Professor Jan Brosens' research centres on the role of steroid hormone signalling in the human endometrium, especially in the context of prevalent reproductive disorders, such as infertility, endometriosis and endometrial cancer. his major translational interest is focused on improving the management of miscarriage, the most common complication of pregnancy. He obtained a PhD from the University of London in 1999, working on the mechanisms underpinning the preparation of the lining of the womb (endometrium) for pregnancy, a process called decidualization. He was awarded a Wellcome Trust Clinical Scientist Fellowship in 1998, then joined Imperial College London as Chair of Reproductive Sciences in 2004 and became Chair of Reproductive Medicine in 2008. In May 2011 he was appointed as Chair of Obstetrics and Gynaecology at the University of Warwick.
- Muter, Joanne, Seng-Kong, Chow, Brosens, Jan J., 2022. The role of decidual subpopulations at implantation, menstruation and miscarriage. Frontiers in Reproductive Health
- 'Grewal, Karen, 'Lee, Yun S., 'Smith, Ann, 'Brosens, Jan J., 'Bourne, Tom, 'Al-Memar, Maya, 'Kundu, Samit, 'MacIntyre, David A., 'Bennett, Phillip R., 2022. 'Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation. BMC Medicine, 20 (1)
- 'Lipecki, Julia, 'Mitchell, Andrew E., 'Muter, Joanne, 'Lucas, Emma S., 'Makwana, Komal, 'Fishwick, Katherine, 'Odendaal, Joshua, 'Hawkes, Amelia, 'Vrljicak, Pavle, 'Brosens, Jan J., 'Ott, Sascha, 2022. 'EndoTime : non-categorical timing estimates for luteal endometrium. Human Reproduction, 37 (4), pp. 747-761
- 'Mann, O. N., 'Kong, C.-S., 'Lucas, E. S., 'Brosens, J. J., 'Hanyaloglu, A. C., 'Brighton, P. J., 2022. 'Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells. Scientific Reports, 12 (1)
- 'Tavares, Manuel, 'Khandelwal, Garima, 'Muter, Joanne, 'Viiri, Keijo, 'Beltran, Manuel, 'Brosens, Jan J., 'Jenner, Richard G., 2022. 'JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation. Cell Reports, 39 (9)
- Gharanei, Seley, Fishwick, Katherine, Peter Durairaj, Ruban Rex, Jin, Tianrong, Siamantouras, Eleftherios, Liu, Kuo-Kang, Straube, Anne, Lucas, Emma S., Weston, Christopher, Rantakari, Pia, Salmi, Marko, Jalkanen, Sirpa, Brosens, Jan J., Tan, Bee K., 2021. Vascular adhesion protein-1 determines the cellular properties of endometrial pericytes. Frontiers in Cell and Developmental Biology, 8
- Harden, Sarah, Zhou, Jieliang, Gharanei, Seley, Diniz-da-Costa, Maria, Lucas, Emma S., Cui, Liang, Murakami, Keisuke, Fang, Jinling, Chen, Qingfeng, Brosens, Jan J., Lee, Yie Hou, 2021. Exometabolomic analysis of decidualizing human endometrial stromal and perivascular cells. Frontiers, 9
- Rawlings, Thomas M., Makwana, Komal, Taylor, Deborah, Molè, Matteo A., Fishwick, Katherine J., Tryfonos, Maria, Odendaal, Joshua, Hawkes, Amelia, Zernicka-Goetz, Magdalena, Hartshorne, Geraldine M., Brosens, Jan J., Lucas, Emma S., 2021. Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids. eLife, 10
- Kong, Chow-Seng, Ordoñez, Alexandra Almansa, Turner, Sarah, Tremaine, Tina, Muter, Joanne, Lucas, Emma S., Salisbury, Emma, Vassena, Rita, Tiscornia, Gustavo, Fouladi-Nashta, Ali, Hartshorne, Geraldine M., Brosens, Jan J., Brighton, Paul, 2021. Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation. The FASEB Journal, 35 (4)
- 'Diniz-da-Costa, Maria, 'Kong, Chow-Seng, 'Fishwick, Katherine, 'Rawlings, Thomas, 'Brighton, Paul (Paul J.), 'Hawkes, Amelia, 'Odendaal, Joshua, 'Quenby, Siobhan, 'Ott, Sascha, 'Lucas, Emma S., 'Vrljicak, Pavle, 'Brosens, Jan J., 2021. 'Characterization of highly proliferative decidual precursor cells during the window of implantation in human endometrium. Stem Cells, 39 (8), pp. 1067-1080
- Lucciola, Raffaella, Vrljicak, Pavle, Gurung, Shanti, Filby, Caitlin, Darzi, Saeedeh, Muter, Joanne, Ott, Sascha, Brosens, Jan J., Gargett, Caroline E., 2020. Impact of sustained transforming growth factor-ß receptor inhibition on chromatin accessibility and gene expression in cultured human endometrial MSC. Frontiers in Cell and Developmental Biology, 8
- Lucas, Emma S., Vrljicak, Pavle, Muter, Joanne, Diniz-da-Costa, Maria, Brighton, Paul (Paul J.), Kong, Chow-Seng, Lipecki, Julia, Fishwick, Katherine J., Odendaal, Joshua, Ewington, Lauren J., Quenby, Siobhan, Ott, Sascha, Brosens, Jan J., 2020. Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window. Communications Biology, 3 (1)
- Tewary, Shreeya, Lucas, Emma S., Fujihara, Risa, Kimani, Peter K., Polanco, Angela, Brighton, Paul (Paul J.), Muter, Joanne, Fishwick, Katherine, Da Costa, Maria José Minhoto Diniz, Ewington, Lauren J., Lacey, Lauren, Takeda, Satoru, Brosens, Jan J., Quenby, Siobhan, 2020. Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial. EBioMedicine, 51
- Brosens, Ivo, Brosens, Jan J., Muter, Joanne, Puttemans, Patrick, Benagiano, Giuseppe, 2019. Preeclampsia: the role of persistent endothelial cells in uteroplacental arteries. American Journal of Obstetrics and Gynecology
- Richardson, Sarah, Rawlings, Thomas M., Muter, Joanne, Walker, Marc, Brosens, Jan J., Cameron, Neil R., Eissa, Ahmed M., 2019. Covalent attachment of fibronectin onto emulsion-templated porous polymer scaffolds enhances human endometrial stromal cell adhesion, infiltration, and function. Macromolecular Bioscience, 19 (2)
- Ochiai, Asako, Kuroda, Keiji, Ozaki, Rie, Ikemoto, Yuko, Murakami, Keisuke, Muter, Joanne, Matsumoto, Akemi, Itakura, Atsuo, Brosens, Jan J., Takeda, Satoru, 2019. Resveratrol inhibits decidualization by accelerating downregulation of the CRABP2-RAR pathway in differentiating human endometrial stromal cells. Cell Death & Disease, 10 (4)
- Craciunas, Laurentiu, Gallos, Ioannis, Chu, Justin, Bourne, Tom, Quenby, Siobhan, Brosens, Jan J., Coomarasamy, Arri, 2019. Conventional and modern markers of endometrial receptivity : a systematic review and meta-analysis. Human Reproduction Update, 25 (2), pp. 202-223
- Muter, Joanne, Alam, Mohammad T., Vrljicak, Pavle, Barros, Flavio S. V., Ruane, Peter T., Ewington, Lauren J., Aplin, John D., Westwood, Melissa, Brosens, Jan J., 2018. The glycosyltransferase EOGT regulates adropin expression in decidualizing human endometrium. Endocrinology, 159 (2), pp. 994-1004
- Aberkane, A, Essahib, W, Spits, C, De Paepe, C, Sermon, K, Adriaenssens, T, Mackens, S, Tournaye, H, Brosens, Jan J., Van de Velde, H, 2018. Expression of adhesion and extracellular matrix genes in human blastocysts upon attachment in a 2D co-culture system. Molecular Human Reproduction, 24 (7), pp. 375-387
- Zaucker, Andreas, Nagorska, Agnieszka, Kumari, Pooja, Hecker, Nikolai, Wang, Ying, Huang, Sizhou, Cooper, Ledean, Sivashanmugam, Lavanya, Vijaykumar, Shruthi, Brosens, Jan J., Gorodkin, Jan, Sampath, Karuna, 2018. Translational co-regulation of a ligand and inhibitor by a conserved RNA element. Nucleic Acids Research, 46 (1), pp. 104-119
- Vrljicak, Pavle, Lucas, Emma S., Lansdowne, Lauren, Lucciola, Raffaella, Muter, Joanne, Dyer, Nigel P., Brosens, Jan J., Ott, Sascha, 2018. Analysis of chromatin accessibility in decidualizing human endometrial stromal cells. FASEB Journal, 32 (5), pp. 2467-2477
- Eissa, Ahmed M., Barros, Flavio, Vrljicak, Pavle, Brosens, Jan J., Cameron, Neil R., 2018. Enhanced differentiation potential of primary human endometrial cells cultured on 3D scaffolds. Biomacromolecules, 19 (8), pp. 3343-3350
- Ewington, Lauren J., Tewary, Shreeya, Brosens, Jan J., 2018. New insights into the mechanisms underlying recurrent pregnancy loss. Journal of Obstetrics and Gynaecology Research, 45 (2), pp. 258-265
- Southcombe, J. H., Mounce, G., McGee, K. C., Elghajiji, A., Brosens, Jan J., Quenby, Siobhan, Child, T., Granne, I., 2017. An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage. Scientific Reports, 7
- Sposini, Silvia, Jean-Alphonse, Frederic G., Ayoub, Mohammed A., Oqua, Affiong, West, Camilla, Lavery, Stuart, Brosens, Jan J., Reiter, Eric, Hanyaloglu, Aylin C., 2017. Integration of GPCR signaling and sorting from very early endosomes via opposing APPL1 mechanisms. Cell Reports, 21 (10), pp. 2855-2867
- Tochigi, Hideno, Kajihara, Takeshi, Mizuno, Yosuke, Mizuno, Yumi, Tamaru, Shunsuke, Kamei, Yoshimasa, Okazaki, Yasushi, Brosens, Jan J., Ishihara, Osamu, 2017. Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells. Scientific Reports, 7
- Brosens, Ivo, Benagiano, Giuseppe, Brosens, Jan J., 2017. Endometriosis and obstetric syndromes : early diagnosis must become a priority. Fertility and Sterility, 107 (1), pp. 66-67
- Peter Durairaj, Ruban Rex, Aberkane, Asma, Polanski, Lukasz T., Maruyama, Yojiro, Baumgarten, Miriam N., Lucas, Emma S., Quenby, Siobhan, Chan, Jerry K. Y., Raine-Fenning, Nick, Brosens, Jan J., Van de Velde, Hilde, Lee, Yie Hou, 2017. Deregulation of the endometrial stromal cell secretome precedes embryo implantation failure. Molecular Human Reproduction, 23 (7), pp. 478-487
- Ozaki, Rie, Kuroda, Keiji, Ikemoto, Yuko, Ochiai, Asako, Matsumoto, Akemi, Kumakiri, Jun, Kitade, Mari, Itakura, Atsuo, Muter, Joanne, Brosens, Jan J., Takeda, Satoru, 2017. Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells. PLoS One, 12 (3)
- Brosens, Jan J., 2017. Decidual Cells at Implantation. Placenta, 57
- Brighton, Paul (Paul J.), Maruyama, Yojiro, Fishwick, Katherine, Vrljicak, Pavle, Tewary, Shreeya, Fujihara, Risa, Muter, Joanne, Lucas, Emma S., Yamada, Taihei, Woods, Laura, Lucciola, Raffaella, Lee, Yie Hou, Takeda, Satoru, Ott, Sascha, Hemberger, Myriam, Quenby, Siobhan, Brosens, Jan J., 2017. Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium. eLife, 6
- Salker, Madhuri S., Steel, Jennifer H., Hosseinzadeh, Zohreh, Nautiyal, Jaya, Webster, Zoe, Singh, Yogesh, Brucker, Sara, Lang, Florian, Brosens, Jan J., 2016. Activation of SGK1 in endometrial epithelial cells in response to PI3K/AKT inhibition impairs embryo implantation. Cellular Physiology and Biochemistry, 39 (5), pp. 2077-2087
- Wongwananuruk, Thanyarat, Sato, Tomomi, Kajihara, Takeshi, Matsumoto, Sachiko, Akita, Masumi, Tamura, Kazuhiro, Brosens, Jan J., Ishihara, Osamu, 2016. Endometrial androgen signaling and decidualization regulate trophoblast expansion and invasion in co-culture : a time-lapse study. Placenta, 47, pp. 56-62
- Barros, Flavio, Brosens, Jan J., Brighton, Paul (Paul J.), 2016. Isolation and primary culture of various cell types from whole human endometrial biopsies. Bio-protocol, 6 (22)
- Salker, Madhuri S., Hosseinzadeh, Zohreh, Alowayed, Nour, Zeng, Ni, Umbach, Anja T., Webster, Zoe, Singh, Yogesh, Brosens, Jan J., Lang, Florian, 2016. LEFTYA activates the epithelial Na+ Channel (ENaC) in endometrial cells via serum and glucocorticoid inducible kinase SGK1. Cellular Physiology and Biochemistry, 39 (4), pp. 1295-1306
- Gysler, Stefan M., Mulla, Melissa J., Guerra, Marta, Brosens, Jan J., Salmon, Jane E., Chamley, Lawrence W., Abrahams, Vikki M., 2016. Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Molecular Human Reproduction, 22 (7), pp. 465-474
- Brosens, Ivo, Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, Jan J., Benagiano, G., 2016. Origins and progression of adolescent endometriosis. Reproductive Sciences, 23 (10), pp. 1282-1288
- Lucas, Emma S., Dyer, Nigel P., Fishwick, Katherine, Ott, Sascha, Brosens, Jan J., 2016. Success after failure : the role of endometrial stem cells in recurrent miscarriage. Reproduction, 152 (5), pp. R159-R166
- Muter, Joanne, Brighton, Paul, Lucas, Emma S., Lacey, Lauren, Shmygol, Anatoly, Quenby, Siobhan, Blanks, Andrew M., Brosens, Jan J., 2016. Progesterone-dependent induction of phospholipase C-related catalytically inactive protein 1 (PRIP-1) in decidualizing human endometrial stromal cells. Endocrinology, 157 (7), pp. 2883-2893
- Lucas, Emma S., Dyer, Nigel P., Murakami, Keisuke, Hou Lee, Yie, Chan, Yi-Wah, Grimaldi, Giulia, Muter, Joanne, Brighton, Paul (Paul J.), Moore, Jonathan D., Patel, Gnyaneshwari, Chan, Jerry K.Y., Takeda, Satoru, Lam, Eric W-F., Quenby, Siobhan, Ott, Sascha, Brosens, Jan J., 2016. Loss of endometrial plasticity in recurrent pregnancy loss. Stem Cells, 34 (2), pp. 346-356
- Brosens, Ivo, Curcic, A., Vejnovic, T., Gargett, Caroline E., Brosens, Jan J., Benagiano, Giuseppe, 2015. The perinatal origins of major reproductive disorders in the adolescent : research avenues. Placenta, 36 (4), pp. 341-344
- Brosens, Jan J., Benagiano, Giuseppe, Brosens, Ivo, 2015. The potential perinatal origin of placentation disorders in the young primigravida. American Journal of Obstetrics and Gynecology, 212 (5), pp. 580-585
- Muter, Joanne, Lucas, Emma S., Chan, Yi-Wah, Brighton, Paul (Paul J.), Moore, Jonathan D., Lacey, Lauren, Quenby, Siobhan, Lam, Eric W.-F., Brosens, Jan J., 2015. The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells. The FASEB Journal, 29 (4), pp. 1603-1614
- Murakami, Keisuke, Lee, Yie Hou, Lucas, Emma S., Chan, Yi-Wah, Peter Durairaj, Ruban Rex, Takeda, Satoru, Moore, Jonathan D., Tan, Bee K., Quenby, Siobhan, Chan, Jerry K. Y., Gargett, Caroline E., Brosens, Jan J., 2014. Decidualization induces a secretome switch in perivascular niche cells of the human endometrium. Endocrinology, 155 (11), pp. 4542-4553
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McCloskey, Conor, Rada, Cara, Bailey, Elizabeth, McCavera, Samantha, Berg, Hugo van den, Atia, Jolene, Rand, D. A., Shmygol, Anatoly, Chan, Yi-Wah, Quenby, Siobhan, Brosens, Jan J., Vatish, Manu, Zhang, Jie, Denton, Jerod S., Taggart, Michael J., Kettleborough, Catherine, Tickle, David, Jerman, Jeff, Wright, Paul, Dale, Timothy et al (Select to open full list), 2014.
- Polanski, Lukasz T., Barbosa, M. A. P., Martins, W. P., Baumgarten, M. N., Campbell, B. (Bruce), Brosens, Jan J., Quenby, Siobhan, Raine-Fenning, Nick, 2014. Interventions to improve reproductive outcomes in women with elevated natural killer cells undergoing assisted reproduction techniques : a systematic review of literature. Human Reproduction, 29 (1), pp. 65-75
- Brosens, Jan J., Blanks, Andrew M., Lucas, Emma S., 2014. LRH-1 : orphaned, adopted and needed for pregnancy. Nature Medicine, 19 (8), pp. 968-969
- Kuroda, Keiji, Uchida, T., Nagai, S., Ozaki, R., Yamaguchi, T., Sato, Y., Brosens, Jan J., Takeda, Satoru, 2014. Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age. Journal of Assisted Reproduction and Genetics, 32 (2), pp. 243-247
- Brosens, Jan J., Salker, Madhuri S., Teklenburg, Gijs, Nautiyal, Jaya, Salter, Scarlett, Lucas, Emma S., Steel, Jennifer H., Christian, Mark, Chan, Yi-Wah, Boomsma, Carolien M., Moore, Jonathan D., Hartshorne, Geraldine M., ?ucurovic, Sandra, Mulac-Jericevic, Biserka, Heijnen, Cobi J., Quenby, Siobhan, Groot Koerkamp, Marian J., Holstege, Frank C. P., Shmygol, Anatoly, Macklon, Nick S., 2014. Uterine selection of human embryos at implantation. Scientific Reports, 4
- Brosens, Ivo, Brosens, Jan J., Benagiano, Giuseppe, 2014. The risk of obstetrical syndromes after solid organ transplantation. Best Practice & Research Clinical Obstetrics & Gynaecology, 28 (8), pp. 1211-1221
- Myatt, Stephen S., Kongsema, M., Man, Cornelia W-Y., Kelly, D. J., Gomes, Ana R., Khongkow, P., Karunarathna, U., Zona, Stefania, Langer, J. K., Dunsby, C. W., Coombes, R. C., French, P. M., Brosens, Jan J., Lam, Eric W.-F., 2014. SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene, 33 (34), pp. 4316-4329
- Gysler, Stefan M., Mulla, Melissa J., Stuhlman, Meredith, Sfakianaki, Anna K., Paidas, Michael J., Stanwood, Nancy L., Gariepy, Aileen, Brosens, Jan J., Chamley, Lawrence W., Abrahams, Vikki M., 2014. Vitamin D reverses aPL-induced inflammation and LMWH-induced sFlt-1 release by human trophoblast. American Journal of Reproductive Immunology, pp. n/a-n/a
- Polanski, Lukasz T., Baumgarten, Miriam N., Quenby, Siobhan, Brosens, Jan J., Campbell, Bruce K., Raine-Fenning, Nicholas J., 2014. What exactly do we mean by ?recurrent implantation failure'? A systematic review and opinion. Reproductive Biomedicine Online, 28 (4), pp. 409-423
- Albert, Caroline R., Schlesinger, William J., Viall, Chez A., Mulla, Melissa J., Brosens, Jan J., Chamley, Lawrence W., Abrahams, Vikki M., 2014. Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function. American Journal of Reproductive Immunology, 71 (2), pp. 154-164
- Macklon, N. S., Brosens, Jan J., 2014. The human endometrium as a sensor of embryo quality. Biology of Reproduction, 91 (4)
- Kajihara, T., Tanaka, K., Oguro, T., Tochigi, H., Prechapanich, J., Uchino, S., Itakura, A., ?ucurovic, Sandra, Murakami, Keisuke, Brosens, Jan J., Ishihara, O., 2014. Androgens modulate the morphological characteristics of human endometrial stromal cells decidualized in vitro. Reproductive Sciences, 21 (3), pp. 372-380
- Murakami, Keisuke, Bhandari, Harish, Lucas, Emma S., Takeda, Satoru, Gargett, Caroline E., Quenby, Siobhan, Brosens, Jan J., Tan, Bee K., 2013. Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure ? a pilot study. PLoS One, 8 (12)
- Kuroda, Keiji, Venkatakrishnan, R., James, S., Sucurovic, S., Mulac-Jericevic, B., Lucas, Emma S., Takeda, Satoru, Shmygol, Anatoly, Brosens, Jan J., Quenby, Siobhan, 2013. Elevated periimplantation uterine natural killer cell density in human endometrium is associated with impaired corticosteroid signaling in decidualizing stromal cells. Journal of Clinical Endocrinology & Metabolism, 98 (11), pp. 4429-4437
- Lam, Eric W.-F., Brosens, Jan J., Gomes, Ana R., Koo, Chuay-Yeng, 2013. Forkhead box proteins : tuning forks for transcriptional harmony. Nature Reviews Cancer, 13 (7), pp. 482-495
- Quenby, Siobhan, Brosens, Jan J., 2013. Human implantation : a tale of mutual maternal and fetal attraction. Biology of Reproduction, 88 (3)
- Kuroda, Keiji, Venkatakrishnan, R., Salker, Madhuri S., Lucas, Emma S., Shaheen, Fozia, Blanks, Andrew M., Christian, Mark, Quenby, Siobhan, Brosens, Jan J., 2013. Induction of 11beta-hydroxysteroid dehydrogenase type 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Molecular Endocrinology, 27 (2), pp. 192-202
- Kuroda, Keiji, Venkatakrishnan, R., Salker, Madhuri S., Lucas, Emma S., Shaheen, Fozia, Kuroda, Masako, Blanks, Andrew M., Christian, Mark, Quenby, Siobhan, Brosens, Jan J., 2013. Induction of 11 -HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Molecular Endocrinology, 27 (2), pp. 192-202
- Shah, Kunal M., Webber, Jason, Dr., Carzaniga, Raffaella, Taylor, Deborah M., Fusi, Luca, Clayton, Aled, Brosens, Jan J., Hartshorne, Geraldine M., Christian, Mark, 2013. Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells. Journal of Molecular Cell Biology, 5 (1), pp. 67-70
- Blanks, Andrew M., Brosens, Jan J., 2013. Meaningful menstruation : cyclic renewal of the endometrium is key to reproductive success. BioEssays, 35 (5), pp. 412-412
- Brosens, Jan J., Lam, Eric W.-F., 2013. Progesterone and FOXO1 signaling : harnessing cellular senescence for the treatment of ovarian cancer. Cell Cycle, 12 (11)
- Lucas, Emma S., Salker, Madhuri S., Brosens, Jan J., 2013. Reprint of : Uterine plasticity and reproductive fitness. Reproductive Biomedicine Online, 27 (6), pp. 664-672
- Kajihara, T., Brosens, Jan J., Ishihara, Osamu, 2013. The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy. Medical Molecular Morphology, 46 (2), pp. 61-68
- Lucas, Emma S., Salker, Madhuri S., Brosens, Jan J., 2013. Uterine plasticity and reproductive fitness. Reproductive Biomedicine Online, 27 (5), pp. 506-514
- Mulla, Melissa J., Salmon, Jane E., Chamley, Larry W., Brosens, Jan J., Boeras, Crina M., Kavathas, Paula B., Abrahams, Vikki M., 2013. A role for uric acid and the nalp3 inflammasome in antiphospholipid antibody-induced IL-1ß production by human first trimester trophoblast. PLoS One, 8 (6)
- Schmidt, S., Schneider, S., Yang, W., Liu, G., Schmidt, E. - M., Schmid, E., Mia, S., Brucker, S., Stournaras, C., Wallwiener, D., Brosens, Jan J., Lang, F., 2013. TGF 1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells. Molecular Human Reproduction, 20 (2), pp. 139-147
- Salker, Madhuri S., Nautiyal, Jaya, Steel, Jennifer H., Webster, Zoe, ?ucurovic, Sandra, Nicou, Marilena, Singh, Yogesh, Dr., Lucas, Emma S., Murakami, Keisuke, Chan, Yi-Wah, James, Sean G., Abdallah, Yazan, Christian, Mark, Croy, B. A. (B. Anne), Mulac-Jericevic, Biserka, Quenby, Siobhan, Brosens, Jan J., 2012. Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss. PLoS One, Vol.7 (No.12)
- Weimar, Charlotte H. E., Kavelaars, Annemieke, Brosens, Jan J., Gellersen, Birgit, de Vreeden-Elbertse, Johanna M. T., Heijnen, Cobi J., Macklon, Nick S., 2012. Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos. PLoS ONE, Vol.7 (No.7)
- Grimaldi, Giulia, Christian, Mark, Quenby, Siobhan, Brosens, Jan J., 2012. Expression of epigenetic effectors in decidualizing human endometrial stromal cells. Molecular Human Reproduction, 18 (9), pp. 451-458
- Kuroda, Masako, Kuroda, Keiji, Arakawa, Atsushi, Fukumura, Yuki, Kitade, Mari, Kikuchi, Iwaho, Kumakiri, Jun, Matsuoka, Shozo, Brosens, Ivo A., Brosens, Jan J., Takeda, Satoru, Yao, Takashi, 2012. Histological assessment of impact of ovarian endometrioma and laparoscopic cystectomy on ovarian reserve. Journal of Obstetrics and Gynaecology Research, 38 (9), pp. 1187-1193
- Al-Sabbagh, Marwa, Lam, Eric W.-F., Brosens, Jan J., 2012. Mechanisms of endometrial progesterone resistance. Molecular and Cellular Endocrinology, 358 (2), pp. 208-215
- Koot, Y.E.M., Teklenburg, G., Salker, M.S., Brosens, Jan J., Macklon, N.S., 2012. Molecular aspects of implantation failure. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1822 (No.12), pp. 1943-1950
- Odiari, E. A., Mulla, M. J., Sfakianaki, A. K., Paidas, M. J., Stanwood, N. L., Gariepy, A., Brosens, Jan J., Chamley, L. W., Abrahams, V. M., 2012. Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function. Human Reproduction, Vol.27 (No.10), pp. 2933-2940
- Diaz, J., Aranda, E., Henriquez, S., Quezada, M., Espinoza, E., Bravo, M. L., Oliva, B., Lange, S., Villalon, M., Jones, M., Brosens, Jan J., Kato, S., Cuello, M. A., Knutson, T. P., Lange, C. A., Leyton, L., Owen, G. I., 2012. Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1. Journal of Endocrinology, Vol.214 (No.2), pp. 165-175
- Brosens, Ivo, Brosens, Jan J., Fusi, Luca, Al-Sabbagh, Marwa, Kuroda, Keiji, Benagiano, Giuseppe, 2012. Risks of adverse pregnancy outcome in endometriosis. Fertility and Sterility, 98 (1), pp. 30-35
- Brosens, Ivo, Brosens, Jan J., Benagiano, Giuseppe, 2012. The eutopic endometrium in endometriosis : are the changes of clinical significance?. Reproductive Biomedicine Online, Vol.24 (No.5), pp. 496-502
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Yusuf, Dimas, Butland, Stefanie L., Swanson, Magdalena I., Bolotin, Eugene, Ticoll, Amy, Cheung, Warren A., Cindy Zhang, Xiao, Dickman, Christopher T. D., Fulton, Debra L., Lim, Jonathan S., Schnabl, Jake M., Ramos, Oscar H. P., Vasseur-Cognet, Mireille, de Leeuw, Charles N., Simpson, Elizabeth M., Ryffel, Gerhart U., Lam, Eric W. -F., Kist, Ralf, Wilson, Miranda S. C., Marco-Ferreres, Raquel et al (Select to open full list), 2012.
- Brosens, Jan J., Gellersen, Birgit, 2012. The uterus under hormonal control ? cycling for life. Molecular and Cellular Endocrinology, 358 (2)
- Lee, Yun, Sooranna, Suren R., Terzidou, Vasso, Christian, Mark, Brosens, Jan J., Huhtinen, Kaisa, Poutanen, Matti, Barton, Geraint, Johnson, Mark R., Bennett, Phillip R., 2012. Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes. Journal of Cellular and Molecular Medicine, 16 (10), pp. 2487-2503
- Karadedou, C. T., Gomes, Ana R., Cheng, J., Petkovic, M., Ho, K.-K., Zwolinska, A. K., Feltes, A., Wong, S. Y., Chan, K. Y. K., Cheung, Y.-N., Tsang, J. W. H., Brosens, Jan J., Khoo, U.-S., Lam, Eric W.-F., 2012. FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene, Vol.31 (No.14), pp. 1845-1858
- Lam, Eric W.-F., Shah, K., Brosens, Jan J., 2012. The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. Journal of Endocrinology, Vol.212 (No.1), pp. 13-25
- Huang, Jia, Li, Tao, Ding, Chen-Hui, Brosens, Jan J., Zhou, Can-Quan, Wang, Hui-Hui, Xu, Yan-Wen, 2012. Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis. Fertility and Sterility, 97 (1), pp. 178-184
- Kajihara, Takeshi, Tochigi, Hideno, Prechapanich, Japarath, Uchino, Satomi, Itakura, Atsuo, Brosens, Jan J., Ishihara, Osamu, 2012. Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress. Fertility and Sterility, 97 (1), pp. 185-191
- Blanks, Andrew M., Brosens, Jan J., 2012. Progesterone action in the myometrium and decidua in preterm birth. Facts, Views & Vision in ObGyn, 4 (3), pp. 188-194
- Mulla, Melissa J., Myrtolli, Kledia, Brosens, Jan J., Chamley, Larry W., Kwak-Kim, Joanne Y., Paidas, Michael J., Abrahams, Vikki M., 2011. Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity. American Journal of Reproductive Immunology, Vol.65 (No.1), pp. 88-88
- Han, Christina S., Mulla, Melissa J., Brosens, Jan J., Chamley, Larry W., Paidas, Michael J., Lockwood, Charles J., Abrahams, Vikki M., 2011. Aspirin and Heparin Effect on Basal and Antiphospholipid Antibody Modulation of Trophoblast Function. Obstetrics & Gynecology, Vol.118 (No.5), pp. 1021-1028
- Han, C. S., Mulla, M. J., Brosens, Jan J., Chamley, Larry W., Paidas, Michael J., Abrahams, Vikki M., 2011. Combination treatment with aspirin and heparin exacerbates the antiphospholipid antibody-induced IL-8 response in first trimester trophoblast. Reproductive Sciences, Vol.18 (S3)
- Salker, Madhuri S, Christian, Mark, Steel, Jennifer H, Nautiyal, Jaya, Lavery, Stuart, Trew, Geoffrey, Webster, Zoe, Al-Sabbagh, Marwa, Puchchakayala, Goverdhan, Föller, Michael, Landles, Christian, Sharkey, Andrew M, Quenby, Siobhan, Aplin, John D, Regan, Lesley, Lang, Florian, Brosens, Jan J., 2011. Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nature Medicine, Vol.17 (No.11), pp. 1509-1513
- Kajihara, T., Tochigi, H., Uchino, S., Itakura, A., Brosens, Jan J., Ishihara, Osamu, 2011. Differential effects of urinary and recombinant chorionic gonadotropin on oxidative stress responses in decidualizing human endometrial stromal cells. Placenta, Vol.32 (No.8), pp. 592-597
- Grimaldi, Giulia, Christian, Mark, Steel, Jennifer H., Henriet, Patrick, Poutanen, Matti, Brosens, Jan J., 2011. Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells. Molecular Endocrinology, Vol.25 (No.11), pp. 1892-1903
- Christian, Mark, Lam, Eric W.-F., Wilson, Miranda S. C., Brosens, Jan J., 2011. FOXO transcription factors and their role in disorders of the female reproductive tract. Current Drug Targets, Vol.12 (No.9), pp. 1291-1302
- Kajihara, T., Uchino, Satomi, Suzuki, Motoharu, Itakura, Atsuo, Brosens, Jan J., Ishihara, Osamu, 2011. Human chorionic gonadotropin confers resistance to oxidative stress?induced apoptosis in decidualizing human endometrial stromal cells. Fertility and Sterility, Vol.95 (No.4), pp. 1302-1307
- Olmos, Yolanda, Brosens, Jan J., Lam, Eric W.-F., 2011. Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer. Drug Resistance Updates, Vol.14 (No.1), pp. 35-44
- Carroll, Tamara Y., Mulla, Melissa J., Han, Christina S., Brosens, Jan J., Chamley, Larry W., Giles, Ian, Pericleous, Charis, Rahman, Anisur, Sfakianaki, Anna K., Paidas, Michael J., Abrahams, Vikki M., 2011. Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin. American Journal of Reproductive Immunology, Vol.66 (No.4), pp. 286-296
- Al-Sabbagh, M., Fusi, L., Higham, J., Lee, Y., Lei, K., Hanyaloglu, A. C., Lam, E. W.- F., Christian, Mark, Brosens, Jan J., 2011. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology, Vol.152 (No.2), pp. 730-740
- Umbach, A. T., Pathare, G., Föller, M., Brosens, Jan J., Artunc, F., Lang, F., 2011. SGK1-dependent salt appetite in pregnant mice. Acta Physiologica, Vol.202 (No.1), pp. 39-45
- Semertzidou, A., Brosens, Jan J., Bennett, P. R., Johnson, M., Terzidou, V., 2011. SUMO modification is linked to the process of human labor by modulating PR signalling. Reproductive Sciences, Vol.18 (No.S3), pp. 299A-300A
- Leitao, B. B., Jones, M. C., Brosens, Jan J., 2011. The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death. FASEB Journal, Vol.25 (No.10), pp. 3416-3425
- Lei, K., Chen, Li, Ph.D., Cryar, B. J., Hua, R., Sooranna, S. R., Brosens, Jan J., Bennett, P. R., Johnson, M. R., 2011. Uterine stretch and progesterone action. Journal of Clinical Endocrinology & Metabolism, Vol.96 (No.6), pp. E1013-E1024
- Wilson, Miranda S. C., Brosens, Jan J., Schwenen, Helma D. C., Lam, Eric W.-F., 2011. FOXO and FOXM1 in cancer : the FOXO-FOXM1 axis shapes the outcome of cancer chemotherapy. Current Drug Targets, Vol.12 (No.9), pp. 1256-1266
- Myatt, Stephen S., Brosens, Jan J., Lam, Eric W.-F., 2011. Sense and sensitivity : FOXO and ROS in cancer development and treatment. Antioxidants & Redox Signaling, Vol.14 (No.4), pp. 675-687
- Mulla, Melissa J., Myrtolli, Kledia, Brosens, Jan J., Chamley, Larry W., Kwak-Kim, Joanne Y., Paidas, Michael J., Abrahams, Vikki M., 2011. Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity. American Journal of Reproductive Immunology, 63 (5), pp. 339-348
- Lam, E. W. -F., Shah, K., Brosens, Jan J., 2011. The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. Journal of Endocrinology, 212 (1), pp. 13-25
- Myatt, Stephen S., Wang, J., Monteiro, L. J., Christian, Mark, Ho, K.-K., Fusi, L., Dina, R. E., Brosens, Jan J., Ghaem-Maghami, S., Lam, Eric W.-F., 2010. Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer. Cancer Research, Vol.70 (No.1), pp. 367-377
- Quezada, Marisol, Diaz, Jorge, Henriquez, Soledad, Bravo, Maria Loreto, Aranda, Evelyn, Oliva, Barbara, Villalon, Manuel, Kato, Sumie, Cuello, Mauricio A., Brosens, Jan J., Lange, Carol A., Owen, Gareth I., 2010. 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. Hormones and Cancer, Vol.1 (No.3), pp. 117-126
- Vitzthum, Virginia J., Teklenburg, Gijs, Salker, Madhuri, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Brosens, Jan J., Macklon, Nick S., 2010. Natural selection of human embryos : decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One, Vol.5 (No.4)
- Vitzthum, Virginia J., Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Macklon, Nick S., Brosens, Jan J., 2010. Natural selection of human embryos : impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One, Vol.5 (No.4)
- Saloniemi, Taija, Järvensivu, Päivi, Koskimies, Pasi, Jokela, Heli, Lamminen, Tarja, Ghaem-Maghami, Sadaf, Dina, Roberto, Damdimopoulou, Pauliina, Mäkelä, Sari, Perheentupa, Antti, Kujari, Harry, Brosens, Jan J., Poutanen, Matti, 2010. Novel hydroxysteroid (17ß) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice. American Journal of Pathology, Vol.176 (No.3), pp. 1443-1451
- Mulla, Melissa J., Myrtolli, Kledia, Brosens, Jan J., Chamley, Larry W., Kwak-Kim, Joanne Y., Paidas, Michael J., Abrahams, Vikki M., 2010. ORIGINAL ARTICLE : Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity. American Journal of Reproductive Immunology, Vol.63 (No.5), pp. 339-348
- Brosens, Jan J., Hodgetts, A., Feroze-Zaidi, F., Sherwin, J. R. A., Fusi, L., Salker, M. S., Higham, J., Rose, G. L., Kajihara, T., Young, S. L., Lessey, B. A., Henriet, P., Langford, P. R., Fazleabas, A. T., 2010. Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. Molecular Human Reproduction, Vol.16 (No.4), pp. 273-285
- Leitao, B., Jones, M. C., Fusi, L., Higham, J., Lee, Y., Takano, M., Goto, T., Christian, Mark, Lam, Eric W.-F., Brosens, Jan J., 2010. Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB Journal, Vol.24 (No.5), pp. 1541-1551
- Brosens, Jan J., Gellersen, B., 2010. Something new about early pregnancy : decidual biosensoring and natural embryo selection. Ultrasound in Obstetrics and Gynecology, Vol.36 (No.1), pp. 1-5
- Dey, Sudhansu Kumar, Kane, Nicole M., Jones, Marius, Brosens, Jan J., Kelly, Rodney W., Saunders, Philippa T. K., Critchley, Hilary O. D., 2010. TGFß1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways. PLoS One, Vol.5 (No.9)
- Brosens, I., Derwig, I., Brosens, Jan J., Fusi, L., Benagiano, G., Pijnenborg, R., 2010. The enigmatic uterine junctional zone : the missing link between reproductive disorders and major obstetrical disorders?. Human Reproduction, Vol.25 (No.3), pp. 569-574
- Teklenburg, G., Salker, M., Heijnen, C., Macklon, N. S., Brosens, Jan J., 2010. The molecular basis of recurrent pregnancy loss : impaired natural embryo selection. Molecular Human Reproduction, Vol.16 (No.12), pp. 886-895
- Cloke, Brianna, Shah, Kunal, Kaneda, Hiroshi, Lavery, Stuart, Trew, Geoffrey, Fusi, Luca, Higham, Jenny, Dina, Roberto E., Ghaem-Maghami, Sadaf, Ellis, Patricia, Brosens, Jan J., Christian, Mark, 2010. The Poly(C)-binding protein-1 regulates expression of the androgen receptor. Endocrinology, Vol.151 (No.8), pp. 3954-3964
- Brosens, Jan J., Parker, Malcolm G., McIndoe, Angus, Pijnenborg, Robert, Brosens, Ivo A., 2009. A role for menstruation in preconditioning the uterus for successful pregnancy. American Journal of Obstetrics and Gynecology, Vol.200 (No.6), pp. 615.e1-615.e6
- Samalecos, Annemarie, Reimann, Katja, Wittmann, Stefanie, Schulte, Heinrich M, Brosens, Jan J., Bamberger, Ana-Maria, Gellersen, Birgit, 2009. Characterization of a novel telomerase-immortalized human endometrial stromal cell line, St-T1b. Reproductive Biology and Endocrinology, Vol.7 (No.1)
- Brosens, Ivo A., Fusi, Luca, Brosens, Jan J., 2009. Endometriosis is a risk factor for spontaneous hemoperitoneum during pregnancy. Fertility and Sterility, Vol.92 (No.4), pp. 1243-1245
- Kajihara, T., Uchino, Satomi, Suzuki, Motoharu, Itakura, Atsuo, Brosens, Jan J., Ishihara, Osamu, 2009. Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. Medical Molecular Morphology, Vol.42 (No.4), pp. 216-221
- Gellersen, B., Fernandes, M.S., Brosens, Jan J., 2009. Non-genomic progesterone actions in female reproduction. Human Reproduction Update, Vol.15 (No.1), pp. 119-138
- Mulla, Melissa J., Brosens, Jan J., Chamley, Larry W., Giles, Ian, Pericleous, Charis, Rahman, Anisur, Joyce, Shawna K., Panda, Britta, Paidas, Michael J., Abrahams, Vikki M., 2009. ORIGINAL ARTICLE : Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway. American Journal of Reproductive Immunology, Vol.62 (No.2), pp. 96-111
- Brosens, Ivo, Hernalsteen, Pierre, Devos, André, Cloke, Brianna, Brosens, Jan J., 2009. Self-assessment of the cervical pupil sign as a new fertility-awareness method. Fertility and Sterility, Vol.91 (No.3), pp. 937-939
- Fernandes, Marcelo, Brosens, Jan J., Gellersen, Birgit, 2008. Honey, we need to talk about the membrane progestin receptors. Steroids, Vol.73 (No.9-10), pp. 942-952
- Fusi, L., Purohit, A., Brosens, Jan J., Woo, L. W. L., Potter, B. V. L., Reed, M. J., 2008. Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate) : a potential new therapy. Scientific World Journal, Vol.8, pp. 1325-1327
- Purohit, A., Fusi, L., Brosens, Jan J., Woo, L. W. L., Potter, B. V. L., Reed, M. J., 2008. Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE : a potential new therapy. Human Reproduction, Vol.23 (No.2), pp. 290-297
- Gomes, Ana R., Brosens, Jan J., Lam, Eric W.-F., 2008. Resist or die : FOXO transcription factors determine the cellular response to chemotherapy. Cell Cycle, Vol.7 (No.20), pp. 3133-3136
- Rexhepaj, R., Boini, K. M., Huang, D. Y., Amann, K., Artunc, F., Wang, K., Brosens, Jan J., Kuhl, D., Lang, F., 2008. Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol.294 (No.6), pp. R2008-R2013
- Kane, N., Jones, M., Brosens, Jan J., Saunders, P. T. K., Kelly, R. W., Critchley, H. O. D., 2008. Transforming growth factor- 1 attenuates expression of both the progesterone receptor and dickkopf in differentiated human endometrial stromal cells. Molecular Endocrinology, Vol.22 (No.3), pp. 716-728
- Gordts, Stephan, Brosens, Jan J., Fusi, Luca, Benagiano, Giuseppe, Brosens, Ivo, 2008. Uterine adenomyosis : a need for uniform terminology and consensus classification. Reproductive Biomedicine Online, Vol.17 (No.2), pp. 244-248
- Cloke, B., Huhtinen, K., Fusi, L., Kajihara, T., Yliheikkila, M., Ho, K.-K., Teklenburg, G., Lavery, S., Jones, M. C., Trew, G., Kim, J. J., Lam, Eric W.-F., Cartwright, J. E., Poutanen, M., Brosens, Jan J., 2008. The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium. Endocrinology, Vol.149 (No.9), pp. 4462-4474
- Goto, T., Takano, M., Albergaria, A., Briese, J., Pomeranz, K. M., Cloke, B., Fusi, L., Feroze-Zaidi, F., Maywald, N., Sajin, M., Dina, R. E., Ishihara, Osamu, Takeda, S., Lam, Eric W.-F., Bamberger, A. M., Ghaem-Maghami, S., Brosens, Jan J., 2008. Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells. Oncogene, Vol.27 (No.1), pp. 9-19
- Hui, R. C.-Y., Gomes, Ana R., Constantinidou, D., Costa, J. R., Karadedou, C. T., Fernandez de Mattos, S., Wymann, M. P., Brosens, Jan J., Schulze, A., Lam, Eric W.-F., 2008. The Forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Molecular and Cellular Biology, Vol.28 (No.19), pp. 5886-5898
- Tan, B. K., Brosens, Jan J., 2015. Pregnancy endocrinology. Reference module in biomedical research, Elsevier
- Brosens, Jan J., Wilson, Miranda S. C., Lam, Eric W.-F., 2009. FOXO transcription factors : from cell fate decisions to regulation of human female reproduction. In Forkhead Transcription Factors : vital elements in biology and medicine, New York ; Austin, Tex., Springer Science+Business Media ; Landes Bioscience, pp. 227-241
- Tewary, Shreeya, Lucas, Emma S., Ewington, Lauren J., Kimani, Peter K., Brosens, Jan J., Quenby, Siobhan, 2019. Pre-conception sitagliptin increases endometrial clonogenicity in women with recurrent pregnancy loss. A double blind randomised placebo controlled trial. Blair Bell Research Society, 17?18 Jan 2019, Published in BJOG-an International Journal of Obstetrics and Gynaecology, pp. E136-E136
- Salker, M. S., Christian, Mark, Steel, J. H., Nautiyal, J., Lang, F., Brosens, Jan J., 2011. Deregulated activity of the serum and glucocorticoid-inducible kinase (SGK1) in the endometrium causes reproductive failure. Reproductive Sciences, Sage Publications, Inc
- Al-Sabbagh, Marwa, Fusi, Luca, Higham, J., Lee, Y., Lei, Kaiyu, Hanyaloglu, A. C., Lam, Eric W. -F., Christian, Mark, Brosens, Jan J., 2011. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Reproductive Sciences, Sage Publications, Inc, pp. 162A-162A
- Odiari, E. A., Mulla, M. J., Brosens, Jan J., Chamley, Larry W., Paidas, Michael J., Abrahams, Vikki M., 2011. Pravastatin does not prevent antiphospholipid antibody-mediated modulation of human first trimester trophoblast IL-8 production and migration. Reproductive Sciences, Sage Publications, Inc, pp. 17A-17A
Title | Funder | Award start | Award end |
---|---|---|---|
Cellular dynamics and regulatory networks controlling endometrial remodelling associated with recurrent miscarriage - WT investigator award | Wellcome Trust | 01 Nov 2018 | 31 Oct 2023 |
Randomised controlled trial of doxycycline versus placebo in women presenting with chronic endometritis for the prevention of miscarriage | National Institute for Health Research (DoH) | 01 Jun 2019 | 31 May 2023 |
Additional funding linked to IDEATE 41344 and 50962 Warwick BRU | University Hospitals Coventry and Warwickshire NHS Trust | 19 May 2022 | 31 Mar 2023 |
Warwick BRU additional funding - linked to IDEATE 41344 | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2016 | 31 Mar 2023 |
Programming GPCR signalling within the endocytic network; mechanisms and therapeutic applications | BBSRC | 01 Nov 2018 | 31 Oct 2021 |
3D Printed Vascularised Polymer Scaffolds: Towards a Womb-on-a-Chip Model to Study Embryo Implantation | UK Research and Innovation | 25 Jan 2021 | 24 Jul 2021 |
CoA Programming GPCR signalling within the endocytic network; mechanisms and therapeutic applications linked to 57383 | UK Research and Innovation | 01 Nov 2020 | 28 Feb 2021 |
Visiting Researcher Agreement - Dr Norikazu Ueki | Juntendo University School of Medicine | 12 May 2018 | 11 May 2020 |
March of Dimes Research Project via Imperial | March of Dimes | 01 Nov 2019 | 31 Mar 2020 |
Endometrial function in women with diabetes- role of Hexosamine Biosythetic Pathway. DUK via Manchester | Diabetes UK | 01 Nov 2015 | 31 Oct 2018 |
Visiting Researcher - Dr Tamaru, Saitama Medical University | Saitama Medical University | 01 Oct 2016 | 31 Mar 2018 |
Biomedical Research Unit in Reproductive Health: Postdoctoral study predicting preterm labour | University Hospitals Coventry and Warwickshire NHS Trust | 01 Mar 2014 | 31 Jan 2018 |
Human endometrial stem cells in patients suffering reproductive failure - visiting research fellow Dr Risa Fujihara | Juntendo University School of Medicine | 01 Sep 2015 | 31 Aug 2017 |
Impact of chronic endometritis on endometrial stem cell population - WT Vacation Scholarship (Elizabeth Hong) | Wellcome Trust | 26 Jun 2017 | 25 Jul 2017 |
Funds for Dr Maruyama who is a visiting academic from Japan | Juntendo University School of Medicine | 12 May 2014 | 27 Dec 2016 |
Funding to extend Anne Reiman for one year 01/04/15 - 31/03/16 | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2015 | 31 Mar 2016 |
Biomedical Research Unit in Reproductive Health project management FundingBRU 14-15 | University Hospitals Coventry and Warwickshire NHS Trust | 01 Apr 2014 | 31 Mar 2016 |
Research Expenses - Dr Keisuke Murakami | Juntendo University School of Medicine | 01 Aug 2013 | 18 Mar 2014 |
Predicting pregnancy problems arising from disordered implantation signaling (embryoscope) | WPH Charitable Trust | 01 May 2012 | 30 Apr 2013 |
Ferring Literature Review | Ferring Pharmaceuticals | 01 Jan 2013 | 28 Feb 2013 |