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Professor Andrew Easton

Job Title
Professor
Department
Life Sciences
Phone
02476 524727
Research Interests

Research in the laboratory focuses on the molecular biology of viruses which use a single stranded negative sense RNA molecule as genome. Of particular interest are paramyxoviruses which are responsible acute respiratory infections in their host, though other negative strand viruses are studied for comparison. We have worked for many years on various aspects of the molecular biology of pneumoviruses, which include respiratory syncytial virus, pneumonia virus of mice and avian pneumovirus. Much of our work uses the technique of reverse genetics for analysis of important regulatory sequences controlling virus RNA synthesis and identification of functional domains in proteins involved in virus RNA synthesis. Recently, we have begun work on the protective capacity of specific genome deletions of influenza virus in collaboration with Professor Nigel Dimmock. More details on these viruses and our research interests are available on the Pneumovirus Laboratory website

Biography

BSc (Biochemistry) University of Aberdeen

PhD (Virology) University of Glasgow

  • Kuhn, Jens H., Adkins, Scott, Agwanda, Bernard R., Al Kubrusli, Rim, Alkhovsky A??xo?c??? Cep?e? B?a????po???, Sergey V., Amarasinghe, Gaya K., Av?ic-?upanc, Tatjana, Ayllón, María A., Bahl, Justin, Balkema-Buschmann, Anne, Ballinger, Matthew J., Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolas, Bennett, Andrew J., Bente, Dennis A., Bergeron, Éric, Bird, Brian H., Blair, Carol D. et al (Select to open full list), 2021. 2021 taxonomic update of phylum Negarnaviricota (Riboviria: Orthornavirae), including the large orders Bunyavirales and Mononegavirales. Archives of Virology, 166, pp. 3513-3566
  • Maes, Piet, Amarasinghe, Gaya K., Ayllón, María A., Basler, Christopher F., Bavari, Sina, Blasdell, Kim R., Briese, Thomas, Brown, Paul A., Bukreyev, Alexander, Balkema-Buschmann, Anne, Buchholz, Ursula J., Chandran, Kartik, Crozier, Ian, de Swart, Rik L., Dietzgen, Ralf G., Dolnik, Olga, Domier, Leslie L., Drexler, Jan F., Dürrwald, Ralf, Dundon, William G. et al (Select to open full list), 2019. Taxonomy of the order Mononegavirales: second update 2018. ARCHIVES OF VIROLOGY, 164 (4), pp. 1233-1244
  • Vandersarren, Lana, Bosteels, Cedric, Vanheerswynghels, Manon, Moon, James J., Easton, A. J. (Andrew J.), Van Isterdael, Gert, Janssens, Sophie, Lambrecht, Bart N., van Helden, Mary J., 2017. Epitope mapping and kinetics of CD4 T cell immunity to pneumonia virus of mice in the C57BL/6 strain. Scientific Reports, 7 (1)
  • Gould, Phillip S., Easton, A. J. (Andrew J.), Dimmock, N. J., 2017. Live attenuated influenza vaccine contains substantial and unexpected amounts of defective viral genomic RNA. Viruses, 9 (10)
  • Postler, Thomas S., Clawson, Anna N., Amarasinghe, Gaya K., Basler, Christopher F., Bavari, Sina, Benko, Mária, Blasdell, Kim R., Briese, Thomas, Buchmeier, Michael J., Bukreyev, Alexander, Calisher, Charles H., Chandran, Kartik, Charrel, Rémi, Clegg, Christopher S., Collins, Peter L., de la Torre, Juan Carlos, DeRisi, Joseph L., Dietzgen, Ralf G., Dolnik, Olga, Dürrwald, Ralf et al (Select to open full list), 2017. Possibility and challenges of conversion of current virus species names to Linnaean Binomials. Systematic Biology, 66 (3), pp. 463-473
  • Amarasinghe, Gaya K., Bào, Yimíng, Basler, Christopher F., Bavari, Sina, Beer, Martin, Bejerman, Nicolás, Blasdell, Kim R., Bochnowski, Alisa, Briese, Thomas, Bukreyev, Alexander, Calisher, Charles H., Chandran, Kartik, Collins, Peter L., Dietzgen, Ralf G., Dolnik, Olga, Dürrwald, Ralf, Dye, John M., Easton, Andrew J., Ebihara, Hideki, Fang, Qi et al (Select to open full list), 2017. Taxonomy of the order Mononegavirales : update 2017. Archives of Virology, 162 (8), pp. 2493-2504
  • Afonso, Claudio L., Amarasinghe, Gaya K., Bányai, Krisztián, Bào, Yimíng, Basler, Christopher F., Bavari, Sina, Bejerman, Nicolás, Blasdell, Kim R., Briand, François-Xavier, Briese, Thomas, Bukreyev, Alexander, Calisher, Charles H., Chandran, Kartik, Chéng, Jiasen, Clawson, Anna N., Collins, Peter L., Dietzgen, Ralf G., Dolnik, Olga, Domier, Leslie L., Dürrwald, Ralf et al (Select to open full list), 2016. Taxonomy of the order Mononegavirales : update 2016. Archives of Virology, 161 (8), pp. 2351-2360
  • Smith, Claire, Scott, Paul, O'Callaghan, Christopher, Easton, A. J. (Andrew J.), Dimmock, N. J., 2016. A defective interfering influenza RNA inhibits infectious influenza virus replication in human respiratory tract cells : a potential new human antiviral. Viruses, 8 (8)
  • Dimmock, N. J., Easton, A. J. (Andrew J.), 2015. Cloned defective interfering influenza RNA and a 7 possible pan-specific treatment of respiratory virus 8 diseases. Viruses, 7 (7), pp. 3768-3788
  • Maunder, Helen E., Taylor, Geraldine, Leppard, Keith, Easton, A. J. (Andrew J.), 2015. Intranasal immunisation with recombinant adenovirus vaccines protects against a lethal 2 challenge with pneumonia virus of mice. Vaccine, 33 (48), pp. 6641-6649
  • Munday, Diane C., Wu, Weining, Smith, Nikki, Fix, Jenna, Noton, Sarah Louise, Galloux, Marie, Touzelet, Olivier, Armstrong, Stuart D., Dawson, Jenna M., Aljabr, Waleed, Easton, A. J. (Andrew J.), Rameix-Welti, Marie-Anne, de Oliveira, Andressa Peres, Simabuco, Fernando M., Ventura, Armando M., Hughes, David J., Barr, John N., Fearns, Rachel, Digard, Paul, Eléouët, Jean-François et al (Select to open full list), 2015. Interactome analysis of the human respiratory Syncytial Virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-Protein stability and RNA synthesis. Journal of Virology, 89 (2), pp. 917-930
  • Dimmock, N. J., Easton, A. J. (Andrew J.), 2014. Defective interfering influenza virus RNAs : time to reevaluate their clinical potential as broad-spectrum antivirals?. Journal of Virology, 88 (10), pp. 5217-5227
  • Marriott, Anthony C., Dove, Brian K., Whittaker, Catherine J., Bruce, Christine, Ryan, Kathryn A., Bean, Thomas J., Rayner, Emma, Pearson, Geoff, Taylor, Irene, Dowall, Stuart, Plank, Jenna, Newman, Edmund, Barclay, Wendy S., Dimmock, N. J., Easton, A. J. (Andrew J.), Hallis, Bassam, Silman, Nigel J., Carroll, Miles W., 2014. Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir. PLoS One, 9 (4)
  • Gould, Phillip S., Dyer, Nigel P., Croft, Wayne D., Ott, Sascha, Easton, A. J. (Andrew J.), 2014. Cellular mRNAs access second ORFs using a novel amino acid sequence-dependent coupled translation termination-reinitiation mechanism. RNA, 20, pp. 373-381
  • Smith, Claire M., Sandrini, Sara, Datta, Sumit, Freestone, Primrose, Shafeeq, Sulman, Radhakrishnan, Priya, Williams, Gwyneth, Glenn, Sarah M., Kuipers, Oscar P., Hirst, Robert A., Easton, Andrew J., Andrew, Peter W., O'Callaghan, Christopher, 2014. Respiratory syncytial virus increases the virulence of streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection. American Journal of Respiratory and Critical Care Medicine, 190 (2), pp. 196-207
  • Stock, Emily, Marriott, Anthony C., Easton, A. J. (Andrew J.), 2014. The host-range tdCE phenotype of Chandipura virus is determined by mutations in the polymerase gene. Journal of General Virology, 95 (1), pp. 38-43
  • Smith, C. M., Kulkarni, H., Radhakrishnan, P., Rutman, A., Bankart, M. J., Williams, G., Hirst, R. A., Easton, A. J. (Andrew J.), Andrew, P. W., O'Callaghan, C., 2014. Ciliary dyskinesia is an early feature of respiratory syncytial virus infection. European Respiratory Journal, 43 (2), pp. 485-496
  • Smith, Claire M., Djakow, Jana, Free, Robert C., Djakow, Petr, Lonnen, Rana, Williams, Gwyneth, Pohunek, Petr, Hirst, Robert A., Easton, A. J. (Andrew J.), Andrew, Peter W., O?Callaghan, Christopher, 2012. ciliaFA : a research tool for automated, high-throughput measurement of ciliary beat frequency using freely available software. Cilia, 1 (1)
  • Dimmock, N. J., Dove, Brian K., Scott, P. D. (Paul D.), Meng, Bo, Taylor, Irene, Cheung, Linda, Hallis, Bassam, Marriott, Anthony C., Carroll, Miles W., Easton, A. J. (Andrew J.), 2012. Cloned defective interfering influenza virus protects ferrets from pandemic 2009 influenza A virus and allows protective immunity to be established. PLoS ONE, Vol.7 (No.12)
  • Behjati, Mohaddeseh, Torktaz, Ibrahim, Mohammadpour, Mehrdad, Ahmadian, Gholamreza, Easton, A. J. (Andrew J.), 2012. Comparative modeling of CCRL1, a key protein in masked immune diseases and virtual screening for finding inhibitor of this protein. Bioinformation, Vol.8 (No.7), pp. 336-340
  • Dimmock, N. J., Dove, Brian K., Meng, Bo, Scott, P. D. (Paul D.), Taylor, Irene, Cheung, Linda, Hallis, Bassam, Marriott, Anthony C., Carroll, Miles W., Easton, A. J. (Andrew J.), 2012. Comparison of the protection of ferrets against pandemic 2009 influenza A virus (H1N1) by 244 DI influenza virus and oseltamivir. Antiviral Research, Vol.96 (No.3), pp. 376-385
  • van Helden, Mary J. G., Kooten, Peter J. S. van, Bekker, Cornelis P. J., Gröne, Andrea, Topham, David J., Easton, A. J. (Andrew J.), Boog, Claire J. P., Busch, Dirk H., Zaiss, Dietmar M. W., Sijts, Alice J. A. M., 2012. Pre-existing virus-specific CD8+ T-cells provide protection against pneumovirus-induced disease in mice. Vaccine, Vol.30 (No.45), pp. 6382-6388
  • Evans, Jennifer S., Horton, Daniel L., Easton, A. J. (Andrew J.), Fooks, Anthony R., Banyard, Ashley C., 2012. Rabies virus vaccines : is there a need for a pan-lyssavirus vaccine?. Vaccine, Vol.30 (No.52), pp. 7447-7454
  • Easton, A. J. (Andrew J.), Scott, P. D. (Paul D.), Edworthy, Nicole Lynn, Meng, Bo, Marriott, Anthony C., Dimmock, N. J., 2011. A novel broad-spectrum treatment for respiratory virus infections : influenza-based defective interfering virus provides protection against pneumovirus infection in vivo. Vaccine, Vol.29 (No.15), pp. 2777-2784
  • Scott, P. D. (Paul D.), Meng, B. (Bo), Marriott, Anthony C., Easton, A. J. (Andrew J.), Dimmock, N. J., 2011. Defective interfering influenza A virus protects in vivo against disease caused by a heterologous influenza B virus. Journal of General Virology, Vol.92 (No.9), pp. 2122-2132
  • Scott, P. D. (Paul D.), Meng, Bo, Marriott, Anthony C., Easton, A. J. (Andrew J.), Dimmock, N. J., 2011. Defective interfering influenza virus confers only short-lived protection against influenza virus disease : evidence for a role for adaptive immunity in DI virus-mediated protection in vivo. Vaccine, Vol.29 (No.38), pp. 6584-6591
  • Scott, P. D. (Paul D.), Meng, Bo, Marriott, Anthony C., Easton, A. J. (Andrew J.), Dimmock, N. J., 2011. Defective interfering virus protects elderly mice from influenza. Virology Journal, Vol.8 (No.212)
  • Smith, C. M. (Claire M.), Hirst, R. A., Bankart, Michael J. G., Jones, D. W. (David W.), Easton, A. J. (Andrew J.), Andrew, P. W., O'Callaghan, Christopher, 2011. Cooling of cilia allows functional analysis of the beat pattern for diagnostic testing. Chest, Vol.140 (No.1), pp. 186-190
  • Woodbine, Kerry A., Turner, M. J., Medley, Graham, Scott, P. D. (Paul D.), Easton, A. J. (Andrew J.), Slevin, J., Brown, J. C., Francis, L., Green, Laura E., 2010. A cohort study of post-weaning multisystemic wasting syndrome and PCV2 in 178 pigs from birth to 14 weeks on a single farm in England. Preventive Veterinary Medicine, Vol.97 (No.2), pp. 100-106
  • Ling, R. (Roger), Sinkovic, Sabrina, Toquin, Didier, Guionie, Olivier, Eterradossi, Nicolas, Easton, A. J. (Andrew J.), 2008. Deletion of the SH gene from avian metapneumovirus has a greater impact on virus production and immunogenicity in turkeys than deletion of the G gene or M2-2 open reading frame. Journal of General Virology, Vol.89 (Part 2), pp. 525-533
  • Dibben, Oliver, Thorpe, Lindsay C., Easton, A. J. (Andrew J.), 2008. Roles of the PVM M2-1, M2-2 and P gene ORF 2 (P-2) proteins in viral replication. Virus Research, Vol.131 (No.1), pp. 47-53
  • Naylor, Clive J., Ling, Roger, Edworthy, Nicole Lynn, Savage, Carol E., Easton, A. J. (Andrew J.), 2007. Avian metapneumovirus SH gene end and G protein mutations influence the level of protection of live-vaccine candidates. Journal of General Virology, Vol.88 (No.6), pp. 1767-1775
  • Dibben, Oliver, Easton, A. J. (Andrew J.), 2007. Mutational analysis of the gene start sequences of pneumonia virus of mice. Virus Research, Vol.130 (No.1-2), pp. 303-309
  • Fuller, C. M., Collins, M. S., Easton, A. J. (Andrew J.), Alexander, D. J., 2007. Partial characterisation of five cloned viruses differing in pathogenicity, obtained from a single isolate of pigeon paramyxovirus type 1 (PPMV-1) following passage in fowls' eggs. Archives of Virology, Vol.152 (No.8), pp. 1575-1582
  • Grimaldi, Elizabeth, Claassen, Erwin A. W., Lord, Mike, Smith, Daniel C., Easton, A. J. (Andrew J.), 2007. Stimulation of pneumovirus-specific CD8(+) T-cells using a non-toxic recombinant ricin delivery system. Molecular Immunology, Vol.44 (No.5), pp. 993-998
  • Gould, Phillip S., Easton, A. J. (Andrew J.), 2007. Coupled translation of the second open reading frame of M2 mRNA is sequence dependent and differs significantly within the subfamily Pneumovirinae. Journal of Virology, Vol.81 (No.16), pp. 8488-8496
  • Spooner, Robert A., Smith, Daniel C., Easton, A. J. (Andrew J.), Roberts, L. M. (Lynne M.), Lord, Mike, 2006. Retrograde transport pathways utilised by viruses and protein toxins. Virology Journal, Vol.3
  • Collins, K. R., Easton, A. J. (Andrew J.), 1995. Sequence variation in the haemagglutinin-neuraminidase gene of human parainfluenza virus type 3 isolates in the UK. Epidemiology and Infection, Vol.114 (No.3), pp. 493-500
  • Easton, A. J. (Andrew J.), Eglin, R. P., 1989. Epidemiology of parainfluenza virus type 3 in England and Wales over a ten-year period. Epidemiology and Infection, Vol.102 (No.3), pp. 531-535
  • Martin, Stuart, Terry, Helen Elizabeth, Bridgeman, Anne, Harris, Claire, Blair, Eric, Arnberg, Niklas, Hanke, Tomas, Easton, A. J. (Andrew J.), Burgert, Hans-Gerhard, 2010. Potential of a new subgroup D adenovirus vector for vaccination. 7th Annual Conference of the British Society for Gene Therapy, Royal Holloway Univ London, Egham, England, Mar 29-31, 2010, Published in Human Gene Therapy, pp. 497-498
Title Funder Award start Award end
Zika virus ? harnessing the powers of molecular and device engineering to counter a global threat EPSRC 01 Jun 2016 31 Mar 2017
Commercial development of antivirals for bovine respiratory syncytial virus (BBSRC FLIP) BBSRC 01 Sep 2014 31 Aug 2015
Translation Award: FluPro - a novel flu antiviral Wellcome Trust 01 May 2010 30 Apr 2015
The Development of Novel Multivalent Vaccines BBSRC 17 Jan 2011 16 Jan 2015
BBSRC Pathfinder March 2014 - Novel Inhibitors of Bovine Respiratory Syncytial Virus BBSRC 01 Jul 2014 30 Sep 2014
Phd Studentship Optimisation of current diagnostic capabilities and restrictions to vaccine efficacy for the LyssaviriusesStudents Name: Jenni Evans Animal Health and Veterinary Laboratories Agency 01 Nov 2011 30 Sep 2014
Analysis of the mechanism for coupled transition in cellular virus mRNAs BBSRC 01 Sep 2011 31 Aug 2014
Studies of Chromosome Folding in BacteriaResearch Career Development Fellowship for David Grainger Wellcome Trust 01 Oct 2008 30 Sep 2013
Respiratory Syncytial Virus RNA Helicase Inhibitors Wellcome Trust 22 Jul 2013 16 Sep 2013
Summer Research Student NeuroSolutions Limited 25 Jun 2012 19 Aug 2012
Research project to test activity of PTC compounds against respiratory syncytial virus in cell-based assays PTC Therapeutics, Inc. 01 Apr 2011 31 Mar 2012
Supplement for additional antiviral test work (for summer student) see 30040 RLFAE3005 PTC Therapeutics, Inc. 15 Aug 2011 30 Sep 2011
Wellcome Trust Value in People Award 2010-11 Wellcome Trust 01 Oct 2010 30 Sep 2011
Coupled translation BBSRC 01 Jan 2008 31 Dec 2010
Regulation of Cortical excitability and seizure activity by purines Epilepsy Research UK 01 Jan 2008 31 Dec 2010
VALUE IN PEOPLE AWARD Wellcome Trust 01 Oct 2009 30 Sep 2010
Helping the brain itself: D-ribose to promote recovery after stroke Research into Ageing 01 Oct 2007 30 Sep 2010
Alzheimers Research Trust 2007 Studentship for Ceri Louise Lynn-Adams Alzheimers Research UK 01 Oct 2007 30 Sep 2010
Properties and in vivo mechanisms of action of cloned influenza virus interfering RNA-a new type of antiviral agent. MRC 01 Jan 2007 31 Dec 2009
Wellcome Trust VIP Award 2008-2009 Wellcome Trust 01 Oct 2008 30 Sep 2009
The Application of Reverse genetics to the Study of Pathogenicity in Avian Pneumovirus BBSRC 01 Nov 2005 30 Oct 2008
Wellcome Trust VIP AwardSplit between BioSCi & WMS - TBC £s Wellcome Trust 01 Oct 2007 30 Sep 2008
Vacation Bursary for Rosemary Ewans BBSRC 19 Jul 2004 12 Sep 2004
Real time PCR & high throughput sequencing facilities for biomedical research, microbiology and cell biology BBSRC 01 Oct 2003 30 Jun 2004
Vacation Studentship for Helena Jane Maier Society for General Microbiology 01 Jul 2003 20 Aug 2003