Professor Jan Brosens

Job Title

Professor of Obstetrics & Gynaecology

Department

WMS - Biomedical Sciences

Phone

024 7696 8704

J.J.Brosens@warwick.ac.uk

Biography

Professor Jan Brosens' research centres on the role of steroid hormone signalling in the human endometrium, especially in the context of prevalent reproductive disorders, such as infertility, endometriosis and endometrial cancer. his major translational interest is focused on improving the management of miscarriage, the most common complication of pregnancy. He obtained a PhD from the University of London in 1999, working on the mechanisms underpinning the preparation of the lining of the womb (endometrium) for pregnancy, a process called decidualization. He was awarded a Wellcome Trust Clinical Scientist Fellowship in 1998, then joined Imperial College London as Chair of Reproductive Sciences in 2004 and became Chair of Reproductive Medicine in 2008. In May 2011 he was appointed as Chair of Obstetrics and Gynaecology at the University of Warwick.

Muter, Joanne, Seng-Kong, Chow, Brosens, Jan J., 2022. The role of decidual subpopulations at implantation, menstruation and miscarriage. Frontiers in Reproductive Health
'Mann, O. N., 'Kong, C.-S., 'Lucas, E. S., 'Brosens, J. J., 'Hanyaloglu, A. C., 'Brighton, P. J., 2022. 'Expression and function of the luteinizing hormone choriogonadotropin receptor in human endometrial stromal cells. Scientific Reports, 12 (1)
'Tavares, Manuel, 'Khandelwal, Garima, 'Muter, Joanne, 'Viiri, Keijo, 'Beltran, Manuel, 'Brosens, Jan J., 'Jenner, Richard G., 2022. 'JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation. Cell Reports, 39 (9)
'Lipecki, Julia, 'Mitchell, Andrew E., 'Muter, Joanne, 'Lucas, Emma S., 'Makwana, Komal, 'Fishwick, Katherine, 'Odendaal, Joshua, 'Hawkes, Amelia, 'Vrljicak, Pavle, 'Brosens, Jan J., 'Ott, Sascha, 2022. 'EndoTime : non-categorical timing estimates for luteal endometrium. Human Reproduction, 37 (4), pp. 747-761
'Grewal, Karen, 'Lee, Yun S., 'Smith, Ann, 'Brosens, Jan J., 'Bourne, Tom, 'Al-Memar, Maya, 'Kundu, Samit, 'MacIntyre, David A., 'Bennett, Phillip R., 2022. 'Chromosomally normal miscarriage is associated with vaginal dysbiosis and local inflammation. BMC Medicine, 20 (1)
'Bortoletto, Pietro, 'Lucas, Emma S., 'Melo, Pedro, 'Gallos, Ioannis D., 'Devall, Adam J., 'Bourne, Tom, 'Quenby, Siobhan, 'Bennett, Phillip R., 'Coomarasamy, Arri, 'Brosens, Jan J., 2022. 'Miscarriage syndrome : linking early pregnancy loss to obstetric and age-related disorders. EBioMedicine, 81
'Diniz-da-Costa, Maria, 'Kong, Chow-Seng, 'Fishwick, Katherine, 'Rawlings, Thomas, 'Brighton, Paul (Paul J.), 'Hawkes, Amelia, 'Odendaal, Joshua, 'Quenby, Siobhan, 'Ott, Sascha, 'Lucas, Emma S., 'Vrljicak, Pavle, 'Brosens, Jan J., 2021. 'Characterization of highly proliferative decidual precursor cells during the window of implantation in human endometrium. Stem Cells, 39 (8), pp. 1067-1080
Gharanei, Seley, Fishwick, Katherine, Peter Durairaj, Ruban Rex, Jin, Tianrong, Siamantouras, Eleftherios, Liu, Kuo-Kang, Straube, Anne, Lucas, Emma S., Weston, Christopher, Rantakari, Pia, Salmi, Marko, Jalkanen, Sirpa, Brosens, Jan J., Tan, Bee K., 2021. Vascular adhesion protein-1 determines the cellular properties of endometrial pericytes. Frontiers in Cell and Developmental Biology, 8
Kong, Chow-Seng, Ordoñez, Alexandra Almansa, Turner, Sarah, Tremaine, Tina, Muter, Joanne, Lucas, Emma S., Salisbury, Emma, Vassena, Rita, Tiscornia, Gustavo, Fouladi-Nashta, Ali, Hartshorne, Geraldine M., Brosens, Jan J., Brighton, Paul, 2021. Embryo biosensing by uterine natural killer cells determines endometrial fate decisions at implantation. The FASEB Journal, 35 (4)
Rawlings, Thomas M., Makwana, Komal, Taylor, Deborah, Molè, Matteo A., Fishwick, Katherine J., Tryfonos, Maria, Odendaal, Joshua, Hawkes, Amelia, Zernicka-Goetz, Magdalena, Hartshorne, Geraldine M., Brosens, Jan J., Lucas, Emma S., 2021. Modelling the impact of decidual senescence on embryo implantation in human endometrial assembloids. eLife, 10
Harden, Sarah, Zhou, Jieliang, Gharanei, Seley, Diniz-da-Costa, Maria, Lucas, Emma S., Cui, Liang, Murakami, Keisuke, Fang, Jinling, Chen, Qingfeng, Brosens, Jan J., Lee, Yie Hou, 2021. Exometabolomic analysis of decidualizing human endometrial stromal and perivascular cells. Frontiers, 9
Lucciola, Raffaella, Vrljicak, Pavle, Gurung, Shanti, Filby, Caitlin, Darzi, Saeedeh, Muter, Joanne, Ott, Sascha, Brosens, Jan J., Gargett, Caroline E., 2020. Impact of sustained transforming growth factor-ß receptor inhibition on chromatin accessibility and gene expression in cultured human endometrial MSC. Frontiers in Cell and Developmental Biology, 8
Tewary, Shreeya, Lucas, Emma S., Fujihara, Risa, Kimani, Peter K., Polanco, Angela, Brighton, Paul (Paul J.), Muter, Joanne, Fishwick, Katherine, Da Costa, Maria José Minhoto Diniz, Ewington, Lauren J., Lacey, Lauren, Takeda, Satoru, Brosens, Jan J., Quenby, Siobhan, 2020. Impact of sitagliptin on endometrial mesenchymal stem-like progenitor cells : a randomised, double-blind placebo-controlled feasibility trial. EBioMedicine, 51
Lucas, Emma S., Vrljicak, Pavle, Muter, Joanne, Diniz-da-Costa, Maria, Brighton, Paul (Paul J.), Kong, Chow-Seng, Lipecki, Julia, Fishwick, Katherine J., Odendaal, Joshua, Ewington, Lauren J., Quenby, Siobhan, Ott, Sascha, Brosens, Jan J., 2020. Recurrent pregnancy loss is associated with a pro-senescent decidual response during the peri-implantation window. Communications Biology, 3 (1)
Richardson, Sarah, Rawlings, Thomas M., Muter, Joanne, Walker, Marc, Brosens, Jan J., Cameron, Neil R., Eissa, Ahmed M., 2019. Covalent attachment of fibronectin onto emulsion-templated porous polymer scaffolds enhances human endometrial stromal cell adhesion, infiltration, and function. Macromolecular Bioscience, 19 (2)
Ochiai, Asako, Kuroda, Keiji, Ozaki, Rie, Ikemoto, Yuko, Murakami, Keisuke, Muter, Joanne, Matsumoto, Akemi, Itakura, Atsuo, Brosens, Jan J., Takeda, Satoru, 2019. Resveratrol inhibits decidualization by accelerating downregulation of the CRABP2-RAR pathway in differentiating human endometrial stromal cells. Cell Death & Disease, 10 (4)
Craciunas, Laurentiu, Gallos, Ioannis, Chu, Justin, Bourne, Tom, Quenby, Siobhan, Brosens, Jan J., Coomarasamy, Arri, 2019. Conventional and modern markers of endometrial receptivity : a systematic review and meta-analysis. Human Reproduction Update, 25 (2), pp. 202-223
Brosens, Ivo, Brosens, Jan J., Muter, Joanne, Puttemans, Patrick, Benagiano, Giuseppe, 2019. Preeclampsia: the role of persistent endothelial cells in uteroplacental arteries. American Journal of Obstetrics and Gynecology
Zaucker, Andreas, Nagorska, Agnieszka, Kumari, Pooja, Hecker, Nikolai, Wang, Ying, Huang, Sizhou, Cooper, Ledean, Sivashanmugam, Lavanya, Vijaykumar, Shruthi, Brosens, Jan J., Gorodkin, Jan, Sampath, Karuna, 2018. Translational co-regulation of a ligand and inhibitor by a conserved RNA element. Nucleic Acids Research, 46 (1), pp. 104-119
Vrljicak, Pavle, Lucas, Emma S., Lansdowne, Lauren, Lucciola, Raffaella, Muter, Joanne, Dyer, Nigel P., Brosens, Jan J., Ott, Sascha, 2018. Analysis of chromatin accessibility in decidualizing human endometrial stromal cells. FASEB Journal, 32 (5), pp. 2467-2477
Ewington, Lauren J., Tewary, Shreeya, Brosens, Jan J., 2018. New insights into the mechanisms underlying recurrent pregnancy loss. Journal of Obstetrics and Gynaecology Research, 45 (2), pp. 258-265
Muter, Joanne, Alam, Mohammad T., Vrljicak, Pavle, Barros, Flavio S. V., Ruane, Peter T., Ewington, Lauren J., Aplin, John D., Westwood, Melissa, Brosens, Jan J., 2018. The glycosyltransferase EOGT regulates adropin expression in decidualizing human endometrium. Endocrinology, 159 (2), pp. 994-1004
Eissa, Ahmed M., Barros, Flavio, Vrljicak, Pavle, Brosens, Jan J., Cameron, Neil R., 2018. Enhanced differentiation potential of primary human endometrial cells cultured on 3D scaffolds. Biomacromolecules, 19 (8), pp. 3343-3350
Aberkane, A, Essahib, W, Spits, C, De Paepe, C, Sermon, K, Adriaenssens, T, Mackens, S, Tournaye, H, Brosens, Jan J., Van de Velde, H, 2018. Expression of adhesion and extracellular matrix genes in human blastocysts upon attachment in a 2D co-culture system. Molecular Human Reproduction, 24 (7), pp. 375-387
Brosens, Ivo, Benagiano, Giuseppe, Brosens, Jan J., 2017. Endometriosis and obstetric syndromes : early diagnosis must become a priority. Fertility and Sterility, 107 (1), pp. 66-67
Tochigi, Hideno, Kajihara, Takeshi, Mizuno, Yosuke, Mizuno, Yumi, Tamaru, Shunsuke, Kamei, Yoshimasa, Okazaki, Yasushi, Brosens, Jan J., Ishihara, Osamu, 2017. Loss of miR-542-3p enhances IGFBP-1 expression in decidualizing human endometrial stromal cells. Scientific Reports, 7
Brosens, Jan J., 2017. Decidual Cells at Implantation. Placenta, 57
Southcombe, J. H., Mounce, G., McGee, K. C., Elghajiji, A., Brosens, Jan J., Quenby, Siobhan, Child, T., Granne, I., 2017. An altered endometrial CD8 tissue resident memory T cell population in recurrent miscarriage. Scientific Reports, 7
Ozaki, Rie, Kuroda, Keiji, Ikemoto, Yuko, Ochiai, Asako, Matsumoto, Akemi, Kumakiri, Jun, Kitade, Mari, Itakura, Atsuo, Muter, Joanne, Brosens, Jan J., Takeda, Satoru, 2017. Reprogramming of the retinoic acid pathway in decidualizing human endometrial stromal cells. PLoS One, 12 (3)
Sposini, Silvia, Jean-Alphonse, Frederic G., Ayoub, Mohammed A., Oqua, Affiong, West, Camilla, Lavery, Stuart, Brosens, Jan J., Reiter, Eric, Hanyaloglu, Aylin C., 2017. Integration of GPCR signaling and sorting from very early endosomes via opposing APPL1 mechanisms. Cell Reports, 21 (10), pp. 2855-2867
Peter Durairaj, Ruban Rex, Aberkane, Asma, Polanski, Lukasz T., Maruyama, Yojiro, Baumgarten, Miriam N., Lucas, Emma S., Quenby, Siobhan, Chan, Jerry K. Y., Raine-Fenning, Nick, Brosens, Jan J., Van de Velde, Hilde, Lee, Yie Hou, 2017. Deregulation of the endometrial stromal cell secretome precedes embryo implantation failure. Molecular Human Reproduction, 23 (7), pp. 478-487
Brighton, Paul (Paul J.), Maruyama, Yojiro, Fishwick, Katherine, Vrljicak, Pavle, Tewary, Shreeya, Fujihara, Risa, Muter, Joanne, Lucas, Emma S., Yamada, Taihei, Woods, Laura, Lucciola, Raffaella, Lee, Yie Hou, Takeda, Satoru, Ott, Sascha, Hemberger, Myriam, Quenby, Siobhan, Brosens, Jan J., 2017. Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium. eLife, 6
Salker, Madhuri S., Steel, Jennifer H., Hosseinzadeh, Zohreh, Nautiyal, Jaya, Webster, Zoe, Singh, Yogesh, Brucker, Sara, Lang, Florian, Brosens, Jan J., 2016. Activation of SGK1 in endometrial epithelial cells in response to PI3K/AKT inhibition impairs embryo implantation. Cellular Physiology and Biochemistry, 39 (5), pp. 2077-2087
Wongwananuruk, Thanyarat, Sato, Tomomi, Kajihara, Takeshi, Matsumoto, Sachiko, Akita, Masumi, Tamura, Kazuhiro, Brosens, Jan J., Ishihara, Osamu, 2016. Endometrial androgen signaling and decidualization regulate trophoblast expansion and invasion in co-culture : a time-lapse study. Placenta, 47, pp. 56-62
Barros, Flavio, Brosens, Jan J., Brighton, Paul (Paul J.), 2016. Isolation and primary culture of various cell types from whole human endometrial biopsies. Bio-protocol, 6 (22)
Brosens, Ivo, Gargett, C. E., Guo, S.-W., Puttemans, P., Gordts, S., Brosens, Jan J., Benagiano, G., 2016. Origins and progression of adolescent endometriosis. Reproductive Sciences, 23 (10), pp. 1282-1288
Lucas, Emma S., Dyer, Nigel P., Fishwick, Katherine, Ott, Sascha, Brosens, Jan J., 2016. Success after failure : the role of endometrial stem cells in recurrent miscarriage. Reproduction, 152 (5), pp. R159-R166
Muter, Joanne, Brighton, Paul, Lucas, Emma S., Lacey, Lauren, Shmygol, Anatoly, Quenby, Siobhan, Blanks, Andrew M., Brosens, Jan J., 2016. Progesterone-dependent induction of phospholipase C-related catalytically inactive protein 1 (PRIP-1) in decidualizing human endometrial stromal cells. Endocrinology, 157 (7), pp. 2883-2893
Lucas, Emma S., Dyer, Nigel P., Murakami, Keisuke, Hou Lee, Yie, Chan, Yi-Wah, Grimaldi, Giulia, Muter, Joanne, Brighton, Paul (Paul J.), Moore, Jonathan D., Patel, Gnyaneshwari, Chan, Jerry K.Y., Takeda, Satoru, Lam, Eric W-F., Quenby, Siobhan, Ott, Sascha, Brosens, Jan J., 2016. Loss of endometrial plasticity in recurrent pregnancy loss. Stem Cells, 34 (2), pp. 346-356
Salker, Madhuri S., Hosseinzadeh, Zohreh, Alowayed, Nour, Zeng, Ni, Umbach, Anja T., Webster, Zoe, Singh, Yogesh, Brosens, Jan J., Lang, Florian, 2016. LEFTYA activates the epithelial Na+ Channel (ENaC) in endometrial cells via serum and glucocorticoid inducible kinase SGK1. Cellular Physiology and Biochemistry, 39 (4), pp. 1295-1306
Gysler, Stefan M., Mulla, Melissa J., Guerra, Marta, Brosens, Jan J., Salmon, Jane E., Chamley, Lawrence W., Abrahams, Vikki M., 2016. Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8. Molecular Human Reproduction, 22 (7), pp. 465-474
Brosens, Ivo, Curcic, A., Vejnovic, T., Gargett, Caroline E., Brosens, Jan J., Benagiano, Giuseppe, 2015. The perinatal origins of major reproductive disorders in the adolescent : research avenues. Placenta, 36 (4), pp. 341-344
Muter, Joanne, Lucas, Emma S., Chan, Yi-Wah, Brighton, Paul (Paul J.), Moore, Jonathan D., Lacey, Lauren, Quenby, Siobhan, Lam, Eric W.-F., Brosens, Jan J., 2015. The clock protein period 2 synchronizes mitotic expansion and decidual transformation of human endometrial stromal cells. The FASEB Journal, 29 (4), pp. 1603-1614
Brosens, Jan J., Benagiano, Giuseppe, Brosens, Ivo, 2015. The potential perinatal origin of placentation disorders in the young primigravida. American Journal of Obstetrics and Gynecology, 212 (5), pp. 580-585
Murakami, Keisuke, Lee, Yie Hou, Lucas, Emma S., Chan, Yi-Wah, Peter Durairaj, Ruban Rex, Takeda, Satoru, Moore, Jonathan D., Tan, Bee K., Quenby, Siobhan, Chan, Jerry K. Y., Gargett, Caroline E., Brosens, Jan J., 2014. Decidualization induces a secretome switch in perivascular niche cells of the human endometrium. Endocrinology, 155 (11), pp. 4542-4553
Polanski, Lukasz T., Barbosa, M. A. P., Martins, W. P., Baumgarten, M. N., Campbell, B. (Bruce), Brosens, Jan J., Quenby, Siobhan, Raine-Fenning, Nick, 2014. Interventions to improve reproductive outcomes in women with elevated natural killer cells undergoing assisted reproduction techniques : a systematic review of literature. Human Reproduction, 29 (1), pp. 65-75
Myatt, Stephen S., Kongsema, M., Man, Cornelia W-Y., Kelly, D. J., Gomes, Ana R., Khongkow, P., Karunarathna, U., Zona, Stefania, Langer, J. K., Dunsby, C. W., Coombes, R. C., French, P. M., Brosens, Jan J., Lam, Eric W.-F., 2014. SUMOylation inhibits FOXM1 activity and delays mitotic transition. Oncogene, 33 (34), pp. 4316-4329
Kuroda, Keiji, Uchida, T., Nagai, S., Ozaki, R., Yamaguchi, T., Sato, Y., Brosens, Jan J., Takeda, Satoru, 2014. Elevated serum thyroid-stimulating hormone is associated with decreased anti-Müllerian hormone in infertile women of reproductive age. Journal of Assisted Reproduction and Genetics, 32 (2), pp. 243-247
Albert, Caroline R., Schlesinger, William J., Viall, Chez A., Mulla, Melissa J., Brosens, Jan J., Chamley, Lawrence W., Abrahams, Vikki M., 2014. Effect of hydroxychloroquine on antiphospholipid antibody-induced changes in first trimester trophoblast function. American Journal of Reproductive Immunology, 71 (2), pp. 154-164
Gysler, Stefan M., Mulla, Melissa J., Stuhlman, Meredith, Sfakianaki, Anna K., Paidas, Michael J., Stanwood, Nancy L., Gariepy, Aileen, Brosens, Jan J., Chamley, Lawrence W., Abrahams, Vikki M., 2014. Vitamin D reverses aPL-induced inflammation and LMWH-induced sFlt-1 release by human trophoblast. American Journal of Reproductive Immunology, pp. n/a-n/a
Kajihara, T., Tanaka, K., Oguro, T., Tochigi, H., Prechapanich, J., Uchino, S., Itakura, A., ?ucurovic, Sandra, Murakami, Keisuke, Brosens, Jan J., Ishihara, O., 2014. Androgens modulate the morphological characteristics of human endometrial stromal cells decidualized in vitro. Reproductive Sciences, 21 (3), pp. 372-380
Macklon, N. S., Brosens, Jan J., 2014. The human endometrium as a sensor of embryo quality. Biology of Reproduction, 91 (4)
Polanski, Lukasz T., Baumgarten, Miriam N., Quenby, Siobhan, Brosens, Jan J., Campbell, Bruce K., Raine-Fenning, Nicholas J., 2014. What exactly do we mean by ?recurrent implantation failure'? A systematic review and opinion. Reproductive Biomedicine Online, 28 (4), pp. 409-423
Brosens, Jan J., Salker, Madhuri S., Teklenburg, Gijs, Nautiyal, Jaya, Salter, Scarlett, Lucas, Emma S., Steel, Jennifer H., Christian, Mark, Chan, Yi-Wah, Boomsma, Carolien M., Moore, Jonathan D., Hartshorne, Geraldine M., ?ucurovic, Sandra, Mulac-Jericevic, Biserka, Heijnen, Cobi J., Quenby, Siobhan, Groot Koerkamp, Marian J., Holstege, Frank C. P., Shmygol, Anatoly, Macklon, Nick S., 2014. Uterine selection of human embryos at implantation. Scientific Reports, 4
McCloskey, Conor, Rada, Cara, Bailey, Elizabeth, McCavera, Samantha, Berg, Hugo van den, Atia, Jolene, Rand, D. A., Shmygol, Anatoly, Chan, Yi-Wah, Quenby, Siobhan, Brosens, Jan J., Vatish, Manu, Zhang, Jie, Denton, Jerod S., Taggart, Michael J., Kettleborough, Catherine, Tickle, David, Jerman, Jeff, Wright, Paul, Dale, Timothy et al (Select to open full list), 2014.

All authors for The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy

McCloskey, Conor, Rada, Cara, Bailey, Elizabeth, McCavera, Samantha, Berg, Hugo van den, Atia, Jolene, Rand, D. A., Shmygol, Anatoly, Chan, Yi-Wah, Quenby, Siobhan, Brosens, Jan J., Vatish, Manu, Zhang, Jie, Denton, Jerod S., Taggart, Michael J., Kettleborough, Catherine, Tickle, David, Jerman, Jeff, Wright, Paul, Dale, Timothy, Kanumilli, Srinivasan, Trezise, Derek J., Thornton, Steven, Brown, Pamela, Catalano, Roberto D., Lin, Nan, England, Sarah, Blanks, Andrew M.

The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy. EMBO Molecular Medicine, 6 (9), pp. 1161-1174
Brosens, Jan J., Blanks, Andrew M., Lucas, Emma S., 2014. LRH-1 : orphaned, adopted and needed for pregnancy. Nature Medicine, 19 (8), pp. 968-969
Kuroda, Keiji, Venkatakrishnan, R., Salker, Madhuri S., Lucas, Emma S., Shaheen, Fozia, Blanks, Andrew M., Christian, Mark, Quenby, Siobhan, Brosens, Jan J., 2013. Induction of 11beta-hydroxysteroid dehydrogenase type 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Molecular Endocrinology, 27 (2), pp. 192-202
Schmidt, S., Schneider, S., Yang, W., Liu, G., Schmidt, E. - M., Schmid, E., Mia, S., Brucker, S., Stournaras, C., Wallwiener, D., Brosens, Jan J., Lang, F., 2013. TGF 1 and SGK1-sensitive store-operated Ca2+ entry and Orai1 expression in endometrial Ishikawa cells. Molecular Human Reproduction, 20 (2), pp. 139-147
Lucas, Emma S., Salker, Madhuri S., Brosens, Jan J., 2013. Uterine plasticity and reproductive fitness. Reproductive Biomedicine Online, 27 (5), pp. 506-514
Shah, Kunal M., Webber, Jason, Dr., Carzaniga, Raffaella, Taylor, Deborah M., Fusi, Luca, Clayton, Aled, Brosens, Jan J., Hartshorne, Geraldine M., Christian, Mark, 2013. Induction of microRNA resistance and secretion in differentiating human endometrial stromal cells. Journal of Molecular Cell Biology, 5 (1), pp. 67-70
Murakami, Keisuke, Bhandari, Harish, Lucas, Emma S., Takeda, Satoru, Gargett, Caroline E., Quenby, Siobhan, Brosens, Jan J., Tan, Bee K., 2013. Deficiency in clonogenic endometrial mesenchymal stem cells in obese women with reproductive failure ? a pilot study. PLoS One, 8 (12)
Kuroda, Keiji, Venkatakrishnan, R., James, S., Sucurovic, S., Mulac-Jericevic, B., Lucas, Emma S., Takeda, Satoru, Shmygol, Anatoly, Brosens, Jan J., Quenby, Siobhan, 2013. Elevated periimplantation uterine natural killer cell density in human endometrium is associated with impaired corticosteroid signaling in decidualizing stromal cells. Journal of Clinical Endocrinology & Metabolism, 98 (11), pp. 4429-4437
Lam, Eric W.-F., Brosens, Jan J., Gomes, Ana R., Koo, Chuay-Yeng, 2013. Forkhead box proteins : tuning forks for transcriptional harmony. Nature Reviews Cancer, 13 (7), pp. 482-495
Lucas, Emma S., Salker, Madhuri S., Brosens, Jan J., 2013. Reprint of : Uterine plasticity and reproductive fitness. Reproductive Biomedicine Online, 27 (6), pp. 664-672
Quenby, Siobhan, Brosens, Jan J., 2013. Human implantation : a tale of mutual maternal and fetal attraction. Biology of Reproduction, 88 (3)
Kajihara, T., Brosens, Jan J., Ishihara, Osamu, 2013. The role of FOXO1 in the decidual transformation of the endometrium and early pregnancy. Medical Molecular Morphology, 46 (2), pp. 61-68
Kuroda, Keiji, Venkatakrishnan, R., Salker, Madhuri S., Lucas, Emma S., Shaheen, Fozia, Kuroda, Masako, Blanks, Andrew M., Christian, Mark, Quenby, Siobhan, Brosens, Jan J., 2013. Induction of 11 -HSD 1 and activation of distinct mineralocorticoid receptor- and glucocorticoid receptor-dependent gene networks in decidualizing human endometrial stromal cells. Molecular Endocrinology, 27 (2), pp. 192-202
Blanks, Andrew M., Brosens, Jan J., 2013. Meaningful menstruation : cyclic renewal of the endometrium is key to reproductive success. BioEssays, 35 (5), pp. 412-412
Mulla, Melissa J., Salmon, Jane E., Chamley, Larry W., Brosens, Jan J., Boeras, Crina M., Kavathas, Paula B., Abrahams, Vikki M., 2013. A role for uric acid and the nalp3 inflammasome in antiphospholipid antibody-induced IL-1ß production by human first trimester trophoblast. PLoS One, 8 (6)
Brosens, Jan J., Lam, Eric W.-F., 2013. Progesterone and FOXO1 signaling : harnessing cellular senescence for the treatment of ovarian cancer. Cell Cycle, 12 (11)
Odiari, E. A., Mulla, M. J., Sfakianaki, A. K., Paidas, M. J., Stanwood, N. L., Gariepy, A., Brosens, Jan J., Chamley, L. W., Abrahams, V. M., 2012. Pravastatin does not prevent antiphospholipid antibody-mediated changes in human first trimester trophoblast function. Human Reproduction, Vol.27 (No.10), pp. 2933-2940
Brosens, Jan J., Gellersen, Birgit, 2012. The uterus under hormonal control ? cycling for life. Molecular and Cellular Endocrinology, 358 (2)
Yusuf, Dimas, Butland, Stefanie L., Swanson, Magdalena I., Bolotin, Eugene, Ticoll, Amy, Cheung, Warren A., Cindy Zhang, Xiao, Dickman, Christopher T. D., Fulton, Debra L., Lim, Jonathan S., Schnabl, Jake M., Ramos, Oscar H. P., Vasseur-Cognet, Mireille, de Leeuw, Charles N., Simpson, Elizabeth M., Ryffel, Gerhart U., Lam, Eric W. -F., Kist, Ralf, Wilson, Miranda S. C., Marco-Ferreres, Raquel et al (Select to open full list), 2012.

All authors for The transcription factor encyclopedia

Yusuf, Dimas, Butland, Stefanie L., Swanson, Magdalena I., Bolotin, Eugene, Ticoll, Amy, Cheung, Warren A., Cindy Zhang, Xiao, Dickman, Christopher T. D., Fulton, Debra L., Lim, Jonathan S., Schnabl, Jake M., Ramos, Oscar H. P., Vasseur-Cognet, Mireille, de Leeuw, Charles N., Simpson, Elizabeth M., Ryffel, Gerhart U., Lam, Eric W. -F., Kist, Ralf, Wilson, Miranda S. C., Marco-Ferreres, Raquel, Brosens, Jan J., Beccari, Leonardo L., Bovolenta, Paola, Benayoun, Bérénice A., Monteiro, Lara J., Schwenen, Helma D. C., Grontved, Lars, Wederell, Elizabeth, Mandrup, Susanne, Veitia, Reiner A., Chakravarthy, Harini, Hoodless, Pamela A., Mancarelli, M Michela, Torbett, Bruce E., Banham, Alison H., Reddy, Sekhar P., Cullum, Rebecca L., Liedtke, Michaela, Tschan, Mario P., Vaz, Michelle, Rizzino, Angie, Zannini, Mariastella, Frietze, Seth, Farnham, Peggy J., Eijkelenboom, Astrid, Brown, Philip J., Laperrière, David, Leprince, Dominique, de Cristofaro, Tiziana, Prince, Kelly L., Putker, Marrit, del Peso, Luis, Camenisch, Gieri, Wenger, Roland H., Mikula, Michal, Rozendaal, Marieke, Mader, Sylvie, Ostrowski, Jerzy, Rhodes, Simon J., Van Rechem, Capucine, Boulay, Gaylor, Olechnowicz, Sam W. Z., Breslin, Mary B., Lan, Michael S., Nanan, Kyster K., Wegner, Michael, Hou, Juan, Mullen, Rachel D., Colvin, Stephanie C., Noy, Peter, Webb, Carol F., Witek, Matthew E., Ferrell, Scott, Daniel, Juliet M., Park, Jason, Waldman, Scott A., Peet, Daniel J., Taggart, Michael, Jayaraman, Padma-Sheela, Karrich, Julien J., Blom, Bianca, Vesuna, Farhad, O'Geen, Henriette, Sun, Yunfu, Gronostajski, Richard M., Woodcroft, Mark W., Hough, Margaret R., Chen, Edwin, Europe-Finner, G. Nicholas, Karolczak-Bayatti, Magdalena, Bailey, Jarrod, Hankinson, Oliver, Raman, Venu, LeBrun, David P., Biswal, Shyam, Harvey, Christopher J., DeBruyne, Jason P., Hogenesch, John B., Hevner, Robert F., Héligon, Christophe, Luo, Xin M., Blank, Marissa, Millen, Kathleen, Sharlin, David S., Forrest, Douglas, Dahlman-Wright, Karin, Zhao, Chunyan, Mishima, Yuriko, Sinha, Satrajit, Chakrabarti, Rumela, Portales-Casamar, Elodie, Sladek, Frances M., Bradley, Philip H., Wasserman, Wyeth W.

The transcription factor encyclopedia. Genome Biology, 13 (3)
Huang, Jia, Li, Tao, Ding, Chen-Hui, Brosens, Jan J., Zhou, Can-Quan, Wang, Hui-Hui, Xu, Yan-Wen, 2012. Insufficient histone-3 lysine-9 deacetylation in human oocytes matured in vitro is associated with aberrant meiosis. Fertility and Sterility, 97 (1), pp. 178-184
Brosens, Ivo, Brosens, Jan J., Benagiano, Giuseppe, 2012. The eutopic endometrium in endometriosis : are the changes of clinical significance?. Reproductive Biomedicine Online, Vol.24 (No.5), pp. 496-502
Salker, Madhuri S., Nautiyal, Jaya, Steel, Jennifer H., Webster, Zoe, ?ucurovic, Sandra, Nicou, Marilena, Singh, Yogesh, Dr., Lucas, Emma S., Murakami, Keisuke, Chan, Yi-Wah, James, Sean G., Abdallah, Yazan, Christian, Mark, Croy, B. A. (B. Anne), Mulac-Jericevic, Biserka, Quenby, Siobhan, Brosens, Jan J., 2012. Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss. PLoS One, Vol.7 (No.12)
Diaz, J., Aranda, E., Henriquez, S., Quezada, M., Espinoza, E., Bravo, M. L., Oliva, B., Lange, S., Villalon, M., Jones, M., Brosens, Jan J., Kato, S., Cuello, M. A., Knutson, T. P., Lange, C. A., Leyton, L., Owen, G. I., 2012. Progesterone promotes focal adhesion formation and migration in breast cancer cells through induction of protease-activated receptor-1. Journal of Endocrinology, Vol.214 (No.2), pp. 165-175
Lee, Yun, Sooranna, Suren R., Terzidou, Vasso, Christian, Mark, Brosens, Jan J., Huhtinen, Kaisa, Poutanen, Matti, Barton, Geraint, Johnson, Mark R., Bennett, Phillip R., 2012. Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes. Journal of Cellular and Molecular Medicine, 16 (10), pp. 2487-2503
Blanks, Andrew M., Brosens, Jan J., 2012. Progesterone action in the myometrium and decidua in preterm birth. Facts, Views & Vision in ObGyn, 4 (3), pp. 188-194
Brosens, Ivo, Brosens, Jan J., Fusi, Luca, Al-Sabbagh, Marwa, Kuroda, Keiji, Benagiano, Giuseppe, 2012. Risks of adverse pregnancy outcome in endometriosis. Fertility and Sterility, 98 (1), pp. 30-35
Weimar, Charlotte H. E., Kavelaars, Annemieke, Brosens, Jan J., Gellersen, Birgit, de Vreeden-Elbertse, Johanna M. T., Heijnen, Cobi J., Macklon, Nick S., 2012. Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos. PLoS ONE, Vol.7 (No.7)
Lam, Eric W.-F., Shah, K., Brosens, Jan J., 2012. The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. Journal of Endocrinology, Vol.212 (No.1), pp. 13-25
Grimaldi, Giulia, Christian, Mark, Quenby, Siobhan, Brosens, Jan J., 2012. Expression of epigenetic effectors in decidualizing human endometrial stromal cells. Molecular Human Reproduction, 18 (9), pp. 451-458
Koot, Y.E.M., Teklenburg, G., Salker, M.S., Brosens, Jan J., Macklon, N.S., 2012. Molecular aspects of implantation failure. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol.1822 (No.12), pp. 1943-1950
Kuroda, Masako, Kuroda, Keiji, Arakawa, Atsushi, Fukumura, Yuki, Kitade, Mari, Kikuchi, Iwaho, Kumakiri, Jun, Matsuoka, Shozo, Brosens, Ivo A., Brosens, Jan J., Takeda, Satoru, Yao, Takashi, 2012. Histological assessment of impact of ovarian endometrioma and laparoscopic cystectomy on ovarian reserve. Journal of Obstetrics and Gynaecology Research, 38 (9), pp. 1187-1193
Kajihara, Takeshi, Tochigi, Hideno, Prechapanich, Japarath, Uchino, Satomi, Itakura, Atsuo, Brosens, Jan J., Ishihara, Osamu, 2012. Androgen signaling in decidualizing human endometrial stromal cells enhances resistance to oxidative stress. Fertility and Sterility, 97 (1), pp. 185-191
Karadedou, C. T., Gomes, Ana R., Cheng, J., Petkovic, M., Ho, K.-K., Zwolinska, A. K., Feltes, A., Wong, S. Y., Chan, K. Y. K., Cheung, Y.-N., Tsang, J. W. H., Brosens, Jan J., Khoo, U.-S., Lam, Eric W.-F., 2012. FOXO3a represses VEGF expression through FOXM1-dependent and -independent mechanisms in breast cancer. Oncogene, Vol.31 (No.14), pp. 1845-1858
Al-Sabbagh, Marwa, Lam, Eric W.-F., Brosens, Jan J., 2012. Mechanisms of endometrial progesterone resistance. Molecular and Cellular Endocrinology, 358 (2), pp. 208-215
Mulla, Melissa J., Myrtolli, Kledia, Brosens, Jan J., Chamley, Larry W., Kwak-Kim, Joanne Y., Paidas, Michael J., Abrahams, Vikki M., 2011. Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity. American Journal of Reproductive Immunology, Vol.65 (No.1), pp. 88-88
Wilson, Miranda S. C., Brosens, Jan J., Schwenen, Helma D. C., Lam, Eric W.-F., 2011. FOXO and FOXM1 in cancer : the FOXO-FOXM1 axis shapes the outcome of cancer chemotherapy. Current Drug Targets, Vol.12 (No.9), pp. 1256-1266
Han, Christina S., Mulla, Melissa J., Brosens, Jan J., Chamley, Larry W., Paidas, Michael J., Lockwood, Charles J., Abrahams, Vikki M., 2011. Aspirin and Heparin Effect on Basal and Antiphospholipid Antibody Modulation of Trophoblast Function. Obstetrics & Gynecology, Vol.118 (No.5), pp. 1021-1028
Lei, K., Chen, Li, Ph.D., Cryar, B. J., Hua, R., Sooranna, S. R., Brosens, Jan J., Bennett, P. R., Johnson, M. R., 2011. Uterine stretch and progesterone action. Journal of Clinical Endocrinology & Metabolism, Vol.96 (No.6), pp. E1013-E1024
Leitao, B. B., Jones, M. C., Brosens, Jan J., 2011. The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death. FASEB Journal, Vol.25 (No.10), pp. 3416-3425
Grimaldi, Giulia, Christian, Mark, Steel, Jennifer H., Henriet, Patrick, Poutanen, Matti, Brosens, Jan J., 2011. Down-regulation of the histone methyltransferase EZH2 contributes to the epigenetic programming of decidualizing human endometrial stromal cells. Molecular Endocrinology, Vol.25 (No.11), pp. 1892-1903
Myatt, Stephen S., Brosens, Jan J., Lam, Eric W.-F., 2011. Sense and sensitivity : FOXO and ROS in cancer development and treatment. Antioxidants & Redox Signaling, Vol.14 (No.4), pp. 675-687
Mulla, Melissa J., Myrtolli, Kledia, Brosens, Jan J., Chamley, Larry W., Kwak-Kim, Joanne Y., Paidas, Michael J., Abrahams, Vikki M., 2011. Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity. American Journal of Reproductive Immunology, 63 (5), pp. 339-348
Kajihara, T., Uchino, Satomi, Suzuki, Motoharu, Itakura, Atsuo, Brosens, Jan J., Ishihara, Osamu, 2011. Human chorionic gonadotropin confers resistance to oxidative stress?induced apoptosis in decidualizing human endometrial stromal cells. Fertility and Sterility, Vol.95 (No.4), pp. 1302-1307
Olmos, Yolanda, Brosens, Jan J., Lam, Eric W.-F., 2011. Interplay between SIRT proteins and tumour suppressor transcription factors in chemotherapeutic resistance of cancer. Drug Resistance Updates, Vol.14 (No.1), pp. 35-44
Semertzidou, A., Brosens, Jan J., Bennett, P. R., Johnson, M., Terzidou, V., 2011. SUMO modification is linked to the process of human labor by modulating PR signalling. Reproductive Sciences, Vol.18 (No.S3), pp. 299A-300A
Han, C. S., Mulla, M. J., Brosens, Jan J., Chamley, Larry W., Paidas, Michael J., Abrahams, Vikki M., 2011. Combination treatment with aspirin and heparin exacerbates the antiphospholipid antibody-induced IL-8 response in first trimester trophoblast. Reproductive Sciences, Vol.18 (S3)
Al-Sabbagh, M., Fusi, L., Higham, J., Lee, Y., Lei, K., Hanyaloglu, A. C., Lam, E. W.- F., Christian, Mark, Brosens, Jan J., 2011. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Endocrinology, Vol.152 (No.2), pp. 730-740
Umbach, A. T., Pathare, G., Föller, M., Brosens, Jan J., Artunc, F., Lang, F., 2011. SGK1-dependent salt appetite in pregnant mice. Acta Physiologica, Vol.202 (No.1), pp. 39-45
Lam, E. W. -F., Shah, K., Brosens, Jan J., 2011. The diversity of sex steroid action : the role of micro-RNAs and FOXO transcription factors in cycling endometrium and cancer. Journal of Endocrinology, 212 (1), pp. 13-25
Kajihara, T., Tochigi, H., Uchino, S., Itakura, A., Brosens, Jan J., Ishihara, Osamu, 2011. Differential effects of urinary and recombinant chorionic gonadotropin on oxidative stress responses in decidualizing human endometrial stromal cells. Placenta, Vol.32 (No.8), pp. 592-597
Carroll, Tamara Y., Mulla, Melissa J., Han, Christina S., Brosens, Jan J., Chamley, Larry W., Giles, Ian, Pericleous, Charis, Rahman, Anisur, Sfakianaki, Anna K., Paidas, Michael J., Abrahams, Vikki M., 2011. Modulation of trophoblast angiogenic factor secretion by antiphospholipid antibodies is not reversed by heparin. American Journal of Reproductive Immunology, Vol.66 (No.4), pp. 286-296
Christian, Mark, Lam, Eric W.-F., Wilson, Miranda S. C., Brosens, Jan J., 2011. FOXO transcription factors and their role in disorders of the female reproductive tract. Current Drug Targets, Vol.12 (No.9), pp. 1291-1302
Salker, Madhuri S, Christian, Mark, Steel, Jennifer H, Nautiyal, Jaya, Lavery, Stuart, Trew, Geoffrey, Webster, Zoe, Al-Sabbagh, Marwa, Puchchakayala, Goverdhan, Föller, Michael, Landles, Christian, Sharkey, Andrew M, Quenby, Siobhan, Aplin, John D, Regan, Lesley, Lang, Florian, Brosens, Jan J., 2011. Deregulation of the serum- and glucocorticoid-inducible kinase SGK1 in the endometrium causes reproductive failure. Nature Medicine, Vol.17 (No.11), pp. 1509-1513
Myatt, Stephen S., Wang, J., Monteiro, L. J., Christian, Mark, Ho, K.-K., Fusi, L., Dina, R. E., Brosens, Jan J., Ghaem-Maghami, S., Lam, Eric W.-F., 2010. Definition of microRNAs that repress expression of the tumor suppressor gene FOXO1 in endometrial cancer. Cancer Research, Vol.70 (No.1), pp. 367-377
Vitzthum, Virginia J., Salker, Madhuri, Teklenburg, Gijs, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Macklon, Nick S., Brosens, Jan J., 2010. Natural selection of human embryos : impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss. PLoS One, Vol.5 (No.4)
Quezada, Marisol, Diaz, Jorge, Henriquez, Soledad, Bravo, Maria Loreto, Aranda, Evelyn, Oliva, Barbara, Villalon, Manuel, Kato, Sumie, Cuello, Mauricio A., Brosens, Jan J., Lange, Carol A., Owen, Gareth I., 2010. 2-Methoxyestradiol inhibits progesterone-dependent tissue factor expression and activity in breast cancer cells. Hormones and Cancer, Vol.1 (No.3), pp. 117-126
Teklenburg, G., Salker, M., Heijnen, C., Macklon, N. S., Brosens, Jan J., 2010. The molecular basis of recurrent pregnancy loss : impaired natural embryo selection. Molecular Human Reproduction, Vol.16 (No.12), pp. 886-895
Vitzthum, Virginia J., Teklenburg, Gijs, Salker, Madhuri, Molokhia, Mariam, Lavery, Stuart, Trew, Geoffrey, Aojanepong, Tepchongchit, Mardon, Helen J., Lokugamage, Amali U., Rai, Raj, Landles, Christian, Roelen, Bernard A. J., Quenby, Siobhan, Kuijk, Ewart W., Kavelaars, Annemieke, Heijnen, Cobi J., Regan, Lesley, Brosens, Jan J., Macklon, Nick S., 2010. Natural selection of human embryos : decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation. PLoS One, Vol.5 (No.4)
Saloniemi, Taija, Järvensivu, Päivi, Koskimies, Pasi, Jokela, Heli, Lamminen, Tarja, Ghaem-Maghami, Sadaf, Dina, Roberto, Damdimopoulou, Pauliina, Mäkelä, Sari, Perheentupa, Antti, Kujari, Harry, Brosens, Jan J., Poutanen, Matti, 2010. Novel hydroxysteroid (17ß) dehydrogenase 1 inhibitors reverse estrogen-induced endometrial hyperplasia in transgenic mice. American Journal of Pathology, Vol.176 (No.3), pp. 1443-1451
Leitao, B., Jones, M. C., Fusi, L., Higham, J., Lee, Y., Takano, M., Goto, T., Christian, Mark, Lam, Eric W.-F., Brosens, Jan J., 2010. Silencing of the JNK pathway maintains progesterone receptor activity in decidualizing human endometrial stromal cells exposed to oxidative stress signals. FASEB Journal, Vol.24 (No.5), pp. 1541-1551
Dey, Sudhansu Kumar, Kane, Nicole M., Jones, Marius, Brosens, Jan J., Kelly, Rodney W., Saunders, Philippa T. K., Critchley, Hilary O. D., 2010. TGFß1 attenuates expression of prolactin and IGFBP-1 in decidualized endometrial stromal cells by both SMAD-dependent and SMAD-independent pathways. PLoS One, Vol.5 (No.9)
Mulla, Melissa J., Myrtolli, Kledia, Brosens, Jan J., Chamley, Larry W., Kwak-Kim, Joanne Y., Paidas, Michael J., Abrahams, Vikki M., 2010. ORIGINAL ARTICLE : Antiphospholipid antibodies limit trophoblast migration by reducing IL-6 production and STAT3 activity. American Journal of Reproductive Immunology, Vol.63 (No.5), pp. 339-348
Brosens, Jan J., Hodgetts, A., Feroze-Zaidi, F., Sherwin, J. R. A., Fusi, L., Salker, M. S., Higham, J., Rose, G. L., Kajihara, T., Young, S. L., Lessey, B. A., Henriet, P., Langford, P. R., Fazleabas, A. T., 2010. Proteomic analysis of endometrium from fertile and infertile patients suggests a role for apolipoprotein A-I in embryo implantation failure and endometriosis. Molecular Human Reproduction, Vol.16 (No.4), pp. 273-285
Brosens, Jan J., Gellersen, B., 2010. Something new about early pregnancy : decidual biosensoring and natural embryo selection. Ultrasound in Obstetrics and Gynecology, Vol.36 (No.1), pp. 1-5
Brosens, I., Derwig, I., Brosens, Jan J., Fusi, L., Benagiano, G., Pijnenborg, R., 2010. The enigmatic uterine junctional zone : the missing link between reproductive disorders and major obstetrical disorders?. Human Reproduction, Vol.25 (No.3), pp. 569-574
Cloke, Brianna, Shah, Kunal, Kaneda, Hiroshi, Lavery, Stuart, Trew, Geoffrey, Fusi, Luca, Higham, Jenny, Dina, Roberto E., Ghaem-Maghami, Sadaf, Ellis, Patricia, Brosens, Jan J., Christian, Mark, 2010. The Poly(C)-binding protein-1 regulates expression of the androgen receptor. Endocrinology, Vol.151 (No.8), pp. 3954-3964
Kajihara, T., Uchino, Satomi, Suzuki, Motoharu, Itakura, Atsuo, Brosens, Jan J., Ishihara, Osamu, 2009. Increased ovarian follicle atresia in obese Zucker rats is associated with enhanced expression of the forkhead transcription factor FOXO1. Medical Molecular Morphology, Vol.42 (No.4), pp. 216-221
Brosens, Jan J., Parker, Malcolm G., McIndoe, Angus, Pijnenborg, Robert, Brosens, Ivo A., 2009. A role for menstruation in preconditioning the uterus for successful pregnancy. American Journal of Obstetrics and Gynecology, Vol.200 (No.6), pp. 615.e1-615.e6
Samalecos, Annemarie, Reimann, Katja, Wittmann, Stefanie, Schulte, Heinrich M, Brosens, Jan J., Bamberger, Ana-Maria, Gellersen, Birgit, 2009. Characterization of a novel telomerase-immortalized human endometrial stromal cell line, St-T1b. Reproductive Biology and Endocrinology, Vol.7 (No.1)
Mulla, Melissa J., Brosens, Jan J., Chamley, Larry W., Giles, Ian, Pericleous, Charis, Rahman, Anisur, Joyce, Shawna K., Panda, Britta, Paidas, Michael J., Abrahams, Vikki M., 2009. ORIGINAL ARTICLE : Antiphospholipid antibodies induce a pro-inflammatory response in first trimester trophoblast via the TLR4/MyD88 pathway. American Journal of Reproductive Immunology, Vol.62 (No.2), pp. 96-111
Brosens, Ivo, Hernalsteen, Pierre, Devos, André, Cloke, Brianna, Brosens, Jan J., 2009. Self-assessment of the cervical pupil sign as a new fertility-awareness method. Fertility and Sterility, Vol.91 (No.3), pp. 937-939
Brosens, Ivo A., Fusi, Luca, Brosens, Jan J., 2009. Endometriosis is a risk factor for spontaneous hemoperitoneum during pregnancy. Fertility and Sterility, Vol.92 (No.4), pp. 1243-1245
Gellersen, B., Fernandes, M.S., Brosens, Jan J., 2009. Non-genomic progesterone actions in female reproduction. Human Reproduction Update, Vol.15 (No.1), pp. 119-138
Rexhepaj, R., Boini, K. M., Huang, D. Y., Amann, K., Artunc, F., Wang, K., Brosens, Jan J., Kuhl, D., Lang, F., 2008. Role of maternal glucocorticoid inducible kinase SGK1 in fetal programming of blood pressure in response to prenatal diet. American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, Vol.294 (No.6), pp. R2008-R2013
Gomes, Ana R., Brosens, Jan J., Lam, Eric W.-F., 2008. Resist or die : FOXO transcription factors determine the cellular response to chemotherapy. Cell Cycle, Vol.7 (No.20), pp. 3133-3136
Fusi, L., Purohit, A., Brosens, Jan J., Woo, L. W. L., Potter, B. V. L., Reed, M. J., 2008. Inhibition of steroid sulfatase activity in endometriotic implants by STX64 (667Coumate) : a potential new therapy. Scientific World Journal, Vol.8, pp. 1325-1327
Goto, T., Takano, M., Albergaria, A., Briese, J., Pomeranz, K. M., Cloke, B., Fusi, L., Feroze-Zaidi, F., Maywald, N., Sajin, M., Dina, R. E., Ishihara, Osamu, Takeda, S., Lam, Eric W.-F., Bamberger, A. M., Ghaem-Maghami, S., Brosens, Jan J., 2008. Mechanism and functional consequences of loss of FOXO1 expression in endometrioid endometrial cancer cells. Oncogene, Vol.27 (No.1), pp. 9-19
Hui, R. C.-Y., Gomes, Ana R., Constantinidou, D., Costa, J. R., Karadedou, C. T., Fernandez de Mattos, S., Wymann, M. P., Brosens, Jan J., Schulze, A., Lam, Eric W.-F., 2008. The Forkhead transcription factor FOXO3a increases phosphoinositide-3 kinase/Akt activity in drug-resistant leukemic cells through induction of PIK3CA expression. Molecular and Cellular Biology, Vol.28 (No.19), pp. 5886-5898
Cloke, B., Huhtinen, K., Fusi, L., Kajihara, T., Yliheikkila, M., Ho, K.-K., Teklenburg, G., Lavery, S., Jones, M. C., Trew, G., Kim, J. J., Lam, Eric W.-F., Cartwright, J. E., Poutanen, M., Brosens, Jan J., 2008. The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium. Endocrinology, Vol.149 (No.9), pp. 4462-4474
Fernandes, Marcelo, Brosens, Jan J., Gellersen, Birgit, 2008. Honey, we need to talk about the membrane progestin receptors. Steroids, Vol.73 (No.9-10), pp. 942-952
Kane, N., Jones, M., Brosens, Jan J., Saunders, P. T. K., Kelly, R. W., Critchley, H. O. D., 2008. Transforming growth factor- 1 attenuates expression of both the progesterone receptor and dickkopf in differentiated human endometrial stromal cells. Molecular Endocrinology, Vol.22 (No.3), pp. 716-728
Gordts, Stephan, Brosens, Jan J., Fusi, Luca, Benagiano, Giuseppe, Brosens, Ivo, 2008. Uterine adenomyosis : a need for uniform terminology and consensus classification. Reproductive Biomedicine Online, Vol.17 (No.2), pp. 244-248
Purohit, A., Fusi, L., Brosens, Jan J., Woo, L. W. L., Potter, B. V. L., Reed, M. J., 2008. Inhibition of steroid sulphatase activity in endometriotic implants by 667 COUMATE : a potential new therapy. Human Reproduction, Vol.23 (No.2), pp. 290-297

Tan, B. K., Brosens, Jan J., 2015. Pregnancy endocrinology. Reference module in biomedical research, Elsevier
Brosens, Jan J., Wilson, Miranda S. C., Lam, Eric W.-F., 2009. FOXO transcription factors : from cell fate decisions to regulation of human female reproduction. In Forkhead Transcription Factors : vital elements in biology and medicine, New York ; Austin, Tex., Springer Science+Business Media ; Landes Bioscience, pp. 227-241

Tewary, Shreeya, Lucas, Emma S., Ewington, Lauren J., Kimani, Peter K., Brosens, Jan J., Quenby, Siobhan, 2019. Pre-conception sitagliptin increases endometrial clonogenicity in women with recurrent pregnancy loss. A double blind randomised placebo controlled trial. Blair Bell Research Society, 17?18 Jan 2019, Published in BJOG-an International Journal of Obstetrics and Gynaecology, pp. E136-E136

Salker, M. S., Christian, Mark, Steel, J. H., Nautiyal, J., Lang, F., Brosens, Jan J., 2011. Deregulated activity of the serum and glucocorticoid-inducible kinase (SGK1) in the endometrium causes reproductive failure. Reproductive Sciences, Sage Publications, Inc
Odiari, E. A., Mulla, M. J., Brosens, Jan J., Chamley, Larry W., Paidas, Michael J., Abrahams, Vikki M., 2011. Pravastatin does not prevent antiphospholipid antibody-mediated modulation of human first trimester trophoblast IL-8 production and migration. Reproductive Sciences, Sage Publications, Inc, pp. 17A-17A
Al-Sabbagh, Marwa, Fusi, Luca, Higham, J., Lee, Y., Lei, Kaiyu, Hanyaloglu, A. C., Lam, Eric W. -F., Christian, Mark, Brosens, Jan J., 2011. NADPH oxidase-derived reactive oxygen species mediate decidualization of human endometrial stromal cells in response to cyclic AMP signaling. Reproductive Sciences, Sage Publications, Inc, pp. 162A-162A

Title	Funder	Award start	Award end
Development of endometrial/myometrial organoids to study disorders of pregnancy and parturition	MRC	01 Dec 2022	30 Nov 2025
Cellular dynamics and regulatory networks controlling endometrial remodelling associated with recurrent miscarriage - WT investigator award	Wellcome Trust	01 Nov 2018	31 Oct 2023
Randomised controlled trial of doxycycline versus placebo in women presenting with chronic endometritis for the prevention of miscarriage	National Institute for Health Research (DoH)	01 Jun 2019	31 May 2023
Additional funding linked to IDEATE 41344 and 50962 Warwick BRU	University Hospitals Coventry and Warwickshire NHS Trust	19 May 2022	31 Mar 2023
Warwick BRU additional funding - linked to IDEATE 41344	University Hospitals Coventry and Warwickshire NHS Trust	01 Apr 2016	31 Mar 2023
Programming GPCR signalling within the endocytic network; mechanisms and therapeutic applications	BBSRC	01 Nov 2018	31 Oct 2021
3D Printed Vascularised Polymer Scaffolds: Towards a Womb-on-a-Chip Model to Study Embryo Implantation	UK Research and Innovation	25 Jan 2021	24 Jul 2021
CoA Programming GPCR signalling within the endocytic network; mechanisms and therapeutic applications linked to 57383	UK Research and Innovation	01 Nov 2020	28 Feb 2021
Visiting Researcher Agreement - Dr Norikazu Ueki	Juntendo University School of Medicine	12 May 2018	11 May 2020
March of Dimes Research Project via Imperial	March of Dimes	01 Nov 2019	31 Mar 2020
Endometrial function in women with diabetes- role of Hexosamine Biosythetic Pathway. DUK via Manchester	Diabetes UK	01 Nov 2015	31 Oct 2018
Visiting Researcher - Dr Tamaru, Saitama Medical University	Saitama Medical University	01 Oct 2016	31 Mar 2018
Biomedical Research Unit in Reproductive Health: Postdoctoral study predicting preterm labour	University Hospitals Coventry and Warwickshire NHS Trust	01 Mar 2014	31 Jan 2018
Human endometrial stem cells in patients suffering reproductive failure - visiting research fellow Dr Risa Fujihara	Juntendo University School of Medicine	01 Sep 2015	31 Aug 2017
Impact of chronic endometritis on endometrial stem cell population - WT Vacation Scholarship (Elizabeth Hong)	Wellcome Trust	26 Jun 2017	25 Jul 2017
Funds for Dr Maruyama who is a visiting academic from Japan	Juntendo University School of Medicine	12 May 2014	27 Dec 2016
Funding to extend Anne Reiman for one year 01/04/15 - 31/03/16	University Hospitals Coventry and Warwickshire NHS Trust	01 Apr 2015	31 Mar 2016
Biomedical Research Unit in Reproductive Health project management FundingBRU 14-15	University Hospitals Coventry and Warwickshire NHS Trust	01 Apr 2014	31 Mar 2016
Research Expenses - Dr Keisuke Murakami	Juntendo University School of Medicine	01 Aug 2013	18 Mar 2014
Predicting pregnancy problems arising from disordered implantation signaling (embryoscope)	WPH Charitable Trust	01 May 2012	30 Apr 2013
Ferring Literature Review	Ferring Pharmaceuticals	01 Jan 2013	28 Feb 2013