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Professor John McCarthy

Job Title
Professor
Department
Life Sciences
Phone
024 76 57343
Research Interests

McCarthy Lab Research Areas

We study multiple aspects of gene expression, whereby most of our work focuses on the posttranscriptional steps in this pathway, with a particular emphasis on the translation of mRNA.

Gene expression is made possible by a very large number of coordinated molecular interactions and transformations and, like many research groups, we investigate the details of these molecular processes. We utilize a combination of biophysical, biochemical, genetic and computational methods to study a subset of the underpinning molecular mechanisms in considerable detail.

However, molecular properties and functions cannot be fully understood simply in isolation living organisms comprise systems of component molecules that are organized in physical and functional networks. We therefore apply experimental and theoretical methods of systems analysis to elucidate how molecular properties and functions combine to generate the system-level properties of gene expression and signaling pathways.

Our understanding of the full complexity of biological systems is in its infancy. Molecular processes are, by their very nature, stochastic, and the significance of the resulting noise in pathways such as gene expression and signaling is only beginning to be understood. We are applying a combination of molecular, systems and synthetic biology approaches to the analysis of stochasticity in cells.

Methodological advances play a key role in driving biological discovery, and we try, wherever possible, to develop new experimental and theoretical tools that will be of value to researchers in our own and related fields.

Title Funder Award start Award end
H20 BioRoboost Fostering Synthetic Biology standardisation through international collaboration European Commission 15 Oct 2018 14 Oct 2021
Warwick Integrative Synthetic Biology Centre (WISB) BBSRC 14 Nov 2014 31 May 2020
An Imperial College led innovation and Knowledge Centre (IKC) in Synethic Biology EPSRC 01 Oct 2013 30 Sep 2018
Trypanosomatid protein synthesis as a target for novel drug therapies MRC 01 Jan 2016 31 Dec 2017
Synthetic Biology Café Scientifique Royal Society of Biology 16 Mar 2016 31 Dec 2016
Integrated systems biology study of the control of protein synthesis capacity and fitness in a eukaryotic microbe BBSRC 01 Aug 2011 30 Sep 2015
Studying stochasticity in eukaryotic gene expression using novel tools of synthetic biology, modelling and analytical science BBSRC 04 Apr 2011 31 Aug 2015
Medical Research Fund of Warwick Medical and Life Sciences Research Fund 25 Mar 2011 31 Dec 2014
BB/H53156X/1 - International Partnering Award BBSRC 01 Oct 2010 30 Sep 2014
Transatlantic SynBio Workshop BBSRC 01 Apr 2014 30 Apr 2014
BBSRC Sparking Impact award to School of Life Sciences BBSRC 01 Apr 2013 31 Mar 2014
An integrated systems approach to posttranscriptional gene expression BBSRC 01 Oct 2010 31 Jan 2013
The Systems-Synthesis Interface in Bioscience BBSRC 16 Oct 2012 16 Nov 2012
Composition, heterogeneity and dynamics of the eukaryotic translation machinery BBSRC 01 Oct 2010 26 Oct 2011
How internal interactions between the processive phases of eukaryotic proteinsynthesis control flux through the overall system BBSRC 01 Oct 2010 30 Sep 2011