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Research at the BRU

In 2012, University Hospital Coventry and Warwickshire (UHCW) NHS Trust and Warwick Medical School (WMS) established the Biomedical Research Unit in Reproductive Health (BRU-RH); a showcase unit built upon the Biomedical Research Unit model from the National Institute of Health Research (NIHR). Our goal is to establish the leading centre in translational reproductive health research in the UK.

The BRU-RH strives to improve the management and outcome of prevalent pregnancy-associated disorders by conducting well-powered observational and interventional clinical studies underpinned by innovative basic and translational research. It provides the infrastructure and resources for systematic sample collection (biobank), deep clinical phenotyping (database), advanced ultrasound imaging and laboratory analyses.

Uniquely, women at risk of reproductive failure and obstetrical complications are seen in dedicated research clinics before pregnancy. This allows us to combine detailed analysis of the intrauterine milieu prior to embryo implantation with longitudinal measurements of subsequent growth and wellbeing of the fetus until birth and beyond.

The development of preconception biomarkers will enable genuine prevention of maternal, fetal, and neonatal disease or death, as well as subsequent childhood handicap and ill health.

The BRU-RH resource supports research programmes aimed at delivering improved patient care, new therapeutics and diagnostics, and more cost-effective healthcare provision for women at risk of adverse pregnancy outcome.