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Prof Józef Lewandowski

My research focuses on the development of solid-state NMR methodology and applications of integrated structural biology approach with emphasis on solution and solid-state NMR and molecular dynamics simulations to study relationships between structure, dynamics, and activity of biomolecular systems. I am particularly interested in atomic resolution characterization of solid and solid-liquid interface biological systems including, but not limited to, protein complexes, fibrils, membrane proteins and antibiotics. Because the line widths in the NMR spectra in the solid-state do not depend on the size of the molecule as they do in solution, solid-state NMR offers unique opportunities to study structure and dynamics of proteins as a part of even very large assemblies. Importantly, solid-state NMR methodology can be applied to soluble and crystallisable systems but also to systems that are not soluble or that cannot be crystallised.

Recently, a large fraction of the efforts in my laboratory concentrates on applications to proteins implicated in natural products biosynthesis, in particular trans-AT polyketide synthases (PKS) and polyketide synthase/non-ribosomal peptide synthase (PKS/NRPS) hybrids.

Groups at Warwick



  • 1995-1997 IB, Nordic United World College, Flekke, Norway
  • 1997-1998 MISMaP, Warsaw University, Warsaw, Poland
  • 1999-2003 BSc in Chemistry and Theater & Dance, Amherst College, Amherst, MA, USA
  • 2002-2008 PhD (supervisor Prof. R. G. Griffin), Massachusetts Institute of Technology, Cambridge, MA, USA
  • 2008-2011 Marie Curie Postdoctoral Fellow (supervisor Prof. L. Emsley), ENS de Lyon/Centre de RMN à Très Haut Champs, Lyon, France
  • 2011-2015 Assistant Professor, Department of Chemistry, University of Warwick
  • 2015-2019 Associate Professor, Department of Chemistry, University of Warwick
  • 2019-present Professor, Department of Chemistry, University of Warwick