Available Projects
Synthetic and engineering biology for new therapeutics and sustainable chemical production
Our work lies at the interface between systems modelling, control and biotechnology with applications in sustainable chemicals manufacture and pharmaceutical production. Our goal is to understanding the biosynthetic constraints of cell based production systems and then use tools from systems and control to overcome these bottlenecks. Projects in the group can range from completely modelling based to completely experimental and everything in between. We urge interested candidates to get in touch!
Primary supervisor: Dr Alexander Darlington - Email: A.Darlington.1@warwick.ac.uk
Project detail:
Synthetic biology and microbial biotechnology offer sustainable routes to the manufacture of commodity and high value chemicals. However, currently designing industrial strains is a time intensive and expensive process. A key cause of this is our difficulty in predicting the impact novel pathways have on the
host metabolism and wider physiology leading to failure of most initial designs. Microbial ‘cell factories’ are also subjected to industrial constraints such as fermentation strategy and cost. In these projects, the candidate will develop mathematical models of microbial growth over the course of industrial processes. Using these models, we will identify key interactions which result in poor yields and production failures. We will develop control strategies to improve pathway performance and robustness to both biological and industrial constraints. We anticipate candidates will spend time undertaking experimental work in a partner lab to generate data to refine their computational models and to validate the design strategies they uncovered during their research. Candidates can also benefit from our links with industrial partners who will provide commercial insights and feedback throughout the project. Specific projects will be co-developed with the applicants to ensure they are tailored to their skills and interests. Candidates will develop a broad skill set in design, engineering and the application of modern biotechnologies providing a strong foundation for future careers in academia or industry.
The University of Warwick provides an inclusive working and learning environment, recognising and respecting every individual’s differences. We welcome applications from individuals who identify with any of the protected characteristics defined by the Equality Act 2010.