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Professor Alex Cameron

Job Title
Life Sciences
024 765 72929
Research Interests

Almost 30 % of all genomes sequenced to date encode membrane proteins. These play vital roles in many areas of cell biology such as signalling, the selective uptake or removal of molecules from the cell and the maintenance of cellular pH or ion concentration. Despite their importance in physiology and drug discovery there is a relative paucity in the number of structures solved. The goal of my research is in understanding the structure and mechanism of these dynamic proteins through the use of X-ray crystallography in combination with other biochemical and biophysical techniques.

In particular my group is focussed on secondary active transporters. These proteins harness electrochemical gradients to transport ions or molecules across membranes.
We have solved the structure of a number of transporters and are probing their mechanisms through a combination of X-ray crystallography, biochemistry, site-directed mutagenesis, chemistry and computational chemistry.


DPhil, Chemistry. University of York, 1993
BSc Biophysics. University of Leeds 1989

Title Funder Award start Award end
BBSRC Mid-range Equipment ALERT 2021 Application - November 2021 BBSRC 01 Aug 2022 31 Jul 2023
Structural and functional characterization of the major auxin uptake carrier AUX1 protein (Chitra Joshi) Medical and Life Sciences Research Fund 01 Aug 2021 31 Mar 2022
Structural and biophysical basis of Connexin26 channel mediated disease MRC 01 Jan 2017 31 Dec 2021
H20 MC: Crystal structures of PIN proteins - CrysPINs. MSCA IF EF ST for Fellow Martin Kubes European Commission 01 Aug 2018 31 Jul 2020
Biochemical and structural characterisation of a unique Rieske oxygenase CntA - FULL RPG application Leverhulme Trust 08 May 2017 31 Jul 2020
Elucidating molecular level details of the plant Borate transporter structure and function BBSRC 03 Oct 2016 31 Mar 2020
In-depth structural characterization of the tetraspanin CD81 BBSRC 01 Apr 2016 31 Mar 2019
Structural basis of the CO2 sensitivity of Cx26 and role in human physiology Leverhulme Trust 01 Jul 2015 31 Mar 2018
Subproject for Institution # 39462 BBSRC 01 Oct 2014 31 Jan 2018
Trypanosomatid protein synthesis as a target for novel drug therapies MRC 01 Jan 2016 31 Dec 2017
Subcontract for BB/K017292/1 from Imperial BBSRC 01 Jul 2013 30 Jun 2016