Dr Alex Jones

Title

Reader

Contact

Life Sciences
University of Warwick
Coventry
CV4 7AL

Tel: 024 765 28144
Email: alex.jones@warwick.ac.uk
WebLink: Signalling and trafficking


Research Interests To flourish plants need to adapt their growth and development in response to changes in their environment. Great progress has been made in determining the mechanisms of signal perception and an essential part of subsequent responses is rapid alteration of cellular membranes and the cell wall. Beyond transport of materials, the internalization and secretion of plasma membrane receptors can regulate signal duration and create local signal gradients. Thus, the trafficking of vesicles within a cell can be viewed as regulating overall cellular output. The mechanisms of how signal pathways and membrane trafficking events interact are largely unknown, but substantial rearrangements occur quickly, likely using pre-formed proteins. The question my research seeks to address is 'how are the mechanisms of membrane trafficking involved in normal growth and development, adapted for responses to biotic and abiotic stress?' My objective is to identify components recruited to responsive trafficking mechanisms and provide targets to uncouple negative impacts on plant growth during adaptation to stress. My group uses the model plant Arabidopsis thaliana, advanced proteomics, confocal microscopy and biochemistry to identify protein complexes and post-translational modifications at the interface between signal perception and responsive trafficking.
Biography Reader, School of Life Sciences, University of Warwick. 2013-present Head of Proteomics at The Sainsbury Laboratory, Norwich, 2005-2013 Post-doctoral researcher Targeting of EDS1/PAD4 resistance signalling complexes by bacterial effector proteins Imperial College, London. 2004-2005 Post-doctoral researcher "Comparative analysis of the defence proteome of Arabidopsis thaliana" Imperial College Wye Campus 2001-2004 Post-doctoral researcher "The impact of transgenes for herbivore and virus resistance on the weediness of crop relatives" at the Centre for Ecology and Hydrology, Dorset. 1999-2001 PhD "Purification and Sequencing of Myrosinase from the Cabbage Aphid". Imperial College Wye campus 1999 MSc Applied Plant Sciences. Imperial College Wye campus 1995 BSc (Hons) Chemistry & Biochemistry. Imperial College London 1990-1993 My publication and citation lists can be viewed at ResearcherID (B-5227-2009)
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Research Interests

To flourish plants need to adapt their growth and development in response to changes in their environment. Great progress has been made in determining the mechanisms of signal perception and an essential part of subsequent responses is rapid alteration of cellular membranes and the cell wall. Beyond transport of materials, the internalization and secretion of plasma membrane receptors can regulate signal duration and create local signal gradients. Thus, the trafficking of vesicles within a cell can be viewed as regulating overall cellular output. The mechanisms of how signal pathways and membrane trafficking events interact are largely unknown, but substantial rearrangements occur quickly, likely using pre-formed proteins.

The question my research seeks to address is 'how are the mechanisms of membrane trafficking involved in normal growth and development, adapted for responses to biotic and abiotic stress?' My objective is to identify components recruited to responsive trafficking mechanisms and provide targets to uncouple negative impacts on plant growth during adaptation to stress.

My group uses the model plant Arabidopsis thaliana, advanced proteomics, confocal microscopy and biochemistry to identify protein complexes and post-translational modifications at the interface between signal perception and responsive trafficking.

Biography

Reader, School of Life Sciences, University of Warwick. 2013-present

Head of Proteomics at The Sainsbury Laboratory, Norwich, 2005-2013

Post-doctoral researcher Targeting of EDS1/PAD4 resistance signalling complexes by bacterial effector proteins Imperial College, London. 2004-2005

Post-doctoral researcher "Comparative analysis of the defence proteome of Arabidopsis thaliana" Imperial College Wye Campus 2001-2004

Post-doctoral researcher "The impact of transgenes for herbivore and virus resistance on the weediness of crop relatives" at the Centre for Ecology and Hydrology, Dorset. 1999-2001

PhD "Purification and Sequencing of Myrosinase from the Cabbage Aphid". Imperial College Wye campus 1999
MSc Applied Plant Sciences. Imperial College Wye campus 1995
BSc (Hons) Chemistry & Biochemistry. Imperial College London 1990-1993

My publication and citation lists can be viewed at ResearcherID (B-5227-2009)

Research Projects

View Current Projects View All Projects

Publications

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Update your user profile on Ideate https://warwick.tribalhosted.co.uk

Research Themes:

Biotechnology
Plant & Crop Science