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To better understand vector-host interactions, and to replace HLC methods, we developed novel immunoassays to quantify demographic patterns in human IgG and IgM anti-saliva antibody to vector saliva as an indicator of vector biting rates. Data collected in Ghana where transmission persists despite years of mass drug administration (MDA), show that Ig responses declined with increasing age, more so in males than in females, suggesting immunotolerance and desensitization with persistent or cumulative exposure. Fitting these data to dynamic mathematical models incorporating antibody acquisition and decay processes have greatly improved our epidemiological understanding.