My PhD project is part of the Marie Curie Initial Training Network CARTNET (Combatting Antimicrobial Resistance Training Network) funded through the European Union's Horizon 2020 research and innovation programme. It aims to train young researchers to address the serious and global problems of antibiotic resistance through a wide array of approaches.
In my project, I will exploit current ecophysiological knowledge to explore the distribution and diversity of potential bioactive molecules found in natural habitats and will use metagenomes from a range of habitats with a focus on soils to identify such bioactive compounds. The biosynthetic genes proposed to direct the assembly of novel antibiotic-like molecules will be expressed in different microbial hosts. The resulting metabolites will be isolated and their chemical structure elucidated. Their antimicrobial properties will then be assessed against a panel of antibiotic resistant bacterial pathogens.