Edit contents

Investigating whether an exercise programme is acceptable to patients, parents and physiotherapists and what training is required to deliver the treatments in NHS hospitals. (Published paper)

Professor Sallie Lamb

BionmArker-guided Duration of Antibiotic treatment in hospitalised PaTients with suspected Sepsis: the ADAPT-Sepsis Trial

Professor Paul D

Assessing the difference in the Manchester-Oxford Foot and Ankle Questionnaire at six months after injury between adults with an ankle fracture treated with functional bracing and exercises versus standard plaster cast care.

Professor Rebecca Kearney

UK study of ankle fracture rehabilitation – multicentre randomised controlled trial

Professor Rebecca Kearney

Randomised trial of a supraglottic airway device versus tracheal intubation during in-hospital cardiac arrest

Professor John Benger

Anticoagulants for LIving FoEtuses in women with recurrent miscarriage and inherited thrombophilia

Professor Siobhan Quenby

Phase 1 safety trial of a natural product cocktail with antibacterial activity in human volunteers

Dr Freya Harrison and Professor Julie Bruce

Axillary management in T1-3N1M0 breast cancer patients with needle biopsy proven nodal metastases at presentation after neoadjuvant chemotherapy

Associate Professor Amit Goyal

Anticoagulants for LIving FoEtuses in women with recurrent miscarriage and inherited thrombophilia

Professor Siobhan Quenby

Acute Rehabilitation following Traumatic anterior shoulder dISlocAtioN (ARTISAN): A Multi Centre Randomised Controlled Trial

Professor Rebecca Kearney

Comparing Platelet Rich Plasma (PRP) to placebo (imitation) injection in adults with Achilles tendon pain

Professor Rebecca Kearney

Awake Prone positioning in patients with acute hypoxaemic respiratory failure not due to COVID-19

Dr Keith Couper

Investigating whether salbutamol improves the health of patients with acute respiratory distress syndrome (ARDS). (Published Paper)

Professor Fang Gao

Big Toe OstEoarthritis Trial: Inserts (BigTOE Inserts)

Associate Professor Michael Backhouse

The Confederation of Respiratory Critical Care Trials (CoReCCT)

Getting Recovery Right After Neck Dissection for Head and Neck Cancer (GRRAND)

Professors Toby Smith and Stuart Winters

Remote multicomponent rehabilitation compared to standard care for survivors of critical illness after hospital discharge: a randomised controlled assessor-blind clinical and cost-effectiveness trial with internal pilot (iRehab)

Dr Brenda O'Neill Prof Danny McAuley

The Meniscal Transplant surgery or Optimised Rehabilitation - Full Randomised Trial (MeTeOR2)

Mr Andrew Metcalfe and Mr Tim Spalding

M-POWER: Mindfulness Prior to Orthopaedic surgery to improve Wellbeing and Enhance Recovery

Debbie Larson

Neurally Adjusted Ventilatory Assist (NAVA) compared to conventional ventilation for patients at risk of difficult or prolonged weaning from invasive mechanical ventilation: The UK NAVA Trial

Dr Daniel Hadfield

Optimal Personalised Treatment of early breast cancer using Multi-parameter Analysis

Professor Rob Stein

A research database to identify best practice and improve patient outcomes for those suffering pre-hospital cardiac arrest.

Professor Gavin Perkins

An online Parenting Intervention to Prevent affective disorders in high-risk Adolescents

Associate Prof Andrew Thompson

Evaluation of PeRsOnalised PrEhabilitation in people with acute myeloid Leukaemia

Professor Janet Dunn & Professor Simon Stanworth

The clinical and cost effectiveness of advanced airways protection device versus conventional endotracheal tubes in Intensive care unit patients requiring mechanical ventilation: a multicentre, pragmatic randomised clinical trial (PROTECT Airways)

Dr Gareth Kitchen

Exploring and Improving Resuscitation Decisions in Out of Hospital Cardiac Arrest

Professor Gavin Perkins

Airway Pressure Release Ventilation (APRV) vs conventional ventilation for patients with moderate to severe acute hypoxemic respiratory failure (RELEASE).

Prof Luigi Camporota and Prof Danny McAuley

Repurposed drugs to improve blood counts and reduce transfusions in myelodysplastic syndromes

Prof Janet Dunn

REcurrent Patellar dislocation: Personalised therapy or OpeRative Treatment?

Professor Andrew Metcalfe and Professor Toby Smith

To run a UK-wide randomised controlled trial (RCT) to test if the ‘Remote STrOke Rehabilitation’ (ReSTORe) intervention, a supervised, live online, home-based, group physical and mental health rehabilitation programme, can improve Health-related quality of life (HRQoL) more than best-practice usual care, for people with long-term mild to moderate physical and/or mental health disability after stroke.

Prof Gordon McGregor

Sugar or Salt (SOS) trial: Hyperosmolar therapy in traumatic brain injury

Prof Gavin Perkins

Improving outcomeS for Women diagnosed with early breast cancer through adhErence to adjuvant Endocrine Therapy (SWEET)

Professor Linda Sharp and Professor Eila Watson

This project aims to understand what “validity” means in economic evaluations that are conducted alongside clinical trials and to begin developing practical guidance for best practice.

Rebecca Kandiyali and May Ee Png