I graduated in 2011 from the University of Warwick with an MChem in Chemical Biology. My 4th year masters project was completed under the supervision of Dr Christophe Corre was entitled ‘Investigation of the Interaction Between Antibiotic Production Inducers and the DNA Binding Proteins MmfR / MmyR’. I was awarded the Andrew McCalmey prize for outstanding fourth year project. I also completed two summer projects in the Bugg group, both of which involved working on the carotenoid cleavage dioxygenase family of enzymes.
I am currently working on a family of enzymes known as the CCDs, which cleave carotenoid substrates to apocarotenoids. The project encompasses many of my research interests, including enzymology, organic synthesis and protein purification.
Harrison, P.J., Bugg, T.D.H. (2013) "Enzymology of the Carotenoid Cleavage Dioxygenases: Reaction Mechanisms, Inhibition & Biochemical Roles." Arch Biochem Biophys. doi: 10.1016/j.abb.2013.10.005
J.M. Van Norman, J. Zhang, C.I. Cazzonelli, B.J. Pogson, P.J. Harrison, T.D.H. Bugg, K.X. Chan, A.J. Thompson and P.N. Benfey. (2014) “Periodic root branching in Arabidopsis requires synthesis of an uncharacterized carotenoid derivative", Proc. Natl. Acad. Sci. USA, 111, E1300-E1309.
M. J. Sergeant, P. J. Harrison, R. Jenkins, G. R. Moran, T. D. H. Bugg & A. J. Thompson. (2013) “Phytotoxic effects of selected N-benzyl-benzoylhydroxamic acid metallo-oxygenase inhibitors: investigation into mechanism of action”, N. J. Chem, 37, 3461 .