| Title | Funder | Award start | Award end |
|---|---|---|---|
| Shapeshifting: how is plant ER architecture manipulated by pathogen effectors? - BBSRC standard research grant | BBSRC | 01 Jun 2022 | 30 Nov 2025 |
| 21ENGBIO - Converting a cellular dustbin into a protein storing organelle | BBSRC | 15 Feb 2023 | 31 Mar 2024 |
| Phase separation drives the development of protein storage vacuoles | Leverhulme Trust | 04 Jan 2021 | 30 Nov 2023 |
| A broadly accessible facility microscope to probe nanoscale cellular dynamics by combined live cell super-resolution microscopy and photomanipulation (BBSRC ALERT 2021) | BBSRC | 01 Aug 2022 | 31 Jul 2023 |
| The cell biology of rubber biosynthesis - the endoplasmic reticulum connection | Leverhulme Trust | 01 Jun 2016 | 31 May 2019 |
| 13 ERA-CAPS PER ASPERA Frigerio | BBSRC | 01 Jul 2014 | 31 Dec 2017 |
| GCRF IAA | BBSRC | 17 Oct 2016 | 31 Mar 2017 |
| Studentship for Daniel Brown, funded by TARRC. Project increasing latex yield in the rubber tree Hevea brasilensis by targeted expression of aquaporins. | Tun Abdul Razak Research Centre (TARRC) | 01 Oct 2012 | 30 Sept 2016 |
| Tissue specific aquaporin expression for plant water stress resistance | BBSRC | 01 Oct 2012 | 31 May 2016 |
| A facility for 3D cellular imaging that bridges light and electron microscopy (BSRC ALERT 14 Equipment grant) | BBSRC | 21 Jan 2015 | 20 Jan 2016 |
| Studying the biogenesis of protein storage vacuoles by reprogramming leaf development | Leverhulme Trust | 01 Jan 2012 | 31 Dec 2014 |
| Developing interdisciplinary omics tools for organelle and cell type-specific analysis of Arabidopsis thaliana | New Phytologist Trust | 01 Sept 2014 | 30 Sept 2014 |
| BSCB Summer Vacation placement - Stephanie Rippon | British Society for Cell Biology | 03 Jul 2013 | 14 Aug 2013 |
| How are proteins sorted to storage vacuoles in plant seeds? | Leverhulme Trust | 01 Jul 2007 | 30 Jun 2010 |
| The role and impact of endoplasmic reticulum associated degradation in plant cells. | Leverhulme Trust | 01 Mar 2007 | 28 Feb 2010 |
| Analysis of Factors Regulating the plant Secretory Pathway | British Council | 01 Jul 2008 | 30 Jun 2009 |
| Maximising the yield of plant-made immunoglobulins | Wellcome Trust | 01 Oct 2006 | 30 Sept 2008 |
| Plant-derived pharmaceuticals for human health pharmaplant - FP6 (IP) | European Commission | 01 Feb 2004 | 31 Jan 2008 |
| Determination of the spatial & temporal parameters governing protein translocation pathways | BBSRC | 01 Jan 2005 | 31 Dec 2007 |
Professor Lorenzo Frigerio
Pro-Vice Chancellor (Education)
Email: L.Frigerio@warwick.ac.uk
Phone: 024 765 23181
Office: C107
Frigerio webpage
Research clusters
Research Interests
The majority of the plant proteins that humans and animals eat are produced and stored in the secretory pathway, which is a system of organelles found inside each plant cell, starting with the endoplasmic reticulum (ER) – a network of membrane tubules that resembles a fishnet – and ending with the vacuole – a large container that can act as both a storage compartment or a dustbin, depending on the cell type.
We study how the endoplasmic reticulum gets its peculiar shape and how this shape relates to its function as a protein assembly factory. When pests or bacterial pathogens attack a plant, the ER changes shape very rapidly. We are trying to work out how this shape change helps the plant protect itself.
We also study how the vacuole changes its function from a site of degradation into a container of protein accumulation during the maturation of plant seeds. Understanding these processes is essential for exploiting the capacity of plants to produce and accumulate large amounts of nutritious, or high-value proteins.
Research: Technical Summary
We use a combination of plant genetics, biochemistry and live imaging to study the biogenesis of secretory pathway organelles in plant cells. In particular, we are interested in endoplasmic reticulum (ER) morphogenic proteins and how they affect ER architecture and function, especially under biotic stress.
We also study the biogenesis of protein storage vacuoles (PSV) in plant seeds. PSV are the main repository of proteins in seeds, therefore essential for human and plant nutrition. We have recently established that PSV arise from pre-existing embryonic lytic vacuoles during seed maturation. We are now elucidating the steps that convert a protease-rich, degradative organelle into a haven for seed storage proteins
PhD Plant Genetics. Universita Cattolica del Sacro Cuore 1995
Breeze, Emily, Vale, Victoria, McLellan, Hazel, Pecrix, Yann, Godiard, Laurence, Grant, Murray and Frigerio, Lorenzo (2023) A tell tail sign : a conserved C-terminal tail-anchor domain targets a subset of pathogen effectors to the plant endoplasmic reticulum. Journal of Experimental Botany, 74 (10). pp. 3188-3202. doi:10.1093/jxb/erad075 ISSN 1460-2431.
Dowson, Amanda J., Lloyd, Adrian J., Cuming, Andrew C., Roper, David I., Frigerio, Lorenzo and Dowson, Christopher G. (2022) Plant peptidoglycan precursor biosynthesis : conservation between moss chloroplasts and Gram-negative bacteria. Plant Physiology, 190 (1). pp. 165-179. doi:10.1093/plphys/kiac176 ISSN 1532-2548.
Cortese, Enrico, Moscatiello, Roberto, Pettiti, Francesca, Carraretto, Luca, Baldan, Barbara, Frigerio, Lorenzo, Vothknecht, Ute C., Szabo, Ildiko, De Stefani, Diego, Brini, Marisa and Navazio, Lorella (2022) Monitoring calcium handling by the plant endoplasmic reticulum with a low‐Ca 2+ ‐affinity targeted aequorin reporter. The Plant Journal, 109 (4). pp. 1014-1027. doi:10.1111/tpj.15610 ISSN 0960-7412.
Kusumaatmaja, Halim, May, Alexander I., Feeney, Mistianne, McKenna, Joseph F., Mizushima, Noboru, Frigerio, Lorenzo and Knorr, Roland L. (2021) Wetting of phase-separated droplets on plant vacuole membranes leads to a competition between tonoplast budding and nanotube formation. Proceedings of the National Academy of Sciences of the United States of America, 118 (36). e2024109118. doi:10.1073/pnas.2024109118 ISSN 0027-8424.
Breeze, Emily, Vale, Victoria, McLellan, Hazel, Godiard, Laurence, Grant, Murray and Frigerio, Lorenzo (2020) The plant endoplasmic reticulum is both receptive and responsive to pathogen effectors. Working Paper. New York: Cold Spring Harbor Laboratory.
Demurtas, Olivia Costantina, de Brito Francisco, Rita, Diretto, Gianfranco, Ferrante, Paola, Frusciante, Sarah, Pietrella, Marco, Aprea, Giuseppe, Borghi, Lorenzo, Feeney, Mistianne, Frigerio, Lorenzo, Coricello, Adriana, Costa, Giosuè, Alcaro, Stefano, Martinoia, Enrico and Giuliano, Giovanni (2019) ABCC transporters mediate the vacuolar accumulation of crocins in saffron stigmas. Plant Cell, 31 (11). pp. 2789-2804. doi:10.1105/tpc.19.00193 ISSN 1040-4651.
Footitt, Steven, Clewes, Rachel, Feeney, Mistianne, Finch-Savage, William E. and Frigerio, Lorenzo (2019) Aquaporins influence seed dormancy and germination in response to stress. Plant, Cell & Environment, 42 (8). pp. 2325-2339. doi:10.1111/pce.13561 ISSN 0140-7791.
Lonoce, Chiara, Marusic, Carla, Morrocchi, Elena, Salzano, Anna Maria, Scaloni, Andrea, Novelli, Flavia, Pioli, Claudio, Feeney, Mistianne, Frigerio, Lorenzo and Donini, Marcello (2019) Enhancing the secretion of a glyco-engineered anti-CD20 scFv-Fc antibody in hairy root cultures. Biotechnology Journal, 14 (3). 1800081. doi:10.1002/biot.201800081 ISSN 1860-6768.
Chow, Michael, Sklepari, Meropi, Frigerio, Lorenzo and Dixon, Ann M. (2018) Bacterial expression, purification and biophysical characterization of the smallest plant reticulon isoform, RTNLB13. Protein Expression and Purification, 152 . pp. 31-39. doi:10.1016/j.pep.2018.06.015 ISSN 1046-5928.
Kriechbaumer, Verena, Breeze, Emily, Pain, Charlotte, Tolmie, Frances, Frigerio, Lorenzo and Hawes, Chris (2018) Arabidopsis Lunapark proteins are involved in ER cisternae formation. New Phytologist, 219 (3). pp. 990-1004. doi:10.1111/nph.15228 ISSN 1469-8137.
Demurtas, Olivia Costantina, Frusciante, Sarah, Ferrante, Paola, Diretto, Gianfranco, Azad, Noraddin Hosseinpour, Pietrella, Marco, Aprea, Giuseppe, Taddei, Anna Rita, Romano, Elena, Mi, Jianing, Al-Babili, Salim, Frigerio, Lorenzo and Giuliano, Giovanni (2018) Candidate enzymes for saffron crocin biosynthesis are localized in multiple cellular compartments. Plant Physiology, 177 (3). pp. 990-1006. doi:10.1104/pp.17.01815 ISSN 0032-0889.
Feeney, Mistianne, Kittelmann, Maike, Menassa, Rima, Hawes, Chris and Frigerio, Lorenzo (2018) Protein storage vacuoles originate from remodelled pre-existing vacuoles in Arabidopsis thaliana. Plant Physiology, 177 (1). pp. 241-255. doi:10.1104/pp.18.00010 ISSN 0032-0889.
Dzimitrowicz, Natasha, Breeze, Emily and Frigerio, Lorenzo (2018) Long-term imaging of endoplasmic reticulum morphology in embryos during seed germination. In: Hawes, C. and Kriechbaumer, V., (eds.) The Plant Endoplasmic Reticulum. Methods in Molecular Biology, 1691 . Humana Press, New York, NY: Springer, pp. 67-74. ISBN 9781493973897
Brown, Daniel, Feeney, Mistianne, Hamadi, Mathin, Lonoce, Chiara, Sajari, Roslinda, Di Cola, Alessandra and Frigerio, Lorenzo (2017) Subcellular localisation and interactions among rubber particle proteins from Hevea braziliensis. Journal of Experimental Botany, 68 (18). pp. 5045-5055. doi:10.1093/jxb/erx331 ISSN 0022-0957.
Breeze, Emily, Dzimitrowicz, Natasha, Kriechbaumer, Verena, Brooks, Rhiannon, Botchway, Stanley W., Brady, Jacob P., Hawes, Chris, Dixon, Ann M., Schnell, Jason R., Fricker, Mark D. and Frigerio, Lorenzo (2016) A C-terminal amphipathic helix is necessary for the in-vivo tubule-shaping function of plant reticulon. Proceedings of the National Academy of Sciences of the United States of America, 113 (39). pp. 10902-10907. doi:10.1073/pnas.1605434113 ISSN 0027-8424.
Lopez, David, Amira, Maroua Ben, Brown, Daniel, Muries, Beatriz, Brunel-Michac, Nicole, Bourgerie, Sylvain, Porcheron, Benoit, Lemoine, Remi, Chrestin, Hervé, Mollison, Ewan, Di Cola, Alessandra, Frigerio, Lorenzo, Julien, Jean-Louis, Gousset-Dupont, Aurélie, Fumanal, Boris, Label, Philippe, Pujade-Renaud, Valérie, Auguin, Daniel and Venisse, Jean-Stéphane (2016) The Hevea brasiliensis XIP aquaporin subfamily : genomic, structural and functional characterizations with relevance to intensive latex harvesting. Plant Molecular Biology, 91 (4). pp. 375-396. doi:10.1007/s11103-016-0462-y ISSN 0167-4412.
Reinhardt , Hagen , Hachez , Charles , Bienert, Manuela Désirée, Beebo , Azeez , Swarup , Kamal , Voss , Ute, Bouhidel , Karim , Frigerio, Lorenzo, Schjoerring, Jan K. , Bennett , Malcolm J. and Chaumont , Francois (2016) Tonoplast aquaporins facilitate lateral root emergence. Plant Physiology, 170 (3). pp. 1640-1654. 01635.2015. doi:10.1104/pp.15.01635 ISSN 0032-0889.
Kriechbaumer, Verena, Botchway, Stanley W., Slade, Susan E., Knox, Kirsten, Frigerio, Lorenzo, Oparka, Karl J. and Hawes, Chris (2015) Reticulomics : protein-protein interaction studies with two plasmodesmata-localised reticulon family proteins identify binding partners enriched at plasmodesmata, ER and the plasma membrane. Plant Physiology, 169 (3). pp. 1933-1945. doi:10.1104/pp.15.01153 ISSN 0032-0889.
Knox, Kirsten, Wang, Pengwei, Kriechbaumer, Verena, Tilsner, Jens, Frigerio, Lorenzo, Sparkes, Imogen, Hawes, C. R. and Oparka, Karl J. (2015) Putting the squeeze on PDs : a role for RETICULONS in primary plasmodesmata formation. Plant Physiology, 168 (4). pp. 1563-1572. doi:10.1104/pp.15.00668 ISSN 0032-0889.
Brandizzi, Federica, Frigerio, Lorenzo, Howell, Stephen H. and Schäfer, Patrick (2014) Endoplasmic reticulum : shape and function in stress translation. Frontiers in Plant Science, Volume 5 . pp. 1-2. doi:10.3389/fpls.2014.00425 ISSN 1664-462X.
Battelli, Riccardo, Lombardi, Lara, Picciarelli, Piero, Lorenzi, Roberto, Frigerio, Lorenzo and Rogers, Hilary J. (2014) Expression and localisation of a senescence-associated KDEL-cysteine protease from Lilium longiflorum tepals. Plant Science, Volume 214 . pp. 38-46. doi:10.1016/j.plantsci.2013.09.011 ISSN 0168-9452.
Feeney, Mistianne, Frigerio, Lorenzo, Kohalmi, Susanne E., Cui, Yuhai and Menassa, Rima (2013) Reprogramming cells to study vacuolar development. Frontiers in Plant Science, Volume 4 . Article number 493. doi:10.3389/fpls.2013.00493 ISSN 1664-462X.
Feeney, Mistianne, Frigerio, Lorenzo, Cui, Y. and Menassa, Rima (2013) Following vegetative to embryonic cellular changes in leaves of arabidopsis thaliana over-expressing LEAFY COTYLEDON2. Plant Physiology, Volume 162 (Number 4). pp. 1881-1896. doi:10.1104/pp.113.220996 ISSN 0032-0889.
Lee, Hannah, Ph.D., Sparkes, Imogen, Gattolin, Stefano, Dzimitrowicz, Natasha, Roberts, L. M. (Lynne M.), Hawes, C. R. and Frigerio, Lorenzo (2012) An Arabidopsis reticulon and the atlastin homologue RHD3-like2 act together in shaping the tubular endoplasmic reticulum. New Phytologist, Volume 197 (Number 2). pp. 481-489. doi:10.1111/nph.12038 ISSN 0028-646X.
Denecke, J., Aniento, F., Frigerio, Lorenzo, Hawes, C., Hwang, I., Mathur, J., Neuhaus, J.-M. and Robinson, D. G. (2012) Secretory pathway research : the more experimental systems the better. The Plant Cell, Volume 24 (Number 4). pp. 1316-1326. doi:10.1105/tpc.112.096362 ISSN 1040-4651.
Sorieul, Mathias, Langhans, Markus, Guetzoyan, Lucie J., Hillmer, Stefan, Clarkson, Guy J., Lord, Mike, Roberts, L. M. (Lynne M.), Robinson, David G., Spooner, Robert A. and Frigerio, Lorenzo (2011) An Exo2 derivative affects ER and Golgi morphology and vacuolar sorting in a tissue-specific manner in arabidopsis. Traffic, Vol.12 (No.11). pp. 1552-1562. doi:10.1111/j.1600-0854.2011.01258.x ISSN 13989219.
Scheuring, David, Viotti, Corrado, Kruger, Falco, Kunzl, Fabian, Sturm, Silke, Bubeck, Julia, Hillmer, Stefan, Frigerio, Lorenzo, Robinson, David G., Pimpl, Peter and Schumacher, Karin (2011) Multivesicular bodies mature from the trans-golgi network/early endosome in Arabidopsis. Plant Cell, Vol.23 (No.9). pp. 3463-3481. doi:10.1105/tpc.111.086918 ISSN 1040-4651.
Wang, Pengwei, Hummel, Eric, Osterrieder, Anne, Meyer, Andreas J., Frigerio, Lorenzo, Sparkes, Imogen and Hawes, C. R. (2011) KMS1 and KMS2, two plant endoplasmic reticulum proteins involved in the early secretory pathway. Plant Journal, Vol.66 (No.4). pp. 613-628. doi:10.1111/j.1365-313X.2011.04522.x ISSN 0960-7412.
Sparkes, Imogen, Hawes, C. R. and Frigerio, Lorenzo (2011) FrontiERs: movers and shapers of the higher plant cortical endoplasmic reticulum. Current Opinion in Plant Biology, Vol.14 (No.6). pp. 658-665. doi:10.1016/j.pbi.2011.07.006 ISSN 1369-5266.
Gattolin, Stefano, Sorieul, Mathias and Frigerio, Lorenzo (2011) Mapping of tonoplast intrinsic proteins in maturing and germinating Arabidopsis seeds reveals dual localization of embryonic TIPs to the tonoplast and plasma membrane. Molecular Plant, Volume 4 (Number 1). pp. 180-189. doi:10.1093/mp/ssq051 ISSN 1674-2052.
Scabone, Camila María, Frigerio, Lorenzo and Petruccelli, Silvana (2011) A fluorescent reporter protein containing AtRMR1 domains is targeted to the storage and central vacuoles in Arabidopsis thaliana and tobacco leaf cells. Plant Cell Reports, Vol.30 (No.10). pp. 1823-1833. doi:10.1007/s00299-011-1089-8 ISSN 0721-7714.
Tolley, Nicholas, Sparkes, Imogen, Craddock, Christian P., Eastmond, Peter J., Runions, John, Hawes, C. R. and Frigerio, Lorenzo (2010) Transmembrane domain length is responsible for the ability of a plant reticulon to shape endoplasmic reticulum tubules in vivo. Plant Journal, Volume 64 (Number 3). pp. 411-418. doi:10.1111/j.1365-313X.2010.04337.x ISSN 0960-7412.
Gattolin, Stefano, Sorieul, Mathias and Frigerio, Lorenzo (2010) Tonoplast intrinsic proteins and vacuolar identity. Biochemical Society Transactions, Vol.38 (No.3). pp. 769-773. doi:10.1042/BST0380769 ISSN 0300-5127.
Marshall, Richard S., Frigerio, Lorenzo and Roberts, L. M. (Lynne M.) (2010) Disulfide formation in plant storage vacuoles permits assembly of a multimeric lectin. Biochemical Journal, Vol.427 (No.Part 3). pp. 513-521. doi:10.1042/BJ20091878 ISSN 0264-6021.
Sparkes, Imogen, Tolley, Nicholas, Aller, Isabel, Svozil, Julia, Osterrieder, Anne, Botchway, Stanley, Mueller, Christopher, Frigerio, Lorenzo and Hawes, C. R. (2010) Five arabidopsis reticulon isoforms share endoplasmic reticulum location, topology, and membrane-shaping properties. Plant Cell, Vol.22 (No.4). pp. 1333-1343. doi:10.1105/tpc.110.074385 ISSN 1040-4651.
Frigerio, Lorenzo and Roberts, L. M. (Lynne M.) (2010) The Synthesis of Ricinus communis Lectins. In: Toxic Plant Proteins. Plant Cell Monographs, Vol.18 . Berlin, Heidelberg: Springer, pp. 191-205. ISBN 978-3-6421-2175-3
Vladimirou, Elina, Li, Michael, Aldridge, Cassie P., Frigerio, Lorenzo, Kirkilionis, Markus A. and Robinson, Colin (2009) Diffusion of a membrane protein, Tat subunit Hcf106, is highly restricted within the chloroplast thylakoid network. FEBS Letters, Volume 583 (Number 22). pp. 3690-3696. doi:10.1016/j.febslet.2009.10.057 ISSN 0014-5793.
Gattolin, Stefano, Sorieul, Mathias, Hunter, P. R. (Paul R.), Khonsari, Roman H. and Frigerio, Lorenzo (2009) In vivo imaging of the tonoplast intrinsic protein family in Arabidopsis roots. BMC Plant Biology, Vol.9 . Article 133. doi:10.1186/1471-2229-9-133 ISSN 1471-2229.
Sparkes, Imogen A., Frigerio, Lorenzo, Tolley, Nicholas and Hawes, C. R. (2009) The plant endoplasmic reticulum: a cell-wide web. Biochemical Journal, Vol.423 (No.2). pp. 145-155. ISSN 0264-6021 doi:10.1042/BJ20091113
Marusic, Carla, Vitale, Alessandro, Pedrazzini, Emanuela, Donini, Marcello, Frigerio, Lorenzo, Bock, Ralph, Dix, Philip J., McCabe, Matthew S., Bellucci, Michele and Benvenuto, Eugenio (2009) Plant-based strategies aimed at expressing HIV antigens and neutralizing antibodies at high levels. Nef as a case study. Transgenic Research, Vol.18 (No.4). pp. 499-512. ISSN 0962-8819 doi:10.1007/s11248-009-9244-5
Marshall, Richard S., Jolliffe, Nicholas A., Ceriotti, Aldo, Snowden, Christopher J., Lord, Mike, Frigerio, Lorenzo and Roberts, L. M. (Lynne M.) (2009) The role of CDC48 in the retro-translocation of non-ubiquitinated toxin substrates in plant cells. Journal of Biological Chemistry, Vol.283 . pp. 15869-15877. doi:10.1074/jbc.M709316200 ISSN 0021-9258.
Bouchekhima, A. -N., Frigerio, Lorenzo and Kirkilionis, Markus (2009) Geometric quantification of the plant endoplasmic reticulum. Journal of Microscopy, Vol.234 (No.2). pp. 158-172. doi:10.1111/j.1365-2818.2009.03158.x ISSN 0022-2720.
Chamberlain, Kerry L., Marshall, Richard S., Jolliffe, Nicholas A., Frigerio, Lorenzo, Ceriotti, Aldo, Lord, Mike and Roberts, L. M. (Lynne M.) (2008) Ricin B chain targeted to the endoplasmic reticulum of tobacco protoplasts is degraded by a CDC48- and vacuole-independent mechanism. Journal of Biological Chemistry, Vol.283 (No.48). pp. 33276-33286. doi:10.1074/jbc.M805222200 ISSN 0021-9258.
Frigerio, Lorenzo, Hinz, Giselbert and Robinson, David G. (2008) Multiple vacuoles in plant cells: Rule or exception? Traffic, Vol.9 (No.10). pp. 1564-1570. ISSN 1398-9219 doi:10.1111/j.1600-0854.2008.00776.x
Aldridge, Cassie, Spence, Edward M., Kirkilionis, Markus, Frigerio, Lorenzo and Robinson, Colin (2008) Tat-dependent targeting of Rieske iron-sulphur proteins to both the plasma and thylakoid membranes in the cyanobacterium Synechocystis PCC6803. Molecular Microbiology, Volume 70 (Number 1). pp. 140-150. doi:10.1111/j.1365-2958.2008.06401.x ISSN 0950-382X.
Frigerio, Lorenzo and Hawes, C. R. (2008) The endomembrane system: A green perspective. Traffic, Vol.9 (No.10). p. 1563. ISSN 1398-9219 doi:10.1111/j.1600-0854.2008.00795.x
Irons, Sarah L., Nuttall, J. (James), Floss, Doreen M., Frigerio, Lorenzo, Kotzer, Amanda M. and Hawes, C. R. (2008) Fluorescent protein fusions to a human immunodeficiency virus monoclonal antibody reveal its intracellular transport through the plant endomembrane system. Plant Biotechnology Journal, Vol.6 (No.7). pp. 649-662. doi:10.1111/j.1467-7652.2008.00348.x ISSN 1467-7644.
Barbante, Alessandra, Irons, Sarah, Hawes, C. R., Frigerio, Lorenzo, Vitale, A. (Alessandro) and Pedrazzini, Emanuela (2008) Anchorage to the cytosolic face of the endoplasmic reticulum membrane : a new strategy to stabilize a cytosolic recombinant antigen in plants. Plant Biotechnology Journal, Volume 6 (Number 6). pp. 560-575. doi:10.1111/j.1467-7652.2008.00342.x ISSN 1467-7644.
Sparkes, Imogen, Tolley, Nicholas, Hawes, C. R. and Frigerio, Lorenzo (2008) Role of reticulons on ER morphology and secretion. In: Annual Meeting of the Society-for-Experimental-Biology, Marseille, France, Jul 06-10, 2008. Published in: Comparative Biochemistry and Physiology. Part A: Molecular & Integrative Physiology, Vol.150 (No.3 Suppl. S). S141-S141. doi:10.1016/j.cbpa.2008.04.349 ISSN 1095-6433.
Craddock, Christian P., Hunter, Paul R., Szakacs, Erika, Hinz, Giselbert, Robinson, David G. and Frigerio, Lorenzo (2008) Lack of a vacuolar sorting receptor leads to non-specific missorting of soluble vacuolar proteins in Arabidopsis seeds. Traffic, Vol.9 (No.3). pp. 408-416. doi:10.1111/j.1600-0854.2007.00693.x/abstract ISSN 1398-9219.
Frigerio, Lorenzo (2008) Multiple vacuoles in plant cells - Response. Plant Physiology, Vol.146 (No.3). pp. 1026-1027. ISSN 0032-0889 doi:10.1104/pp.104.900250
Tolley, Nicholas, Sparkes, Imogen, Hunter, P. R. (Paul R.), Craddock, Christian P., Nuttall, J. (James), Roberts, L. M. (Lynne M.), Hawes, C. R., Pedrazzini, Emanuela and Frigerio, Lorenzo (2008) Overexpression of a plant reticulon remodels the lumen of the cortical endoplasmic reticulum but does not perturb protein transport. Traffic, Vol.9 (No.1). pp. 94-102. doi:10.1111/j.1600-0854.2007.00670.x ISSN 1398-9219.
Hunter, Paul R., Craddock, Christian P., Di Benedetto, Sara, Roberts, L. M. (Lynne M.) and Frigerio, Lorenzo (2007) Fluorescent reporter proteins for the tonoplast and the vacuolar lumen identify a single vacuolar compartment in Arabidopsis cells. Plant Physiology, Vol.145 (No.4). pp. 1371-1382. doi:10.1104/pp.107.103945 ISSN 0032-0889.
Paul, Matthew J. and Frigerio, Lorenzo (2007) Coated vesicles in plant cells. Seminars in Cell and Developmental Biology, Vol.18 (No.4). pp. 471-478. ISSN 1084-9521 doi:10.1016/j.semcdb.2007.07.005
Marusic, Carla, Nuttall, James, Buriani, Giampaolo , Lico, Chiara, Lombardi, Raffaele , Baschieri , Selene, Benvenuto, Eugenio and Frigerio, Lorenzo (2007) Expression, intracellular targeting and purification of HIV Nef variants in tobacco cells. BMC Biotechnology, Vol.7 (No.12). doi:10.1186/1472-6750-7-12 ISSN 1472-6750.
Maggio, Caterina, Barbante, Alessandra, Ferro, Flavia, Frigerio, Lorenzo and Pedrazzini, Emanuela (2007) Intracellular sorting of the tail-anchored protein cytochrome b5 in plants : a comparative study using different isoforms from rabbit and Arabidopsis. Journal of Experimental Botany, Volume 58 (Number 6). pp. 1365-1379. doi:10.1093/jxb/erl303 ISSN 0022-0957.
Jolliffe, Nicholas A., Di Cola, Alessandra, Marsden, Catherine J., Lord, Mike, Ceriotti, Aldo, Frigerio, Lorenzo and Roberts, L. M. (Lynne M.) (2006) The N-terminal ricin propeptide influences the fate of ricin A-chain in tobacco protoplasts. JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (33). pp. 23377-23385. doi:10.1074/jbc.M602678200 ISSN 0021-9258.
Obregon, Patricia, Chargelegue, Daniel, Drake, Pascal M.W., Prada, Alessandra, Nuttall, James, Frigerio, Lorenzo and Ma, Julian K.-C. (2006) HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production. Plant Biotechnology Journal, Vol.4 (No.2). pp. 195-207. doi:10.1111/j.1467-7652.2005.00171.x ISSN 1467-7644.
Hadlington, Jane L., Santoro, Aniello, Nuttall, James, Denecke, J. (Jurgen), Ma, Julian K.-C., Vitale, A. (Alessandro) and Frigerio, Lorenzo (2003) The c-terminal extension of a hybrid immunoglobulin A/G heavy chain is responsible for its Golgi-mediated sorting to the vacuole. Molecular Biology of the Cell, Vol.14 (No.6). pp. 2592-2602. doi:10.1091/mbc.E02-11-0771 ISSN 1059-1524.
Vice Provost and Chair of the Faculty of Science, Engineering and Medicine
2021 - 2024
Research Themes:
Synthetic Biology and Biotechnology
Plant & Crop Science