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Broken Heart Syndrome

Esther Knights (History)

takotsubo

Can Heartbreak be Lethal?

Takotsubo Cardiomyopathy, or 'broken heart syndrome', is a condition where the heart suddenly changes shape and is weakened. The syndrome’s association with a broken heart is because it often appears to be triggered by emotionally or physically stressful events, with women who have heard distressing news being particularly vulnerable. Its name, 'Takotsubo', originated because when the syndrome was first observed in Japan in 1990, the left ventricle (as shown in picture A) resembled the shape of Japanese Octopus pots, which are called ‘takotsubos’ (as shown in picture B). Whilst there is a long history of the heart being seen as vulnerable, the details of this syndrome are still emerging. This Cabinet, placed in the Postgraduate Private Study area, shows an ongoing development in the history of heartbreak in modernity.

Further Reading

Books

Chiles, Christopher D, Patel, Rikin; Baggett, Charles, Netter’s Cardiology, (Philadelphia: Elsevier, 1 January 2019), pp. 235-238.

Kaddoura, Sam, Echo Made Easy (Elsevier, 2025), pp. 62-119.

Shen, Jasmine, Crash Course Cardiology (Elsevier, Jan 2025), pp. 203-12.

Stamp, Nikki, Can You Die of a Broken Heart? (London, Sydney: Murdoch Books, 2018), pp. 18-39.

Chapters

Mitsuma W et al, ‘Takotsubo Cardiomyopathy’ in Charles, Fred H.D., MD, MPH; Afari, Maxwell Eyram, MD, Ferri's Clinical Advisor 2026 (Philadelphia: Elsevier Inc, 2026).

Articles

Templin, Christian, Ghadri, Diekmann, Jelena R., Johanna, et al. “Clinical Features and Outcomes of Takotsubo (Stress) Cardiomyopathy”, New England Journal of Medicine, Vol. 373, No. 10 (2015), pp. 929–38.

Assad J, Femia G, Pender P, Badie T, Rajaratnam R, "Takotsubo Syndrome: A Review of Presentation, Diagnosis and Management", Clinical Med Insights: Cardiology (January 2022).
Ravindran, Jayant and Brieger, David, “Clinical perspectives: Takotsubo cardiomyopathy”, Internal Medicine Journal, Vol. 54, Issue. 11 (September 2024), pp. 1785-1795.
Crea Filippo, Iannaccone Giulia, La Vecchiahia Giulia and Montone Rocco A, “An update on the mechanisms of Takotsubo syndrome: 'At the end an acute coronary syndrome’”, Journal of Molecular and Cellular Cardiology, Vol. 191 (June 2024), pp. 1-6
Sealove, Brett, Tiyyagura, Satish and Fuster, Valentin, “Takotsubo Cardiomyopathy”, Journal of General Internal Medicine, Vol. 23 (2009), pp. 1904-1908
Amin, Hilman, Amin, Lukman and Pradipta, Ariel, “Takotsubo Cardiomyopathy: A Brief Review”, Journal of Medicine and Life (2020)
Online Resources

British Heart Foundation, Takotsubo Cardiomyopathy (1 July 2024)

Harvard Health Publishing, Broken-heart syndrome (takotsubo cardiomyopathy) (13 June 2023) <https://www.health.harvard.edu/heart-health/takotsubo-cardiomyopathy-broken-heart-syndromeLink opens in a new window> [accessed 2 January 2026]
Cardiomyopathyuk, Takotsubo Syndrome Online (February 2024) <https://www.cardiomyopathy.org/about-cardiomyopathy/types-cardiomyopathy/takotsubo-syndromeLink opens in a new window> [accessed 3 January 2026]
Cossens Marianne, ‘Takotsubo cardiomyopathy’, 22 Dec 2018<https://radiopaedia.org/cases/takotsubo-cardiomyopathy-4?lang=gb> [accessed 25 Feb 2026]

Saeed Bilal, M.D., University of Toledo Medical Center, Toledo, Ohio (A); and Satoshi Kurisu, M.D., Hiroshima City Hospital, Hiroshima, Japan (B), from Harvard Health Publishing, 'Broken-heart syndrome (takotsubo cardiomyopathy)' (13 June 2023) <https://www.health.harvard.edu/heart-health/takotsubo-cardiomyopathy-broken-heart-syndromeLink opens in a new window> [accessed 2 January 2026]
St Vincent’s Hospital Heart Health, ‘Takutsubo cardiomyopathy’, St Vincent’s Hospital Heart Health, <https://www.svhhearthealth.com.au/conditions/takotsubo-cardiomyopathyLink opens in a new window> [accessed 25 February 2026]

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