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Keith Leppard - Publications


2011-2015

Chen, Y., Wright, J., Meng, X., and Leppard, K.N. (2015) 'Promyelocytic Leukemia Protein Isoform II Promotes Transcription Factor Recruitment to Activate Interferon beta and Interferon-Responsive Gene Expression', Molecular And Cellular Biology, 35 (10), 1660 - 1672 (0270-7306) [article]

Wright, J., Atwan, Z., Morris, S. J., and Leppard, K. N. (2015) 'The human adenovirus type 5 L4 promoter is negatively regulated by TFII-I and by L4-33K', Journal Of Virology, published on-line, 29 Apr 2015 (0022-538X) [article]

Leppard, Keith N. (2014) 'Adenoviruses: Molecular Biology', in Reference Module in Biomedical Science 1- 9, Elsevier

Wright J. and Leppard K.N. (2013) 'The human adenovirus type 5 L4 promoter is activated by cellular stress response protein p53', Journal Of Virology, 87 (21), 11617 - 11625 (0022-538X) [article]

Seto Donald; Chodosh James; Brister J. Rodney; et al. (2011) 'Using the Whole-Genome Sequence To Characterize and Name Human Adenoviruses', Journal Of Virology, 85 (11), 5701 - 5702 (0022-538X)

Leppard K. N., Wright J. (2011) 'Targeting of PML proteins and PML nuclear bodies by DNA tumour viruses', in The small DNA tumour viruses, 257- 282, Editors: Gaston K (978-1-904455-99-8) Caistor Academic Press



2006 - 2010

SJ Morris, DC Farley,KN Leppard (2010). Generation of cell lines to complement adenovirus vectors using recombination-mediated cassette exchange. BMC Biotechnology 10: 92. [FULL TEXT].

SJ Morris, GE Scott, KN Leppard. Adenovirus late-phase infection is controlled by a novel L4 promoter. Published on-line by Journal Of Virology [FULL TEXT],05 May 2010, and in print: Journal Of Virology 84, 7096-7104 (2010). [ABSTRACT]

KN Leppard, E Emmott, MS Cortese, T Rich (2009). Adenovirus type 5 E4 Orf3 protein targets PML nuclear domains for disruption via a sequence in promyelocytic leukaemia protein isoform II that is predicted as a protein interaction site by bioinformatic analysis. Journal Of General Virology 90, 95-104. [ABSTRACT]

SJ Morris, KN Leppard (2009). Adenovirus serotype 5 L4-22K and L4-33K proteins have distinct functions in regulating late gene expression. Journal Of Virology 83, 3049-3058. [ABSTRACT]

KN Leppard (2008). Adenoviridae: Molecular Biology in Encyclopedia of Virology, vol 1, BWJ Mahy, MHV van Regenmortel (ed.), Elsevier, pp17-23.

A Hoppe, SJ Beech, J Dimmock, KN Leppard (2006). Interaction of the adenovirus type 5 E4 Orf3 protein with promyelocytic leukaemia protein isoform II is required for PML body disruption. Journal Of Virology 80, 3042-3049. [ABSTRACT] [View PDF]

NJ Dimmock, AJ Easton, KN Leppard. Introduction to Modern Virology 6th edition. Blackwell Publishing, 2006.

KN Leppard, J Dimmock (2006). Virus interactions with PML nuclear bodies in Viruses and the Nucleus, JA Hiscox (ed.), Wiley, pp213-246.

 


2001 - 2005

SJ Beech, KJ Lethbridge, N Killick, N McGlincy, KN Leppard (2005). Isoforms of the promyelocytic leukemia protein differ in their effects on ND10 organization. Exp Cell Res 307, 109-117. [ABSTRACT]

DC Farley, JL Brown, KN Leppard (2004). Activation of the early-late switch in adenovirus major late transcription unit expression by L4 gene products. J Virol 78, 1782-1791. [ABSTRACT]

E Guccione, KJ Lethbridge, N Killick, KN Leppard, L Banks (2004). HPV E6 proteins interact with specific PML isoforms and allow distinctions to be made between different POD structures. Oncogene 23, 4662-4672. [ABSTRACT]

J Vellinga, MJWE Rabelink, SJ Cramer, DJM van der Wollenberg, H van der Meulen, KN Leppard, FJ Fallaux, RC Hoeben (2004). Spacers increase the accessibility of peptide ligands linked to the carboxy terminus of adenovirus minor capsid protein IX. Journal Of Virology 78, 3470-3479. [ABSTRACT]

KJ Lethbridge, GE Scott, KN Leppard. Nuclear matrix localization and SUMO-1 modification of adenovirus type 5 E1b 55K protein are controlled by E4 Orf6 protein. Published on-line by J Gen Virol [FULL TEXT],18 Nov 2002, and in print: J Gen Virol 84, 259-268 (2003). [ABSTRACT]

NJ Dimmock, AJ Easton, KN Leppard. Introduction to Modern Virology 5th edn. Blackwell Scientific, 2001.


1996 - 2000

K. N. Leppard. (1999). Mutagenesis of DNA virus genomes, in 'DNA viruses: A practical approach', A. J. Cann (ed.), Oxford University Press, pp47-81.

K. N. Leppard and R. D. Everett (1999). The adenovirus type 5 E1b 55K and E4 Orf3 proteins associate in infected cells and affect ND10 components. J. Gen. Virol. 80, 997-1008. [ABSTRACT]

E. Harfst and K. N. Leppard. (1999). A comparative analysis of the phosphorylation and biochemical properties of wild type and host range variant DNA binding proteins of human adenovirus 5. Virus Genes 18, 97-106. [ABSTRACT]

J. Horridge and K. N. Leppard (1998). The adenovirus 5 E1b 55 kd protein has a functional RNA binding domain. Journal of Virology 72, 9374-9379. [ABSTRACT]

K. N. Leppard (1998). Regulated RNA processing and RNA transport during adenovirus infection. Seminars Virol. 8, 301-307. [Review]

K. N. Leppard. (1997). E4 gene function in adenovirus, adenovirus vector and adeno-associated virus infections. J. Gen. Virol. 78, 2131-2138. [Review]

B. Flanagan, C. R. Pringle and K. N. Leppard. (1997). Live recombinant adenovirus expressing SIV gag protein as an immunogen in mice. Vaccines 97, 321-325.

B. Flanagan, C. R. Pringle and K. N. Leppard (1997). A recombinant human adenovirus expressing the simian immunodeficiency virus Gag antigen can induce long-lived immune responses in mice. J. Gen. Virol.78, 991-997. [ABSTRACT]

R. D. Williams and K. N. Leppard (1996). Human immunodeficiency virus type 1 Rev - dependent effects on the late gene expression of a recombinant human adenovirus. Virus Genes 13: 111-120. [ABSTRACT]

C. Caravokyri and K. N. Leppard (1996). Human adenovirus type 5 variants with sequence alterations flanking the E2A gene: effects on E2 expression and DNA replication. Virus Genes 12: 65-75. [ABSTRACT]

K. N. Leppard and C. R. Pringle (1996). Virus mutants in 'Virology Methods Manual', B. W. J. Mahy and H. O. Kangro eds., Academic Press.


1991 - 1995

C. Caravokyri and K. N. Leppard (1995). Constitutive episomal expression of polypeptide IX in a 293 - based cell line complements the deficiency of pIX-mutant adenovirus type 5. J. Virol. 69: 6627-6633. [ABSTRACT]

M. J. Imperiale, G. Akusjarvi and K. N. Leppard (1995). Post-transcriptional control of adenovirus gene expression. Curr. Topics Microbiol. Immunol. 199(II), Chapter 6, pp139-171.

I. Dix and K. N. Leppard (1995). Expression of adenovirus type 5 E4 Orf2 protein during lytic infection. J. Gen. Virol. 76: 1051-1055.

C. Caravokyri, C. R. Pringle and K. N. Leppard (1993). Human adenovirus type 5 recombinants expressing simian immunodeficiency virus macaque strain gag antigens. J. Gen. Virol. 74: 2819-2824.

I. Dix and K. N. Leppard (1993). Regulated splicing of adenovirus type 5 E4 transcripts and regulated cytoplasmic accumulation of E4 mRNA. J. Virol. 67: 3226-3231.

K. N. Leppard (1993). Selective effects on adenovirus late gene expression of deleting the E1b 55K protein. J. Gen. Virol. 74: 575-582.

I. Dix and K. N. Leppard (1992). Open reading frames 1 and 2 of adenovirus region E4 are conserved between human serotypes 2 and 5. J. Gen. Virol. 73: 2975-2976.


1981 - 1990

K. N. Leppard and T. Shenk (1989). The adenovirus E1B 55kd protein influences mRNA metabolism via an intranuclear effect on RNA metabolism. EMBO Journal 8: 2329-2336.

K. Leppard, S. Pilder, M. Moore, J. Logan and T. Shenk (1987). An adenovirus oncogene post-transcriptionally modulates mRNA accumulation in 'Viral Carcinogenesis', Alfred Benzon Symposium 24, N. O. Kjeldgaard and J. Forchhammer eds., Munksgaard, Copenhagen.

S. Pilder, K. Leppard, J. Logan and T. Shenk (1986). Functional analysis of the adenovirus E1b-55K polypeptide. Cancer Cells 4: 285-290.

S. Benchimol, J. R. Jenkins, L. V. Crawford, K. Leppard, P. Lamb, N. M. Williamson, D. C. Pim and E. Harlow (1984). Molecular analysis of the gene for the p53 cellular tumor antigen. Cancer Cells 2: 383-391

K. N. Leppard and L. V. Crawford (1984). An oligomeric form of Simian Virus 40 T-antigen is immunologically related to the cellular tumor antigen, p53. J.Virol. 50: 457-464.

K. Leppard, N. Totty, M. Waterfield, E. Harlow, J. Jenkins and L. Crawford (1983). Purification and partial amino acid sequence analysis of the cellular tumour antigen, p53, from mouse SV40-transformed cells. EMBO Journal 2: 1993-1999.

K. Leppard and L. Crawford (1983). Monoclonal antibodies displaying a novel species specificity for the primate transformation-related protein p53. EMBO Journal 2: 1457-1464.

L. Crawford, K. Leppard, D. Lane and E. Harlow (1982). Cross-reactions between cellular proteins and SV40 T-antigen in 'Tumor Viruses and Differentiation', E. M. Scolnick and A. J. Levine, eds., A.R.Liss Inc, New York.

L. Crawford, K. Leppard, D. Lane and E. Harlow (1982). Cellular proteins reactive with monoclonal antibodies directed against Simian Virus 40 T-antigen. J.Virol. 42: 612-620.