Dr Siew Wan Hee

Job Title

Senior Research Fellow

Department

WMS - Health Sciences

Phone

02476151652

S.W.Hee@warwick.ac.uk_FORMER

Research Interests

Dr Hee's main research interests are in design and analysis of clinical trials in particular for small population disease. She is also interested in the setting and designing issues of database for individual participant data meta-analysis.

Biography

Siew Wan is a Research Fellow for the Statistics and Epidemiology Unit, Division of Health Sciences, Warwick Medical School. Her first degree was in statistics from the National University of Singapore (NUS) and this was followed by an MSc. also in statistics from NUS. The title of her dissertation was "Exploration of Probes Selection Criteria of Oligonucleotide Array". She was awarded a PhD from The University of Warwick in 2012, thesis titled "Designing a Series of Clinical Trials". She has previously worked as a biostatistician in National Cancer Centre Singapore. Her primary role was to support, assist and advise the design, conduct and analysis of early phase trials and observational studies.

'Bradley, Christopher, 'Hee, Siew Wan, 'Andronis, Lazaros, 'Persaud, Krishna, 'Hull, Mark A, 'Todd, John, 'Taylor-Phillips, Sian, 'Smith, Steve, 'Constable, Rachel, 'Waugh, Norman, 'Arasaradnam, Ramesh P., 2022. 'REducing Colonoscopies in patients without significant bowEl DiseasE : the RECEDE Study - protocol for a prospective diagnostic accuracy study. BMJ Open, 12 (3)
'McGregor, Gordon, 'Evans, Becky, 'Sandhu, Harbinder, 'Simmonds, Jane, 'Joshi, Shivam, 'Devi, Gita, 'Zhupaj, Albiona, 'Holliday, Nikki, 'Pearce, Gemma, 'Patel, Chloe, 'Hee, Siew Wan, 'Powell, Richard, 'Heine, Peter J., 'Patel, Shilpa, 'Kavi, Lesley, 'Bruce, Julie, 'Hayat, Sajad, 'Lim, Boon, 'Eftekhari, Helen, 'Panikker, Sandeep, 2022. 'Protocol update for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome : the PULSE study. Pilot and Feasibility Studies, 8 (1)
Hee, Siew Wan, Mistry, Dipesh, Friede, Tim, Lamb, Sarah E., Stallard, Nigel, Underwood, Martin, Patel, Shilpa, 2021. Identification of subgroup effect with an individual participant data meta-analysis of randomised controlled trials of three different types of therapist-delivered care in low back pain. BMC Musculoskeletal Disorders, 22 (1)
McGregor, Gordon, Hee, Siew Wan, Eftekhari, Helen, Holliday, Nikki, Pearce, Gemma, Sandhu, Harbinder, Simmonds, Jane, Joshi, Shivam, Kavi, Lesley, Bruce, Julie, Panikker, Sandeep, Lim, Boon, Hayat, Sajad, 2020. Protocol for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome : the PULSE study. Protocol for a randomised controlled feasibility trial of exercise rehabilitation for people with postural tachycardia syndrome: the PULSE study, 6
Patel, Shilpa, Achana, Felix A., Carnes, Dawn, Eldridge, Sandra, Ellard, David R., Griffiths, Frances, Haywood, Kirstie L., Hee, Siew Wan, Mistry, Dipesh, Mistry, Hema, Nichols, Vivien P., Petrou, Stavros, Pincus, Tamar, Potter, Rachel, Sandhu, Harbinder, Stewart, Kimberley, Taylor, Stephanie, Underwood, Martin, Matharu, Manjit, 2020. Usual care and a self-management support programme versus usual care and a relaxation programme for people living with chronic headache disorders : a randomised controlled trial protocol (CHESS). BMJ Open, 10 (4)
Potter, Rachel, Hee, Siew Wan, Griffiths, Frances, Dodd, Katherine, Hoverd, Eleanor, Underwood, Martin, Matharu, Manjit, 2019. Development and validation of a telephone classification interview for common chronic headache disorders. Journal of Headache and Pain, 20
White, Kimberley, Potter, Rachel, Patel, Shilpa, Nichols, Vivien P., Haywood, Kirstie L., Hee, Siew Wan, Mistry, Dipesh, Carnes, Dawn, Taylor, Stephanie S. J., Underwood, Martin, Matharu, Manjit S., 2019. Chronic headache education and self-management study (CHESS) - a mixed method feasibility study to inform the design of a randomised controlled trial. BMC Medical Research Methodology, 19
Hee, Siew Wan, Parsons, Nicholas R., Stallard, Nigel, 2018. Decision-theoretic designs for a series of trials with correlated treatment effects using the Sarmanov multivariate beta-binomial distribution. Biometrical Journal, 60 (2), pp. 232-245
Pearce, Michael, Hee, Siew Wan, Madan, Jason, Posch, Martin, Day, Simon, Miller, Frank, Zohar, Sarah, Stallard, Nigel, 2018. Value of information methods to design a clinical trial in a small population to optimise a health economic utility function. BMC Medical Research Methodology, 18 (1)
Friede, Tim, Posch, Martin, Zohar, Sarah, Alberti, Corinne, Benda, Norbert, Comets, Emmanuelle, Day, Simon, Dmitrienko, Alex, Graf, Alexandra, Günhan, Burak Kürsad, Hee, Siew Wan, Lentz, Frederike, Madan, Jason, Miller, Frank, Ondra, Thomas, Pearce, Michael, Röver, Christian, Toumazi, Artemis, Unkel, Steffen, Ursino, Moreno et al (Select to open full list), 2018.

All authors for Recent advances in methodology for clinical trials in small populations : the InSPiRe project

Friede, Tim, Posch, Martin, Zohar, Sarah, Alberti, Corinne, Benda, Norbert, Comets, Emmanuelle, Day, Simon, Dmitrienko, Alex, Graf, Alexandra, Günhan, Burak Kürsad, Hee, Siew Wan, Lentz, Frederike, Madan, Jason, Miller, Frank, Ondra, Thomas, Pearce , Michael, Röver, Christian, Toumazi, Artemis, Unkel, Steffen, Ursino, Moreno, Wassmer, Gernot, Stallard, Nigel

Recent advances in methodology for clinical trials in small populations : the InSPiRe project. Orphanet Journal of Rare Diseases, 13 (1)
Miller, Frank, Zohar, Sarah, Stallard, Nigel, Madan, Jason, Posch, Martin, Hee, Siew Wan, Pearce , Michael, Vågerö, Mårten, Day, Simon, 2018. Approaches to sample size calculation for clinical trials in rare diseases. Pharmaceutical Statistics, 17 (3), pp. 214-230
Stallard, Nigel, Miller, Frank, Day, Simon, Hee, Siew Wan, Madan, Jason, Zohar, Sarah, Posch, Martin, 2017. Determination of the optimal sample size for a clinical trial accounting for the population size. Biometrical Journal, 59 (4), pp. 609-625
Hee, Siew Wan, Dritsaki, Melina, Willis, Adrian, Underwood, M. (Martin) M.D., Patel, Shilpa, 2017. Development of a repository of individual participant data from randomized controlled trials of therapists delivered interventions for low back pain. European Journal of Pain, 21 (5), pp. 815-826
Hee, Siew Wan, Willis, Adrian, Tudur Smith, Catrin, Day, Simon, Miller, Frank, Madan, Jason, Posch, Martin, Zohar, Sarah, Stallard, Nigel, 2017. Does the low prevalence affect the sample size of interventional clinical trials of rare diseases? An analysis of data from the aggregate analysis of clinicaltrials.gov. Orphanet Journal of Rare Diseases, 12 (44)
Hee, Siew Wan, Hamborg, Thomas, Day, Simon, Madan, Jason, Miller, F., Posch, Martin, Zohar, Sarah, Stallard, Nigel, 2016. Decision-theoretic designs for small trials and pilot studies : a review. Statistical methods in medical research, 25 (3), pp. 1022-1038
Patel, Shilpa, Hee, Siew Wan, Mistry, Dipesh, Jordan, Jake, Brown, S., Dritsaki, Melina, Ellard, David R., Friede, Tim, Lamb, S. E., Lord, Joanne, Madan, Jason, Morris, Tom, Stallard, Nigel, Tysall, Colin, Willis, Adrian, Underwood, Martin, 2016. Identifying back pain subgroups : developing and applying approaches using individual patient data collected within clinical trials. Programme Grants for Applied Research, 4 (10)
Morris, Tom, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, Patel, Shilpa, 2015. Can we convert between outcome measures of disability for chronic low back pain?. Spine, 40 (10), pp. 734-739
Patel, Shilpa, Ngunjiri, Anne, Hee, Siew Wan, Yang, Yaling, Brown, Sally, Friede, Tim, Griffiths, Frances, Lord, J., Sandhu, Harbinder, Thistlethwaite, Jill, Tysall, Colin, Underwood, Martin, 2014. Primum non nocere : shared informed decision making in low back pain : a pilot cluster randomised trial. BMC Musculoskeletal Disorders, 15
Mistry, Dipesh, Patel, Shilpa, Hee, Siew Wan, Stallard, Nigel, Underwood, Martin, 2014. Evaluating the quality of subgroup analyses in randomized controlled trials of therapist delivered interventions for non-specific low back pain : a systematic review. Spine, 39 (7), pp. 618-629
Ragin, Camille, Obikoya-Malomo, Monisola, Kim, Sungjin, Chen, Zhengjia, Flores-Obando, Rafael, Gibbs, Denise, Koriyama, Chihaya, Aguayo, Francisco, Koshiol, Jill, Caporaso, Neil E., Carpagnano, Giovanna E., Ciotti, Marco, Dosaka-Akita, Hirotoshi, Fukayama, Masashi, Goto, Akiteru, Spandidos, Demetrios A., Gorgoulis, Vassilis, Heideman, Daniëlle A. M., van Boerdonk, Robert A. A., Hiroshima, Kenzo et al (Select to open full list), 2014.

All authors for HPV-associated lung cancers : an international pooled analysis

Ragin, Camille, Obikoya-Malomo, Monisola, Kim, Sungjin, Chen, Zhengjia, Flores-Obando, Rafael, Gibbs, Denise, Koriyama, Chihaya, Aguayo, Francisco, Koshiol, Jill, Caporaso, Neil E., Carpagnano, Giovanna E., Ciotti, Marco, Dosaka-Akita, Hirotoshi, Fukayama, Masashi, Goto, Akiteru, Spandidos, Demetrios A., Gorgoulis, Vassilis, Heideman, Daniëlle A. M., van Boerdonk, Robert A. A., Hiroshima, Kenzo, Iwakawa, Reika, Kastrinakis, Nikolaos G., Kinoshita, Ichiro, Akiba, Suminori, Landi, Maria T., Eugene Liu, H., Wang, Jinn-Li, Mehra, Ranee, Khuri, Fadlo R., Lim, Wan-Teck, Owonikoko, Taofeek K., Ramalingam, Suresh, Sarchianaki, Emmanuela, Syrjanen, Kari, Tsao, Ming-Sound, Sykes, Jenna, Hee, Siew Wan, Yokota, Jun, Zaravinos, Apostolos, Taioli, Emanuela

HPV-associated lung cancers : an international pooled analysis. Carcinogenesis, 35 (6), pp. 1267-1275
Hee, Siew Wan, Stallard, Nigel, 2012. Designing a series of decision-theoretic phase II trials in a small population. Statistics in Medicine, Vol.31 (No.30), pp. 4337-4351
Toh, Han Chong, Chia, Whay Kuang, Sun, L., Thng, C. H., Soe, Y., Phoon, Y. P., Yap, Swee Peng, Lim, W. T., Tai, W. M., Hee, Siew Wan, Tan, S. H. (Seow-Hwei), Leong, S. S., Tan, E. H., 2011. Graft-vs-tumor effect in patients with advanced nasopharyngeal cancer treated with nonmyeloablative allogeneic PBSC transplantation. Bone Marrow Transplantation, 46 (4), pp. 573-579
Chiang, J., Chan, A., Shih, V., Hee, Siew Wan, Tao, M., Lim, S. T., 2010. A prospective study to evaluate the feasibility and economic benefits of rapid infusion rituximab at an Asian cancer center. International Journal of Hematology, 91 (5), pp. 826-830
Leong, S. S., Fong, K. W., Lim, W. T., Toh, C. K., Yap, S. P., Hee, Siew Wan, Tan, E. H., 2010. A phase II trial of induction gemcitabine and vinorelbine followed by concurrent vinorelbine and radiotherapy in locally advanced non-small cell lung cancer. Lung Cancer, 67 (3), pp. 325-329
Lim, W. T., Tan, E. H., Toh, C. K., Hee, Siew Wan, Leong, S. S., Ang, P. C. S., Wong, N. S., Chowbay, B., 2010. Phase I pharmacokinetic study of a weekly liposomal paclitaxel formulation (Genexol®-PM) in patients with solid tumors. Annals of Oncology, 21 (2), pp. 382-388
Toh, C. K., Ahmad, B., Soong, R., Chuah, K. L., Tan, S. H., Hee, Siew Wan, Leong, S. S., Tan, E. H., Lim, W. T., 2010. Correlation between epidermal growth factor receptor mutations and expression of female hormone receptors in East-Asian Lung adenocarcinomas. Journal of Thoracic Oncology, 5 (1), pp. 17-22
Toh, H. C., Wang, W.-W., Chia, W. K., Kvistborg, P., Sun, L., Teo, K., Phoon, Y. P., Soe, Y., Tan, S. H., Hee, Siew Wan, Foo, K. F., Ong, S., Koo, W. H., Zocca, M.-B., Claesson, M. H., 2009. Clinical benefit of allogeneic melanoma cell lysate-pulsed autologous dendritic cell vaccine in MAGE-positive colorectal cancer patients. Clinical Cancer Research, 15 (24), pp. 7726-7736
Tham, Ivan Weng-Keong, Hee, Siew Wan, Yeo, Richard Ming-Chert, Salleh, Patemah Bte, Lee, James, Tan, Terence Wee-Kiat, Fong, Kam Weng, Chua, Eu Tiong, Wee, Joseph Tien-Seng, 2009. Treatment of nasopharyngeal carcinoma using intensity-modulated radiotherapy - the national cancer centre Singapore experience. International Journal of Radiation Oncology*Biology*Physics, 75 (5), pp. 1481-1486
Ang, Mei-Kim, Hee, Siew Wan, Quek, Richard, Yap, Swee Peng, Loong, Susan, Tan, Leonard, Tao, Miriam, Lim, Soon Thye, 2009. Presence of a high-grade component in gastric mucosa-associated lymphoid tissue (MALT) lymphoma is not associated with an adverse prognosis. Annals of Hematology, 88 (5), pp. 417-424
Ngeow, J. Y. Y., Quek, R. H. H., Ng, D. C. E., Hee, Siew Wan, Tao, M., Lim, L. C., Tan, Y. H., Lim, S. T., 2009. High SUV uptake on FDG-PET/CT predicts for an aggressive B-cell lymphoma in a prospective study of primary FDG-PET/CT staging in lymphoma. Annals of Oncology, 20 (9), pp. 1543-1547
Shih, Vivianne, Hee, Siew Wan, Chan, Alexandre, 2009. Clinical predictors of chemotherapy-induced nausea and vomiting in breast cancer patients receiving adjuvant doxorubicin and cyclophosphamide. Annals of Pharmacotherapy, 43 (3), pp. 444-452
Yeo, R., Fong, K. W., Hee, Siew Wan, Chua, E. T., Tan, T., Wee, J., 2009. Brachytherapy boost for T1/T2 nasopharyngeal carcinoma. Head and Neck, 31 (12), pp. 1610-1618
Chia, Whay Kuang, Ong, Simon, Toh, Han Chong, Hee, Siew Wan, Choo, Su Pin, Poon, Donald Y. H., Tay, Miah Hiang, Tan, Chee Kiat, Koo, Wen Hsin, Foo, Kian Fong, 2008. Phase II trial of gemcitabine in combination with cisplatin in inoperable or advanced hepatocellular carcinoma. Annals of the Academy of Medicine, Singapore, 37 (7), pp. 554-558
Ho, Juliana Teng-Swan, Tan, Puay-Hoon, Hee, Siew Wan, Wong, Jill Su-Lin, 2008. Underestimation of malignancy of atypical ductal hyperplasia diagnosed on 11-gauge stereotactically guided Mammotome breast biopsy : an Asian breast screen experience. The Breast, 17 (4), pp. 401-406
Lambert, Caroline, Berlin, Ivan, Lee, Tat-Leang, Hee, Siew Wan, Tan, Audrey S. L., Picard, David, Han, Ji Sheng, 2008. A standardized transcutaneous electric acupoint stimulation for relieving tobacco urges in dependent smokers. Evidence-based Complementary and Alternative Medicine, 2011
Leong, S. S., Wee, J., Rajan, S., Toh, C. K., Lim, W. T., Hee, Siew Wan, Tay, M. H., Poon, D., Tan, E. H., 2008. Triplet combination of gemcitabine, paclitaxel, and carboplatin followed by maintenance 5-fluorouracil and folinic acid in patients with metastatic nasopharyngeal Carcinoma. Cancer, 113 (6), pp. 1332-1337
Lim, S. T., Hee, Siew Wan, Quek, R., Lim, L. C., Yap, S. P., Loong, E. L., Sng, I., Tan, L. H. C., Ang, M. K., Ngeow, J., Tham, C. K., Ngo, L., Tan, M. H., Tao, M., 2008. Comparative analysis of extra-nodal NK/T-cell lymphoma and peripheral T-cell lymphoma : significant differences in clinical characteristics and prognosis. European Journal of Haematology, 80 (1), pp. 55-60
Ngo, L., Hee, Siew Wan, Lim, L. C., Tao, M., Quek, R., Yap, S. P., Loong, E. L., Sng, I., Hwan-Cheong, T. L., Ang, M. K., Ngeow, J., Tham, C. K., Tan, M. H., Lim, S. T., 2008. Prognostic factors in patients with diffuse large B cell lymphoma : before and after the introduction of rituximab. Leukemia and Lymphoma, 49 (3), pp. 462-469
Yap, S. P., Lim, W. T., Foo, K. F., Hee, Siew Wan, Leong, S. S., Fong, K. W., Eng, P., Hsu, A. A. L., Wee, J. T. S., Agasthian, T., Koong, H. N., Tan, E. H., 2008. Induction concurrent chemoradiotherapy using paclitaxel and carboplatin combination followed by surgery in locoregionally advanced non-small cell lung cancer - Asian experience. Annals of the Academy of Medicine Singapore, 37 (5), pp. 377-382
Khor, T. H., Tuan, J. K. L., Hee, Siew Wan, Tham, I. W. K., 2007. Radical radiotherapy with high-dose-rate brachytherapy for uterine cervix cancer long-term results. Australasian Radiology, 51 (6), pp. 570-577
Toh, C. K., Hee, Siew Wan, Lim, W. T., Leong, S. S., Fong, K. W., Yap, S. P., Hsu, A. A. L., Eng, P., Koong, H. N., Agasthian, T., Tan, E. H., 2007. Survival of small-cell lung cancer and its determinants of outcome in Singapore. Annals of the Academy of Medicine Singapore, 36 (3), pp. 181-188
Quek, R., Ty, A., Lim, S. T., See, S. J., Wong, M. C., Yap, S. P., Sng, I., Hee, Siew Wan, Tao, M., 2006. Primary central nervous system lymphoma in an Asian population : a 15-year experience. Oncology Research and Treatment, 29 (10), pp. 455-459
Teo, Melissa, Tan, Yu-Meng, Chung, Alex Y, Chow, Pierce K, Cheow, Peng C, Soo, Khee-Chee, Hee, Siew Wan, Ooi, London, 2006. Metastectomy for non-colorectal, non-neuroendocrine liver secondaries. ANZ Journal of Surgery, 76 (7), pp. 575-578

Mistry, D., Hee, S. W., Eldridge, S., Underwood, M., 2019. Chronic Headache Education and Self-management Study (CHESS) : Statistical Analysis Plan [v1.1]. University of Warwick ; Warwick Medical School
Patel, Shilpa, Hee, Siew Wan, Sandhu, Harbinder, Yang, Yaling, Underwood, Martin, 2014. Safety, effectiveness, and cost effectiveness of decision aids still unclear. BMJ, BMJ Publishing Group Ltd
Hee, Siew Wan, 2012. Designing a series of clinical trials.
Lim, S. T., Hee, Siew Wan, Quek, R., Tao, M., 2008. Performance status is the single most important prognostic factor in lymphoma patients aged greater than 75 overriding other prognostic factors such as histology. Leukemia and Lymphoma, Taylor & Francis, pp. 149-151

Title	Funder	Award start	Award end
Research Design Service renewal 2018	National Institute for Health Research (DoH)	01 Oct 2018	30 Sep 2023
RECEDE study (Reducing Colonoscopies in those without bowEl DiseasE) HS&DR Stage 2 (Stage 1 - 60439)	National Institute for Health Research (DoH)	01 May 2020	31 Oct 2022
Postural tachycardia syndrome Exercise (PulSE) BHF grant via Coventry University	British Heart Foundation	01 Aug 2019	31 Jul 2022
NIHR RfPB 2nd stage. GARFIELD-AF in Primary Care - Optimising prediction of mortality, stroke, and major bleeding for patients with atrial fibrillation using routinely collected primary care electronic health records (Stage 1 - 58973)	National Institute for Health Research (DoH)	01 Mar 2020	28 Feb 2021
PGfAR Full application: Chronic Headache Educations and Self-management Study (CHESS): Resubmission	National Institute for Health Research (DoH)	05 Jan 2015	31 Oct 2020
EU FP7 Health Call 2013.4.2-3 (FULL Proposal): InsPiRe - Innovative Methodology for Small Populations Research	European Commission	01 Sep 2013	30 Nov 2016