Dr Fabrizio Alberti
UKRI Future Leaders Fellow - Associate Professor
Phone: 024 765 23516
Twitter: @Alberti.FabrizioLink opens in a new window
Alberti Lab webpage
Quantitative, Systems & Engineering Biology
Microbiology & Infectious Disease
Vacancies and Opportunities
For PhD and postdoctoral opportunities, and interest in potential collaborations, please contact me at the above email address.
Fungi represent an incredibly rich reservoir of natural products, which often show potent bioactivity and find applications in different fields, including medicine and crop protection. Research in the Alberti Lab aims to discover new molecules from fungi with useful bioactivities and understand how these compounds are assembled.
To this aim, we have recently developed a platform, based on Saccharomyces cerevisiae (baker's yeast), that accumulates increased amounts of precursors to a specific class of natural products called isoprenoid quinones.
We are also developing new synthetic biology tools to be used in basidiomycete (mushroom-forming) fungi that will enable us and the wider scientific community to exploit the genetic potential of this underexplored class of microorganisms.
You can read Fabrizio's interview taken as part of the School's 'Get to know us' series hereLink opens in a new windowLink opens in a new window.
Research: Technical Summary
Research in the Alberti Lab is focused on the discovery of novel natural products from fungi of the phyla Ascomycota and Basidiomycota. We are also interested in the study of the biosynthesis of known bioactive natural products, such as meroterpenoids.
We use a combination of CRISPR/Cas9 - for the genome editing of native host producers - and heterologous gene expression in a range of hosts, such as Saccharomyces cerevisiae and Aspergillus oryzae.
We are also developing tools for the heterologous expression of genes of interest in basidiomycete fungi that will enable for the easier study of complex biosynthetic gene clusters and enzymes that may be developed into biocatalysts.
For a full list of publications, see WRAP
- UKRI Future Leaders Fellow (Associate Professor), University of Warwick (2022 - present)
- Leverhulme Trust Early Career Fellow (Assistant Professor), University of Warwick (2018 - 2022)
- Postdoctoral Research Fellow, University of Warwick (2015 - 2018)
- PhD in Microbiology, University of Bristol (2012 - 2015)