Acute pain warns us of danger allowing us to initiate protective behaviours and is thus beneficial. However, chronic and sustained pain is debilitating and harmful to health. It has become one of the most common medical conditions associated with many diseases such as arthritis, cancer and diabetes. We aim to understand how pain signals are generated and then transmitted to the brain, and how it is maintained for a long period with a view to devising novel therapies for a better treatment of chronic pain.
We are interested in the molecular and cellular mechanisms of acute and chronic pain. Acute pain arises from the activation of nociceptors and generation of action potentials. They are then transmitted to the central nervous system through afferent nerve fibres. However, this pain pathway is subjected to alteration and remoulding under disease conditions such as inflammation, nerve injury and chronic arthritis leading to chronic pain.
We investigate ion channels such as TRP channels and voltage-gated Na+ channels responsible for the generation and transmission of pain signals. We also examine the signalling molecules critical to remoulding of the pain pathway. Our ambitions are to identify the targets critical to chronic pain facilitating the development of efficacious analgesics.
I obtained my Ph.D degree at Tongji Medical College, Huazhong University of Science and Technology, China, in 2001. I then did my postdoctoral training at the University of Cambridge followed by lectureship first at the University of Aberdeen and then at Aston University. I joined the University of Warwick in 2022.
Member of IASP (International Association for the Study of Pain)
Member of BNA (British Neuroscience Association)
- 'Zhang, Xuming, 2019. 'Direct G?q gating is the sole mechanism for TRPM8 inhibition caused by Bradykinin receptor activation. Cell Reports, 27 (12), pp. 3672-3683.e4
- 'Hasan, Raquibul, 'Zhang, Xuming, 2018. 'Ca2+ regulation of TRP ion channels. International Journal of Molecular Sciences, 19 (4)
- 'Peng, Yawen, 'Guo, Genhua, 'Shu, Bin, 'Liu, Daiqiang, 'Su, Peng, 'Zhang, Xuming, 'Gao, Feng, 2017. 'Spinal CX3CL1/CX3CR1 may not directly participate in the development of morphine tolerance in rats. Neurochemical Research, 42 (11), pp. 3254-3267
- 'Wang, Wei, 'Peng, Yawen, 'Yang, Hui, 'Bu, Huilian, 'Guo, Genhua, 'Liu, Daiqiang, 'Shu, Bin, 'Tian, Xuebi, 'Luo, Ailin, 'Zhang, Xuming, 'Gao, Feng, 2017. 'Potential role of CXCL10/CXCR3 signaling in the development of morphine tolerance in periaqueductal gray. Neuropeptides, 65, pp. 120-127
- 'Hasan, Raquibul, 'Leeson-Payne, Alasdair T. S., 'Jaggar, Jonathan H., 'Zhang, Xuming, 2017. 'Calmodulin is responsible for Ca2+-dependent regulation of TRPA1 Channels. Scientific Reports, 7 (1)
- 'Zhang, Xuming, 2015. 'Molecular sensors and modulators of thermoreception. Channels, 9 (2), pp. 73-81
- 'Zhang, Xuming, 2015. 'Targeting TRP ion channels for itch relief. Naunyn-Schmiedeberg's Archives of Pharmacology, 388 (4), pp. 389-399
- 'Li, L., 'Hasan, R., 'Zhang, Xuming, 2014. 'The basal thermal sensitivity of the TRPV1 ion channel is determined by PKC II. Journal of Neuroscience, 34 (24), pp. 8246-8258
- 'Than, Jonathan Y -X. L., 'Li, Lin, 'Hasan, Raquibul, 'Zhang, Xuming, 2013. 'Excitation and modulation of TRPA1, TRPV1, and TRPM8 channel-expressing sensory neurons by the pruritogen chloroquine. Journal of Biological Chemistry, 288 (18), pp. 12818-12827
- 'Li, Lin, 'Zhang, Xuming, 2013. 'Differential inhibition of the TRPM8 ion channel by G?qand G?11. Channels, 7 (2), pp. 115-118
- 'Zhang, Xuming, 'Mak, Stephanie, 'Li, Lin, 'Parra, Andres, 'Denlinger, Bristol, 'Belmonte, Carlos, 'McNaughton, Peter A., 2012. 'Direct inhibition of the cold-activated TRPM8 ion channel by G?q. Nature Cell Biology, 14 (8), pp. 851-858
- 'Fan, Hueng-Chuen, 'Zhang, Xuming, 'McNaughton, Peter A., 2009. 'Activation of the TRPV4 ion channel Is enhanced by phosphorylation. Journal of Biological Chemistry, 284 (41), pp. 27884-27891
- 'Zhang, Xuming, 'Li, Lin, 'McNaughton, Peter A., 2008. 'Proinflammatory mediators modulate the heat-activated ion channel TRPV1 via the scaffolding protein AKAP79/150. Neuron, 59 (3), pp. 450-461
- 'Zhang, Xuming, 'Huang, Jiehong, 'McNaughton, Peter A., 2005. 'NGF rapidly increases membrane expression of TRPV1 heat-gated ion channels. The EMBO Journal, 24 (24), pp. 4211-4223