desorption/ionization Fourier-transform mass spectrometry for minimization of ganglioside fragmentation J. Am. Soc. Mass Spectrom. 2002, 13, 402-407 Link.
  • 21. Lim, A.; Prokaeva, T.; McComb, M. E.; O’Connor, P. B.; Theberge, R.; Connors, L. H.; Skinner, M.; Costello, C. E. Characterization of transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping and DNA sequence analysis Anal. Chem. 2002, 74, 741-751 Link.
  • 20. Costello, C. E.; Lim, A.; O’Connor, P. B.; Prokaeva, T.; Connors, L. H.; Skinner, M. Identification of novel transthyretin variants in familial transthyretin amyloidosis by mass spectrometric peptide mapping Amyloid 2001, 8, 104-105.
  • 19. O’Connor, P. B.; Costello, C. E. A high pressure matrix-assisted laser desorption/ionization Fourier-transform mass spectrometry ion source for thermal stabilization of labile biomolecules Rapid Commun. Mass Spectrom. 2001, 15, 1862-1868.
  • 18. van den Brink, O. F.; Boon, J. J.; O’Connor, P. B.; Duursma, M. C.; Heeren, R. M. A. Matrix-assisted laser desorption/ionization Fourier transform mass spectrometric analysis of oxygenated triglycerides and phosphatidylcholines in egg tempera paint dosimeters used for environmental monitoring of museum display conditions J. Mass Spectrom. 2001, 36, 479-492.
  • 17. O’Connor, P. B.; Costello, C. E. Application of multishot acquisition in Fourier transform mass spectrometry Anal. Chem. 2000, 72, 5125-5130 Link.
  • 16. O’Connor, P. B.; Costello, C. E. Internal calibration on adjacent samples (INCAS) with Fourier-transform mass spectrometry Anal. Chem. 2000, 72, 5881-5885 Link.
  • 15. O’Connor, P. B.; Duursma, M. C.; Rooij, G. J. v.; Heeren, R. M. A.; Boon, J. J. Correction of time of flight shifted polymeric molecular weight distributions in MALDI-FTMS Anal. Chem. 1997, 69, 2751-2755 Link.
  • 14. Guan, Z.; Kelleher, N. L.; O’Connor, P. B.; Aaserud, D. J.; Little, D. P.; McLafferty, F. W. 193 nm photodissociation of larger multiply charged biomolecules Int. J. Mass Spectrom. Ion Processes 1996, 157/158, 357-364.
  • 13. Moertz, E.; O’Connor, P. B.; Roepstorff, P.; Kelleher, N. L.; Wood, T. D.; McLafferty, F. W.; Mann, M. Sequence tag identification of intact proteins by matching tandem mass spectral data against sequence databases Proc. Nat. Acad. Sci. USA 1996, 93, 8264-8267.
  • 12. O’Connor, P. B.; McLafferty, F. W. Oligomer characterizationof 4-22 kDa polymers by electrospray Fourier-transform mass spectrometry J. Am. Chem. Soc. 1995, 117, 12826-12831 Link.
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Colloquia, Invited Talks, etc:

July, 2017, UCL, London, UK, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (invited lecture)
July, 2017, Cornell, NY, USA, "Electron Capture Dissociaiton and 2-dimensional mass spectrometry for top-down proteomics" (Uppcon invited lecture)
June, 2017, ASMS, Indianapolis, IN, USA, "Using 2-Dimensional Mass Spectrometry (2DMS) for Proteomics" (ASMS invited lecture)
April, 2017, Maastricht, The Netherlands, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (invited lecture)
April, 2017, Metz, France, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (invited lecture)
November 2016, Shenzhen, China, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (invited lecture)
September 2016, Eastbourne, UK, "Using 2-Dimensional Mass Spectrometry (2DMS) for Proteomics" (BMSS invited lecture)
June 2016, Warwick School of Life Sciences, UK, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (invited lecture)
April 2016, Beijing, China, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (invited lecture - 3 different institutes)
April 2016, Matera, Italy, "Using 2-Dimensional Mass Spectrometry (2DMS) for Proteomics" (European FTMS invited lecture)
April 2016, Matera, Italy, “FTICR mass spectrometry – a tutorial workshop” (School with the European FTMS meeting)
October 2015, Les Houches, France, "Using 2-Dimensional Mass Spectrometry (2DMS) for Proteomics" (invited lecture)
October 2015, Warwick, UK, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry"
September 2015, Korea, Jeju Island, KSMS, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (Keynote lecture)
September 2015, Korea, Daegu, "Use of multiple fragmentation techniques for detailed structural studies" (invited lecture)
July 2015, Rostok, Germany, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (invited lecture)
March 2015, Lake Arrowhead, CA, USA, "Does Deamidation cause Protein Misfolding" (Uppcon invited lecture)
March 2015, Wuppertal, Germany, "Pushing the limits on Fourier Transform Ion Cyclotron Resonance Mass Spectrometry" (DGMS invited lecture)
November 2014, Antwerp, Belgium, "Does Deamidation cause Protein Misfolding" (invited lecture)
November 2014, Brussels, Belgium, "Polymer analysis with high resolution FTICR mass spectrometry." (invited lecture)
October 2014, Durham, UK, "Top-Down Analysis of Protein Reactions with Anticancer Metallodrugs" (invited lecture)
April 2014, Paris, France, "Top-Down Analysis of Protein Reactions with Anticancer Metallodrugs" (European FTMS invited lecture)
April 2014, Obergurgle, Austria, "Does Deamidation cause Protein Misfolding" (Uppcon invited lecture)
January, 2014, Unviersity of Amsterdam, Amsterdam, The Netherlands "High Resolution Tandem Mass Spectrometry of Large Biomoledules" (invited lecture)
December 2012, Warwick, UK, "High Resolution Tandem Mass Spectrometry of Large Biomoledules" (invited lecture)
September 2012, Macclesfield, UK, "Absorption Mode Fourier Transform Mass Spectrometry" (BMSS invited lecture)
September 2012, Warwick, UK, "What's in a Mass Spectrum?" (invited lecture)
April 2012, Ardgour, Scotland, UK, "High Resolution Tandem Mass Spectrometry of Large Biomoledules" (invited lecture)
March, 2012, Charlston SC, USA, "Absorption Mode Fourier Transform Mass Spectrometry: Advantages for ECD Spectra of Modified Proteins" (Uppcon invited lecture)
March, 2011, York, UK, University of York, “Advanced Mass Spectrometers and their uses in PTM analysis on Proteins” (invited lecture)
February, 2011, 9th Uppcon meeting, Charleston South Carolina, “Absorption mode and it's uses in ECT-Top down analysis of proteins” (invited lecture)
February, 2011, Oxford, UK, University of Oxford, “Advanced Mass Spectrometers and their uses in PTM analysis on Proteins” (invited lecture)
September 2010, Cardiff, UK, "Peak Splitting in FTICR mass spectra" (BMSS invited lecture)
March, 2009, Swansea, UK, University of Swansea, EPSRC Mass Spectrometry Facility, “Recent Advances in Fourier Transform Ion Cyclotron Resonance Mass Spectrometry” (invited lecture)
April 2009, Aarhus, Denmark, "High Resolution Tandem Mass Spectrometry of Large Biomoledules" (invited lecture)
April, 2008, Coventry, UK, University of Warwick Department of Chemistry, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in the Post-Genomic World” (interview lecture)
March, 2008, PACMASS Discussion Group, Seattle, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in the Post-Genomic World” (invited lecture)
March, 2008, University of Washington, Seattle, “Cryogenic Fourier Transform Mass Spectrometry: How and Why” (invited lecture)
March, 2008, Pittcon, “Cryogenic Fourier Transform Mass Spectrometry (invited lecture)
January, 2008, Clemson University, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in the Post-Genomic World” (interview lecture)
December 2007, Paris, France, 5th Uppsala meeting on ECD (invited lecture)
November 2007, Geneva, Switzerland, “Discussions on the Mechanism of ECD” (invited lecture)
November 2007, University of Illinois Chicago “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry in the Post-Genomic World” (interview lecture)
November 2007, University of Maryland - College Park, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Research Plan” (interview lecture)
November 2007, University of Maryland - College Park, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Instrumentation and Applications” (interview lecture)
November 2007, University of Texas San Antonio, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Combining Engineering, Chemistry, and Biomedical Research for Fun and Profit” (interview lecture)
November 2007, University of Arkansas, Fayetteville, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Instrumentation and Applications” (invited lecture)
September 2007, NHLBI Proteomics Centers PI Meeting, Bethesda, Maryland, “The State of Mass Spectrometry Instrumentation for Proteomics.”
September 2007, Greater Boston Mass Spectrometry Discussion Group, Bruker Daltonics, Billerica, MA, “Cryogenic FTMS”
August 2007, North Carolina Central University, Biomanufacturing Research Institute and Technology Enterprise, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Improving Performance and Extending Applications” (invited lecture)
July 2007, University of Texas San Antonio, Department of Biology, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Improving Performance and Extending Applications” (interview lecture)
June 2007, Indianapolis, ASMS meeting FTMS workshop, “Cryogenic FTMS: First results”
May 2007, Canadian Pharmaceutical & Biomedical Analysis Symposium, Montreal, Canada, “Deamidation and isoaspartic acid analysis using ECD” (invited lecture)
May 2007, Virginia Bioinformatics Institute, Virginia Tech, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Improving Performance and Extending Applications” (interview lecture)
May 2007, University of Nebraska - Lincoln, Department of Chemistry, “Fourier Transform Ion Cyclotron Resonance Mass Spectrometry: Improving Performance and Extending Applications” (interview lecture)
April 2007, North American FTMS meeting, Lake Tahoe, CA, “Cryogenic FTMS” (invited lecture)
Feb 2007, Korean Institute for Science and Standards, Daejeon, South Korea “Deamidation and isoaspartic acid analysis using ECD” (invited lecture)
Dec 2006, Weisinger Health Center, Danville PA, “Post-translational modification analysis using high performance FTICRMS” (invited lecture)
Dec 2006, Hong Kong, China, 4th Uppsala meeting on ECD, “Deamidation and isoaspartic acid analysis using ECD” (invited lecture)
Nov 2006, Beatenberg, Switzerland, Swiss Mass Spectrometry Society Meeting (SGMS) “On the role of free radical rearrangements in ECD” (invited lecture)
Oct 2006, Boston, MA, OPTM workshop “FTMS and Proteomics” (invited lecture)
Sept 2006, Athens, Greece, “Cryogenic FTMS” (invited lecture)
Apr 2006; Agilent, Santa Clara, CA, “Deamidation and Isomerization of Amino Acids in Proteins”
Dec 2005; 3rd Uppsala meeting on ECD, Seattle, “On the role of free radical rearrangments in ECD”
Oct 2005; FACCS meeting Quebec “Cryogenic FTMS”
August 2005; 7th International Workshop on Mass Spectrometry in Biology and Medicine “Deamidation and Isomerization of Amino Acids in Proteins”
June 2005; 53rd ASMS Conference, San Antonio, Texas “Deamidation and Isomerization of Amino Acids in Proteins”
Oct. 2004; MGH Sympsium, Boston, MA, “Fundamentals of Electrospray Ionization”
Sept. 2004; Desorption 2004 conference, St. Petersburgh, Russia (Invited Talk) “Cryogenic FTMS Design”
Sept. 2004; 2nd Upsala conference on ECD, Edinburgh, Scotland (Invited Talk) “Distinguishing isomers of aspartic acid by ECD, and new results on the ECD mechanism”
August, 2004; Cornell University Department of Chemistry, “Distinguishing isomers of aspartic acid by ECD, and new results on the ECD mechanism”
March, 30, 2004; 7th European FTMS Workshop, Konstanz, Germany (Invited Talk) “Complete Design of the Cryogenic FTMS”
February, 6, 2004; MDS Sciex, Toronto, Canada (Invited Talk) “A new ESI qQq-FTMS: Design and performance”
November, 6, 2003; Uppsala conference on Electron Capture Dissociation and Related topics; Stockholm, Sweden (Invited Talk) “Electron Capture Dissociation initiates a Free Radical Cascade”
August, 18 2003; Institute for Systems Biology, Seattle Washington (Departmental Colloquium) “Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
August, 19 2003; University of Washinton, Department of Chemistry, Seattle Washington (Invited Talk) “Electron Capture Dissociation Initiates a Free Radical Reaction Cascade”
August, 20 2003; Oregon State University, Department of Chemistry, Corvallis, OR (Departmental Colloquium) “Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
April 17, 2003; Boston University, Boston, MA (Electrical and Computer Engineering Departmental Seminar) “Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
March 11, 2003; NIH NHLBI Proteomics Center PI Meeting, Washington DC “Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Feb 22, 2003; BU School of Medicine, Boston, MA (Cardiovascular Proteomics Center invited talk) “Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Dec. 12, 2002; Boston University, Boston, MA (Biomedical Engineering Departmental Seminar)”Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Dec. 5, 2002; East Tennessee Mass Spectrometry Discussion Group Meeting, Knoxville, TN (invited talk)”Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Dec. 5, 2002; Oak Ridge National Lab, Oak Ridge, TN (Analytical Division Seminar) “Electron Capture Dissociation of Cyclic Peptides”
Nov. 22, 2002; University of Maine, Orono, ME (Chemistry Departmental Seminar) “Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Nov. 7, 2002; FOM-AMOLF Institute, Amsterdam (invited talk)
“Electron Capture Dissociation of Cyclic Peptides”
Nov. 7, 2002; FOM-AMOLF Institute, Amsterdam (invited talk)
“Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Nov. 4, 2002; Max Planck Institute, Berlin (invited talk)
“Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Oct. 31, 2002; Cambridge University, UK, (invited talk)
“Advantages and Challenges in the design and application of MALDI-Cryogenic FTMS for Proteomics”
Oct. 9, 2002; National High Magnetic Field Lab, Tallahassee FL (Invited Talk) “Electron Capture Dissociation of Cyclic Peptides”
Sept. 4, 2002; Desorption 2002, Estes Park, CO (invited talk) “High Pressure MALDI-FTMS”
Aug. 23, 2002; MDS Sciex, Toronto, CA (invited talk) “Fourier Transform Mass Spectrometry: New Developments and Commercial Prospects”
Oct. 2001; 6th European FTMS Meeting (invited talk) “High Pressure MALDI-FTMS”
Nov. 2001; Northeastern University (Chemistry Departmental Seminar) “High Pressure MALDI-FTMS”
July 2001; Northeast Section American Chemical Society (invited talk)
June 2001; 49th ASMS, Chicago, IL (invited talk)
March 2001; North American FTICR meeting, Austin, TX (invited talk)
Spring 2000; Boston University School of Medicine (Biochemistry Colloquium)
Summer 1999; BU Mass Spectrometry Resource (invited talk)
Spring 1999; American Chemical Society meeting, San Francisco, CA (invited talk)
June 1998; 46th ASMS, Orlando, Fl (invited talk)
Fall, 1997; Merck Research Institute, NJ (invited talk)
March 1997; North American FTICR Meeting, Tallahassee, FL (invited talk)
March 1997; Schering-Plough Research Institute, NJ (invited talk)
June 1995; 44th ASMS (invited talk)