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Professor Peter Scott FRSC CChem

PSc

Prof. Peter Scott BSc(Salford), DPhil(Oxon), DSc (Warwick), CChem, FRSC

Professor of Chemistry

Director, Institute of Advanced Study

Royal Society Industry Fellow

+44 24 7652 3238
peter dot scott at warwick dot ac dot uk

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Metallo-organic chemistry, design of self-assembling chiral systems and applications as medicines for challenging diseases (superbugs, cancer), polyolefin catalysis and applications in materials, polymer synthesis … group website.

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Discovery of selective, antimetastatic and anti-cancer stem cell metallohelices via post-assembly modification, Hualong Song, Nicola J. Rogers, Simon J. Allison, Viktor Brabec, Hannah Bridgewater, Hana Kostrhunova, Lenka Markova, Roger M. Phillips, Emma C. Pinder, Samantha L. Shepherd, Lawrence S. Young, Juraj Zajacc and Peter Scott, Chem. Sci. 2019, in press

Mirror-Image Dependence: Targeting Enantiomeric G-Quadruplex DNA Using Triplex Metallohelices, Chuanqi Zhao, Hualong Song, Peter Scott, Andong Zhao, Hisae Tateishi-Karimata, Naoki Sugimoto, Jinsong Ren, Xiaogang Qu, Angew. Chemie. Int. Ed., 2019, 57, 15723-15727.

Polyolefin-Polar Block Copolymers from Versatile New Macromonomers, Christopher J. Kay, Paul D. Goring, Connah A. Burnett,, Ben Hornby, Kenneth Lewtas, Shaun Morris, Colin Morton, Tony McNally, Giles W. Theaker, Carl Waterson, Peter M Wright, Peter Scott, J. Am. Chem. Soc. 2018, 140, 13921-13934.

Stereochemistry and amyloid inhibition: Asymmetric triplex metallohelices enantioselectively bind to Aβ peptide Yijia Guan, Zhi Du, Nan Gao, Yue Cao, Xiaohui Wang, Peter Scott, Hualong Song, Jinsong Ren, Xiaogang Qu, Science Adv., 2018, 4(1)

Antifreeze Protein Mimetic Metallohelices with Potent Ice Recrystallization Inhibition Activity, Daniel E. Mitchell Guy Clarkson, Guy, David J. Fox, Rebecca A. Vipond, Peter Scott, Matthew I Gibson, J. Am. Chem. Soc, 2017, 139, 9835-9838.

Anticancer metallohelices: nanomolar potency and high selectivity, Rebecca A. Kaner, Simon J. Allison, Alan D. Faulkner, Roger M. Phillips, David I. Roper, Samantha L. Shepherd, Daniel H. Simpson, Nicholas R. Waterfield and Peter Scott, Chem. Sci., 2016, 7, 951–958

Shape-selective recognition of DNA abasic sites by metallohelices: inhibition of human AP endonuclease 1, Jaroslav Malina, Peter Scott, Viktor Brabec, Nuc. Acids. Res, 2015, 43, 5297-5306

Fe and Mn complexes of 2-carbonyl pyrrolyls; scorpionate sandwich anions and extended structures; Lihong Li, Guy J Clarkson, Martin R. Lees, Suzanne E. Howson, Sze-yin Tan, Scott S. Turner, Peter Scott, Organometallics, 2015, 34, 2543–2549

Chiral metallo-helical complexes enantioselectively target amyloid β for treating Alzheimer’s disease, Meng Li, Suzanne E. Howson, Kai Dong, Nan Gao, Jinsong Ren, Peter Scott, Xiaogang Qu, J. Am. Chem. Soc. 2014, 136, 11655-11663

Asymmetric peptidomimetic ‘triplex’ metallohelices with high and selective activity against cancer cells, Alan D. Faulkner, Rebecca A. Kaner, Qasem M. A. Abdallah, Guy Clarkson, David J. Fox, Pratik Gurnani, Suzanne E. Howson, Roger M. Phillips, David I. Roper, Daniel H. Simpson, Peter Scott, Nature Chem. 2014, 6, 797-803

Metallohelices with Activity Against Cisplatin-Resistant Cancer Cells; does the mechanism involve DNA binding? Viktor Brabec, Suzanne E. Howson, Rianne M. Lord, Jaroslav Malina, Patrick C. McGowan, Alison Rodger, Peter Scott, Chem. Sci. 2013, 4, 4407-4416

Optically pure, water-stable metallo-helical ‘flexicate’ assemblies with antibiotic activity, Suzanne E. Howson, Albert Bolhuis, Viktor Brabec, Guy J. Clarkson, Jaroslav Malina, Alison Rodger, Peter Scott, Nature Chem., 2012, 4, 31–36