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Publications

‡ denotes EF as corresponding author

For Citation data, see Google Scholar

2016

24‡. "Structural and functional analysis of the solute-binding protein UspC from Mycobacterium tuberculosis that is specific for amino sugars: Fullam E*, Prokes, I, Futterer K, Besra GS Open Biology 2016 6:160105

23. "Discrimination between bacterial species by ratiometric analysis of their carbohydrate binding profile." Otten L, Fullam E, Gibson MI Mol. BioSyst. 2016 - Hot article

2015

22‡. "Deuterated Carbohydrate Probes as ‘Label-Free’ Substrates for Probing Nutrient Uptake in Mycobacteria by Nuclear Reaction Analysis" Lowery R, Gibson MI, Thomspon R, Fullam E* Chem Commun 2015 - Emerging Investigators Issue

2014

21. "Exploration of piperidinols as potential antitubercular agents" Abuhammed A, Fullam E, Bhakta S, Russell AJ, Finn PW, Sim E Molecules 2014 19(10):16274-90

20‡. "Selective detection of epimeric pentose saccharides at physiological pH using a fluorescent receptor" Gibson MI, Neres J, Fullam E* Carbohydr Res 2014 391:61-65

19. "Discrimination between bacterial phenotypes using glyco-nanoparticles and the impact of polymer coating on detection readouts" Richards SJ, Fullam E, Besra GS, Gibson MI J. Mater. Chem. B. 2014 2: 1490-98

2013

18. “Gold Nanoparticle-Linked Analysis of Carbohydrate-Protein Interactions, and Polymeric Inhibitors, using Unlabelled Proteins; Easy Measurements Using a ‘Simple’ Digital Camera.” Otten L, Richards SJ, Fullam E, Besra GS, Gibson MI J. Mater. Chem. B 2013 1: 2665-2672

17‡. “Design, synthesis and structure-activity relationships of 3,5-diaryl-1H-pyrazoles as inhibitors of arylamine N-acetyltransferase” Fullam E*, Talbot J, Abuhammed A, Westwood IM, Davies SG, Russell AJ, Sim E Bioorg Med Chem Lett 2013 23(9): 2759-64

2012

16. “Piperidinols That Show Anti-Tubercular Activity as Inhibitors of Arylamine N-Acetyltransferase: An Essential Enzyme for Mycobacterial Survival Inside Macrophages” Abuhammad A, Fullam E, Lowe ED, Staunton D, Kawamura A, Westwood, IM, Bhakta S, Garner AC, Wilson DL, Seden PT, Davies SG, Russell AJ, Garman EF, Sim E PLoS ONE 2012 7(12): e52790

15. “Structural basis for benzothiazinone-mediated killing of Mycobacterium tuberculosis” Neres J, Pojer F, Molteni E, Chiarelli LR, Dhar N, Boy-Röttger S, Buroni S, Fullam E, Degiacomi G, Lucarelli AP, Read RJ, Zanoni G, Edmondson DE, De Rossi E, Rosalia Pasca M, McKinney JD, Dyson PJ, Riccardi G, Mattevi A, Cole ST, Binda C Science Translational Medicine 2012 4 (150):150ra121

14. “Structure and function of the transketolase from Mycobacterium tuberculosis and comparison with the human enzyme” Fullam E, Pojer F, Bergfors T, Jones TA, Cole ST Open Biology 2012 2(1): 110026

2011

13. “Analysis of β-amino alcohols as inhibitors of the potential anti-tubercular target N-acetyltransferase” Fullam E, Abuhammad A, Wilson DL, Anderton MC, Davies SG, Russell AJ, Sim E Bioorg Med Chem Lett 2011 21(4):1185-90

2010

12. “Probing the architecture of the Mycobacterium marinum arylamine N-acetyltransferase active site” Abuhammad AM, Lowe ED, Fullam E, Noble M, Garman EF, Sim E Protein and Cell 2010 1(4):384-392

11. “Identification of arylamine N-acetyltransferase inhibitors as an approach towards novel anti-tuberculars” Westwood I, Bhakta S, Russell AJ, Fullam E, Anderton MC, Kawamura A, Mulvaney AW, Vickers RJ, Bhowruth V, Besra GS, Lalvani A, Davies SG, Sim E Protein and Cell 2010 1(1):82-95

2009

10. “Comparison of the arylamine N-acetyltransferase from Mycobacterium marinum and Mycobacterium tuberculosis” Fullam E, Kawamura A, Wilkinson H, Abuhammad A, Westwood I, Sim E Protein J. 2009 28(6):281-93

9. “Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis” Makarov V, Manina G, Mikusova K, Möllmann U, Ryabova O, Saint-Joanis B, Dhar N, Pasca MR, Buroni S, Lucarelli AP, Milano A, De Rossi E, Belanova M, Bobovska A, Dianiskova P, Kordulakova J, Sala C, Fullam E, Schneider P, McKinney JD, Brodin P, Christophe T, Waddell S, Butcher P, Albrethsen J, Rosenkrands I, Brosch R, Nandi V, Bharath S, Gaonkar S, Shandil RK, Balasubramanian V, Balganesh T, Tyagi S, Grosset J, Riccardi G, Cole ST Science 2009 324(5928):801-4

8. “Temperature stability of proteins essential for the intracellular survival of Mycobacterium tuberculosis” Lack NA, Kawamura A, Fullam E, Laurieri N, Beard S, Russell AJ, Evangelopoulos D, Westwood I, Sim E Biochem J. 2009 418(2):369-78

2008

7. “Arylamine N-acetyltransferases: structural and functional implications of polymorphisms” Sim E, Lack N, Wang CJ, Long H, Westwood I, Fullam E, Kawamura A Toxicology 2008 254(3):170-83

6. “Arylamine N-acetyltransferases in mycobacteria” Sim E, Sandy J, Evangelopoulos D, Fullam E, Bhakta S, Westwood I, Krylova A, Lack N, Noble M Curr Drug Metab. 2008 9(6):510-9

5. “Divergence of cofactor recognition across evolution: coenzyme A binding in a prokaryotic arylamine N-acetyltransferase” Fullam E, Westwood IM, Anderton MC, Lowe ED, Sim E, Noble ME J Mol Biol. 2008 375(1):178-91

2007

4. “Arylamine N-acetyltransferases” Sim E, Westwood I, Fullam E Expert Opin Drug Metab Toxicol. 2007 3(2):169-84

2006

3. “Comparison of the Bis(ferrocenylethynyl)phenylmethylium Cation with Bis(ferrocenylethenyl)methylium Analogues” Arisandy C, Fullam E, Barlow S J. Organomet. Chem. 2006 691(15):3285-3292

2. Structure and function of arylamine N-acetyltransferases.” Westwood I, Kawamura A, Fullam E, Russell AJ, Sim E Curr. Top. Med. Chem. 2006 6(15):1641-54

2005

1. “Binding of the anti-tubercular drug isoniazid to the arylamine N-acetyltransferase protein from Mycobacterium smegmatis” Sandy J, Holton S, Fullam E, Sim E, Noble M Protein Sci. 2005 14(3):775-82

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