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Professor Bruno Frenguelli

Job Title
Life Sciences
Web Link
Research Interests

The capacity of the human brain to learn and remember is enormous and has intrigued scientists,clinicians and philosophers for centuries. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying the processes of learning and memory, and how these processes may become disordered in disease states such as Alzheimer's Disease or after conditions such as Stroke.

Our laboratory is interested in several aspects of the brain: its ability to learn and remember, its vulnerability to stroke, epilepsy and injury and the role that the purines ATP and adenosine, play in these processes.


PhD Pharmacology 1993. University of Birmingham

  • Dulla, Chris G., Frenguelli, Bruno G., Staley, Kevin, Masino, Susan A., 2008. Intracellular acidification causes adenosine release during states of hyperexcitability in the hippocampus. Purines 2008 Meeting, Copenhagen, Denmark, 29 June ? 2 July 2008, Published in Purinergic Signalling, pp. S160-S161
  • Frenguelli, Bruno G., 2008. Simultaneous measurement of ATP and adenosine in intact tissues by biosensors. Purines 2008 Meeting, Copenhagen, Denmark, 29 June ? 2 July 2008, Published in Purinergic Signalling, pp. S90-S90
  • Heal, David J., Henningfield, Jack, Frenguelli, Bruno G., Nutt, David J., Smith, Sharon L., 2018. Psychedelics ? Re-opening the doors of perception. Neuropharmacology, Elsevier, pp. 1-6
  • Frenguelli, Bruno G., 2011. Purinergic signalling between neurones and glia : for those about to rock. Seminars in Cell and Developmental Biology, Elsevier Science Ltd. / Academic Press Ltd, pp. 193-193
  • Caudron, Q., Lyn-Adams, Ceri Louise, Aston, John A. D., Frenguelli, Bruno G., Moffat, Kevin G., 2010. Quantitative assessment of ommatidial distortion in Drosophila melanogaster : a tool to investigate genetic interactions. Journal of Neurogenetics, Informa Healthcare
  • Lyn-Adams, Ceri Louise, Frenguelli, Bruno G., Moffat, Kevin G., Sutherland, Calum, 2010. Regulation of tau-dependent toxicity by brain selective/SAD kinases. Journal of Neurogenetics, Informa Healthcare
  • Dale, Nicholas, Frenguelli, Bruno G., 2009. Release of adenosine and ATP during ischemia and epilepsy. Current Neuropharmacology, Bentham Science Publishers Ltd, pp. 160-179
  • Frenguelli, Bruno G., 2008. Special issue on cerebral ischemia - Foreword. Neuropharmacology, Pergamon, pp. 249-249
Title Funder Award start Award end
Lab-on-a-Tip: Real-time nanoscale analysis of living cells - LT Research project Grant Leverhulme Trust 05 Jan 2017 04 Jan 2019
Environmental enrichment and cognitive function across the lifespan WPH Charitable Trust 01 Jan 2014 31 Dec 2016
Environmental enrichment and cognitive function across the lifespan BBSRC 27 Jan 2014 31 Dec 2016
Factors influencing cognition and ageing in a simple model organism - WT Vacation Scholarship 2016 - Miss Melissa Apted Wellcome Trust 18 Jul 2016 17 Sep 2016
Helping the brain help itself to recover after injury The Teresa Rosenbaum Golden Charitable Trust (Rosetrees Trust) 01 Jul 2014 31 Mar 2016
Telemetric recordings of neuronal and systemic activity during enrichment and anxiety protocols BBSRC 01 Oct 2011 30 Sep 2014
Case Studentship: Role of MSK and Arc/Arg3.1 glutamate receptor trafficking during long term depression GlaxoSmithKline PLC 01 Oct 2009 30 Sep 2013
Drosophila melanogaster as a model for Alzheimers Disease MRC 01 Feb 2010 31 Jan 2013
Imaging adenosine receptor trafficking in seizure models MRC 01 Oct 2007 30 Sep 2011
Hippocampal, Subcortical and Cortical Ineractions in Memory and Plasticity MRC 01 Jan 2008 30 Sep 2011
Medical Research Fund Bursary - Provision of equipment for Integrated Imaging Facility Medical Research Fund of Warwick 01 Oct 2010 31 Jul 2011
Regulation of Cortical excitability and seizure activity by purines Epilepsy Research UK 01 Jan 2008 31 Dec 2010

Research Themes:

Biomedical Science