A full list of publications can be found at the NCBILink opens in a new window

ORIGINAL RESEARCH

More L, Privitera L, Lopes M, Arthur JSC, Lauterborn JC, Correa SAL, Frenguelli BG. MSK1 is required for the experience- and ampakine-dependent enhancement of spatial reference memory and reversal learning and for the induction of Arc and BDNF. Neuropharmacology 261, 110110 (2024).

More L, Privitera L, Cooper DD, Tsogka M, Arthur JSC, Frenguelli BG. MSK1 is required for the beneficial synaptic and cognitive effects of enriched experience across the lifespan. Aging (Albany NY) 15, 6031-6072 (2023).

Haley M, Bertrand J, Anderson VT, Fuad M, Frenguelli BG, Correa SAL, Wall MJ. Arc expression regulates long-term potentiation magnitude and metaplasticity in area CA1 of the hippocampus in ArcKR mice. Eur J Neurosci 58, 4166-4180 (2023).

Gessner P, Lum J, Frenguelli BG. The mammalian purine salvage pathway as an exploitable route for cerebral bioenergetic support after brain injury. Neuropharmacology 224, 109370 (2023).

Garcia-Durillo M, Frenguelli BG. Antagonism of P2X7 receptors enhances lorazepam action in delaying seizure onset in an in vitro model of status epilepticus. Neuropharmacology 239, 109647 (2023).

Wall MJ, et al. Selective activation of Gαob by an adenosine A1 receptor agonist elicits analgesia without cardiorespiratory depression. Nature Communications, 2020.2004.2004.023945 (2022).

More L, Privitera L, Perrett P, Cooper DD, Bonnello MVG, Arthur JSC, Frenguelli BG. CREB serine 133 is necessary for spatial cognitive flexibility and long-term potentiation. Neuropharmacology 219, 109237 (2022).

Olateju OI, More L, Arthur JSC, Frenguelli BG. Mitogen and Stress-activated Protein Kinase 1 Negatively Regulates Hippocampal Neurogenesis. Neuroscience 452, 228-234 (2021).

Deganutti G, et al. Deciphering the Agonist Binding Mechanism to the Adenosine A1 Receptor. ACS Pharmacol Transl Sci 4, 314-326 (2021).

Watkins JC, et al. 21st century excitatory amino acid research: A Q & A with Jeff Watkins and Dick Evans. Neuropharmacology 198, 108743 (2021).

Chen B, et al. Artificial Synapse: Spatiotemporal Heterogeneities in Dopamine Electrochemistry at a Carbon Fiber Ultramicroelectrode. ACS Meas Sci Au 1, 6-10 (2021).

Privitera L, et al. Experience Recruits MSK1 to Expand the Dynamic Range of Synapses and Enhance Cognition. J Neurosci 40, 4644-4660 (2020).

Lalo U, Bogdanov A, Moss GW, Frenguelli BG, Pankratov Y. Role for astroglia-derived BDNF and MSK1 in homeostatic synaptic plasticity. Neuroglia 1, 14 (2018).

Hall J, Frenguelli BG. The combination of ribose and adenine promotes adenosine release and attenuates the intensity and frequency of epileptiform activity in hippocampal slices: Evidence for the rapid depletion of cellular ATP during electrographic seizures. J Neurochem 147, 178-189 (2018).

Perry D, Page A, Chen B, Frenguelli BG, Unwin PR. Differential-Concentration Scanning Ion Conductance Microscopy. Anal Chem 89, 12458-12465 (2017).

Hunter CJ, et al. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS Open Bio 7, 821-834 (2017).

Galasso A, Cameron CS, Frenguelli BG, Moffat KG. An AMPK-dependent regulatory pathway in tau-mediated toxicity. Biol Open 6, 1434-1444 (2017).

Faller KME, Leach J, Johnston P, Holmes WM, Macrae IM, Frenguelli BG. Proof of concept and feasibility studies examining the influence of combination ribose, adenine and allopurinol treatment on stroke outcome in the rat. Brain Neurosci Adv 1, 2398212817717112 (2017).

Faller, K. M., Leach, J., Johnston, P., Holmes, W. M., Macrae, I. M. & Frenguelli, B. G. Proof of concept and feasibility studies examining the influence of combination ribose, adenine and allopurinol treatment on stroke outcome in the rat. Brain and Neuroscience Advances, In Press (2017).

Hunter, C. J., Remenyi, J., Correa, S. A., Privitera, L., Reyskens, K., Martin, K. J., Toth, R., Frenguelli, B. G. & Arthur, J. S. C. MSK1 regulates transcriptional induction of Arc/Arg3.1 in response to neurotrophins. FEBS Open Bio, 7 821-834 (2017).

Daumas, S., Hunter, C. J., Mistry, R. B., More, L., Privitera, L., Cooper, D. D., Reyskens, K. M., Flynn, H. T., Morris, R. G., Arthur, J. S. & Frenguelli, B. G. The kinase function of MSK1 regulates BDNF signaling to CREB and basal synaptic transmission, but is not required for hippocampal long-term potentiation or spatial memory. eNeuro, 4 (2017).

Galasso, A., Cameron, C. S., Frenguelli, B. G. & Moffat, K. G. An AMPK-dependent regulatory pathway in tau-mediated toxicity. Biol Open, (2017).

Perry, D., Paulose Nadappuram, B., Momotenko, D., Voyias, P. D., Page, A., Tripathi, G., Frenguelli, B. G. & Unwin, P. R. Surface charge visualization at viable living cells. J Am Chem Soc, 138 3152-3160 (2016).

Page, A., Perry, D., Young, P., Mitchell, D., Frenguelli, B. G. & Unwin, P. R. Fast nanoscale surface charge mapping with pulsed-potential scanning ion conductance microscopy. Anal Chem, 88 10854-10859 (2016).

Knight, A., Hemmings, J. L., Winfield, I., Leuenberger, M., Frattini, E., Frenguelli, B. G., Dowell, S. J., Lochner, M. & Ladds, G. Discovery of novel adenosine receptor agonists that exhibit subtype selectivity. J Med Chem, 59 947-964 (2016).

Lopatar, J., Dale, N. & Frenguelli, B. G. Pannexin-1-mediated ATP release from area CA3 drives mGlu5-dependent neuronal oscillations. Neuropharmacology, 93 219-228 (2015).

zur Nedden, S., Doney, A. S. & Frenguelli, B. G. Modulation of intracellular ATP determines adenosine release and functional outcome in response to metabolic stress in rat hippocampal slices and cerebellar granule cells. J Neurochem, 128 111-124 (2014).

Diogenes, M. J., Neves-Tome, R., Fucile, S., Martinello, K., Scianni, M., Theofilas, P., Lopatar, J., Ribeiro, J. A., Maggi, L., Frenguelli, B. G., Limatola, C., Boison, D. & Sebastiao, A. M. Homeostatic control of synaptic activity by endogenous adenosine is mediated by adenosine kinase. Cereb Cortex, 24 67-80 (2014).

Eleanor Q. Blatherwick, Camilla I. Svensson, Bruno G. Frenguelli and James H. Scrivens (2013) 'Localisation of adenine nucleotides in heat-stabilised mouse brains using ion mobility enabled MALDI imaging', International Journal Of Mass Spectroscopy 345–347, 19–27.

Remenyi J, van den Bosch MW, Palygin O, Mistry RB, McKenzie C, Macdonald A, Hutvagner G, Arthur JS, Frenguelli BG, Pankratov Y. (2013) miR-132/212 knockout mice reveal roles for these miRNAs in regulating cortical synaptic transmission and plasticity. PLoS One. 8(4):e62509.

Correa S; Hunter C; Palygin O; Wauters S; martin KJ; McKenzie C; McKelvery K; Morris RGM; Pankratov Y; Arthur S; Frenguelli BG (2012) 'MSK1 regulates homeostatic and experience-dependent synaptic plasticity' Journal of Neuroscience 32 (38), 13039 - 13051.

Nuritova F; Frenguelli BG (2012) 'Putative depolarisation-induced retrograde signalling accelerates the repeated hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus via group I metabotropic glutamate receptors' Neuroscience 222 159 - 172.

Dale N. and Frenguelli B.G (2012) 'Measurement of purine release with microelectrode biosensors' Purinergic Signalling 8 (supp. 1) 27 - 40.

zur Nedden, S., et al. (2011) 'Intracellular ATP influences synaptic plasticity in area CA1 of rat hippocampus via metabolism to adenosine and activity-dependent activation of adenosine A1 receptors', Journal of Neuroscience, 31 (16), 6221 - 6234.

Lopatar, J., Dale, N. and Frenguelli, B. G. (2011) 'Minor contribution of ATP P2 receptors to electrically-evoked electrographic seizure activity in hippocampal slices : evidence from purine biosensors and P2 receptor agonists and antagonists' Neuropharmacology 61 25 - 34.

Baines, A. E., Correa, S. A. L., Irving, A. J. and Frenguelli, B. G. (2011) 'Differential trafficking of adenosine receptors in hippocampal neurons monitored using GFP- and super-ecliptic pHluorin-tagged receptors' Neuropharmacology 61 1 - 11.

Redondo,R.L., Okuno,H., Spooner,P.A., Frenguelli,B.G., Bito,H. & Morris,R.G. (2010) Synaptic tagging and capture: differential role of distinct calcium/calmodulin kinases in protein synthesis-dependent long-term potentiation. J.Neurosci., 30, 4981-4989.

Dulla,C.G., Frenguelli,B.G., Staley,K.J. & Masino,S.A. (2009) Intracellular acidification causes adenosine release during States of hyperexcitability in the hippocampus. J.Neurophysiol., 102, 1984-1993.

Dale,N. & Frenguelli,B.G. (2009) Release of adenosine and ATP during ischemia and epilepsy. Current Neuropharmacology, 160-179.

zur Nedden,S., Eason,R., Doney,A.S. & Frenguelli,B.G. (2009) An ion-pair reversed-phase HPLC method for determination of fresh tissue adenine nucleotides avoiding freeze-thaw degradation of ATP. Analytical Biochemistry, 388, 108-114.

Etherington,L.A., Patterson,G.E., Meechan,L., Boison,D., Irving,A.J., Dale,N. & Frenguelli,B.G. (2009) Astrocytic adenosine kinase regulates basal synaptic adenosine levels and seizure activity but not activity-dependent adenosine release in the hippocampus. Neuropharmacol., 56, 429-437.

Wall,M.J., Wigmore,G., Lopatar,J., Frenguelli,B.G. & Dale,N. (2008) The novel NTPDase inhibitor sodium polyoxotungstate (POM-1) inhibits ATP breakdown but also blocks central synaptic transmission, an action independent of NTPDase inhibition. Neuropharmacol., 55, 1251-1258.

Frenguelli,B.G. (2008) Special issue on cerebral ischemia. Foreword. Neuropharmacol., 55, 249.

Hardie,D.G. & Frenguelli,B.G. (2007) A neural protection racket: AMPK and the GABA(B) receptor. Neuron, 53, 159-162.

Greenwood,S.M., Mizielinska,S.M., Frenguelli,B.G., Harvey,J. & Connolly,C.N. (2007) Mitochondrial dysfunction and dendritic beading during neuronal toxicity. J.Biol.Chem., 282, 26235-26244.

Youssef,F.F., Hormuzdi,S.G., Irving,A.J. & Frenguelli,B.G. (2007) Cannabinoid modulation of neuronal function after oxygen/glucose deprivation in area CA1 of the rat hippocampus. Neuropharmacol., 52, 1327-1335.

Frenguelli,B.G., Wigmore,G., Llaudet,E. & Dale,N. (2007) Temporal and mechanistic dissociation of ATP and adenosine release during ischemia in the mammalian hippocampus. J.Neurochem., 101, 1400-1413.

O'carroll,C.M., Martin,S.J., Sandin,J., Frenguelli,B. & Morris,R.G. (2006) Dopaminergic modulation of the persistence of one-trial hippocampus-dependent memory. Learn.Mem., 13, 760-769.

Pearson,T., Damian,K., Lynas,R. & Frenguelli,B.G. (2006) Sustained elevation of extracellular adenosine and activation of A1 receptors underlie the post-ischaemic inhibition of neuronal function in rat hippocampus in vitro. J.Neurochem., 97, 1357-1368.

Avignone,E., Frenguelli,B.G. & Irving,A.J. (2005) Differential responses to NMDA receptor activation in rat hippocampal interneurons and pyramidal cells may underlie enhanced pyramidal cell vulnerability. Eur.J.Neurosci., 22, 3077-3090.

Hawley,S.A., Pan,D.A., Mustard,K.J., Ross,L., Bain,J., Edelman,A.M., Frenguelli,B.G. & Hardie,D.G. (2005) Calmodulin-dependent protein kinase kinase-b is an alternative upstream kinase for AMP-activated protein kinase. Cell Metabolism, 2, 9-19.

Dulla,C., Dobelis,P., Pearson,T., Frenguelli,B.G., Staley,K.J. & Masino,S.A. (2005) Adenosine and ATP link PCO2 to cortical excitability via pH. Neuron, 48, 1011-1023.

Pearson,T. & Frenguelli,B.G. (2004) Adrenoceptor subtype-specific acceleration of the hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus. Eur.J.Neurosci., 20, 1555-1565.

Etherington,L.A. & Frenguelli,B.G. (2004) Endogenous adenosine modulates epileptiform activity in rat hippocampus in a receptor subtype-dependent manner. Eur.J.Neurosci., 19, 2539-2550.

Gadalla,A.E., Pearson,T., Currie,A.J., Dale,N., Hawley,S.A., Sheehan,M., Hirst,W., Michel,A.D., Randall,A., Hardie,D.G. & Frenguelli,B.G. (2004) AICA riboside both activates AMP-activated protein kinase and competes with adenosine for the nucleoside transporter in the CA1 region of the rat hippocampus. J.Neurochem., 88, 1272-1282.

Harney,S.C., Frenguelli,B.G. & Lambert,J.J. (2003) Phosphorylation influences neurosteroid modulation of synaptic GABAA receptors in rat CA1 and dentate gyrus neurones. Neuropharmacol., 45, 873-883.

Pearson,T., Currie,A.J., Etherington,L.A., Gadalla,A.E., Damian,K., Llaudet,E., Dale,N. & Frenguelli,B.G. (2003) Plasticity of purine release during cerebral ischemia: clinical implications? J.Cell Mol.Med., 7, 362-375.

Frenguelli,B.G., Llaudet,E. & Dale,N. (2003) High-resolution real-time recording with microelectrode biosensors reveals novel aspects of adenosine release during hypoxia in rat hippocampal slices. J.Neurochem., 86, 1506-1515.

Kalikulov,D., Ayar,A., Nuritova,F., Frenguelli,B.G., McClelland,D., Martin,D.J., Davidson,I. & Scott,R.H. (2001) Venom from Anemesia species of spider modulates high voltage-activated Ca(2+) currents from rat cultured sensory neurones and excitatory post synaptic currents from rat hippocampal slices. Cell Calcium, 30, 212-221.

Lambert,J.J., Belelli,D., Harney,S.C., Peters,J.A. & Frenguelli,B.G. (2001) Modulation of native and recombinant GABA(A) receptors by endogenous and synthetic neuroactive steroids. Brain Res.Brain Res.Rev., 37, 68-80.

Ward,M.W., Rego,A.C., Frenguelli,B.G. & Nicholls,D.G. (2000) Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. J.Neurosci., 20, 7208-7219.

Pearson,T., Nuritova,F., Caldwell,D., Dale,N. & Frenguelli,B.G. (2001) A depletable pool of adenosine in area CA1 of the rat hippocampus. J.Neurosci., 21, 2298-2307.

Pearson,T. & Frenguelli,B.G. (2000) Volume-regulated anion channels do not contribute extracellular adenosine during the hypoxic depression of excitatory synaptic transmission in area CA1 of rat hippocampus. Eur.J.Neurosci., 12, 3064-3066.

Dale,N., Pearson,T. & Frenguelli,B.G. (2000) Direct measurement of adenosine release during hypoxia in the CA1 region of the rat hippocampal slice. J.Physiol., 526, 143-155.

Frenguelli,B.G. (1997) The effects of metabolic stress on glutamate receptor-mediated depolarisations in the in vitro rat hippocampal slice. Neuropharmacol., 36, 981-991.

Frenguelli,B.G. & Malinow,R. (1996) Fluctuations in intracellular calcium responses to action potentials in single en passage presynaptic boutons of layer V neurons in neocortical slices. Learning & Memory, 3, 150-159.

Frenguelli,B.G., Irving,A.J. & Collingridge,G.L. (1996) Ca2+ stores and hippocampal synaptic plasticity. Sem.Neurosci., 8, 301-309.

Chapman,P.F., Frenguelli,B.G., Smith,A., Chen,C.-M. & Silva,A.J. (1995) The a-Ca2+/calmodulin kinase II: A bidirectional modulator of presynaptic plasticity. Neuron, 14, 591-597.

Bourtchuladze,R., Frenguelli,B.G., Blendy,J., Cioffi,D., Schutz,G. & Silva,A.J. (1994) Deficient long-term memory in mice with a targeted mutation of the cAMP-responsive element-binding protein. Cell, 79, 59-68.

Frenguelli,B.G., Potier,B., Slater,N.T., Alford,S. & Collingridge,G.L. (1993) Metabotropic glutamate receptors and calcium signalling in dendrites of hippocampal CA1 neurones. Neuropharmacol., 32, 1229-1237.

Alford,S., Frenguelli,B.G., Schofield,J.G. & Collingridge,G.L. (1993) Characterisation of Ca2+ signals induced in hippocampal CA1 neurones by the synaptic activation of NMDA receptors. J.Physiol., 469, 693-716.

Frenguelli,B.G., Blake,J.F., Brown,M.W. & Collingridge,G.L. (1991) Electrogenic uptake contributes a major component of the depolarizing action of L-glutamate in rat hippocampal slices. Br.J.Pharmacol., 102, 355-362.

REVIEWS:

Cooper DD, Frenguelli BG. The influence of sensory experience on the glutamatergic synapse. Neuropharmacology 193, 108620 (2021).

Frenguelli BG, Dale N. Purines: From Diagnostic Biomarkers to Therapeutic Agents in Brain Injury. Neurosci Bull 36, 1315-1326 (2020).

Frenguelli BG. The Purine Salvage Pathway and the Restoration of Cerebral ATP: Implications for Brain Slice Physiology and Brain Injury. Neurochem Res 44, 661-675 (2019).

Frenguelli, B. G. & Wall, M. J. Combined electrophysiological and biosensor approaches to study purinergic regulation of epileptiform activity in cortical tissue. J Neurosci Methods, 260 202-214 (2016).

Lidster, K., Jefferys, J. G., Blumcke, I., Crunelli, V., Flecknell, P., Frenguelli, B. G., Gray, W. P., Kaminski, R., Pitkanen, A., Ragan, I., Shah, M., Simonato, M., Trevelyan, A., Volk, H., Walker, M., Yates, N. & Prescott, M. J. Opportunities for improving animal welfare in rodent models of epilepsy and seizures. J Neurosci Methods, 260 2-25 (2016).

Dale, N. & Frenguelli, B. G. Measurement of purine release with microelectrode biosensors. Purinergic Signal, 8 27-40 (2012).

Dale, N. & Frenguelli, B. G. Release of adenosine and ATP during ischemia and epilepsy. Curr Neuropharmacol, 7 160-179 (2009).

Pearson, T., Currie, A. J., Etherington, L. A., Gadalla, A. E., Damian, K., Llaudet, E., Dale, N. & Frenguelli, B. G. Plasticity of purine release during cerebral ischemia: clinical implications? J Cell Mol Med, 7 362-375 (2003).

Lambert, J. J., Belelli, D., Harney, S. C., Peters, J. A. & Frenguelli, B. G. Modulation of native and recombinant GABAA receptors by endogenous and synthetic neuroactive steroids. Brain Res Brain Res Rev, 37 68-80 (2001).

EDITORIALS:

Frenguelli BG. The glutamatergic synapse - A key hub in neuronal metabolism, signalling and plasticity. Neuropharmacology 207, 108945 (2022).

Heal DJ, Henningfield J, Frenguelli BG, Nutt DJ, Smith SL. Psychedelics - Re-opening the doors of perception. Neuropharmacology 142, 1-6 (2018).

Collingridge, G. L., Lodge, D., Mayer, M., Turrigiano, G. & Frenguelli, B. G. Ionotropic glutamate receptors: Still exciting after all these years. Neuropharmacology, 112 1-3 (2017).

Frenguelli, B. G. Glutamate receptor-dependent synaptic plasticity. Neuropharmacology, 74 1 (2013).

Frenguelli, B. G. Cognitive enhancers: molecules, mechanisms and minds. Neuropharmacology, 64 1 (2013).

Frenguelli, B. G. Purinergic signalling between neurones and glia: For those about to rock. Semin Cell Dev Biol, 22 193 (2011).

Frenguelli, B. G. Special Issue on cerebral ischemia. Foreword. Neuropharmacology, 55 249 (2008).

Hardie, D. G. & Frenguelli, B. G. A neural protection racket: AMPK and the GABAB receptor. Neuron, 53 159-162 (2007).

RECENT BOOK CHAPTERS:

zur Nedden, S., Doney, A. S. & Frenguelli, B. G. The double edged sword: gaining adenosine at the expense of ATP. How to balance the books. in Adenosine:A Key Link Between Metabolism and Central Nervous System Activity (eds S.A. Masino & D. Boison) Springer (2012).

Frenguelli, B. G. & Corrêa, S. A. Regulation and role of MSK in the mammalian brain in MSKs (eds L. Vermeulen & J.S. Arthur) Landes Bioscience (2012).