Publications
A complete up-to-date list of publications of Robert can be found on Google Scholar and full-texts might be available from the Warwick Research Active Portal (WRAP).
Dose and time-dependent tolerability and efficacy of organo-osmium complex FY26 and its tissue pharmacokinetics in hepatocarcinoma-bearing mice
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The organo-osmium complex [OsII(ɳ6-p-cym)(PhAzPy-NMe2)I]+ (FY26) exhibits promising in vitro antitumour activity against mouse hepatocarcinoma Hepa1-6 and other mouse or human cancer cell lines. Here, we drastically enhance water solubility of FY26 through the replacement of the PF6-counter-anion with chloride using a novel synthesis method. FY26.PF6 and FY26.Cl displayed similar in vitro cytoxicity in two cancer cell models. We then show the moderate and late anticancer efficacy of FY26.PF6 and FY26.Cl in a subcutaneous murine hepatocarcinoma mouse model. Both efficacy and tolerability varied according to FY26 circadian dosing time in hepatocarcinoma tumour-bearing mice. Tumour and liver uptake of the drug were determined over 48 h following FY26.Cl administration at Zeitgeber 6 (ZT6), when the drug is least toxic (in the middle of the light span when mice are resting). Our studies suggest the need to administer protracted low doses of FY26 at ZT6 in order to optimize its delivery schedule, for example through the use of chrono-releasing nanoparticles. |
Low-Cost Microfabrication Tool Box
Microsystems are key enabling technologies, with applications found in almost every industrial field, including in vitro diagnostic, energy harvesting, automotive, telecommunication, drug screening. Yet, their development for commercial or educational purposes has typically been limited to specialized laboratories in upper-income countries. In this paper, we describe a range of low-cost approaches and equipment (below £1000), which will enable researchers to build a low-cost toolbox.
Review on how stress increases the susceptibility to herpes simplex virus type 1 primary and recurrent infections
Following primary infection, HSV-1 establishes latency and reactivates under stress. Stress disturbs inner immune Yin–Yang balance, increasing the susceptibility to HSV-1 infection. In latent infection, stress induces changes in hormone level, chromosomal modification and oxidation, thereby disturbing the Yin–Yang balance between HSV-1 and the host defense, leading to recurrent diseases.
Pgp expression is modulated by the circadian clock, food intake and sex
Co-lead author Swati A. Kumar in a collaboration with Annabelle Ballesta, Alper Okyar, Francis Lévi, Enza Piccolo and us entitled: Sex-, feeding-, and circadian time-dependency of P-glycoprotein expression and activity - implications for mechanistic pharmacokinetics modeling, we described how time-of-day of drug administration might lead to different pharmacokinetic profiles in male and female mice.
Alper Okyar, Swati Kumar, Elisabeth Filipski, Enza Piccolo, Narin Ozturk, Helena Xandri-Monje, Zeliha Pala, Kristin Abraham, Ana Rita Gato de Jesus Gomes, Mehmet N. Orman, Xiao-Mei Li, Robert Dallmann, Francis Lévi, Annabelle Ballesta, Scientific Reports, 2019, DOI: 10.1038/s41598-019-46977-0
Hyperbranched poly(ethylenimine-co-oxazoline) by thiol-yne chemistry for non-viral gene delivery:investigating the role of polymer architecture
Happy to have been able to help out for this interesting new paper looking into new ways of transfecting cells.