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Professor Bruno Frenguelli

Job Title
Life Sciences
Web Link
Research Interests

The capacity of the human brain to learn and remember is enormous and has intrigued scientists,clinicians and philosophers for centuries. Today, a greater understanding has been achieved of the cellular and molecular mechanisms underlying the processes of learning and memory, and how these processes may become disordered in disease states such as Alzheimer's Disease or after conditions such as Stroke.

Our laboratory is interested in several aspects of the brain: its ability to learn and remember, its vulnerability to stroke, epilepsy and injury and the role that the purines ATP and adenosine, play in these processes.


PhD Pharmacology 1993. University of Birmingham

Title Funder Award start Award end
Repurposing existing compounds for the hyperacute treatment of ischemic stroke Stroke Association 01 Jun 2021 31 May 2024
MTA for the Transfer of Mutated Mouse Lines from the Canadian Mouse Mutant Repository Default Funder 02 May 2022 01 Jul 2023
Harnessing the Purine Salvage Pathway for the Treatment of Cerebral Ischemia Medical and Life Sciences Research Fund 01 Jan 2022 31 Dec 2022
Lab-on-a-Tip: Real-time nanoscale analysis of living cells - LT Research project Grant Leverhulme Trust 05 Jan 2017 04 Jan 2019
Environmental enrichment and cognitive function across the lifespan BBSRC 27 Jan 2014 31 Dec 2016
Environmental enrichment and cognitive function across the lifespan WPH Charitable Trust 01 Jan 2014 31 Dec 2016
Factors influencing cognition and ageing in a simple model organism - WT Vacation Scholarship 2016 - Miss Melissa Apted Wellcome Trust 18 Jul 2016 17 Sep 2016
Helping the brain help itself to recover after injury The Teresa Rosenbaum Golden Charitable Trust (Rosetrees Trust) 01 Jul 2014 31 Mar 2016
Telemetric recordings of neuronal and systemic activity during enrichment and anxiety protocols BBSRC 01 Oct 2011 30 Sep 2014
Case Studentship: Role of MSK and Arc/Arg3.1 glutamate receptor trafficking during long term depression GlaxoSmithKline PLC 01 Oct 2009 30 Sep 2013
Drosophila melanogaster as a model for Alzheimers Disease MRC 01 Feb 2010 31 Jan 2013
Hippocampal, Subcortical and Cortical Ineractions in Memory and Plasticity MRC 01 Jan 2008 30 Sep 2011
Imaging adenosine receptor trafficking in seizure models MRC 01 Oct 2007 30 Sep 2011
Medical Research Fund Bursary - Provision of equipment for Integrated Imaging Facility Medical Research Fund of Warwick 01 Oct 2010 31 Jul 2011
Regulation of Cortical excitability and seizure activity by purines Epilepsy Research UK 01 Jan 2008 31 Dec 2010

Research Themes:

Biomedical Science