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Autophagy in health and disease

Lab web page: https://nezislab.wordpress.com

Autophagy is an evolutionarily conserved catabolic process that involves the degradation of cytoplasmic material through the lysosomal pathway. It is a cellular response in nutrient starvation but it is also responsible for the removal of aggregated proteins, damaged organelles and developmental remodeling. Dysfunction in autophagy has been implicated in an increasing number of diseases from bacterial and viral infections to cancer and more recently in neurodegeneration and other ageing-related diseases. Although it was initially believed that autophagy occurs randomly inside the cell, during the last years there is growing evidence that sequestration and degradation of cytoplasmic material by autophagy can be selective through receptor and adaptor proteins. We are using mammalian cells in vitro and the fruit fly Drosophila melanogaster, as a genetically modifiable model organism to investigate the mechanisms of autophagy and selective autophagy in the context of the physiology of the cell, the system and the living organism. We are particularly interested to study selective autophagy in the context of neurodegeneration, ageing, obesity, infections and tumorigenesis.

 

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Autophagy journal interview October 2013

As a member of the Autophagy research community, Ioannis Nezis was interviewed by the Autophagy Journal. To find out why Ioannis studies this topic and where he thinks the field is heading read his journal interview (PDF Document)

 

Nezis group 2014

Group Members:

Dr Ioannis P Nezis, Group leader, Principal Investigator

Dr Anne-Claire Jacomin, Post-doc

Dr Stavroula Petridi, Post-doc

Bhavini Patel, PhD student

Panos Tsapras, PhD student

Marisa Di Monaco, PhD student

Laura Prisco, Master student

Joseph Davies, Master student

From left Nitha, Radu, Ioannis, Anne-Claire

 

 

Former members:

Radu Tusco, PhD student

Zunoon Hussain, Master student

Nitha Charles Mulakkal, PhD student (now Scientist at Immunocore, Oxford)

Richard Osgood, URSS summer student (now PhD student at University of Sussex)

Emma Powell, Master student (now PhD student at Francis Crick Institute)

Anthimi Palara, Erasmus student (now PhD student at University of Tromso, Norway)

Ilias Dervenagas, Erasmus student

Rachel Barton, Wellcome Trust summer student (now PhD student at Imperial College London)

Koorosh Fatemian, Master student (now PhD student at University of Warwick)

Bonita Chung, Master student

Shifquat Ullah, Master student

Funding

BBSRC

Leverhulme Trust

Wellcome Trust

University of Warwick

Web links

Ioannis Nezis comments on 2016 Nobel Prize for Medicine

New book on 'Oogenesis' edited by Ioannis Nezis recently published

iLIR database press release

iLIR database

Citations Google Scholar

Researchgate profile

ResearcherID

First UK Autophagy Network Meeting

AutophagyUK

Warwick-Monash Alliance funds Autophagy Workshop

Autophagy research collaboration seeks answers to cell mystery