a-Fetoprotein as a Physiological Zinc Carrier - Role in Fetal Development

 

Two of the many factors involved in the complicated etiology of fetal malformations are alphafetoprotein (AFP) and zinc. Strong support for the idea that AFP has a role in zinc homeostasis comes from the finding that its expression is regulated by MTF-1, a zinc-responsive transcription factor. The research emphasis is to explore the molecular basis of zinc binding and delivery by AFP, employing structure elucidation, in vitro zinc binding studies, and metalloproteomics, with a view to discover links between inadequacies in zinc transport, fetal malformations, and liver cancer.

 

Albumin as a zinc carrier – properties of its high-affinity zinc-binding site

Biochemical Society Transaction (2008) In press

Jin Lu, Alan Stewart, Peter J. Sadler, Teresa Pinheiro, Claudia A. Blindauer*

 

One-Step isolation of plasma membrane proteins using magnetic beads with immobilized concanavalin A

Protein Expression and Purification (2008) In Press

Jin Lu, etc.

 

Determination of Aminoheterocycle and Azabicycle in Gliclazide Bulk by Capillary Zone Electrophoresis with Amperometric Detection

J. Pharm & Biomed Anal 39 (2005) 843-847 

Jin Lv, Qingjiang Wang, Xiang Chen, Pingang He*, Yuzhi Fang*

 

Determination of Active Ingredients in Vc Yinqiao Tablets by Capillary Zone Electrophoresis with Amperometric Detection

Chinese Journal of Chemistry 24 (2006) 1117-1121

Jin Lv, Qingjiang Wang, Xiang Chen, Haiyan Liu, Pingang He* and Yuzhi Fang*

 

Separation and Determination of Nitroaniline Isomers by Capillary Zone Electrophoresis with Amperometric Detection

Talanta 69 (2006) 121-125 

Xifeng Guo, Jin Lv, Weidong Zhang, Qingjiang Wang, Pingang He*, Yuzhi Fang*

 

Study on Sensitivity Development of 2,3-dihydroxybenzoic Acid by Capillary Zone Electrophoresis Amperometric Detection with p-methyl Benzoate as Stacking Agent

Electrophoresis 26 (2005) 3273-C3278

Qingjiang Wang, Xiang Chen, Jin Lv, Haiyan Liu, Pingang He* and Yuzhi Fang*

 

Determination of Water Soluble Small Molecules Antioxidant Power by Capillary Zone Electrophoresis with Amperometric Detection

Chinese Journal of Analytical Chemistry 33 (2005) 969-971

Qingjiang Wang, Xiang Chen, Din Fei, Jin Lv, Haiyan Liu, Pingang He* and Yuzhi Fang