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Dr Alex Jones

Job Title
Reader
Department
Life Sciences
Phone
024 765 28144
Research Interests

To flourish plants need to adapt their growth and development in response to changes in their environment. Great progress has been made in determining the mechanisms of signal perception and an essential part of subsequent responses is rapid alteration of cellular membranes and the cell wall. Beyond transport of materials, the internalization and secretion of plasma membrane receptors can regulate signal duration and create local signal gradients. Thus, the trafficking of vesicles within a cell can be viewed as regulating overall cellular output. The mechanisms of how signal pathways and membrane trafficking events interact are largely unknown, but substantial rearrangements occur quickly, likely using pre-formed proteins.

The question my research seeks to address is 'how are the mechanisms of membrane trafficking involved in normal growth and development, adapted for responses to biotic and abiotic stress?' My objective is to identify components recruited to responsive trafficking mechanisms and provide targets to uncouple negative impacts on plant growth during adaptation to stress.

My group uses the model plant Arabidopsis thaliana, advanced proteomics, confocal microscopy and biochemistry to identify protein complexes and post-translational modifications at the interface between signal perception and responsive trafficking.

Biography

Reader, School of Life Sciences, University of Warwick. 2013-present

Head of Proteomics at The Sainsbury Laboratory, Norwich, 2005-2013

Post-doctoral researcher Targeting of EDS1/PAD4 resistance signalling complexes by bacterial effector proteins Imperial College, London. 2004-2005

Post-doctoral researcher "Comparative analysis of the defence proteome of Arabidopsis thaliana" Imperial College Wye Campus 2001-2004

Post-doctoral researcher "The impact of transgenes for herbivore and virus resistance on the weediness of crop relatives" at the Centre for Ecology and Hydrology, Dorset. 1999-2001

PhD "Purification and Sequencing of Myrosinase from the Cabbage Aphid". Imperial College Wye campus 1999
MSc Applied Plant Sciences. Imperial College Wye campus 1995
BSc (Hons) Chemistry & Biochemistry. Imperial College London 1990-1993

My publication and citation lists can be viewed at ResearcherID (B-5227-2009)
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  • Raybould, A. F., Alexander, M. J., Mitchell, E., Thurston, M. I., Pallett, D. W., Hunter, P., Walsh, J. A., Edwards, M. L., Jones, Alexandra M., Moyes, C. L., Gray, A. J., Cooper, J. I., 2003. The ecology of turnip mosaic virus in wild populations of Brassica species. The Fifteenth Special Symposium of the British Ecological Society, 17-19 Sep 2001, Published in Genes in the Environment. The Fifteenth Special Symposium of the British Ecological Society, pp. 226-244
  • Syed, Junetha, Palani, Saravanan, Clarke, Scott T., Asad, Zainab, Bottrill, Andrew R., Jones, Alexandra M. E., Sampath, Karuna, Balasubramanian, Mohan K., 2019. Expanding the Zebrafish genetic code through site-specific introduction of diazirine-lysine, bicyclononyne-lysine and azido-lysine [pre-print]. BioRxiv
  • Haas, Brian J., Kamoun, Sophien, Zody, Michael C., Jiang, Rays H. Y., Handsaker, Robert E., Cano, Liliana M., Grabherr, Manfred, Kodira, Chinnappa D., Raffaele, Sylvain, Torto-Alalibo, Trudy, Bozkurt, Tolga O., Ah-Fong, Audrey M. V., Alvarado, Lucia, Anderson, Vicky L., Armstrong, Miles R., Avrova, Anna, Baxter, Laura, Beynon, Jim, Boevink, Petra C., Bollmann, Stephanie R. et al, 2009. Genome sequence and analysis of the Irish potato famine pathogen Phytophthora infestans. Nature, Nature Publishing, pp. 393-398
Title Funder Award start Award end
Elucidating molecular level details of the plant Borate transporter structure and function BBSRC 03 Oct 2016 31 Mar 2020
Phosphorus cycling in the soil-microbe-plant continuum of agri-ecosystems BBSRC 31 Dec 2014 31 Jul 2019
MLSRF Mohan T Chandrashekarai Medical and Life Sciences Research Fund 01 Mar 2018 28 Feb 2019
Neuropeptide function in a decentalized nervous system BBSRC 01 Jan 2015 31 Dec 2017
Control of seed and organ size by a ubiquitin-mediated signalling cascade BBSRC 01 Oct 2013 30 Sep 2016
Regulation of polar growth in plant roots: the interplay of signalling and vesicle trafficking Medical and Life Sciences Research Fund 01 Aug 2015 31 Jul 2016
Pilot study to develop methodologies and acquire data, allowing elucidation of the coordinated control of splicing in oestrogen positive and negative breast cancer tissues Medical and Life Sciences Research Fund 01 Jun 2014 31 May 2015
Developing interdisciplinary omics tools for organelle and cell type-specific analysis of Arabidopsis thaliana New Phytologist Trust 01 Sep 2014 30 Sep 2014