We are interested in deciphering the complex signalling relationships between the developing skull and the underlying brain by combining the power of developmental genetics, lineage analysis and in vivo single cell imaging across vertebrate systems. One key organizing tissue, the embryonic neural crest, has been the focus of my attention for the past 2 decades. Understanding how it interacts and builds complex patterns of bones and muscles and what it influences (i.e. the brain) and how this has changed over hundreds of millions of years is a great challenge. Deciphering this has relevance for the deep evolution of the vertebrate skeleton & the skeletomuscular system. This also pertains to understanding the exact causes and time courses responsible for devastating human craniofacial ailments such as microcephaly, sometimes caused by viruses such as Zika. Our main conceptual interest is to track lineages across organisms, look at its evolution through ontogenetic and deep time in order to understand both their evolutionary history responsible for the diversity of craniofacial shapes as well as their biomedical relevance to understand complex human diseases. These lineages become cryptic, not visible easily by eye but require fancy genetics and fancy microscopes to be revealed.
1988: German High-school (Apostelgymnasium), focus on Classics and Biology
1988-1989 Military service, German Army.
1989-1997: Fellow of German National Scholarship Foundation (Studienstiftung des Deutschen Volkes) for undergraduate and PhD studies.
1989-1994 Studies in Tuebingen and Freiburg: Trained in comparative vertebrate anatomy, genetics, palaeontology, vertebrate embryology and (largely) Greek philosophy. Diplombiologe (equivalent to BSc)
1994-1997:PhD with Professor Andrew Lumsden FRS in vertebrate embryology: Work on the role of neural crest in craniofacial pattern. This work discovered how neural crest segmentation is maintained in the segmentally specific pattern of skeleto-muscular connections, it has taught us how muscles get anchored to the right places in the skull. This work was awarded the Thomas Henry Huxley Prize 1998 for the best zoological PhD thesis in the UK/N.Ireland.
1997-2001: Human Frontiers Long term fellow and BASF special postdoctoral fellow at Harvard University. Also awarded EMBO fellowship (but I declined it). Work with Professor Catherine Dulac (Harvard) and Nobel Prize winner Richard Axel on the development and wiring of the olfactory system (pheromonal perception system): work on genetically tracing neuronal circuitry. Development of novel methods to expression-profile single cells on microarrays using laser-capture microscopy, a technique still being used in the lab.
April 2001-March 2007: Senior Lecturer in Functional Genomics and Evolutionary biology at UCL (WIBR). Discovery of a novel origin of the neck and shoulder region (Matsuoka et al. Nature 2005). Refocus of work into areas of gene-regulation within stem cells. 2 Wellcome Trust Programme Grants, 1BBSRC Project grant, 1 ARC grant, several smaller grants.
Since April 2007: Professor of Genomic Systems Biology and Evolution,University of Warwick, School of Life Sciences
Human Frontiers Programme Grant (as Principle Investigator), 2 MRC grants and several Charity grants. Focus on fundamental aspects of gene regulation and how these relate to anatomical features and how these have been subjected to evolutionary change of craniofacial structures. A most recent MRC project grant (starting Dec 2015 for 4 yrs) with my colleague Prof Nick Dale will examine the role of neural crest lineages in postnatal and adult breathing control.
- Vance, Keith W., Woodcock, Dan J., Reid, John E., Bretschneider, Till, Ott, Sascha, Koentges, Georgy, 2015. Conserved cis-regulatory modules control robustness in Msx1 expression at single-cell resolution. Genome Biology and Evolution, 7 (9), pp. 2762-2778
- Woodcock, Dan J., Vance, Keith W., Komorowski, Michal, Koentges, Georgy, Finkenstädt, Bärbel, Rand, D. A. (David A.), 2013. A hierarchical model of transcriptional dynamics allows robust estimation of transcription rates in populations of single cells with variable gene copy number. Bioinformatics, 29 (12), pp. 1519-1525
- Jeziorska, Danuta M., Koentges, Georgy, Vance, K. W., 2012. Novel cis-regulatory modules control expression of the hairy and enhancer of split-1 (HES1) transcription factor in myoblasts. Journal of Biological Chemistry, Vol.287 (No.8), pp. 5687-5697
- Downey, Mike J., Jeziorska, Danuta M., Ott, Sascha, Tamai, T. Katherine, Koentges, Georgy, Vance, Keith W., Bretschneider, Till, 2011. Extracting fluorescent reporter time courses of cell lineages from high-throughput microscopy at low temporal resolution. PLoS ONE, Vol.6 (No.12)
- Granier, Céline, Gurchenkov, Vasily, Perea-Gomez, Aitana, Camus, Anne, Ott, Sascha, Papanayotou, Costis, Iranzo, Julian, Moreau, Anne, Reid, John, Koentges, Georgy, Sabéran-Djoneidi, Délara, Collignon, Jérôme, 2011. Nodal cis-regulatory elements reveal epiblast and primitive endoderm heterogeneity in the peri-implantation mouse embryo. Developmental Biology, Vol.349 (No.2), pp. 350-362
- Koohy, Hashem, Dyer, Nigel, Reid, John E., Koentges, Georgy, Ott, Sascha, 2010. An alignment-free model for comparison of regulatory sequences. Bioinformatics, Vol.26 (No.19), pp. 2391-2397
- Koentges, Georgy, 2010. Journal club. A genomic systems biologist muses on how shared DNA mistakes reveal shared cellular ancestry. Nature, Vol.467 (No.7313), pp. 255-255
- Koentges, Georgy, 2008. Evolution of anatomy and gene control. Nature, 451 (7179), pp. 658-663
- Koentges, Georgy, 2008. Teeth in double trouble. Nature, Nature Publishing Group, pp. 747-748
|Title||Funder||Award start||Award end|
|Connexin 26-mediated breathing control by the healthy and obese brain||MRC||28 Sep 2015||21 Apr 2020|
|Zika virus ? harnessing the powers of molecular and device engineering to counter a global threat||EPSRC||01 Jun 2016||31 Mar 2017|
|Cellular architecture of the posterior cranial fossa||Column of Hope||22 Jun 2015||21 Feb 2016|
|Investigating the growth of postcranial fossa and cranial base||Ann Conroy Trust||01 Oct 2012||30 Sep 2015|
|Cellular and molecular processes affecting the PCF volume||Conquer Chiari||01 Oct 2011||30 Sep 2014|
|How the brain senses CO2||MRC||01 Apr 2011||31 Mar 2014|
|Deterministic and stochastic choices of cell fate & wiring specificity in the CNS||Human Frontier Science Program Organization||01 Oct 2007||30 Sep 2010|
|Molecular neural crest-mesoderm interactions and control networks affected in Chiari||Conquer Chiari||01 Jun 2009||31 May 2010|
|Functional Genomics of Neuronal Identity - Time Only Extension||Wellcome Trust||31 May 2008||30 Nov 2009|
|Subcontract on Wellcome Trust project Functional genomics of pluripotent stem cells and their progeny||University College London||01 Apr 2007||31 Aug 2009|
|Microarray-based discovery of genes active in post-otic neural crest at critical stages and places of head morphogenesis affected in Chiari I/II||The C&S Patient Education Foundation||01 Mar 2007||28 Feb 2009|
|Functional Genomics of Neuronal Identity||Wellcome Trust||01 Apr 2007||31 May 2008|