Guy, Collette S., Gott, James A., Ramírez-Cárdenas, Jonathan, de Wolf, Christopher, Furze, Christopher M., West, Geoffrey D., Muñoz-García, Juan C., Angulo, Jesus and Fullam, Elizabeth (2024) Fluorinated trehalose analogues for cell surface engineering and imaging of Mycobacterium tuberculosis. Chemical Science . doi:10.1039/D4SC00721B ISSN 2041-6520. (In Press)
Brown, Chelsea M., Corey, Robin A., Gao, Ya, Kyo Choi, Yeol, Gilleron, Martine, Destainville, Nicolas, Fullam, Elizabeth, Im, Wonpil, Chavent, Matthieu G. and Stansfeld, Phillip J. (2023) Supramolecular organisation and dynamics of mannosylated phosphatidylinositol lipids in the mycobacterial plasma membrane. Biophysical Journal, 122 (3). 136a. ISSN 0006-3495 doi:10.1016/j.bpj.2022.11.897
Brown, Chelsea M., Corey, Robin A., Grélard, Axelle , Gao, Ya, Kyo Choi, Yeol, Luna, Emanuel, Gilleron, Martine, Destainville, Nicolas, Nigou, Jérôme, Loquet, Antoine, Fullam, Elizabeth, Im, Wonpil, Stansfeld, Phillip J. and Chavent, Matthieu (2023) Supramolecular organisation and dynamics of mannosylated phosphatidylinositol lipids in the mycobacterial plasma membrane. Proceedings of the National Academy of Sciences of the United States of America, 120 (5). e2212755120. doi:10.1073/pnas.2212755120 ISSN 0027-8424.
Radhakrishnan, Anjana, Brown, Chelsea M., Guy, Collette S., Cooper, Charlotte, Pacheco-Gómez, Raúl, Stansfeld, Phillip J. and Fullam, Elizabeth (2022) Interrogation of the pathogen box reveals small molecule ligands against the mycobacterial trehalose transporter LpqY-SugABC. RSC Medicinal Chemistry, 13 (10). pp. 1225-1233. doi:10.1039/D2MD00104G ISSN 2632-8682.
Guy, Collette S., Tomás, Ruben M. F., Tang, Qiao, Gibson, Matthew I. and Fullam, Elizabeth (2022) Imaging of antitubercular dimeric boronic acids at the mycobacterial cell surface by click-probe capture. Chemical Communications, 58 (67). pp. 9361-9364. doi:10.1039/D2CC02407A ISSN 1359-7345.
Karlikowska, Magdalena, Singh, Albel, Bhatt, Apoorva, Ott, Sascha, Bottrill, Andrew R., Besra, Gurdyal S. and Fullam, Elizabeth (2021) Biochemical and phenotypic characterisation of the Mycobacterium smegmatis transporter UspABC. The Cell Surface, 7 . 100052. doi:10.1016/j.tcsw.2021.100052 ISSN 2468-2330.
Coverdale, James P. C., Guy, Collette S., Bridgewater, Hannah E., Needham, Russell J., Fullam, Elizabeth and Sadler, Peter J. (2021) Osmium–arene complexes with high potency towards Mycobacterium tuberculosis. Metallomics, 13 (4). mfab007. doi:10.1093/mtomcs/mfab007 ISSN 1756-5901.
Furze, Christopher M., Delso, Ignacio, Casal, Enriqueta, Guy, Collette S., Seddon, Chloe, Brown, Chelsea M., Parker, Hadyn L., Radhakrishnan, Anjana, Pacheco-Gomez, Raul, Stansfeld, Phillip J., Angulo, Jesus, Cameron, Alexander D. and Fullam, Elizabeth (2021) Structural basis of trehalose recognition by the mycobacterial LpqY-SugABC transporter. Journal of Biological Chemistry, 296 . 100307. doi:10.1016/j.jbc.2021.100307 ISSN 0021-9258.
Parker, Hadyn, Tomás, Ruben M. F., Furze, Christopher M., Guy, Collette S. and Fullam, Elizabeth (2020) Asymmetric trehalose analogues to probe disaccharide processing pathways in mycobacteria. Organic & Biomolecular Chemistry (18). pp. 3607-3612. doi:10.1039/D0OB00253D ISSN 1477-0520.
Fenn, Jonathan S., Nepravishta, Ridvan, Guy, Collette S., Harrison, James, Angulo, Jesus, Cameron, Alexander and Fullam, Elizabeth (2019) Structural basis of glycerophosphodiester recognition by the mycobacterium tuberculosis substrate-binding protein UgpB. ACS Chemical Biology, 14 (9). pp. 1879-1887. doi:10.1021/acschembio.9b00204 ISSN 1554-8929.
Guy, Collette S., Gibson, Matthew I. and Fullam, Elizabeth (2019) Targeting extracellular glycans : tuning multimeric boronic acids for pathogen-selective killing of Mycobacterium tuberculosis. Chemical Science, 10 (23). 5935-5942 . doi:10.1039/C9SC00415G ISSN 2041-6520.
Guy, Collette S., Murray, Kathryn, Gibson, Matthew I. and Fullam, Elizabeth (2019) Dimeric benzoboroxoles for targeted activity against Mycobacterium tuberculosis. Organic & Biomolecular Chemistry, 17 (43). pp. 9524-9528. doi:10.1039/C9OB02222H ISSN 1477-0520.
Radhakrishnan, Anjana, Furze, Christopher M., Ahangar, Mohd Syed and Fullam, Elizabeth (2018) A GFP-strategy for efficient recombinant protein overexpression and purification in Mycobacterium smegmatis. RSC Advances , 8 (58). pp. 33087-33095. doi:10.1039/c8ra06237d ISSN 2046-2069.
Ahangar, Mohd Syed, Furze, Christopher M., Guy, Collette S., Cooper, Charlotte, Maskew, Kathryn S, Graham, Ben, Cameron, Alexander and Fullam, Elizabeth (2018) Structural and functional determination of homologs of the Mycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA). Journal of Biological Chemistry, 293 (25). pp. 9770-9783. doi:10.1074/jbc.RA118.002597 ISSN 0021-9258.
Abuhammad, Areej and Fullam, Elizabeth (2018) Mycobacterial arylamine N-acetyltrasferases and tuberculosis. In: Laurieri , Nicola and Sim, Edith, (eds.) Arylamine N-Acetyltransferases in Health and Disease : from Pharmacogenetics to Drug Discovery and Diagnostic. Singapore ; Hackensack, NJ: World Scientific Publishing Co. Pte. Ltd., pp. 385-410. ISBN 9789813232006
Fullam, Elizabeth (2018) Structural and functional analysis of the N-acetylglucosamine-6-phosphate deacetylase (NagA) from Mycobacterium tuberculosis. In: 255th ACS National Meeting - Nexus of Food, Energy, and Water, New Orleans, LA, U.S.A., March 18-22, 2018. Published in: Abstracts of papers of the American Chemical Society, 255 ISSN 0065-7727.
Richards, Sarah-Jane, Isulfi, Klea, Wilkins, Laura E., Lipecki, Julia, Fullam, Elizabeth and Gibson, Matthew I. (2017) Multivalent antimicrobial polymer nanoparticles target mycobacteria and gram-negative bacteria by distinct mechanisms. Biomacromolecules, 19 (1). pp. 256-264. doi:10.1021/acs.biomac.7b01561 ISSN 1525-7797.
Guy, Collette S., Tichauer, Esther, Kay, Gemma L., Phillips, Daniel J., Bailey, Trisha L., Harrison, James, Furze, Christopher M., Millard, Andrew D., Gibson, Matthew I., Pallen, Mark J. and Fullam, Elizabeth (2017) Identification of the anti-mycobacterial functional properties of piperidinol derivatives. British Journal of Pharmacology, 174 (14). pp. 2183-2193. doi:10.1111/bph.13744 ISSN 1476-5381.
Phillips, Daniel J., Harrison, James, Richards, Sarah-Jane, Mitchell, Daniel E., Tichauer, Esther, Hubbard, Alasdair T. M., Guy, Collette S., Hands-Portman, Ian, Fullam, Elizabeth and Gibson, Matthew I. (2017) Evaluation of the antimicrobial activity of cationic polymers against mycobacteria : toward antitubercular macromolecules. Biomacromolecules, 18 (5). pp. 1592-1599. doi:10.1021/acs.biomac.7b00210 ISSN 1525-7797.
Fullam, Elizabeth, Prokes, Ivan, Fütterer, Klaus and Besra, Gurdyal S. (2016) Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars. Open Biology (6). doi:10.1098/rsob.160105 ISSN 2046-2441.
Otten, Lucienne, Fullam, Elizabeth and Gibson, Matthew I. (2016) Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile. Molecular BioSystems, 12 (2). pp. 341-344. doi:10.1039/c5mb00720h ISSN 1742-206X.
Lowery, Richard, Gibson, Matthew I., Thompson, Richard C. and Fullam, Elizabeth (2015) Deuterated carbohydrate probes as ‘label-free’ substrates for probing nutrient uptake in mycobacteria by nuclear reaction analysis. Chemical communications, 51 (23). pp. 4838-4841. doi:10.1039/c4cc09588j ISSN 1359-7345.
Abuhammad, Areej, Fullam, Elizabeth, Bhakta, Sanjib, Russell, Angela, Morris, Garrett, Finn, Paul and Sim, Edith (2014) Exploration of piperidinols as potential antitubercular agents. Molecules, Volume 19 (Number 10). pp. 16274-16290. doi:10.3390/molecules191016274 ISSN 1420-3049.
Gibson, Matthew I., Neres, João and Fullam, Elizabeth (2014) Selective detection of epimeric pentose saccharides at physiological pH using a fluorescent receptor. Carbohydrate research, Volume 391 . pp. 61-65. doi:10.1016/j.carres.2014.02.007 ISSN 1873-426X.
Richards, Sarah-Jane, Fullam, Elizabeth, Besra, Gurdyal S. and Gibson, Matthew I. (2014) Discrimination between bacterial phenotypes using glyco-nanoparticles and the impact of polymer coating on detection readouts. Journal of Materials Chemistry B, Volume 2 (Number 11). pp. 1490-1498. doi:10.1039/c3tb21821j ISSN 2050-750X.
Fullam, Elizabeth, Talbot, James, Abuhammed, Areej, Westwood, Isaac, Davies, Stephen G., Russell, Angela J. and Sim, Edith (2013) Design, synthesis and structure–activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, Vol.23 (No.9). pp. 2759-2764. doi:10.1016/j.bmcl.2013.02.052 ISSN 0960-894X.
Otten, Lucienne, Richards, Sarah-Jane, Fullam, Elizabeth, Besra, Gurdyal S. and Gibson, Matthew I. (2013) Gold nanoparticle-linked analysis of carbohydrate–protein interactions, and polymeric inhibitors, using unlabelled proteins; easy measurements using a ‘simple’ digital camera. Journal of Materials Chemistry B, Volume 1 (Number 20). pp. 2665-2672. doi:10.1039/c3tb20259c ISSN 2050-750X.
Abuhammad, Areej, Fullam, Elizabeth, Lowe, Edward D., Staunton, David, Kawamura, Akane, Westwood, Isaac, Bhakta, Sanjib, Garner, Alun Christopher, Wilson, David L., Seden, Peter T., Davies, Stephen G., Russell, Angela J., Garman, Elspeth F. and Sim, Edith (2012) Piperidinols that show anti-tubercular activity as inhibitors of arylamine N-acetyltransferase: an essential enzyme for mycobacterial survival inside macrophages. PLoS One, Volume 7 (Number 12). Article number e52790. doi:10.1371/journal.pone.0052790 ISSN 1932-6203.
Fullam, Elizabeth, Pojer, Florence, Bergfors, Terese, Jones, T. Alwyn and Cole, Stewart T. (2012) Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme. Open Biology, Volume 2 (110026). Article number 110026. doi:10.1098/rsob.110026 ISSN 2046-2441.
Neres, J., Pojer, F., Molteni, E., Chiarelli, L. R., Dhar, N., Boy-Rottger, S., Buroni, S., Fullam, Elizabeth, Degiacomi, G., Lucarelli, A. P.
et al.
(2012)
Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis. Science Translational Medicine, Vol.4 (No.150). Article no. 150ra121. doi:
10.1126/scitranslmed.3004395 ISSN 1946-6234.
Fullam, Elizabeth, Abuhammad, Areej, Wilson, David L., Anderton, Matthew C., Davies, Steve G., Russell, Angela J. and Sim, Edith (2011) Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase. Bioorganic & Medicinal Chemistry Letters, Volume 21 (Number 4). pp. 1185-90. doi:10.1016/j.bmcl.2010.12.099 ISSN 0960-894X.
Abuhammad, Areej M., Lowe, Edward D., Fullam, Elizabeth, Noble, Martin, Garman, Elspeth F. and Sim, Edith (2010) Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site. Protein & Cell, Volume 1 (Number 4). pp. 384-92. doi:10.1007/s13238-010-0037-7 ISSN 1674-8018 .
Westwood, Isaac M., Bhakta, Sanjib, Russell, Angela J., Fullam, Elizabeth, Anderton, Matthew C., Kawamura, Akane, Mulvaney, Andrew W., Vickers, Richard J., Bhowruth, Veemal, Besra, Gurdyal S., Lalvani, Ajit, Davies, Stephen G. and Sim, Edith (2010) Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars. Protein & Cell, Volume 1 (Number 1). pp. 82-95. doi:10.1007/s13238-010-0006-1 ISSN 1674-8018 .
Fullam, Elizabeth, Kawamura, Akane, Wilkinson, Helen, Abuhammad, Areej, Westwood, Isaac and Sim, Edith (2009) Comparison of the Arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis. The Protein Journal, Volume 28 (Number 6). pp. 281-293. doi:10.1007/s10930-009-9193-0 ISSN 1875-8355.
Makarov, Vadim, Manina, Giulia, Mikusova, Katarina, Möllmann, Ute, Ryabova, Olga, Saint-Joanis, Brigitte, Dhar, Neeraj, Pasca, Maria Rosalia, Buroni, Silvia, Lucarelli, Anna Paola
et al.
(2009)
Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis. Science (New York, N.Y.), Volume 324 (Number 5928). pp. 801-804. doi:
10.1126/science.1171583 ISSN 1095-9203.
Sandy, James, Holton, Simon, Fullam, Elizabeth, Sim, Edith and Noble, Martin (2009) Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis. Protein science : a publication of the Protein Society, Volume 14 (Number 3). pp. 775-782. doi:10.1110/ps.041163505 ISSN 0961-8368.
Sim, Edith, Lack, Nathan, Wang, Chan-Ju, Long, Hilary, Westwood, Isaac, Fullam, Elizabeth and Kawamura, Akane (2008) Arylamine N-acetyltransferases : structural and functional implications of polymorphisms. Toxicology , Volume 254 (Number 3). pp. 170-83. doi:10.1016/j.tox.2008.08.022 ISSN 0300-483X.
Lack, Nathan A, Kawamura, Akane, Fullam, Elizabeth, Laurieri, Nicola, Beard, Stacey, Russell, Angela J, Evangelopoulos, Dimitrios, Westwood, Isaac and Sim, Edith (2008) Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis. The Biochemical journal, Volume 418 (Number 2). pp. 369-78. doi:10.1042/BJ20082011 ISSN 1470-8728.
Sim, Edith, Sandy, James, Evangelopoulos, Dimitrios, Fullam, Elizabeth, Bhakta, Sanjib, Westwood, Isaac, Krylova, Anna, Lack, Nathan and Noble, Martin (2008) Arylamine N-acetyltransferases in mycobacteria. Current drug metabolism , Volume 9 (Number 6). pp. 510-519. doi:10.2174/138920008784892100 ISSN 1389-2002.
Fullam, Elizabeth, Westwood, Isaac M., Anderton, Matthew C., Lowe, Edward D., Sim, Edith and Noble, Martin E. M. (2007) Divergence of cofactor recognition across evolution : coenzyme A binding in a prokaryotic arylamine N-acetyltransferase. Journal of Molecular Biology, Volume 375 (Number 1). pp. 178-91. doi:10.1016/j.jmb.2007.10.019 ISSN 0022-2836.
Sim, Edith, Westwood, Isaac and Fullam, Elizabeth (2007) Arylamine N-acetyltransferases. Expert Opinion on Drug Metabolism & Toxicology, Volume 3 (Number 2). pp. 169-84. doi:10.1517/17425255.3.2.169 ISSN 1742-5255.
Arisandy, Christofer, Fullam, Elizabeth and Barlow, Stephen (2006) Comparison of the bis(ferrocenylethynyl)phenylmethylium cation with bis(ferrocenylethenyl)methylium analogues. Journal of Organometallic Chemistry, Volume 691 (Number 15). pp. 3285-3292. doi:10.1016/j.jorganchem.2006.04.002 ISSN 0022-328X.
Westwood, I. M., Kawamura, A., Fullam, Elizabeth, Russell, A. J., Davies, S. G. and Sim, E. (2006) Structure and mechanism of arylamine N-acetyltransferases. Current topics in medicinal chemistry , Volume 6 (Number 15). pp. 1641-1654. doi:10.2174/156802606778108979 ISSN 1568-0266.